Requirement for the NF-kappaB family member RelA in the development of secondary lymphoid organs

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Requirement for the NF-kappaB family member RelA in the development of secondary lymphoid organs is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1084/JEM.20011885
P932PMC publication ID2193608
P698PubMed publication ID11805150
P5875ResearchGate publication ID11554279

P50authorNir HacohenQ42799920
P2093author name stringRichard O Hynes
Paul D Rennert
David Baltimore
Elizabeth Alcamo
Leah C Schulte
P2860cites workRANK is essential for osteoclast and lymph node developmentQ24598872
Retinoid-related orphan receptor gamma (RORgamma) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesisQ24642725
Requirement for RORgamma in thymocyte survival and lymphoid organ developmentQ28139666
Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient miceQ28140546
Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathwayQ28214369
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NF-kappa B RelA-deficient lymphocytes: normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responsesQ28505819
Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxinQ28507630
Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κBQ28508403
Lymphotoxin-alpha-deficient mice. Effects on secondary lymphoid organ development and humoral immune responsivenessQ28510392
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Abnormal development of secondary lymphoid tissues in lymphotoxin beta-deficient miceQ28587099
Distinct roles in lymphoid organogenesis for lymphotoxins alpha and beta revealed in lymphotoxin beta-deficient miceQ28587819
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesisQ28589430
Involvement of distinct cellular compartments in the abnormal lymphoid organogenesis in lymphotoxin-alpha-deficient mice and alymphoplasia (aly) mice defined by the chimeric analysisQ28589889
Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune reQ28594116
Expression of relB is required for the development of thymic medulla and dendritic cellsQ28594949
Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseasesQ29547555
An essential role for NF-kappaB in preventing TNF-alpha-induced cell deathQ29614707
Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociationQ29615580
Characterization of the promoter for vascular cell adhesion molecule-1 (VCAM-1)Q30990350
Pro-inflammatory signaling: last pieces in the NF-kappaB puzzle?Q33368441
Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2.Q33854381
Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel familyQ34317095
Signaling through the lymphotoxin beta receptor induces the death of some adenocarcinoma tumor linesQ34381306
Induction of the gene encoding mucosal vascular addressin cell adhesion molecule 1 by tumor necrosis factor alpha is mediated by NF-kappa B proteinsQ34454872
Absence of tumor necrosis factor rescues RelA-deficient mice from embryonic lethalityQ35064315
The combined absence of the transcription factors Rel and RelA leads to multiple hemopoietic cell defectsQ35716042
Regulatory elements and transcription factors controlling basal and cytokine-induced expression of the gene encoding intercellular adhesion molecule 1.Q35927303
Lymphotoxins: from cytotoxicity to lymphoid organogenesisQ36034780
Peyer's patch organogenesis is intact yet formation of B lymphocyte follicles is defective in peripheral lymphoid organs of mice deficient for tumor necrosis factor and its 55-kDa receptorQ36184139
Chronic inflammation caused by lymphotoxin is lymphoid neogenesisQ36366337
Regulation of peripheral lymph node genesis by the tumor necrosis factor family member TRANCEQ36368551
Nuclear factor kappa B is required for the development of marginal zone B lymphocytesQ36376076
Lymphotoxin-alpha (LTalpha) supports development of splenic follicular structure that is required for IgG responsesQ36377326
On the key role of secondary lymphoid organs in antiviral immune responses studied in alymphoplastic (aly/aly) and spleenless (Hox11(-)/-) mutant mice.Q36377346
Distinct roles of lymphotoxin alpha and the type I tumor necrosis factor (TNF) receptor in the establishment of follicular dendritic cells from non-bone marrow-derived cellsQ36380985
Mice deficient in nuclear factor (NF)-kappa B/p52 present with defects in humoral responses, germinal center reactions, and splenic microarchitectureQ36400143
Nuclear factor (NF)-kappa B2 (p100/p52) is required for normal splenic microarchitecture and B cell-mediated immune responsesQ36400158
Disrupted splenic architecture, but normal lymph node development in mice expressing a soluble lymphotoxin-beta receptor-IgG1 fusion protein.Q36688075
