Beyond Antibodies: B Cells and the OPG/RANK-RANKL Pathway in Health, Non-HIV Disease and HIV-Induced Bone Loss

scientific article published on 22 December 2017

Beyond Antibodies: B Cells and the OPG/RANK-RANKL Pathway in Health, Non-HIV Disease and HIV-Induced Bone Loss is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3389/FIMMU.2017.01851
P932PMC publication ID5743755
P698PubMed publication ID29312334

P2093author name stringKehmia Titanji
P2860cites workRituximab abrogates joint destruction in rheumatoid arthritis by inhibiting osteoclastogenesis.Q53207044
Ovariectomy-induced bone loss occurs independently of B cells.Q53510692
Fragility fractures and bone mineral density in HIV positive women: a case-control population-based studyQ57902645
Decreased bone mineral density in HIV-infected patients is independent of antiretroviral therapyQ73911593
Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulate aortic valve calcificationQ75301236
Osteoprotegerin deficiency and juvenile Paget's diseaseQ78515359
Inflammatory T cells rapidly induce differentiation of human bone marrow stromal cells into mature osteoblastsQ78955391
Bacterial-responsive B lymphocytes induce periodontal bone resorptionQ81645835
Role of RANKL inhibition in osteoporosisQ21195417
Antiretroviral therapy and the prevalence of osteopenia and osteoporosis: a meta-analytic reviewQ22242702
Life expectancy of recently diagnosed asymptomatic HIV-infected patients approaches that of uninfected individualsQ22242705
Human osteoclast-poor osteopetrosis with hypogammaglobulinemia due to TNFRSF11A (RANK) mutationsQ24310432
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activationQ24311588
Osteoprotegerin: a novel secreted protein involved in the regulation of bone densityQ24313918
TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cellsQ24315251
A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell functionQ24336057
RANK is essential for osteoclast and lymph node developmentQ24598872
osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcificationQ24603266
Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligandQ24653311
Aging, inflammation, and HIV infectionQ26865415
HIV: inflammation and boneQ27010898
Bone versus immune systemQ28140389
Bench to bedside: elucidation of the OPG-RANK-RANKL pathway and the development of denosumabQ28265584
Osteoprotegerin as a predictor of coronary artery disease and cardiovascular mortality and morbidityQ28281515
Stimulation of B-cell progenitors by cloned murine interleukin-7Q28294062
Denosumab in postmenopausal women with low bone mineral densityQ28298728
Genetic regulation of osteoclast development and functionQ29617421
Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligandQ29619331
HIV infection and bone diseaseQ30249771
The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption.Q33823576
Increased risk of fragility fractures among HIV infected compared to uninfected male veteransQ33832012
Alterations in the immuno-skeletal interface drive bone destruction in HIV-1 transgenic ratsQ34068440
Minireview: the OPG/RANKL/RANK systemQ34102256
How B cells influence bone biology in health and diseaseQ34137037
B cell development pathwaysQ34178187
Estrogen deficiency stimulates B lymphopoiesis in mouse bone marrowQ34183981
Involvement of T-lymphocytes in periodontal disease and in direct and indirect induction of bone resorptionQ34246960
Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritisQ34327451
Biology of the RANKL-RANK-OPG System in Immunity, Bone, and BeyondQ34366449
Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitroQ34459310
Periodontal diseases.Q34468885
Microenvironmental niches in the bone marrow required for B-cell developmentQ34496406
Dysregulated B cell expression of RANKL and OPG correlates with loss of bone mineral density in HIV infectionQ34506677
B-cell targeting in rheumatoid arthritis and other autoimmune diseasesQ34514813
B cells in HIV infection and diseaseQ34605780
Bone disease in HIV infection: a practical review and recommendations for HIV care providersQ35019051
Aging and infectious diseases: workshop on HIV infection and aging: what is known and future research directionsQ35088160
T-cell involvement in osteoclast biology: implications for rheumatoid bone erosionQ35179608
B and T lymphocytes are the primary sources of RANKL in the bone resorptive lesion of periodontal diseaseQ35222008
Cytokine mRNA profiling identifies B cells as a major source of RANKL in rheumatoid arthritisQ35249619
Expression of FcRL4 defines a pro-inflammatory, RANKL-producing B cell subset in rheumatoid arthritisQ35350935
Aging with HIV vs. HIV seroconversion at older age: a diverse population with distinct comorbidity profilesQ35393050
Osteoimmunology: interactions of the immune and skeletal systemsQ35727803
B cells and T cells are critical for the preservation of bone homeostasis and attainment of peak bone mass in vivoQ35804512
Future challenges for clinical care of an ageing population infected with HIV: a modelling studyQ35925654
The molecular triad OPG/RANK/RANKL: involvement in the orchestration of pathophysiological bone remodelingQ35961678
The role of RANK ligand/osteoprotegerin in rheumatoid arthritisQ36111285
Receptor activator of nuclear factor κB ligand (RANKL) protein expression by B lymphocytes contributes to ovariectomy-induced bone lossQ36216058
Osteoblasts and osteoclasts in bone remodeling and inflammationQ36230480
