Afadin cooperates with Claudin-2 to promote breast cancer metastasis

scientific article published on 28 January 2019

Afadin cooperates with Claudin-2 to promote breast cancer metastasis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1101/GAD.319194.118
P932PMC publication ID6362814
P698PubMed publication ID30692208

P50authorIngrid HedenfalkQ55816354
Véronique OuelletQ76400070
P2093author name stringMatthew G Annis
Peter M Siegel
Hans-Georg Simon
Atilla Omeroglu
Siker Kimbung
Sébastien Tabariès
Logan A Walsh
Alexander McNulty
Brennan Lavoie
Maude Vinette
Mireille Dessureault
Yasmina Hachem
P2860cites workGenome engineering using the CRISPR-Cas9 systemQ22122027
Phosphorylation of claudin-3 at threonine 192 by cAMP-dependent protein kinase regulates tight junction barrier function in ovarian cancer cellsQ24302552
MED12 controls the response to multiple cancer drugs through regulation of TGF-β receptor signalingQ24304423
Afadin: A novel actin filament-binding protein with one PDZ domain localized at cadherin-based cell-to-cell adherens junctionQ24678766
Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudinsQ24682136
Identification of brain- and bone-specific breast cancer metastasis genesQ39900757
Phosphorylation of claudin-4 is required for tight junction formation in a human keratinocyte cell lineQ39940922
AF6/s-afadin is a dual residency protein and localizes to a novel subnuclear compartment.Q40225192
Differential expression of claudin-2 in normal human tissues and gastrointestinal carcinomasQ40343656
The transcription factors Slug and Snail act as repressors of Claudin-1 expression in epithelial cells.Q40360748
Claudins 2, 3, 4, and 5 in Paget's disease and breast carcinomaQ42472265
Increased expressions of claudin-1 and claudin-7 during the progression of cervical neoplasiaQ42476044
Involvement of the nectin-afadin complex in PDGF-induced cell survivalQ42812519
Localization of nectin-free afadin at the leading edge and its involvement in directional cell movement induced by platelet-derived growth factorQ42832490
Role of afadin in vascular endothelial growth factor- and sphingosine 1-phosphate-induced angiogenesisQ43088240
The expression of claudin-1, claudin-2, claudin-3, and claudin-4 in gastric cancer tissueQ43529684
CLDN6 enhances chemoresistance to ADM via AF-6/ERKs pathway in TNBC cell line MDAMB231.Q47380086
Down-regulation of claudin-2 in breast carcinomas is associated with advanced disease.Q53321282
Correlated break at PARK2/FRA6E and loss of AF-6/Afadin protein expression are associated with poor outcome in breast cancer.Q55042166
CLDN2 inhibits the metastasis of osteosarcoma cells via down-regulating the afadin/ERK signaling pathwayQ57813171
Prognostic significance of claudin expression changes in breast cancer with regional lymph node metastasisQ62091628
The cytoplasmic tails of claudins can influence tight junction barrier properties through effects on protein stabilityQ80561465
Selective up-regulation of claudin-1 and claudin-2 in colorectal cancerQ81520359
Claudin-3 and claudin-4 expression in ovarian epithelial cells enhances invasion and is associated with increased matrix metalloproteinase-2 activityQ95796280
Concomitant binding of Afadin to LGN and F-actin directs planar spindle orientationQ27703589
Osteoactivin promotes breast cancer metastasis to boneQ28254151
SUMOylation of claudin-2Q28269524
Enigma prevents Cbl-c-mediated ubiquitination and degradation of RETMEN2AQ28539113
Genes that mediate breast cancer metastasis to lungQ29547479
Epithelial barrier assembly requires coordinated activity of multiple domains of the tight junction protein ZO-1Q30009921
Involvement of the interaction of afadin with ZO-1 in the formation of tight junctions in Madin-Darby canine kidney cellsQ30157022
LMP4 regulates Tbx5 protein subcellular localization and activityQ30480448
LPP is a Src substrate required for invadopodia formation and efficient breast cancer lung metastasisQ30847518
Symplekin promotes tumorigenicity by up-regulating claudin-2 expressionQ33664419
Coordinated nuclear and synaptic shuttling of afadin promotes spine plasticity and histone modificationsQ33675888
Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancerQ33890758
Enigma negatively regulates p53 through MDM2 and promotes tumor cell survival in miceQ34360157
Structure and function of claudins.Q34585322
Loss of AF-6/afadin induces cell invasion, suppresses the formation of glandular structures and might be a predictive marker of resistance to chemotherapy in endometrial cancerQ35440276
Claudin-5 is involved in breast cancer cell motility through the N-WASP and ROCK signalling pathways.Q36202958
Claudin-2 promotes breast cancer liver metastasis by facilitating tumor cell interactions with hepatocytesQ36210944
Claudin-1 expression confers resistance to anoikis in colon cancer cells in a Src-dependent mannerQ36435764
Phosphorylation of claudin-2 on serine 208 promotes membrane retention and reduces trafficking to lysosomesQ36452928
The tumor cell-host organ interface in the early onset of metastatic organ colonisationQ37023821
Targeting tight junction proteins-significance for drug developmentQ37085094
Evolution of metastasis revealed by mutational landscapes of chemically induced skin cancersQ37392200
Tight junctions in cancer metastasisQ37825185
Afadin/AF-6 and canoe: roles in cell adhesion and beyondQ38088490
Claudin-2 is an independent negative prognostic factor in breast cancer and specifically predicts early liver recurrencesQ38394007
A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasionQ38715630
Loss of polarity protein AF6 promotes pancreatic cancer metastasis by inducing Snail expressionQ38870713
The role of claudins in cancer metastasisQ38927656
Nuclear distribution of claudin-2 increases cell proliferation in human lung adenocarcinoma cellsQ38987317
Disrupted interaction between CFTR and AF-6/afadin aggravates malignant phenotypes of colon cancerQ39039014
Loss of AF6/afadin, a marker of poor outcome in breast cancer, induces cell migration, invasiveness and tumor growth.Q39561464
Claudin-2 expression increases tumorigenicity of colon cancer cells: role of epidermal growth factor receptor activation.Q39579734
Claudin-2 is selectively enriched in and promotes the formation of breast cancer liver metastases through engagement of integrin complexes.Q39631925
Participation of the second extracellular loop of claudin-5 in paracellular tightening against ions, small and large moleculesQ39723716
P433issue3-4
P407language of work or nameEnglishQ1860
P921main subjectlung metastasisQ1877473
liver metastasisQ18967325
Claudin-2Q24720260
cancer metastasisQ120912394
P304page(s)180-193
P577publication date2019-01-28
P1433published inGenes & DevelopmentQ1524533
P1476titleAfadin cooperates with Claudin-2 to promote breast cancer metastasis
P478volume33

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cites work (P2860)
Q98778804Claudin-1 Is a Valuable Prognostic Biomarker in Colorectal Cancer: A Meta-Analysis
Q90521215Claudins: New Players in Human Fertility and Reproductive System Cancers
Q91823910Metastasis Organotropism: Redefining the Congenial Soil

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