The molecular triad OPG/RANK/RANKL: involvement in the orchestration of pathophysiological bone remodeling

scientific article

The molecular triad OPG/RANK/RANKL: involvement in the orchestration of pathophysiological bone remodeling is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1016/J.CYTOGFR.2004.06.004
P698PubMed publication ID15561602

P50authorDominique HeymannQ43131742
P2093author name stringYohann Wittrant
Yannick Fortun
Francoise Redini
Steeve Kwan Tat
Sandrine Theoleyre
P433issue6
P921main subjectpathophysiologyQ1135939
P304page(s)457-475
P577publication date2004-12-01
P1433published inCytokine and Growth Factor ReviewsQ15763303
P1476titleThe molecular triad OPG/RANK/RANKL: involvement in the orchestration of pathophysiological bone remodeling
P478volume15

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cites work (P2860)
Q38965673A cellular automata model of bone formation
Q54431091A genome-wide copy number association study of osteoporotic fractures points to the 6p25.1 locus.
Q34171853A review of lifestyle, smoking and other modifiable risk factors for osteoporotic fractures
Q34664057Activation of NF-kappa B signaling promotes growth of prostate cancer cells in bone
Q51684688Acute effects of dietary fatty acids on osteclastogenesis via RANKL/RANK/OPG system.
Q31063890Adjunctive antimicrobial photodynamic treatment of experimentally induced periodontitis in rats with ovariectomy
Q36063108Adjunctive effect of antimicrobial photodynamic therapy in induced periodontal disease. Animal study with histomorphometrical, immunohistochemical, and cytokine evaluation
Q34156735Alpha-Calcitonin Gene-Related Peptide Can Reverse The Catabolic Influence Of UHMWPE Particles On RANKL Expression In Primary Human Osteoblasts
Q37258283Alterations in the Synthesis of IL-1β, TNF-α, IL-6, and Their Downstream Targets RANKL and OPG by Mouse Calvarial Osteoblasts In vitro: Inhibition of Bone Resorption by Cyclic Mechanical Strain
Q26863493Anti-RANKL therapy for bone tumours: Basic, pre-clinical and clinical evidences
Q81888549Anti-TNF alpha therapy and safety monitoring. Clinical tool guide elaborated by the Club Rhumatismes et Inflammations (CRI), section of the French Society of Rheumatology (Société Française de Rhumatologie, SFR)
Q35834684Antimicrobial photodynamic therapy minimizes the deleterious effect of nicotine in female rats with induced periodontitis
Q40284981Antitumor and antimetastatic activities of docetaxel are enhanced by genistein through regulation of osteoprotegerin/receptor activator of nuclear factor-kappaB (RANK)/RANK ligand/MMP-9 signaling in prostate cancer
Q33744420Areca nut extract protects against ovariectomy-induced osteoporosis in mice
Q47166692Artemisia annua extract prevents ovariectomy-induced bone loss by blocking receptor activator of nuclear factor kappa-B ligand-induced differentiation of osteoclasts
Q51154398Association of the (TTTA)n repeat polymorphism of CYP19 gene with bone mineral density in Greek peri- and postmenopausal women.
Q39177486Associations between polymorphisms of HLA-B gene and postmenopausal osteoporosis in Chinese Han population
Q37133071Avenanthramides Prevent Osteoblast and Osteocyte Apoptosis and Induce Osteoclast Apoptosis in Vitro in an Nrf2-Independent Manner
Q49979732B cell subset distribution is altered in patients with severe periodontitis.
Q89536683Baicalin Ameliorates Dexamethasone-Induced Osteoporosis by Regulation of the RANK/RANKL/OPG Signaling Pathway
Q47194100Beyond Antibodies: B Cells and the OPG/RANK-RANKL Pathway in Health, Non-HIV Disease and HIV-Induced Bone Loss
Q24701763Bindarit, an inhibitor of monocyte chemotactic protein synthesis, protects against bone loss induced by chikungunya virus infection
Q47438464Bioactive treatments in bone grafts for implant-based rehabilitation: Systematic review and meta-analysis
Q38673908Bioprinting and Organ-on-Chip Applications Towards Personalized Medicine for Bone Diseases.