A developmental switch in lymphocyte homing receptor and endothelial vascular addressin expression regulates lymphocyte homing and permits CD4+ CD3- cells to colonize lymph nodesQ37307203
Crucial role of tumor necrosis factor receptor 1 expression on nonhematopoietic cells for B cell localization within the splenic white pulpQ39526308
Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-kappa b-inducing kinaseQ40954925
Lymphotoxin beta receptor triggering induces activation of the nuclear factor kappaB transcription factor in some cell typesQ41159609
A set of inducible genes expressed by activated human monocytic and endothelial cells contain kappa B-like sites that specifically bind c-Rel-p65 heterodimers.Q41447943
Regulation of immune responses by NF-kappa B/Rel transcription factorQ41683917
Signal transduction through NF-kappa B.Q41724478
p50-NF-kappaB complexes partially compensate for the absence of RelB: severely increased pathology in p50(-/-)relB(-/-) double-knockout miceQ41954424
Essential role of nuclear factor (NF)-kappaB-inducing kinase and inhibitor of kappaB (IkappaB) kinase alpha in NF-kappaB activation through lymphotoxin beta receptor, but not through tumor necrosis factor receptor IQ42015911
Surface lymphotoxin alpha/beta complex is required for the development of peripheral lymphoid organsQ42196937
Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responsesQ42488424
Multiple immune abnormalities in tumor necrosis factor and lymphotoxin-alpha double-deficient miceQ42519120
Differentiation of follicular dendritic cells and full antibody responses require tumor necrosis factor receptor-1 signalingQ42573173
Mature follicular dendritic cell networks depend on expression of lymphotoxin beta receptor by radioresistant stromal cells and of lymphotoxin beta and tumor necrosis factor by B cellsQ42753323
Defective Peyer's patch organogenesis in mice lacking the 55-kD receptor for tumor necrosis factorQ42943618
Lymph node genesis is induced by signaling through the lymphotoxin beta receptorQ47713223
The lymphotoxin beta receptor controls organogenesis and affinity maturation in peripheral lymphoid tissuesQ47713235
Cytokine regulation of secondary lymphoid organ development.Q47933757
Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2.Q52192178
Cytotoxic activities of recombinant soluble murine lymphotoxin-alpha and lymphotoxin-alpha beta complexes.Q52559033
Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expressionQ62817899
The splenic marginal zone is absent in alymphoplastic aly mutant miceQ71011987
Role of lymphotoxin and the type I TNF receptor in the formation of germinal centersQ71095987
A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in miceQ72753495
Synergistic activation of intercellular adhesion molecule 1 (ICAM-1) by TNF-alpha and IFN-gamma is mediated by p65/p50 and p65/c-Rel and interferon-responsive factor Stat1 alpha (p91) that can be activated by both IFN-gamma and IFN-alphaQ72798753
Lack of type 2 T cell-independent B cell responses and defect in isotype switching in TNF-lymphotoxin alpha-deficient miceQ73082045
Three distinctive steps in Peyer's patch formation of murine embryoQ73312318
Failure of lymphopoiesis after adoptive transfer of NF-kappaB-deficient fetal liver cellsQ73479969
Developing lymph nodes collect CD4+CD3- LTbeta+ cells that can differentiate to APC, NK cells, and follicular cells but not T or B cellsQ73838320
Abnormal immune function of hemopoietic cells from alymphoplasia (aly) mice, a natural strain with mutant NF-kappa B-inducing kinaseQ73948741
Targeted mutation of TNF receptor I rescues the RelA-deficient mouse and reveals a critical role for NF-kappa B in leukocyte recruitmentQ74244267
Essential role of IL-7 receptor alpha in the formation of Peyer's patch anlageQ74261728
Transfer of primitive stem/progenitor bone marrow cells from LT alpha-/- donors to wild-type hosts: implications for the generation of architectural events in lymphoid B cell domainsQ77436789
IkappaB-NF-kappaB structures: at the interface of inflammation controlQ77726306
IL-7 receptor alpha+ CD3(-) cells in the embryonic intestine induces the organizing center of Peyer's patchesQ77756301
The p65 subunit of NF-kappa B is redundant with p50 during B cell proliferative responses, and is required for germline CH transcription and class switching to IgG3Q78109757
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectNF-κBQ411114
P304page(s)233-244
P577publication date2002-01-01
P1433published inJournal of Experimental MedicineQ3186912
P1476titleRequirement for the NF-kappaB family member RelA in the development of secondary lymphoid organs
P478volume195

Reverse relations

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