Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: Implications for cell therapy of bone

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Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: Implications for cell therapy of bone is …
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scholarly articleQ13442814

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P819ADS bibcode2002PNAS...99.8932H
P356DOI10.1073/PNAS.132252399
P932PMC publication ID124401
P698PubMed publication ID12084934
P5875ResearchGate publication ID11290326

P2093author name stringEdwin M Horwitz
Linda Muul
Michael D Neel
Patricia L Gordon
Jeffrey C Marx
Ted Hofmann
Rene Y McNall
Winston K K Koo
P2860cites workBone marrow-derived mesenchymal stem cells remain host-derived despite successful hematopoietic engraftment after allogeneic transplantation in patients with lysosomal and peroxisomal storage diseasesQ73180485
Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapyQ73358706
Pamidronate treatment of severe osteogenesis imperfecta in children under 3 years of ageQ73866982
Intravenous pamidronate treatment in osteogenesis imperfectaQ73916090
Adult rat and human bone marrow stromal cells differentiate into neuronsQ28142919
Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivoQ29619355
Postnatal development of bone mineral status during infancyQ32112309
Bone marrow transplantation as effective treatment of central nervous system disease in globoid cell leukodystrophy, metachromatic leukodystrophy, adrenoleukodystrophy, mannosidosis, fucosidosis, aspartylglucosaminuria, Hurler, Maroteaux-Lamy, and SQ33607275
Bone marrow transplantation for globoid cell leukodystrophy, adrenoleukodystrophy, metachromatic leukodystrophy, and Hurler syndromeQ33765215
Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfectaQ33855709
Cyclic administration of pamidronate in children with severe osteogenesis imperfectaQ34067536
Cultured adherent cells from marrow can serve as long-lasting precursor cells for bone, cartilage, and lung in irradiated miceQ34269619
Rapid expansion of recycling stem cells in cultures of plastic-adherent cells from human bone marrowQ35107753
Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species.Q36894740
High-efficiency transduction and long-term gene expression with a murine stem cell retroviral vector encoding the green fluorescent protein in human marrow stromal cellsQ40812546
Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine.Q41268880
Physical growth: National Center for Health Statistics percentilesQ41435134
Bone marrow transplantation for inherited diseasesQ41479760
Differentiation of muscle, fat, cartilage, and bone from progenitor cells present in a bone-derived clonal cell population: effect of dexamethasoneQ41552587
Continuously growing bipotential and monopotential myogenic, adipogenic, and chondrogenic subclones isolated from the multipotential RCJ 3.1 clonal cell lineQ41711691
Multipotential marrow stromal cells transduced to produce L-DOPA: engraftment in a rat model of Parkinson diseaseQ45863206
Introduction of a xenogeneic gene via hematopoietic stem cells leads to specific tolerance in a rhesus monkey modelQ45870043
Clinical responses to bone marrow transplantation in children with severe osteogenesis imperfectaQ45875073
Osteogenesis imperfecta. Rehabilitation and prospects for gene therapyQ45880744
Muscle regeneration by bone marrow-derived myogenic progenitorsQ45885806
Proliferation kinetics and differentiation potential of ex vivo expanded human bone marrow stromal cells: Implications for their use in cell therapyQ46549703
Phenotypic and functional comparison of cultures of marrow-derived mesenchymal stem cells (MSCs) and stromal cellsQ48000642
In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells.Q50525701
Dystrophin expression in the mdx mouse restored by stem cell transplantation.Q52174025
Differentiation potential of conditionally immortalized mesenchymal progenitor cells from adult marrow of a H-2Kb-tsA58 transgenic mouse.Q52201430
Retroviral vectorsQ60160345
Characterization of cells with osteogenic potential from human marrowQ68117980
Culture-expanded human periosteal-derived cells exhibit osteochondral potential in vivoQ70179983
Cellular expression of bone-related proteins during in vitro osteogenesis in rat bone marrow stromal cell culturesQ72288052
P433issue13
P407language of work or nameEnglishQ1860
P921main subjectosteogenesis imperfectaQ749409
bone marrowQ546523
P304page(s)8932-8937
P577publication date2002-06-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleIsolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: Implications for cell therapy of bone
P478volume99

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Q42000663Immunoregulatory effects of bone marrow-derived mesenchymal stem cells in the nasal polyp microenvironment.