Q34802870Bone Healing in Ovariectomized-rabbit Calvarial Defect with Tricalcium Phosphate Coated with Recombinant Human Bone Morphogenetic Protein-2 Genetically Engineered in Escherichia coli
Q26771376Bone Tumor Environment as a Potential Therapeutic Target in Ewing Sarcoma
Q51565203Bone quality is partially recovered after the discontinuation of RANKL administration in rats by increased bone mass on existing trabeculae: an in vivo micro-CT study.
Q38494091Bone turnover markers for early detection of fracture healing disturbances: A review of the scientific literature
Q28611365Boon and Bane of Inflammation in Bone Tissue Regeneration and Its Link with Angiogenesis
Q97527734CSF-1 in Osteocytes Inhibits Nox4-mediated Oxidative Stress and Promotes Normal Bone Homeostasis
Q37668709Cell interactions in bone tissue engineering.
Q39137409Chrysoeriol isolated from Eurya cilliata leaves protects MC3T3‐E1 cells against hydrogen peroxide‐induced inhibition of osteoblastic differentiation
Q37133815Circulating angiogenic modulatory factors predict survival and functional class in pulmonary arterial hypertension
Q37418258Colony-stimulating factor-1 (CSF-1) directly inhibits receptor activator of nuclear factor-{kappa}B ligand (RANKL) expression by osteoblasts
Q35617758Constitutive expression of cathepsin K in the human intervertebral disc: new insight into disc extracellular matrix remodeling via cathepsin K and receptor activator of nuclear factor-κB ligand
Q37571564Cord blood--an alternative source for bone regeneration
Q38161735Current therapeutic strategies and novel approaches in osteosarcoma
Q28067502Cytokine Profile in Chronic Periodontitis Patients with and without Obesity: A Systematic Review and Meta-Analysis
Q38010350Denosumab--a powerful RANKL inhibitor to stop lytic metastases and other bone loss actions by osteoclasts
Q42805731Deoxyactein stimulates osteoblast function and inhibits bone-resorbing mediators in MC3T3-E1 cells
Q92343929Development of calcific aortic valve disease: Do we know enough for new clinical trials?
Q39327736Differential Effects of IL-17A and TNF-α on Osteoblastic Differentiation of Isolated Synoviocytes and on Bone Explants from Arthritis Patients.
Q36491383Differential effect of zoledronic acid on normal trabecular and cortical bone density in oncologic patients with bone metastases
Q30412235Differential expression and tumor necrosis factor-mediated regulation of TNFRSF11b/osteoprotegerin production by human melanomas
Q37594768Differential modulation of RANKL isoforms by human osteoarthritic subchondral bone osteoblasts: influence of osteotropic factors
Q35677638Disturbance of the OPG/RANK/RANKL pathway and systemic inflammation in COPD patients with emphysema and osteoporosis
Q41874349Dlx5, a positive regulator of osteoblastogenesis, is essential for osteoblast-osteoclast coupling.
Q38264673Drug design strategies for the treatment of prostate cancer
Q38955517Drugs in early clinical development for the treatment of osteosarcoma
Q38129954Drugs targeting the bone microenvironment: new therapeutic tools in Ewing's sarcoma?
Q81356317Early effects of tocilizumab on bone and bone marrow lesions in a collagen-induced arthritis monkey model
Q36390099Effect of gallium nitrate on the expression of osteoprotegerin and receptor activator of nuclear factor‑κB ligand in osteoblasts in vivo and in vitro
Q37083062Effect of glucocorticoids on osteoclast function in a mouse model of bone necrosis
Q34657931Effect of orthodontic forces on cytokine and receptor levels in gingival crevicular fluid: a systematic review
Q64267362Effectiveness of electric toothbrush as vibration method on orthodontic tooth movement: a split-mouth study
Q64891933Effects of RANKL, osteoprotegerin, calcium and phosphorus on survival and activation of Muscovy duck osteoclasts in vitro.
