The Modulatory Effects of Mesenchymal Stem Cells on Osteoclastogenesis

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The Modulatory Effects of Mesenchymal Stem Cells on Osteoclastogenesis is …
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scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1155/2016/1908365
P932PMC publication ID4707367
P698PubMed publication ID26823668
P5875ResearchGate publication ID288700106

P50authorWessam E Sharaf-EldinQ87181517
Marwa MahmoudQ87181520
Nourhan Abu-ShahbaQ64503968
P2093author name stringNagwa El-Badri
P2860cites workMesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural killer cellsQ79208808
Bone marrow metastatic myeloma cells promote osteoclastogenesis through RANKL on endothelial cellsQ79361043
Mesenchymal stem cells inhibit generation and function of both CD34+-derived and monocyte-derived dendritic cellsQ80057941
Specific plasma membrane protein phenotype of culture-amplified and native human bone marrow mesenchymal stem cellsQ80216977
Human mesenchymal stem cells require monocyte-mediated activation to suppress alloreactive T cellsQ80415050
Interleukin-4 and interleukin-13 stimulate the osteoclast inhibitor osteoprotegerin by human endothelial cells through the STAT6 pathwayQ80637499
Interleukin-6 directly inhibits osteoclast differentiation by suppressing receptor activator of NF-kappaB signaling pathwaysQ80763818
Hepatocyte growth factor significantly suppresses collagen-induced arthritis in miceQ81386359
Detection of osteoprotegerin (OPG) and its ligand (RANKL) mRNA and protein in femur and tibia of the ratQ81387247
Inhibition of hormone and cytokine-stimulated osteoclastogenesis and bone resorption by interleukin-4 and interleukin-13 is associated with increased osteoprotegerin and decreased RANKL and RANK in a STAT6-dependent pathwayQ81406086
Osteoprotegerin (OPG) and RANKL expression and distribution in developing human craniomandibular jointQ81756339
Characterization and functionality of the CD200-CD200R system during mesenchymal stromal cell interactions with T-lymphocytesQ84105212
Action at a distance: systemically administered adult stem/progenitor cells (MSCs) reduce inflammatory damage to the cornea without engraftment and primarily by secretion of TNF-α stimulated gene/protein 6Q84753164
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activationQ24311588
Osteoprotegerin: a novel secreted protein involved in the regulation of bone densityQ24313918
Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligandQ24653311
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKLQ24682139
Stem cell therapy to cure type 1 diabetes: from hype to hopeQ26823294
Skeletal stem cellsQ26823973
Osteoimmunology and the influence of pro-inflammatory cytokines on osteoclastsQ26828486
The role of osteoclasts and tumour-associated macrophages in osteosarcoma metastasisQ26864614
A review of therapeutic effects of mesenchymal stem cell secretions and induction of secretory modification by different culture methodsQ26998969
Immunobiology of mesenchymal stem cellsQ27004487
Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statementQ27861120
Matrix-embedded cells control osteoclast formationQ28247746
Evidence for osteocyte regulation of bone homeostasis through RANKL expressionQ28247757
Human mesenchymal stem cells modulate allogeneic immune cell responsesQ28288692
Regulation of osteoclast differentiationQ28593319
Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II studyQ29617267
Mesenchymal stem cells reside in virtually all post-natal organs and tissuesQ29617740
Pluripotency of mesenchymal stem cells derived from adult marrowQ29617959
Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cellsQ29618766
Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuliQ29618769
Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligandQ29619331
Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6Q29620590
Human mesenchymal stem cells modulate B-cell functionsQ29620705
Interleukin-10 inhibits osteoclastogenesis by reducing NFATc1 expression and preventing its translocation to the nucleusQ33269870
Mesenchymal stromal cells ameliorate experimental autoimmune encephalomyelitis by inhibiting CD4 Th17 T cells in a CC chemokine ligand 2-dependent mannerQ33438830
Transforming growth factor beta inhibits formation of osteoclast-like cells in long-term human marrow culturesQ33636797
The interaction between mesenchymal stem cells and steroids during inflammationQ33695051
Placental mesenchymal stem cells of fetal and maternal origins demonstrate different therapeutic potentialsQ33746577