Q36609696Immunoregulatory function of mesenchymal stem cells
Q38707655Impact of starting material (fresh versus cryopreserved marrow) on mesenchymal stem cell culture
Q36282399Impaired osteoblastogenesis in a murine model of dominant osteogenesis imperfecta: a new target for osteogenesis imperfecta pharmacological therapy.
Q38693545Implications of mesenchymal stem cells in regenerative medicine
Q38210863Improved human mesenchymal stem cell isolation.
Q39608956In Vivo Bioluminescence Imaging of Transplanted Mesenchymal Stromal Cells and Their Rejection Mediated by Intrahepatic NK Cells
Q34741419In utero therapy for congenital disorders using amniotic fluid stem cells
Q37271063In utero transplantation of adult bone marrow decreases perinatal lethality and rescues the bone phenotype in the knockin murine model for classical, dominant osteogenesis imperfecta
Q35832011In vitro analysis of integrin expression in stem cells from bone marrow and cord blood during chondrogenic differentiation
Q41083978In vitro expansion impaired the stemness of early passage mesenchymal stem cells for treatment of cartilage defects.
Q40246487In vitro transfection of plasmid DNA by cationized gelatin prepared from different amine compounds
Q34870479In vivo Differentiation Potential of Mesenchymal Stem Cells: Prenatal and Postnatal Model Systems.
Q35347210In vivo gene transfer into adult stem cells in unconditioned mice by in situ delivery of a lentiviral vector
Q90216409In vivo tracking of intravenously injected mesenchymal stem cells in an Alzheimer's animal model
Q42236941Inactivated human platelet lysate with psoralen: a new perspective for mesenchymal stromal cell production in Good Manufacturing Practice conditions.
Q39454582Informing future cartilage repair strategies: a comparative study of three different human cell types for cartilage tissue engineering
Q49715523Innate immune responses of equine monocytes cultured in equine platelet lysate
Q30415068Interferon gamma and T cells inhibit osteogenesis induced by allogeneic mesenchymal stromal cells
Q50509527Interleukin-1β induces differentiation of human mesenchymal stem cells into osteoblasts via the Wnt-5a/receptor tyrosine kinase-like orphan receptor 2 pathway.
Q44878272Internalized antigens must be removed to prepare hypoimmunogenic mesenchymal stem cells for cell and gene therapy
Q37281919Intra-subject variability in human bone marrow stromal cell (BMSC) replicative senescence: molecular changes associated with BMSC senescence
Q27321287Intraperitoneal injection (IP), Intravenous injection (IV) or anal injection (AI)? Best way for mesenchymal stem cells transplantation for colitis
Q36290920Intrauterine Bone Marrow Transplantation in Osteogenesis Imperfecta Mice Yields Donor Osteoclasts and Osteomacs but Not Osteoblasts.
Q34534085Irradiation induces bone injury by damaging bone marrow microenvironment for stem cells.
Q52866935Isolation and Manufacture of Clinical-Grade Bone Marrow-Derived Human Mesenchymal Stromal Cells.