Q34332098Effects of alpha-calcitonin gene-related peptide on osteoprotegerin and receptor activator of nuclear factor-κB ligand expression in MG-63 osteoblast-like cells exposed to polyethylene particles.
Q34547523Effects of conjugated linoleic acid and exercise on bone mass in young male Balb/C mice
Q35808641Effects of erythropoietin on the bone microenvironment
Q64230351Effects of mechanical forces on osteogenesis and osteoclastogenesis in human periodontal ligament fibroblasts: A systematic review of studies
Q33580516Effects of neuropeptides and mechanical loading on bone cell resorption in vitro
Q38664528Effects of pulsed electromagnetic fields on postmenopausal osteoporosis
Q33716948Effects of total flavonoids from Drynariae Rhizoma prevent bone loss in vivo and in vitro
Q38207147Emerging therapeutic targets for osteoporosis treatment
Q54276180Enhanced production of CTGF and IL-11 from highly metastatic hepatoma cells under hypoxic conditions: an implication of hepatocellular carcinoma metastasis to bone.
Q53538395Estimation of bone loss biomarkers as a diagnostic tool for peri-implantitis.
Q41984586Evaluation of melatonin levels in saliva in gingivitis and periodontitis cases: A pilot study
Q37163213Evidence for a calcification process in the trabecular meshwork
Q60659190Expression of bone resorption genes in osteoarthritis and in osteoporosis
Q53622328Expression of neuropeptides and bone remodeling-related factors during periodontal tissue regeneration in denervated rats.
Q42948793Factor VIII-von Willebrand factor complex inhibits osteoclastogenesis and controls cell survival
Q90600722Femoral condylar necrosis: treatment with hyperbaric oxygen therapy
Q51135670Formulation and in vitro and in vivo evaluation of a new osteoprotegerin-chitosan gel for bone tissue regeneration.
Q36700779Functions of RANKL/RANK/OPG in bone modeling and remodeling
Q51558602Genetic variation in the TNFRSF11A gene encoding RANK is associated with susceptibility to Paget's disease of bone.
Q93140455Geniposide attenuates cadmium‑induced oxidative stress injury via Nrf2 signaling in osteoblasts
Q35238712Ghrelin Increases Beta-Catenin Level through Protein Kinase A Activation and Regulates OPG Expression in Rat Primary Osteoblasts
Q37200573Granulocyte colony-stimulating factor induces osteoblast apoptosis and inhibits osteoblast differentiation
Q30354085Hearts and bones: shared regulatory mechanisms in heart valve, cartilage, tendon, and bone development.
Q50618057High osteoprotegerin serum levels in primary biliary cirrhosis are associated with disease severity but not with the mRNA gene expression in liver tissue.
Q48149932Histological analysis and gene expression profile following augmentation of the anterior maxilla using rhBMP-2/ACS versus autogenous bone graft.
Q47310464Hyperbaric oxygen therapy modulates serum OPG/RANKL in femoral head necrosis patients.
Q91992936Hypoalbuminemia differently affects the serum bone turnover markers in hemodialysis patients
Q48184294IL-3 Differentially Regulates Membrane and Soluble RANKL in Osteoblasts through Metalloproteases and the JAK2/STAT5 Pathway and Improves the RANKL/OPG Ratio in Adult Mice.
Q24657159Identification of LRRc17 as a negative regulator of receptor activator of NF-kappaB ligand (RANKL)-induced osteoclast differentiation
Q36387944Identification of key genes and pathways for peri-implantitis through the analysis of gene expression data
Q42834177Immunohistochemical analysis of low-grade and high-grade prostate carcinoma: relative changes of parathyroid hormone-related protein and its parathyroid hormone 1 receptor, osteoprotegerin and receptor activator of nuclear factor-kB ligand
Q41847832Increased serum OPG in atrophic nonunion shaft fractures
Q46130063Indications for a genetic association of a VCP polymorphism with the pathogenesis of sporadic Paget's disease of bone, but not for TNFSF11 (RANKL) and IL-6 polymorphisms
Q46291802Induction of osteogenesis in mesenchymal stem cells by activated monocytes/macrophages depends on oncostatin M signaling
Q54338829Induction of prostaglandin E(2) and interleukin-6 in gingival fibroblasts by oral biofilms.
