RelB is required for Peyer's patch development: differential regulation of p52-RelB by lymphotoxin and TNF

scientific article

RelB is required for Peyer's patch development: differential regulation of p52-RelB by lymphotoxin and TNF is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/EMBOJ/CDG004
P932PMC publication ID140043
P698PubMed publication ID12505990
P5875ResearchGate publication ID10970038

P50authorFalk WeihQ128792570
P2093author name stringDebra S Weih
Vallabhapurapu Sivakumar
Z Buket Yilmaz
P2860cites workNF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100Q24290908
NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176Q24319941
Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaBQ24564927
Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cellsQ27860599
Phosphorylation meets ubiquitination: the control of NF-[kappa]B activityQ27860643
NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responsesQ27861101
The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signallingQ28139111
Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathwayQ28214369
Specific inhibition of RelB/p52 transcriptional activity by the C-terminal domain of p100Q28236909
Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infectionQ28509078
Role of TNF ligand and receptor family in the lymphoid organogenesis defined by gene targetingQ28510883
Distinct activities of p52/NF-kappa B required for proper secondary lymphoid organ microarchitecture: functions enhanced by Bcl-3Q28585330
Expression of relB is required for the development of thymic medulla and dendritic cellsQ28594949
CD40 regulates the processing of NF-kappaB2 p100 to p52Q28610678
Activators and target genes of Rel/NF-kappaB transcription factorsQ29547882
NF-kappaB in cancer: from innocent bystander to major culpritQ29614603
NF-kappaB at the crossroads of life and deathQ29619302
Development and maturation of secondary lymphoid tissues.Q33652498
Development of Peyer's patches, follicle-associated epithelium and M cell: lessons from immunodeficient and knockout miceQ33669584
Genetic approaches in mice to understand Rel/NF-kappaB and IkappaB function: transgenics and knockoutsQ33797150
Control of apoptosis by Rel/NF-kappaB transcription factorsQ33797163
NF-kappaB and the innate immune responseQ33840493
Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2.Q33854381
Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel familyQ34317095
Peyer's patch organogenesis is intact yet formation of B lymphocyte follicles is defective in peripheral lymphoid organs of mice deficient for tumor necrosis factor and its 55-kDa receptorQ36184139
Requirement for the NF-kappaB family member RelA in the development of secondary lymphoid organsQ36369876
Mice deficient in nuclear factor (NF)-kappa B/p52 present with defects in humoral responses, germinal center reactions, and splenic microarchitectureQ36400143
Nuclear factor (NF)-kappa B2 (p100/p52) is required for normal splenic microarchitecture and B cell-mediated immune responsesQ36400158
Gastric hyperplasia and increased proliferative responses of lymphocytes in mice lacking the COOH-terminal ankyrin domain of NF-kappaB2.Q38342766
The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathwaysQ40696432
NF-kappaB-inducing kinase is dispensable for activation of NF-kappaB in inflammatory settings but essential for lymphotoxin beta receptor activation of NF-kappaB in primary human fibroblastsQ40769837
RelB cellular regulation and transcriptional activity are regulated by p100.Q40771390
Two distinct mechanisms contribute to the constitutive activation of RelB in lymphoid cells.Q40793043
Activation of NF-kappa B in vivo is regulated by multiple phosphorylationsQ40793376
Differential interactions of Rel-NF-kappa B complexes with I kappa B alpha determine pools of constitutive and inducible NF-kappa B activityQ40793381
Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-kappa b-inducing kinaseQ40954925
Expanding the role of Peyer's patches in B-cell ontogeny.Q40999712
Lymphotoxin beta receptor triggering induces activation of the nuclear factor kappaB transcription factor in some cell typesQ41159609