Concerted action of Smad and CREB-binding protein regulates bone morphogenetic protein-2-stimulated osteoblastic colony-stimulating factor-1 expressionQ40278602
Treatment of Myoblastic C2C12 Cells with BMP-2 Stimulates Vitamin D-induced Formation of OsteoclastsQ40631790
IL-12 alone and in synergy with IL-18 inhibits osteoclast formation in vitroQ40814402
The expression of osteoprotegerin and RANK ligand and the support of osteoclast formation by stromal-osteoblast lineage cells is developmentally regulatedQ40838648
Human mesenchymal stem cells promote human osteoclast differentiation from CD34+ bone marrow hematopoietic progenitorsQ40937743
Transforming growth factor-beta stimulates the production of osteoprotegerin/osteoclastogenesis inhibitory factor by bone marrow stromal cellsQ41004339
The role of osteoblast density and endogenous interleukin-6 production in osteoclast formation from the hemopoietic stem cell line FDCP-MIX C2GM in coculture with primary osteoblastsQ41030938
Heat-treated osteoblastic cell (ROS17/2.8)-conditioned medium induces the formation of osteoclast-like cellsQ41515614
Cloning of an osteoblastic cell line involved in the formation of osteoclast-like cellsQ41713781
Mechanisms of T-cell immunosuppression by mesenchymal stromal cells: what do we know so far?Q42103653
Mesenchymal stem cells inhibit the differentiation of dendritic cells through an interleukin-6-dependent mechanismQ42828277
Regeneration of human bones in hip osteonecrosis and human cartilage in knee osteoarthritis with autologous adipose-tissue-derived stem cells: a case series.Q42862373
Tumour cells produce receptor activator of NF-kappaB ligand (RANKL) in skeletal metastasesQ43011355
Accelerated alveolar bone loss in mice lacking interleukin-10: late onsetQ43520837
Transforming growth factor-beta induces osteoclast ruffling and chemotaxis: potential role in osteoclast recruitment.Q43671898
Human umbilical cord mesenchymal stem cell therapy for patients with active rheumatoid arthritis: safety and efficacyQ43823986
PTH differentially regulates expression of RANKL and OPG.Q43832667
Species variation in the mechanisms of mesenchymal stem cell-mediated immunosuppression.Q45959326
Inhibiting and stimulating effects of TGF-beta 1 on osteoclastic bone resorption in fetal mouse bone organ culturesQ46192845
Role for interferon-gamma in the immunomodulatory activity of human bone marrow mesenchymal stem cells.Q46670167
Inhibition of histone deacetylase suppresses osteoclastogenesis and bone destruction by inducing IFN-beta productionQ46763990
Mesenchymal stem cells secrete factors that inhibit inflammatory processes in short-term osteoarthritic synovium and cartilage explant cultureQ47409578
Tumor necrosis factor-alpha alters the modulatory effects of mesenchymal stem cells on osteoclast formation and functionQ47991417
Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cellsQ33803260
The cell biology of osteoclast function.Q33819720
Human leukocyte antigen-G5 secretion by human mesenchymal stem cells is required to suppress T lymphocyte and natural killer function and to induce CD4+CD25highFOXP3+ regulatory T cells.Q34007524
Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: Implications for cell therapy of boneQ34066339
Two histone deacetylase inhibitors, trichostatin A and sodium butyrate, suppress differentiation into osteoclasts but not into macrophagesQ34168340
CD200 positive human mesenchymal stem cells suppress TNF-alpha secretion from CD200 receptor positive macrophage-like cellsQ34171231
Mesenchymal stem cells: Emerging mechanisms of immunomodulation and therapyQ34259085
Biology of the RANKL-RANK-OPG System in Immunity, Bone, and BeyondQ34366449
Physiological functions of osteoblast lineage and T cell-derived RANKL in bone homeostasisQ34369482
Mesenchymal stem cells markedly suppress inflammatory bone destruction in rats with adjuvant-induced arthritisQ34396114
Interleukin-17 enhances immunosuppression by mesenchymal stem cellsQ34413472
Targeted and nontargeted bone remodeling: relationship to basic multicellular unit origination and progressionQ34495205
Age-related changes in human bone marrow-derived mesenchymal stem cells: consequences for cell therapiesQ34744250
CD200R/CD200 inhibits osteoclastogenesis: new mechanism of osteoclast control by mesenchymal stem cells in humanQ34938505
Stem cells derived from amniotic fluid: new potentials in regenerative medicineQ34961663
The genetic basis for skeletal diseasesQ35128232
Human amniotic fluid stem cells can integrate and differentiate into epithelial lung lineagesQ35215695