Immune response: the key to bone resorption in periodontal diseaseQ36309235
Osteoprotegerin reverses osteoporosis by inhibiting endosteal osteoclasts and prevents vascular calcification by blocking a process resembling osteoclastogenesisQ36368706
Increased B-lymphopoiesis by interleukin 7 induces bone loss in mice with intact ovarian function: similarity to estrogen deficiencyQ36566505
B cell depletion therapy in autoimmune diseasesQ36664171
HIV and bone metabolismQ36671233
Immunology of Osteoporosis: A Mini-ReviewQ36766801
Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individualsQ36851936
Fracture prevalence among human immunodeficiency virus (HIV)-infected versus non-HIV-infected patients in a large U.S. healthcare systemQ36938343
Osteoblastic regulation of B lymphopoiesis is mediated by Gs{alpha}-dependent signaling pathwaysQ36964283
Enhanced RANK ligand expression and responsivity of bone marrow cells in Paget's disease of boneQ37202226
Inflammation and bone loss in periodontal diseaseQ37232619
The Role of Inflammatory Cytokines, the RANKL/OPG Axis, and the Immunoskeletal Interface in Physiological Bone Turnover and OsteoporosisQ37287589
Role of RANKL-RANK/osteoprotegerin pathway in cardiovascular and bone disease associated with HIV infectionQ37344527
Increased acute myocardial infarction rates and cardiovascular risk factors among patients with human immunodeficiency virus diseaseQ37390635
Insights into the heterogeneity of human B cells: diverse functions, roles in autoimmunity, and use as therapeutic targetsQ37436035
Osteoimmunology and the effects of the immune system on boneQ37626412
B cells as under-appreciated mediators of non-auto-immune inflammatory diseaseQ37728724
RANK ligand: effects of inhibition.Q37738754
Do RANKL inhibitors (denosumab) affect inflammation and immunity?Q37767159
Regulation of bone by the adaptive immune system in arthritisQ37884121
New developments in osteoimmunologyQ38052462
Bone health and human immunodeficiency virus infectionQ38095828
The effects of untreated and treated HIV infection on bone diseaseQ38165037
Inhibition of joint damage and improved clinical outcomes with rituximab plus methotrexate in early active rheumatoid arthritis: the IMAGE trialQ38498967
Osteoprotegerin, a crucial regulator of bone metabolism, also regulates B cell development and functionQ38525468
Physiological and pathophysiological bone turnover - role of the immune systemQ38867785
Osteoprotegerin concentrations relate independently to established cardiovascular disease in rheumatoid arthritis.Q39104753
Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerinQ39116155
Circulating osteoprotegerin levels are elevated in rheumatoid arthritis: a systematic review and meta-analysis.Q39429775
Receptor activator NF kappaB ligand (RANKL) and osteoprotegerin (OPG) protein expression in periodontitisQ39653219
Expression of osteoprotegerin and its ligands, RANKL and TRAIL, in rheumatoid arthritisQ40655784
OPG/FDCR-1, a TNF receptor family member, is expressed in lymphoid cells and is up-regulated by ligating CD40.Q40991620
Denosumab and bone-metastasis-free survival in men with castration-resistant prostate cancer: results of a phase 3, randomised, placebo-controlled trialQ41489196
Bone alterations associated with HIV.Q42203594
Increased rates of bone fracture among HIV-infected persons in the HIV Outpatient Study (HOPS) compared with the US general population, 2000-2006.Q42694082
The effect of a single dose of osteoprotegerin in postmenopausal womenQ43520860
Osteoprotegerin is a risk factor for progressive atherosclerosis and cardiovascular diseaseQ43865169
The presence of local and circulating autoreactive B cells in patients with advanced periodontitisQ43967409
B-lymphocyte deficiency increases atherosclerosis in LDL receptor-null miceQ44212443
Regulatory effects of osteoprotegerin on cellular and humoral immune responsesQ44707640
Reduced bone mineral density in human immunodeficiency virus-infected patients and its association with increased central adiposity and postload hyperglycemiaQ44786963
Osteoprotegerin and osteopontin are expressed at high concentrations within symptomatic carotid atherosclerosisQ44895972
Development and function of murine B cells lacking RANK.Q45766850
A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal womenQ46133598
Independent relationship of osteoprotegerin concentrations with endothelial activation and carotid atherosclerosis in patients with severe rheumatoid arthritisQ46178905
Osteoprotegerin deficiency and juvenile Paget's diseaseQ48292818
Relation of osteoprotegerin to coronary calcium and aortic plaque (from the Dallas Heart Study).Q51767101
P304page(s)1851
P577publication date2017-12-22
P1433published inFrontiers in ImmunologyQ27723748
P1476titleBeyond Antibodies: B Cells and the OPG/RANK-RANKL Pathway in Health, Non-HIV Disease and HIV-Induced Bone Loss
P478volume8

Reverse relations

cites work (P2860)
Q93079405Bone Diseases in Patients with Chronic Liver Disease
Q93271890D-mannose attenuates bone loss in mice via Treg cell proliferation and gut microbiota-dependent anti-inflammatory effects
Q59356917Interferon-Gamma-Mediated Osteoimmunology
Q99557259PKC-δ deficiency in B cells displays osteopenia accompanied with upregulation of RANKL expression and osteoclast-osteoblast uncoupling
Q61798703Transcriptome Sequencing Identifies Novel Immune Response Genes Highly Related to the Severity of Human Adenovirus Type 55 Infection