Q34115689Inflammatory responses improve with milk ribonuclease-enriched lactoferrin supplementation in postmenopausal women
Q34503355Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human
Q92351335Interference of miR-212 and miR-384 promotes osteogenic differentiation via targeting RUNX2 in osteoporosis
Q44022501KLF5 promotes cervical cancer proliferation, migration and invasion in a manner partly dependent on TNFRSF11a expression
Q28287394Key roles of the OPG-RANK-RANKL system in bone oncology
Q36981095Long-chain polyunsaturated fatty acids and the regulation of bone metabolism
Q42799147Mechanical loading differentially regulates membrane-bound and soluble RANKL availability in MC3T3-E1 cells
Q36366450Mechanisms of disease: roles of OPG, RANKL and RANK in the pathophysiology of skeletal metastasis.
Q37186468Mechanobiology of tooth movement
Q36076041Melatonin and oral cavity
Q36029570Meox2Cre-mediated disruption of CSF-1 leads to osteopetrosis and osteocyte defects
Q64076402Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice
Q34555532Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels
Q36086080MicroRNA-145 Mediates Steroid-Induced Necrosis of the Femoral Head by Targeting the OPG/RANK/RANKL Signaling Pathway
Q92494094Minocycline-loaded PLGA electrospun membrane prevents alveolar bone loss in experimental peridontitis
Q38068600Monoclonal antibodies for the treatment of osteoporosis
Q39142554NF-κB as a Therapeutic Target in Inflammatory-Associated Bone Diseases
Q52018491NFATc1 expression in the developing heart valves is responsive to the RANKL pathway and is required for endocardial expression of cathepsin K.
Q37935523New targets for intervention in the treatment of postmenopausal osteoporosis
Q40346323No association between selected candidate gene polymorphisms and severe chronic periodontitis
Q51760981Novel RANK antagonists for the treatment of bone-resorptive disease: theoretical predictions and experimental validation.
Q44001600Olmesartan decreases IL-1β and TNF-α levels; downregulates MMP-2, MMP-9, COX-2, and RANKL; and upregulates OPG in experimental periodontitis.
Q39190775Osteoblast-osteoclast interactions
Q50130540Osteoblastic heparan sulfate regulates osteoprotegerin function and bone mass.
Q28077461Osteoblasts Are the Centerpiece of the Metastatic Bone Microenvironment
Q36973979Osteocytes as mechanosensors in the inhibition of bone resorption due to mechanical loading
Q36693328Osteoimmunology
Q35173349Osteoporosis in chronic obstructive pulmonary disease
Q38409333Osteoprotegerin (OPG) and related proteins (RANK, RANKL and TRAIL) in thyroid disease
Q53619763Osteoprotegerin Levels Decrease in Abstinent Alcohol-Dependent Patients.
Q36273402Osteoprotegerin and breast cancer risk by hormone receptor subtype: a nested case-control study in the EPIC cohort
Q39474045Osteoprotegerin deficiency leads to deformation of the articular cartilage in femoral head
Q37109337Osteoprotegerin disrupts peripheral adhesive structures of osteoclasts by modulating Pyk2 and Src activities.
Q41184194Osteoprotegerin exposure at different stages of osteoclastogenesis differentially affects osteoclast formation and function.
Q34950497Osteoprotegerin expressed by osteoclasts: an autoregulator of osteoclastogenesis.
Q50436161Osteoprotegerin expression and sensitivity in otosclerosis with different histological activity
Q35640787Osteoprotegerin in Cardiometabolic Disorders
Q36491545Osteoprotegerin inhibits bone resorption and prevents tumor development in a xenogenic model of Ewing's sarcoma by inhibiting RANKL
Q26748804Osteoprotegerin rich tumor microenvironment: implications in breast cancer
Q38741874Osteoprotegerin: A novel biomarker for inflammatory bowel disease and gastrointestinal carcinoma.
