| scholarly article | Q13442814 |
| P50 | author | Harold E. Varmus | Q295691 |
| P2093 | author name string | L Xing | |
| A Chen | |||
| B F Boyce | |||
| P L Schwartzberg | |||
| L Garrett-Beal | |||
| A M Venegas | |||
| P2860 | cites work | Activation of Src family kinases by colony stimulating factor-1, and their association with its receptor | Q24308705 |
| RANK is essential for osteoclast and lymph node development | Q24598872 | ||
| pp60c-src activation in human colon carcinoma | Q24623701 | ||
| Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation | Q27734052 | ||
| Three-dimensional structure of the tyrosine kinase c-Src | Q27734749 | ||
| Crystal structure of the Src family tyrosine kinase Hck | Q27734750 | ||
| Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery | Q27860586 | ||
| TRANCE is a TNF family member that regulates dendritic cell and osteoclast function | Q28137948 | ||
| Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gbetagamma subunit-mediated activation of mitogen-activated protein kinases | Q41175767 | ||
| Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability | Q41714210 | ||
| Macrophage colony-stimulating factor stimulates survival and chemotactic behavior in isolated osteoclasts | Q41773356 | ||
| Osteoclasts express high levels of pp60c-src in association with intracellular membranes | Q41774224 | ||
| Translocation of pp60c-src from the plasma membrane to the cytosol after stimulation by platelet-derived growth factor. | Q42806500 | ||
| Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis | Q44956032 | ||
| Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-beta. | Q51005281 | ||
| Tyrosine phosphorylation of p130Cas is involved in actin organization in osteoclasts. | Q52530335 | ||
| Osteoblastic cells are involved in osteoclast formation. | Q54374668 | ||
| Bone and haematopoietic defects in mice lacking c-fos | Q58326969 | ||
| The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene | Q59092154 | ||
| Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow cultures | Q68274092 | ||
| Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo | Q71207806 | ||
| Use of an in vivo model to determine the effects of interleukin-1 on cells at different stages in the osteoclast lineage | Q72248104 | ||
| TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src | Q28142620 | ||
| The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor | Q28285539 | ||
| Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit | Q28508052 | ||
| TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling | Q28513445 | ||
| OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis | Q28589430 | ||
| Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: summation of both c-Src- and focal adhesion kinase-initiated tyrosine phosphorylation events | Q28609216 | ||
| Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice | Q29547898 | ||
| Cellular functions regulated by Src family kinases | Q29616038 | ||
| Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand | Q29619331 | ||
| SH2 and SH3 domains: from structure to function | Q29620259 | ||
| Regulation, substrates and functions of src | Q30014830 | ||
| c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism | Q30193362 | ||
| Association of the amino-terminal half of c-Src with focal adhesions alters their properties and is regulated by phosphorylation of tyrosine 527. | Q30194001 | ||
| Association of p60src with Triton X-100-resistant cellular structure correlates with morphological transformation | Q30450902 | ||
| Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouse | Q33646429 | ||
| Cell biology of the osteoclast | Q33700885 | ||
| The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption. | Q33823576 | ||
| Activating SRC mutation in a subset of advanced human colon cancers | Q34492512 | ||
| Activation of pp60c-src protein kinase activity in human colon carcinoma | Q34612607 | ||
| Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice | Q35194925 | ||
| Requirement for NF-kappaB in osteoclast and B-cell development | Q35199657 | ||
| Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in mice | Q35607627 | ||
| Osteopetrosis in Src-deficient mice is due to an autonomous defect of osteoclasts. | Q36301037 | ||
| TRANCE is necessary and sufficient for osteoblast-mediated activation of bone resorption in osteoclasts. | Q36404187 | ||
| The Src family tyrosine kinases are required for platelet-derived growth factor-mediated signal transduction in NIH 3T3 cells | Q36485178 | ||
| Association of p60c-src with endosomal membranes in mammalian fibroblasts | Q36533201 | ||
| Redistribution of activated pp60c-src to integrin-dependent cytoskeletal complexes in thrombin-stimulated platelets | Q36676794 | ||
| Requirement of phosphatidylinositol-3 kinase modification for its association with p60src | Q36688195 | ||
| RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism | Q37108966 | ||
| Colony-stimulating factor-1 induces cytoskeletal reorganization and c-src-dependent tyrosine phosphorylation of selected cellular proteins in rodent osteoclasts | Q37374745 | ||
| PYK2 in osteoclasts is an adhesion kinase, localized in the sealing zone, activated by ligation of alpha(v)beta3 integrin, and phosphorylated by src kinase | Q37384701 | ||