Negative regulation of osteoclastogenesis and bone resorption by cytokines and transcriptional repressorsQ35617591
IL-6, RANKL, TNF-alpha/IL-1: interrelations in bone resorption pathophysiologyQ35640443
Transplantation of mesenchymal stem cells ameliorates secondary osteoporosis through interleukin-17-impaired functions of recipient bone marrow mesenchymal stem cells in MRL/lpr miceQ35761240
The relationship between osteoclastogenic and anti-osteoclastogenic pro-inflammatory cytokines differs in human osteoporotic and osteoarthritic bone tissuesQ35838186
Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injuryQ35841729
RANKL/RANK/OPG: new therapeutic targets in bone tumours and associated osteolysisQ35885679
Modulation of osteoclast differentiationQ35957509
The molecular triad OPG/RANK/RANKL: involvement in the orchestration of pathophysiological bone remodelingQ35961678
Vascular endothelial growth factor is a key mediator in the development of T cell priming and its polarization to type 1 and type 17 T helper cells in the airwaysQ36065935
Transforming growth factor-beta1 to the boneQ36131663
Mesenchymal stem cells: a double-edged sword in regulating immune responsesQ36174037
Receptor activator of nuclear factor κB ligand (RANKL) protein expression by B lymphocytes contributes to ovariectomy-induced bone lossQ36216058
TNF-alpha and pathologic bone resorptionQ36291539
Evolving paradigms for repair of tissues by adult stem/progenitor cells (MSCs).Q36372136
Commitment and differentiation of osteoclast precursor cells by the sequential expression of c-Fms and receptor activator of nuclear factor kappaB (RANK) receptorsQ36375584
TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factorQ36380989
Molecular mechanism of the life and death of the osteoclastQ36532524
TGF-beta1 on osteoimmunology and the bone component cellsQ36591727
Age-related intrinsic changes in human bone-marrow-derived mesenchymal stem cells and their differentiation to osteoblastsQ36681378
Functions of RANKL/RANK/OPG in bone modeling and remodelingQ36700779
Dissociation between bone resorption and bone formation in osteopenic transgenic miceQ36800774
Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulation of bone remodeling in health and disease.Q36860987
The osteoclast: a multinucleated, hematopoietic-origin, bone-resorbing osteoimmune cellQ36979047
Concise review: mesenchymal stem cells and translational medicine: emerging issues.Q37056276
Cross-talk between T cells and osteoclasts in bone resorptionQ37056309
Commitment to the osteoblast lineage is not required for RANKL gene expressionQ37176364
IL-10 suppresses calcium-mediated costimulation of receptor activator NF-kappa B signaling during human osteoclast differentiation by inhibiting TREM-2 expressionQ37342418
Mesenchymal stem cells suppress B-cell terminal differentiation.Q37355322
Inhibition of RANK expression and osteoclastogenesis by TLRs and IFN-gamma in human osteoclast precursorsQ37438518
Identification of specific cell-surface markers of adipose-derived stem cells from subcutaneous and visceral fat depotsQ37581652
Osteoclasts have multiple roles in bone in addition to bone resorptionQ37626090
Mechanisms involved in the therapeutic properties of mesenchymal stem cellsQ37635499
Mesenchymal stem cells: a new strategy for immunosuppression and tissue repairQ37724579
Immunosuppression by mesenchymal stem cells: mechanisms and clinical applicationsQ37760962
Mesenchymal stromal cell 'licensing': a multistep processQ37880625
Immunosuppressive properties of mesenchymal stem cellsQ37926524
The skeleton: a multi-functional complex organ: the role of key signalling pathways in osteoclast differentiation and in bone resorptionQ37929460
Therapeutic applications of mesenchymal stromal cells: paracrine effects and potential improvementsQ37945318
Role of mesenchymal stem cell therapy in Crohn's diseaseQ37995012
Inflammation in aging: cause, effect, or both?Q38022324
Immunological goings-on in visceral adipose tissueQ38112933
Clinical applications of mesenchymal stem cellsQ38122364
Mesenchymal stromal cells: sensors and switchers of inflammationQ38149359
Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implicationsQ38261365
Rationale for the potential use of mesenchymal stromal cells in liver transplantationQ38282065
Mesenchymal stem cells: a friend or foe in immune-mediated diseases.Q38319943
Gefitinib inhibits the ability of human bone marrow stromal cells to induce osteoclast differentiation: implications for the pathogenesis and treatment of bone metastasisQ39365959