Q40516503Isolation and characterisation of mesenchymal stem cells from adult mouse bone marrow
Q41787137Isolation and therapeutic potential of human haemopoietic stem cells
Q81241941Isolation murine mesenchymal stem cells by positive selection
Q47347899Isolation, characterisation and osteogenic potential of human bone marrow stromal cells derived from the medullary cavity of the femur
Q61796570KIAA1199 is a secreted molecule that enhances osteoblastic stem cell migration and recruitment
Q35075538Keratinocyte growth factor gene delivery via mesenchymal stem cells protects against lipopolysaccharide-induced acute lung injury in mice
Q36738749Kupffer cells-dependent inflammation in the injured liver increases recruitment of mesenchymal stem cells in aging mice
Q36189956LIGHT (TNFSF14) Increases the Survival and Proliferation of Human Bone Marrow-Derived Mesenchymal Stem Cells
Q46754972Lactate modulates gene expression in human mesenchymal stem cells
Q35919694Lentivirus transduced interleukin-1 receptor antagonist gene expression in murine bone marrow-derived mesenchymal stem cells in vitro
Q37955704Lessons from genetically altered mesenchymal stem cells (MSCs): candidates for improved MSC-directed myocardial repair
Q45703658Light-activated gene transduction of recombinant adeno-associated virus in human mesenchymal stem cells
Q46670660Lipidomics of Mesenchymal Stromal Cells: Understanding the Adaptation of Phospholipid Profile in Response to Pro-Inflammatory Cytokines
Q42062735Local transplantation is an effective method for cell delivery in the osteogenesis imperfecta murine model
Q64116753Long noncoding RNA LINC00707 sponges miR-370-3p to promote osteogenesis of human bone marrow-derived mesenchymal stem cells through upregulating WNT2B
Q33634455Long-term outcome of EBV-specific T-cell infusions to prevent or treat EBV-related lymphoproliferative disease in transplant recipients
Q42556916Low Oxygen Modulates Multiple Signaling Pathways, Increasing Self-Renewal, While Decreasing Differentiation, Senescence, and Apoptosis in Stromal MIAMI Cells
Q33527133Low physiologic oxygen tensions reduce proliferation and differentiation of human multipotent mesenchymal stromal cells
Q84491370MSC for the improvement of hematopoietic engraftment
Q37781509MSCs: Biological characteristics, clinical applications and their outstanding concerns
Q39356606MSCs: Delivery Routes and Engraftment, Cell-Targeting Strategies, and Immune Modulation
Q28079988Making the Switch: Alternatives to Fetal Bovine Serum for Adipose-Derived Stromal Cell Expansion
Q39258533Malignant melanoma induces migration and invasion of adult mesenchymal stem cells
Q35030040Malignant tumor formation after transplantation of short-term cultured bone marrow mesenchymal stem cells in experimental myocardial infarction and diabetic neuropathy.
Q89965054Management of Osteogenesis Imperfecta
Q39431469Manufacturing mesenchymal stromal cells for phase I clinical trials
Q64078455Mechanism of Action of Icariin in Bone Marrow Mesenchymal Stem Cells
Q36901342Mechanisms of immunomodulation by mesenchymal stem cells
Q28079649Mechanisms of mesenchymal stem/stromal cell function
Q51610305Mechanisms underlying the osteo- and adipo-differentiation of human mesenchymal stem cells.
Q34475694Mesenchymal Progenitor Cells and Their Orthopedic Applications: Forging a Path towards Clinical Trials
Q89449438Mesenchymal Stem Cell Mediated Immuno-Modulatory and Anti-Inflammatory Mechanisms in Immune and Allergic Disorders
Q58720492Mesenchymal Stem Cell Therapy for Bone Regeneration
Q37690626Mesenchymal Stem Cell Therapy for Inflammatory Skin Diseases: Clinical Potential and Mode of Action
Q50733062Mesenchymal Stem Cells Attenuate the Adverse Effects of Immunosuppressive Drugs on Distinct T Cell Subopulations.
Q90056972Mesenchymal Stem Cells Beyond Regenerative Medicine
Q41635867Mesenchymal Stem Cells Deliver Exogenous MicroRNA-let7c via Exosomes to Attenuate Renal Fibrosis
Q36036209Mesenchymal Stem Cells from Human Extra Ocular Muscle Harbor Neuroectodermal Differentiation Potential.
Q41212597Mesenchymal Stem/Stromal Cells in Regenerative Medicine: Can Preconditioning Strategies Improve Therapeutic Efficacy?
Q97519174Mesenchymal Stromal Cells for Graft Versus Host Disease: Mechanism-Based Biomarkers
Q40201999Mesenchymal cells
Q38038473Mesenchymal dental stem cells in regenerative dentistry.
Q41831728Mesenchymal stem cell secreted vesicles provide novel opportunities in (stem) cell-free therapy
Q27007499Mesenchymal stem cell secretome and regenerative therapy after cancer
Q35971980Mesenchymal stem cell therapy in the treatment of acute and chronic graft versus host disease
Q26999783Mesenchymal stem cell transplantation in multiple sclerosis
Q37860414Mesenchymal stem cell-based therapies in regenerative medicine: applications in rheumatology
Q37427468Mesenchymal stem cell-based therapy for cartilage repair: a review.