RelB, a member of the Rel/NF-kappa B family of transcription factors.Q41384432
Genetic approaches to study Rel/NF-kappa B/I kappa B function in miceQ41595434
Expression of different Jun and Fos proteins during the G0-to-G1 transition in mouse fibroblasts: in vitro and in vivo associationsQ41685639
Essential role of nuclear factor (NF)-kappaB-inducing kinase and inhibitor of kappaB (IkappaB) kinase alpha in NF-kappaB activation through lymphotoxin beta receptor, but not through tumor necrosis factor receptor IQ42015911
Molecular basis for hematopoietic/mesenchymal interaction during initiation of Peyer's patch organogenesis.Q42076869
Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responsesQ42488424
Chronic inflammation and susceptibility to bacterial infections in mice lacking the polypeptide (p)105 precursor (NF-kappaB1) but expressing p50.Q42971521
p105 and p98 precursor proteins play an active role in NF-kappa B-mediated signal transductionQ46602560
Lymph node genesis is induced by signaling through the lymphotoxin beta receptorQ47713223
The lymphotoxin beta receptor controls organogenesis and affinity maturation in peripheral lymphoid tissuesQ47713235
Multifocal defects in immune responses in RelB-deficient mice.Q52525661
Defective lymphotoxin-beta receptor-induced NF-kappaB transcriptional activity in NIK-deficient mice.Q52542561
Abnormal organogenesis of Peyer's patches in mice deficient for NF-kappaB1, NF-kappaB2, and Bcl-3.Q52546319
BAFF-induced NEMO-independent processing of NF-kappa B2 in maturing B cells.Q53664665
Constitutive and inducible Rel/NF-kappa B activities in mouse thymus and spleenQ72744175
A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in miceQ72753495
Three distinctive steps in Peyer's patch formation of murine embryoQ73312318
Compartmentalization of Peyer's patch anlagen before lymphocyte entryQ73586921
Essential role of IL-7 receptor alpha in the formation of Peyer's patch anlageQ74261728
Essential role of RelB in germinal center and marginal zone formation and proper expression of homing chemokinesQ74321402
Inhibition of NF-kappaB in T cells blocks lymphoproliferation and partially rescues autoimmune disease in gld/gld miceQ74460546
Identification of multiple isolated lymphoid follicles on the antimesenteric wall of the mouse small intestineQ77373865
Transcription of the RelB gene is regulated by NF-kappaBQ77378999
IL-7 receptor alpha+ CD3(-) cells in the embryonic intestine induces the organizing center of Peyer's patchesQ77756301
Peyer's patch organogenesis as a programmed inflammation: a hypothetical modelQ77903801
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectTNFQ18032037
P304page(s)121-130
P577publication date2003-01-01
P1433published inThe EMBO JournalQ1278554
P1476titleRelB is required for Peyer's patch development: differential regulation of p52-RelB by lymphotoxin and TNF
P478volume22

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cites work (P2860)
Q47614119A TNF-p100 pathway subverts noncanonical NF-κB signaling in inflamed secondary lymphoid organs.
Q92293255A detrimental role of RelB in mature oligodendrocytes during experimental acute encephalomyelitis
Q51766948A new RelB-dependent CD117+ CD172a+ murine DC subset preferentially induces Th2 differentiation and supports airway hyperresponses in vivo.
Q36025311A role for the IkappaB family member Bcl-3 in the control of central immunologic tolerance
Q37811890A single NFκB system for both canonical and non-canonical signaling
Q36538837Abnormal lymphoid organ development in immunodeficient mutant mice.
Q33636652Accumulation of p100, a precursor of NF-κB2, enhances osteoblastic differentiation in vitro and bone formation in vivo in aly/aly mice.
Q24562579Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers
Q36254865Activation of NF-kappaB by HTLV-I and implications for cell transformation
Q38959978Activation of NF-κB by the Kaposi's sarcoma-associated herpesvirus K15 protein involves recruitment of the NF-κB-inducing kinase, IκB kinases, and phosphorylation of p65.