Human mesenchymal stem cells inhibit osteoclastogenesis through osteoprotegerin production.Q39584342
Restoration of bone mass and strength in glucocorticoid-treated mice by systemic transplantation of CXCR4 and cbfa-1 co-expressing mesenchymal stem cellsQ39900835
Osteoprotegerin inhibits prostate cancer-induced osteoclastogenesis and prevents prostate tumor growth in the boneQ39946634
Mesenchymal stem cell inhibition of T-helper 17 cell- differentiation is triggered by cell-cell contact and mediated by prostaglandin E2 via the EP4 receptor.Q51002334
Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-beta.Q51005281
Temporal and spatial expression of osteoprotegerin and receptor activator of nuclear factor -kappaB ligand during mandibular distraction in rats.Q51021098
Human mesenchymal stem cells induce T cell anergy and downregulate T cell allo-responses via the TH2 pathway: relevance to tissue engineering human heart valves.Q51134056
Osteoclastogenesis on tissue-engineered bone.Q51703633
Human first-trimester fetal MSC express pluripotency markers and grow faster and have longer telomeres than adult MSC.Q52001009
Localization of RANKL (receptor activator of NF kappa B ligand) mRNA and protein in skeletal and extraskeletal tissues.Q52172979
Mesenchymal stem cells inhibit dendritic cell differentiation and function by preventing entry into the cell cycle.Q53753309
Stromal cells responsible for transferring the microenvironment of the hemopoietic tissues. Cloning in vitro and retransplantation in vivo.Q54011232
A role for TGFbeta(1) in osteoclast differentiation and survival.Q54048285
A role for heme oxygenase-1 in the immunosuppressive effect of adult rat and human mesenchymal stem cellsQ56765649
Vitamin D Action and Regulation of Bone Remodeling: Suppression of Osteoclastogenesis by the Mature OsteoblastQ57533550
RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-βQ57675150
Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cellsQ61645531
Mesenchymal Stem Cell-Mediated Immunosuppression Occurs via Concerted Action of Chemokines and Nitric OxideQ61645540
Mesenchymal Stem Cells Require a Sufficient, Ongoing Immune Response to Exert Their Immunosuppressive FunctionQ61878551
The bone marrow-derived stromal cell lines MC3T3-G2/PA6 and ST2 support osteoclast-like cell differentiation in cocultures with mouse spleen cellsQ69541163
Interleukin-1 and tumor necrosis factor stimulate the formation of human osteoclastlike cells in vitroQ69738552
Synovial tissue in rheumatoid arthritis is a source of osteoclast differentiation factorQ73490934
Tumor necrosis factor-alpha cooperates with receptor activator of nuclear factor kappaB ligand in generation of osteoclasts in stromal cell-depleted rat bone marrow cell cultureQ73853199
Osteoblast maturation suppressed osteoclastogenesis in coculture with bone marrow cellsQ74027807
A combination of osteoclast differentiation factor and macrophage-colony stimulating factor is sufficient for both human and mouse osteoclast formation in vitroQ77342999
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectmesenchymal stem cellQ1922379
P304page(s)1908365
P577publication date2015-12-28
P1433published inStem Cells InternationalQ26842114
P1476titleThe Modulatory Effects of Mesenchymal Stem Cells on Osteoclastogenesis
P478volume2016

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cites work (P2860)
Q92001233Bone Defect Repair Using a Bone Substitute Supported by Mesenchymal Stem Cells Derived from the Umbilical Cord
Q91712822CR6-interacting factor-1 contributes to osteoclastogenesis by inducing receptor activator of nuclear factor κB ligand after radiation
Q93061354Changes in gene expression in human skeletal stem cells transduced with constitutively active Gsα correlates with hallmark histopathological changes seen in fibrous dysplastic bone
Q91960184Hydroxylapatite-collagen hybrid scaffold induces human adipose-derived mesenchymal stem cells to osteogenic differentiation in vitro and bone regrowth in patients
Q90411548Oral Mesenchymal Stem/Progenitor Cells: The Immunomodulatory Masters
Q46183672Pro-inflammatory M1 macrophages promote Osteogenesis by mesenchymal stem cells via the COX-2-prostaglandin E2 pathway.
Q33695185Soluble Factors on Stage to Direct Mesenchymal Stem Cells Fate.
Q100490792Tankyrase inhibitor XAV-939 enhances osteoblastogenesis and mineralization of human skeletal (mesenchymal) stem cells
Q47167957The Effect of RANKL/OPG Balance on Reducing Implant Complications

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