| Cell transformation by the viral src oncogene | Q38182098 | ||
| Genetics of src: structure and functional organization of a protein tyrosine kinase | Q38211750 | ||
| c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption. | Q38352423 | ||
| Osteopetrosis in mice lacking haematopoietic transcription factor PU.1. | Q41121255 | ||
| P433 | issue | 2 | |
| P304 | page(s) | 241-253 | |
| P577 | publication date | 2001-01-01 | |
| P1433 | published in | Genes & Development | Q1524533 |
| P1476 | title | Genetic evidence for a role for Src family kinases in TNF family receptor signaling and cell survival | |
| P478 | volume | 15 |
| Q35351495 | 5-Azacytidine-induced protein 2 (AZI2) regulates bone mass by fine-tuning osteoclast survival |
| Q28364534 | A Glanzmann's mutation in beta 3 integrin specifically impairs osteoclast function |
| Q33907394 | CFTR in a lipid raft-TNFR1 complex modulates gap junctional intercellular communication and IL-8 secretion. |
| Q35609713 | Cancer metastasis therapeutic targets and drug discovery: emerging small-molecule protein kinase inhibitors |
| Q35860261 | Evidence that the kinase-truncated c-Src regulates NF-κB signaling by targeting NEMO. |
| Q36532578 | Future anti-catabolic therapeutic targets in bone disease |
| Q34159764 | Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues |
| Q39138504 | HIV-1 Nef interacts with HCV Core, recruits TRAF2, TRAF5 and TRAF6, and stimulates HIV-1 replication in macrophages. |
| Q37590011 | Immunohistochemical expression of Src protein in peripheral and central giant cell granulomas of the jaws. |
| Q35989359 | Inhibition of cytokine signaling in human retinal endothelial cells through modification of caveolae/lipid rafts by docosahexaenoic acid |
| Q44591611 | M-CSF, TNFα and RANK ligand promote osteoclast survival by signaling through mTOR/S6 kinase |
| Q37146973 | Mechanisms of tooth eruption and orthodontic tooth movement |
| Q40663935 | Membrane rafts play a crucial role in receptor activator of nuclear factor kappaB signaling and osteoclast function |
| Q36532524 | Molecular mechanism of the life and death of the osteoclast |
| Q40686068 | PTEN regulates RANKL- and osteopontin-stimulated signal transduction during osteoclast differentiation and cell motility |
| Q30278906 | Pannexin 1 channels regulate leukocyte emigration through the venous endothelium during acute inflammation |
| Q34216245 | Plasticity versus specificity in RTK signalling modalities for distinct biological outcomes in motor neurons. |
| Q35053943 | RANK-Fc: a therapeutic antagonist for RANK-L in myeloma |
| Q52668582 | Raddeanin A suppresses breast cancer-associated osteolysis through inhibiting osteoclasts and breast cancer cells. |
| Q28205568 | Regulation of Akt/PKB activation by tyrosine phosphorylation |
| Q38113962 | Regulation of PI-3-Kinase and Akt Signaling in T Lymphocytes and Other Cells by TNFR Family Molecules |
| Q37263070 | Role of protein-tyrosine phosphatases in regulation of osteoclastic activity. |
| Q36177501 | Roles for NF-kappaB and c-Fos in osteoclasts |
| Q44208143 | Src activation regulates anoikis in human colon tumor cell lines |
| Q34182834 | Src inhibitors in the treatment of metastatic bone disease: rationale and clinical data |
| Q34481586 | Src inhibitors: genomics to therapeutics |
| Q58134094 | Src protein tyrosine kinases in stress responses |
| Q33571888 | TRAF2-MLK3 interaction is essential for TNF-alpha-induced MLK3 activation |
| Q30159856 | TRAF6 activation of PI 3-kinase-dependent cytoskeletal changes is cooperative with Ras and is mediated by an interaction with cytoplasmic Src. |
| Q40664782 | TRAF6 and C-SRC induce synergistic AP-1 activation via PI3-kinase-AKT-JNK pathway |
| Q37160930 | Targeted transgenic expression of an osteoclastic transmembrane protein-tyrosine phosphatase in cells of osteoclastic lineage increases bone resorption and bone loss in male young adult mice |
| Q37175318 | The diverse functions of Src family kinases in macrophages |
| Q54487255 | The role of TNF-α and TNF superfamily members in the pathogenesis of calcific aortic valvular disease. |
| Q36325944 | The tyrosine kinase activity of c-Src regulates actin dynamics and organization of podosomes in osteoclasts |
| Q46192344 | Therapeutic concentrations of dasatinib inhibit in vitro osteoclastogenesis. |
| Q37453357 | Transgenic mice with OIP-1/hSca overexpression targeted to the osteoclast lineage develop an osteopetrosis bone phenotype |
| Q37109228 | Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts. |
| Q40685684 | Tumor necrosis factor regulates intestinal epithelial cell migration by receptor-dependent mechanisms |
| Q39647223 | VEGF-C, a lymphatic growth factor, is a RANKL target gene in osteoclasts that enhances osteoclastic bone resorption through an autocrine mechanism |
| Q50438614 | WHI-131 Promotes Osteoblast Differentiation and Prevents Osteoclast Formation and Resorption in Mice. |
| Q24296702 | c-Src control of chloride channel support for osteoclast HCl transport and bone resorption |
| Q30010102 | c-Src links a RANK/αvβ3 integrin complex to the osteoclast cytoskeleton |
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