Q35889077Mesenchymal stem cell-based therapy: a new paradigm in regenerative medicine
Q33719419Mesenchymal stem cell-based treatment for microvascular and secondary complications of diabetes mellitus
Q83142880Mesenchymal stem cell-conditioned medium accelerates skin wound healing: an in vitro study of fibroblast and keratinocyte scratch assays
Q55438460Mesenchymal stem cell-mediated Notch2 activation overcomes radiation-induced injury of the hematopoietic system.
Q58136326Mesenchymal stem cells
Q26753086Mesenchymal stem cells (MSCs) as skeletal therapeutics - an update
Q43408684Mesenchymal stem cells and endothelial progenitor cells stimulate bone regeneration and mineral density
Q38073795Mesenchymal stem cells and the lung.
Q33914228Mesenchymal stem cells and their therapeutic applications in inflammatory bowel disease
Q37390890Mesenchymal stem cells and their use as cell replacement therapy and disease modelling tool.
Q42625406Mesenchymal stem cells as a potent cell source for bone regeneration.
Q33918923Mesenchymal stem cells as cellular vectors for pediatric neurological disorders
Q37707034Mesenchymal stem cells as therapeutic tools and gene carriers in liver fibrosis and hepatocellular carcinoma.
Q37138080Mesenchymal stem cells as therapeutics
Q34349428Mesenchymal stem cells as therapeutics and vehicles for gene and drug delivery
Q34676808Mesenchymal stem cells at the intersection of cell and gene therapy
Q54979810Mesenchymal stem cells attenuate blood-brain barrier leakage after cerebral ischemia in mice.
Q43833299Mesenchymal stem cells combined with barrier domes enhance vertical bone formation
Q37863214Mesenchymal stem cells derived from dental tissues.
Q40434694Mesenchymal stem cells facilitate fracture repair in an alcohol-induced impaired healing model
Q37606972Mesenchymal stem cells for bone repair and metabolic bone diseases.
Q38062875Mesenchymal stem cells for systemic therapy: shotgun approach or magic bullets?
Q29617267Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study
Q38272566Mesenchymal stem cells improve murine acute coxsackievirus B3-induced myocarditis
Q82283820Mesenchymal stem cells improve small intestinal integrity through regulation of endogenous epithelial cell homeostasis
Q37668484Mesenchymal stem cells in alleviating sepsis-induced mice cardiac dysfunction via inhibition of mTORC1-p70S6K signal pathway
Q47123592Mesenchymal stem cells in idiopathic pulmonary fibrosis
Q36547852Mesenchymal stem cells in immunoregulation
Q37995014Mesenchymal stem cells in osteoarticular pediatric diseases: an update
Q38210869Mesenchymal stem cells in regenerative medicine for musculoskeletal diseases: bench, bedside, and industry
Q26743836Mesenchymal stem cells in regenerative rehabilitation
Q38127615Mesenchymal stem cells in the treatment of pediatric diseases
Q46622786Mesenchymal stem cells induce apoptosis of activated T cells
Q48617824Mesenchymal stem cells maintain blood-brain barrier integrity by inhibiting aquaporin-4 upregulation after cerebral ischemia
Q44486370Mesenchymal stem cells reduce inflammation while enhancing bacterial clearance and improving survival in sepsis.
Q53563416Mesenchymal stem cells stimulate antibody secretion in human B cells.
Q42133000Mesenchymal stem cells: From bench to bedside
Q34992277Mesenchymal stem cells: Molecular characteristics and clinical applications
Q37729093Mesenchymal stem cells: a new trend for cell therapy
Q35951877Mesenchymal stem cells: cell biology and potential use in therapy.
Q34422955Mesenchymal stem or stromal cells: a review of clinical applications and manufacturing practices.
Q37342808Mesenchymal stem/progenitor cells promote the reconstitution of exogenous hematopoietic stem cells in Fancg-/- mice in vivo
Q26825272Mesenchymal stem/stromal cells: a new ''cells as drugs'' paradigm. Efficacy and critical aspects in cell therapy
Q47694971Mesenchymal stromal cell phenotype is not influenced by confluence during culture expansion
Q36629367Mesenchymal stromal cells
Q40567182Mesenchymal stromal cells enhance the engraftment of hematopoietic stem cells in an autologous mouse transplantation model
Q37976114Mesenchymal stromal cells for tissue-engineered tissue and organ replacements
Q38206879Mesenchymal stromal cells in the antimicrobial host response of hematopoietic stem cell recipients with graft-versus-host disease--friends or foes?