Q50446121Otosclerosis: an organ-specific inflammatory disease with sensorineural hearing loss.
Q41655118Oxidized Titanium Implants Enhance Osseointegration via Mechanisms Involving RANK/RANKL/OPG Regulation
Q38308220PTX3 stimulates osteoclastogenesis by increasing osteoblast RANKL production
Q48073269Palliative Oncology: Denosumab
Q55082811Paracrine and endocrine actions of bone-the functions of secretory proteins from osteoblasts, osteocytes, and osteoclasts.
Q36966222Pediatric bone density and fracture
Q46175204Periodontal ligament fibroblasts sustain destructive immune modulators of chronic periodontitis.
Q37862366Perspectives on the use of melatonin to reduce cytotoxic and genotoxic effects of methacrylate-based dental materials
Q34828137Plasma and drainage fluid levels of soluble receptor activator of nuclear factor-kB (sRANK), soluble receptor activator of nuclear factor-kB ligand (sRANKL) and osteoprotegerin (OPG) during proximal humerus fracture healing
Q36824764Possible involvement of AMP-activated protein kinase in PGE1-induced synthesis of osteoprotegerin in osteoblasts
Q26750631Present Advances and Future Perspectives of Molecular Targeted Therapy for Osteosarcoma
Q47738511Prognostic Value of Osteoprotegerin and sRANKL in Bronchoalveolar Lavage Fluid of Patients with Advanced Non-small Cell Lung Cancer
Q36203010Proteoglycans and osteolysis
Q36088188RANK (TNFRSF11A) is epigenetically inactivated and induces apoptosis in gliomas
Q64939796RANK-RANKL Signaling in Cancer of the Uterine Cervix: A Review.
Q26747442RANK-RANKL signalling in cancer
Q47215322RANK/RANKL/OPG Expression in Rapid Maxillary Expansion.
Q90152388RANKL/RANK/OPG Pathway: A Mechanism Involved in Exercise-Induced Bone Remodeling
Q88622314Radiological, Histological and Chemical Analysis of Breast Microcalcifications: Diagnostic Value and Biological Significance
Q36731426Recent advances in the management of osteosarcoma and forthcoming therapeutic strategies.
Q36860987Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulation of bone remodeling in health and disease.
Q55008249Role of Serum Osteoprotegerin as a Diagnostic Indicator of Primary Osteoporosis in Perimenopausal and Postmenopausal Women: An Indian Perspective.
Q57116604Role of TCF/LEF Transcription Factors in Bone Development and Osteogenesis
Q90250824Root Resorption Classifications: A Narrative Review and a Clinical Aid Proposal for Routine Assessment
Q36157326Rosiglitazone induces decreases in bone mass and strength that are reminiscent of aged bone
Q34993353Runx2-upregulated receptor activator of nuclear factor κB ligand in calcifying smooth muscle cells promotes migration and osteoclastic differentiation of macrophages.
Q33289750Rutile and titanium particles differentially affect the production of osteoblastic local factors.
Q59049436Salivary Melatonin and the Severity of Attachment Loss: A Case-Control Study
Q51426858Serum bone turnover markers may be involved in the metastatic potential of lung cancer patients.
Q33307072Single nucleotide polymorphisms in bone turnover-related genes in Koreans: ethnic differences in linkage disequilibrium and haplotype
Q48177889Sodium butyrate has anti-proliferative, pro-differentiating, and immunomodulatory effects in osteosarcoma cells and counteracts the TNFα-induced low-grade inflammation.
Q44625527Static and dynamic cultivation of bone marrow stromal cells on biphasic calcium phosphate scaffolds derived from an indirect rapid prototyping technique
Q90225894Strontium inhibits osteoclastogenesis by enhancing LRP6 and β-catenin-mediated OPG targeted by miR-181d-5p
Q89563079Strontium ranelate inhibits wear particle-induced aseptic loosening in mice
Q27665673Structure-based development of a receptor activator of nuclear factor- B ligand (RANKL) inhibitor peptide and molecular basis for osteopetrosis
Q36591727TGF-beta1 on osteoimmunology and the bone component cells
Q37996112TRAF6 activation in multiple myeloma: a potential therapeutic target
Q37972139TRAIL receptor signaling and therapeutic option in bone tumors: the trap of the bone microenvironment.