Q35319917Activation of alternative NF-kappa B pathway by human herpes virus 8-encoded Fas-associated death domain-like IL-1 beta-converting enzyme inhibitory protein (vFLIP).
Q33883378Allosteric regulation of the ubiquitin:NIK and ubiquitin:TRAF3 E3 ligases by the lymphotoxin-beta receptor
Q33965210Anatomical basis of tolerance and immunity to intestinal antigens
Q33581388B-cell CLL/lymphoma 10 (BCL10) is required for NF-kappaB production by both canonical and noncanonical pathways and for NF-kappaB-inducing kinase (NIK) phosphorylation
Q34677647Biallelic loss-of-function mutation in NIK causes a primary immunodeficiency with multifaceted aberrant lymphoid immunity.
Q92283518Biological characteristics of transcription factor RelB in different immune cell types: implications for the treatment of multiple sclerosis
Q34033430CD137 is required for M cell functional maturation but not lineage commitment
Q40211722Carbon dioxide-dependent regulation of NF-κB family members RelB and p100 gives molecular insight into CO2-dependent immune regulation.
Q42144467Celebrating 25 years of NF-κB research
Q36220879Cell signals influencing hepatic fibrosis
Q92263460Cholesterol restricts lymphotoxin β receptor-triggered NF-κB signaling
Q34514908Circuitry of nuclear factor kappaB signaling
Q40505444Classical and alternative NF-κB signaling cooperate in regulating adipocyte differentiation and function.
Q24685416Coordination between NF-kappaB family members p50 and p52 is essential for mediating LTbetaR signals in the development and organization of secondary lymphoid tissues
Q42799106Critical role of RelB serine 368 for dimerization and p100 stabilization
Q39734014Cross talk between stimulated NF-kappaB and the tumor suppressor p53.
Q37178526Crosstalk via the NF-kappaB signaling system
Q48232446Development of intestinal M cells and follicle-associated epithelium is regulated by TRAF6-mediated NF-κB signaling.
Q34764895Development of secondary lymphoid organs
Q33393459Differential RelA- and RelB-dependent gene transcription in LTbetaR-stimulated mouse embryonic fibroblasts
Q42944908Differential requirement for Rel/nuclear factor kappa B family members in natural killer T cell development
Q30498322Differential utilization of NF-kappaB RELA and RELB in response to extracellular versus intracellular polyIC stimulation in HT1080 cells
Q35216954Dissecting the role of lymphotoxin in lymphoid organs by conditional targeting
Q37075235Ectopic lymphoid tissues and local immunity
Q35121711Epstein-Barr virus latent infection membrane protein 1 TRAF-binding site induces NIK/IKK alpha-dependent noncanonical NF-kappaB activation
Q34789652Epstein-Barr virus latent membrane protein 1 activation of NF-kappaB through IRAK1 and TRAF6.
Q48046412Falk Herbert Weih (1959-2014).
Q34650781Frequent engagement of RelB activation is critical for cell survival in multiple myeloma
Q35815962Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology
Q37730952Functions of nuclear factor kappaB in bone
Q24641914Generation and activation of multiple dimeric transcription factors within the NF-kappaB signaling system
Q34654418HAX1 regulates E3 ubiquitin ligase activity of cIAPs by promoting their dimerization
Q60617037IGHV unmutated CLL B cells are more prone to spontaneous apoptosis and subject to environmental prosurvival signals than mutated CLL B cells
Q34384130IKK phosphorylates RelB to modulate its promoter specificity and promote fibroblast migration downstream of TNF receptors
Q36637874IkappaB kinase complexes: gateways to NF-kappaB activation and transcription
Q38814358Importance of the alternative NF-κB activation pathway in inflammation-associated gastrointestinal carcinogenesis.
Q33997736Interferon induces NF-kappa B-inducing kinase/tumor necrosis factor receptor-associated factor-dependent NF-kappa B activation to promote cell survival
Q61797502Intestinal non-canonical NFκB signaling shapes the local and systemic immune response
Q37603373Late-phase synthesis of IκBα insulates the TLR4-activated canonical NF-κB pathway from noncanonical NF-κB signaling in macrophages.