Q35760116Mitochondrial function and energy metabolism in umbilical cord blood- and bone marrow-derived mesenchymal stem cells.
Q36795173Modulation of immune responses by mesenchymal stem cells
Q90327770Modulatory and regenerative potential of transplanted bone marrow-derived mesenchymal stem cells on rifampicin-induced kidney toxicity
Q39175513Molecular and Cellular Interactions of Allogenic and Autologus Mesenchymal Stem Cells with Innate and Acquired Immunity and Their Role in Regenerative Medicine
Q38157926Molecular mechanisms of mesenchymal stem cell differentiation towards osteoblasts.
Q37962744Molecular mediators of mesenchymal stem cell biology
Q37678413More insight into mesenchymal stem cells and their effects inside the body
Q34791234Multipotent Mesenchymal Stromal Cells for Autoimmune Diseases
Q37421286Multipotent mesenchymal stromal cells for autoimmune diseases: teaching new dogs old tricks.
Q36547021Multipotent stromal cells are activated to reduce apoptosis in part by upregulation and secretion of stanniocalcin-1.
Q30478228Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice.
Q46275076Murine mesenchymal stem cell isolated and expanded in low and high density culture system: surface antigen expression and osteogenic culture mineralization.
Q57777088Murine mesenchymal stem cells isolated by low density primary culture system
Q37591126Myogenic-induced mesenchymal stem cells are capable of modulating the immune response by regulatory T cells
Q34948033N-formyl-methionyl-leucyl-phenylalanine (fMLP) promotes osteoblast differentiation via the N-formyl peptide receptor 1-mediated signaling pathway in human mesenchymal stem cells from bone marrow
Q33258763N-glycolylneuraminic acid xenoantigen contamination of human embryonic and mesenchymal stem cells is substantially reversible.
Q57776854Nanotissue Engineering of Musculoskeletal Cells
Q36347990Neurorestoration induced by mesenchymal stem cells: potential therapeutic mechanisms for clinical trials.
Q37396444New era of cell-based orthopedic therapies.
Q58270335New frontiers for dominant osteogenesis imperfecta treatment: gene/cellular therapy approaches
Q37989396New insights on translational development of mesenchymal stromal cells for suppressor therapy
Q36144893Non-hematopoietic bone marrow stem cells: molecular control of expansion and differentiation
Q40339136Normal collagen and bone production by gene-targeted human osteogenesis imperfecta iPSCs
Q61446442Nucleic acid delivery to mesenchymal stem cells: a review of nonviral methods and applications
Q34582606One strategy for cell and gene therapy: harnessing the power of adult stem cells to repair tissues.
Q33456591Optimizing isolation culture and freezing methods to preserve Wharton's jelly's mesenchymal stem cell (MSC) properties: an MSC banking protocol validation for the Hellenic Cord Blood Bank.
Q89359657Origin of Reparative Stem Cells in Fracture Healing
Q33713231Orthopedic gene therapy in 2008.
Q41493518Osmotic behaviour of human mesenchymal stem cells: Implications for cryopreservation
Q35932671Osteogenesis Imperfecta: A Review with Clinical Examples.
Q34316613Osteogenesis imperfecta
Q39062996Osteogenic Differentiation in Healthy and Pathological Conditions
Q42957949Osteogenic and adipogenic cell fractions isolated from postnatal mouse calvaria
Q36035697Osteogenic differentiation of mesenchymal stromal cells in two-dimensional and three-dimensional cultures without animal serum
Q53000571Ovariectomized Rats with Established Osteopenia have Diminished Mesenchymal Stem Cells in the Bone Marrow and Impaired Homing, Osteoinduction and Bone Regeneration at the Fracture Site.
Q47245037PEG hydrogel containing calcium-releasing particles and mesenchymal stromal cells promote vessel maturation
Q34501852Paracrine effects of mesenchymal stem cells in cisplatin-induced renal injury require heme oxygenase-1.
Q40099637Pathogen reduction through additive-free short-wave UV light irradiation retains the optimal efficacy of human platelet lysate for the expansion of human bone marrow mesenchymal stem cells
Q34204513Periurethral injection of autologous adipose-derived regenerative cells for the treatment of male stress urinary incontinence: Report of three initial cases
Q38078084Perivascular mesenchymal stem cells in the adult human brain: a future target for neuroregeneration?