Q37293344Targeting NF-kappaB: a promising molecular therapy in inflammatory arthritis.
Q28731449Targeting bone remodeling by isoflavone and 3,3'-diindolylmethane in the context of prostate cancer bone metastasis
Q51693699The Association Between Periodontal Inflammation and Labor Triggers (Elevated Cytokine Levels) in Preterm Birth: A Cross-Sectional Study.
Q39061470The Effect of Orthognathic Surgery on Osteoprotegerin as Immunological Caliper of Bone Healing
Q47167957The Effect of RANKL/OPG Balance on Reducing Implant Complications
Q36537771The Function of Naringin in Inducing Secretion of Osteoprotegerin and Inhibiting Formation of Osteoclasts
Q91687260The Influence of TLR4, CD14, OPG, and RANKL Polymorphisms in Periodontitis: A Case-Control Study
Q57790452The Intrinsic and Extrinsic Implications of RANKL/RANK Signaling in Osteosarcoma: From Tumor Initiation to Lung Metastases
Q26773017The Modulatory Effects of Mesenchymal Stem Cells on Osteoclastogenesis
Q64062131The Molecular Mechanism of Vitamin E as a Bone-Protecting Agent: A Review on Current Evidence
Q84990028The balance between soluble receptors regulating IL-6 trans-signaling is predictive for the RANKL/osteoprotegerin ratio in postmenopausal women with rheumatoid arthritis
Q56546058The effect of alendronate on the expression of osteopontin and osteoprotegerin in calcified aortic tissue of the rat
Q50903399The effect of chronic long-term intermittent hypobaric hypoxia on bone mineral density in rats: role of nitric oxide.
Q41143290The effect of marrow stromal cells on TRAF6 expression levels in myeloma cells
Q60723669The effect of polyunsaturated fatty acids on bone health
Q36376105The effects of lung and prostate cancer bone metastasis on serum osteoprotegerin levels: a meta-analysis
Q50105018The material and biological characteristics of osteoinductive calcium phosphate ceramics
Q37615017The osteoblastic and osteoclastic interactions in spinal metastases secondary to prostate cancer
Q35838186The relationship between osteoclastogenic and anti-osteoclastogenic pro-inflammatory cytokines differs in human osteoporotic and osteoarthritic bone tissues
Q37268896The role of T cells in osteoporosis, an update.
Q100512479The third case of TNFRSF11A-associated dysosteosclerosis with a mutation producing elongating proteins
Q53167439Titanium surfaces with nanotopography modulate cytokine production in cultured human gingival fibroblasts.
Q34118018Trabecular bone volume and osteoprotegerin expression in uremic rats given high calcium
Q35087758Treatment with N- and C-terminal peptides of parathyroid hormone-related protein partly compensate the skeletal abnormalities in IGF-I deficient mice
Q37641468Tumor-stroma co-evolution in prostate cancer progression and metastasis
Q24289320Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies
Q38139382Understanding the advances in biology of orthodontic tooth movement for improved ortho-perio interdisciplinary approach
Q38109107Using functional nanomaterials to target and regulate the tumor microenvironment: diagnostic and therapeutic applications
Q41854584VEGF and RANKL regulation of NFATc1 in heart valve development.
Q80805288Variations along the 24-hour cycle of circulating osteoprotegerin and soluble RANKL: a rhythmometric analysis
Q38135885Vitamin D and bone health outcomes in older age.
Q36813284Vitamin D: the secosteroid hormone and human reproduction
Q88126401WITHDRAWN: Associations between polymorphisms of HLA-B gene and postmenopausal osteoporosis in Chinese Han population
Q29614274Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression
Q36467025Wnt-signaling-mediated antiosteoporotic activity of porcine placenta hydrolysates in ovariectomized rats
Q24316366α-Actinin-3 deficiency is associated with reduced bone mass in human and mouse

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