Q42123677Lipopolysaccharide-induced activation of NF-κB non-canonical pathway requires BCL10 serine 138 and NIK phosphorylations
Q34592567Loss of function of the mouse Sharpin gene results in Peyer's patch regression
Q40630236Lymphotoxin pathway directs thymic Aire expression
Q49795149Lymphotoxin β receptor-mediated NFκB signaling promotes glial lineage differentiation and inhibits neuronal lineage differentiation in mouse brain neural stem/progenitor cells
Q37000942Lymphotoxin-alpha 1 beta 2 and LIGHT induce classical and noncanonical NF-kappa B-dependent proinflammatory gene expression in vascular endothelial cells
Q37257195Lymphotoxin-β receptor signaling through NF-κB2-RelB pathway reprograms adipocyte precursors as lymph node stromal cells
Q91938983M Cells: Intelligent Engineering of Mucosal Immune Surveillance
Q40166610Mechanisms of genotype-phenotype correlation in autosomal dominant anhidrotic ectodermal dysplasia with immune deficiency
Q38068182Mesenchymal cell differentiation during lymph node organogenesis
Q34298341Modulating the intestinal immune system: the role of lymphotoxin and GALT organs
Q40625717Molecular Genetic Analysis of Human Herpes Virus 8-encoded Viral FLICE Inhibitory Protein-induced NF-κB Activation
Q33869955Mouse aorta smooth muscle cells differentiate into lymphoid tissue organizer-like cells on combined tumor necrosis factor receptor-1/lymphotoxin beta-receptor NF-kappaB signaling
Q28271031NF-kappaB and the immune response
Q28301261NF-kappaB and the regulation of hematopoiesis
Q37363042NF-kappaB p100 limits TNF-induced bone resorption in mice by a TRAF3-dependent mechanism
Q24656611NF-kappaB p52:RelB heterodimer recognizes two classes of kappaB sites with two distinct modes
Q41979732NF-κB in T-cell Acute Lymphoblastic Leukemia: Oncogenic Functions in Leukemic and in Microenvironmental Cells.
Q35348282NF-κB in immunobiology.
Q38025541NF-κB signaling pathways: role in nervous system physiology and pathology
Q35241505NFkappaB1/p50 is not required for tumor necrosis factor-stimulated growth of primary mammary epithelial cells: implications for NFkappaB2/p52 and RelB.
Q27024640Non-Canonical NF-κB Signaling Initiated by BAFF Influences B Cell Biology at Multiple Junctures
Q36635311Non-canonical NF-κB signalling and ETS1/2 cooperatively drive C250T mutant TERT promoter activation.
Q39161693Noncanonical NF-κB activation by the oncoprotein Tio occurs through a nonconserved TRAF3-binding motif
Q89011918Noncanonical NF-κB in Cancer
Q43142702Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling
Q24305527Notch3 and pre-TCR interaction unveils distinct NF-kappaB pathways in T-cell development and leukemia.
Q52311688Nuclear Factor-kappaB in Autoimmunity: Man and Mouse.
Q36209682Organizing a mucosal defense
Q35096187Organogenesis of lymphoid tissues
Q28593804Osteoclast differentiation is impaired in the absence of inhibitor of kappa B kinase alpha
Q26751459Post-Translational Modifications of RelB NF-κB Subunit and Associated Functions
Q35216951Regulation of secondary lymphoid organ development by the nuclear factor-kappaB signal transduction pathway
Q41879561Regulation of the polymeric immunoglobulin receptor by the classical and alternative NF-κB pathways in intestinal epithelial cells
Q46251286Rel/NF-kappaB family member RelA regulates NK1.1- to NK1.1+ transition as well as IL-15-induced expansion of NKT cells
Q34078586RelA repression of RelB activity induces selective gene activation downstream of TNF receptors
Q39952776RelB is differentially regulated by IkappaB Kinase-alpha in B cells and mouse lung by cigarette smoke
Q42444933RelB, together with RelA, sustains cell survival and confers proteasome inhibitor sensitivity of chronic lymphocytic leukemia cells from bone marrow
Q33348553RelB-dependent stromal cells promote T-cell leukemogenesis
Q57093168RelB/p50 Dimers Are Differentially Regulated by Tumor Necrosis Factor-α and Lymphotoxin-β Receptor Activation
Q34124144RelB/p52 NF-kappaB complexes rescue an early delay in mammary gland development in transgenic mice with targeted superrepressor IkappaB-alpha expression and promote carcinogenesis of the mammary gland
Q37238291RelB: an outlier in leukocyte biology
Q40568050Requirement of Hsp90 activity for IkappaB kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-kappaB activation.
Q28506895Rescue of TRAF3-null mice by p100 NF-kappa B deficiency
Q41445006Resistance of chemokine receptor 6-deficient mice to Yersinia enterocolitica infection: evidence of defective M-cell formation in vivo
Q33800318Roles of the NF-kappaB pathway in lymphocyte development and function
Q90506024STIM- and Orai-mediated calcium entry controls NF-κB activity and function in lymphocytes
Q35608607Stimulus-selective crosstalk via the NF-κB signaling system reinforces innate immune response to alleviate gut infection
Q41841106Stroma cell priming in enteric lymphoid organ morphogenesis
Q91711303Substrate complex competition is a regulatory motif that allows NFκB RelA to license but not amplify NFκB RelB
Q24297399TNAP, a novel repressor of NF-kappaB-inducing kinase, suppresses NF-kappaB activation
Q34533668TNF activates calcium-nuclear factor of activated T cells (NFAT)c1 signaling pathways in human macrophages
Q36885702TNF-α Modulation of Intestinal Tight Junction Permeability Is Mediated by NIK/IKK-α Axis Activation of the Canonical NF-κB Pathway.
Q37374579TNFR and LTbetaR agonists induce follicle-associated epithelium and M cell specific genes in rat and human intestinal epithelial cells.
Q37769438TRAF-mediated regulation of immune and inflammatory responses
Q31148506TWEAK induces NF-kappaB2 p100 processing and long lasting NF-kappaB activation.
Q38194552TWEAK-Fn14 Cytokine-Receptor Axis: A New Player of Myocardial Remodeling and Cardiac Failure
Q99594459Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study
Q40553944Tax-independent constitutive IkappaB kinase activation in adult T-cell leukemia cells
Q35126481The IkappaB kinase complex and NF-kappaB act as master regulators of lipopolysaccharide-induced gene expression and control subordinate activation of AP-1.
Q39350735The non-canonical NF-κB pathway in immunity and inflammation
Q34031207The noncanonical NF-κB pathway
Q35145632The role of lymphotoxin in development and maintenance of secondary lymphoid tissues
Q46667078Transcriptional repression by the HDAC4-RelB-p52 complex regulates multiple myeloma survival and growth
Q38862080Two specific drugs, BMS-345541 and purvalanol A induce apoptosis of HTLV-1 infected cells through inhibition of the NF-kappaB and cell cycle pathways
Q34331911Unique CD40-mediated biological program in B cell activation requires both type 1 and type 2 NF-kappaB activation pathways
Q36637897Unravelling the complexities of the NF-kappaB signalling pathway using mouse knockout and transgenic models.
Q35356927Visualization of the entire differentiation process of murine M cells: suppression of their maturation in cecal patches
Q39355760c-Rel is dispensable for the differentiation and functional maturation of M cells in the follicle-associated epithelium
Q27324491p100 Deficiency is insufficient for full activation of the alternative NF-κB pathway: TNF cooperates with p52-RelB in target gene transcription

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