Q34581991Persistence of intracellular and extracellular changes after incompletely suppressing expression of the R789C (p.R989C) and R992C (p.R1192C) collagen II mutants
Q34768188Phenotype, donor age and gender affect function of human bone marrow-derived mesenchymal stromal cells
Q35242096Phenotypic and functional characterization of human bone marrow stromal cells in hollow-fibre bioreactors
Q34751358Placental mesenchymal stromal cells derived from blood vessels or avascular tissues: what is the better choice to support endothelial cell function?
Q52642345Platelet lysate as a novel serum-free media supplement for the culture of equine bone marrow-derived mesenchymal stem cells.
Q53288262Platelet lysate consisting of a natural repair proteome supports human mesenchymal stem cell proliferation and chromosomal stability.
Q42242005Platelet lysate from whole blood-derived pooled platelet concentrates and apheresis-derived platelet concentrates for the isolation and expansion of human bone marrow mesenchymal stromal cells: production process, content and identification of activ
Q47783595Platelet lysate obtained via plateletpheresis performed in standing and awake equine donors
Q37257628Poly(ε-caprolactone)-carbon nanotube composite scaffolds for enhanced cardiac differentiation of human mesenchymal stem cells
Q33863266Potential implications of cell therapy for osteogenesis imperfecta
Q37523900Potential of human fetal chorionic stem cells for the treatment of osteogenesis imperfecta
Q37315399Potential role of mesenchymal stromal cells in pediatric hematopoietic SCT.
Q37585445Pre- and postnatal transplantation of fetal mesenchymal stem cells in osteogenesis imperfecta: a two-center experience
Q64926918Preconditioning in an Inflammatory Milieu Augments the Immunotherapeutic Function of Mesenchymal Stromal Cells.
Q34312131Prenatal transplantation of mesenchymal stem cells to treat osteogenesis imperfecta
Q28757126Prevention of LPS-induced acute lung injury in mice by mesenchymal stem cells overexpressing angiopoietin 1
Q51009753Profiling and semiquantitative analysis of the cell surface proteome in human mesenchymal stem cells.
Q34480435Progressive vascular smooth muscle cell defects in a mouse model of Hutchinson-Gilford progeria syndrome
Q36050692Properties of mechano-transduction via simulated microgravity and its effects on intracellular trafficking of VEGFR's
Q36275783Prospects and limitations of improving skeletal growth in a mouse model of spondyloepiphyseal dysplasia caused by R992C (p.R1192C) substitution in collagen II.
Q30431697Prospects for osteoprogenitor stem cells in fracture repair and osteoporosis
Q47274328Prospects of Pluripotent and Adult Stem Cells for Rare Diseases.
Q34548370Prostacyclin suppresses twist expression in the presence of indomethacin in bone marrow-derived mesenchymal stromal cells.
Q41767093Rapid growth and osteogenic differentiation of mesenchymal stem cells isolated from human bone marrow
Q26824117Recent advances in bone regeneration using adult stem cells
Q26781674Recent developments in osteogenesis imperfecta
Q37947153Recent progress in osteogenesis imperfecta
Q33588206Recipient Glycemic Micro-environments Govern Therapeutic Effects of Mesenchymal Stem Cell Infusion on Osteopenia
Q33711085Recommendations and considerations for the use of biologics in orthopedic surgery
Q38131118Reconciling the effects of inflammatory cytokines on mesenchymal cell osteogenic differentiation
Q64096010Reduction of Inflammation and Enhancement of Motility after Pancreatic Islet Derived Stem Cell Transplantation Following Spinal Cord Injury
Q43375908Regulation of Osteogenic Differentiation of Placental-Derived Mesenchymal Stem Cells by Insulin-Like Growth Factors and Low Oxygen Tension.
Q64099263Regulation of Redox Homeostasis by Nonthermal Biocompatible Plasma Discharge in Stem Cell Differentiation
Q35222931Rejuvenation: an integrated approach to regenerative medicine
Q53272398Repair of bone defect with vascularized tissue engineered bone graft seeded with mesenchymal stem cells in rabbits.
Q45855295Restoration of cellular function of mesenchymal stem cells from a hypophosphatasia patient
Q89133396Retrieval of a periodontally compromised tooth by allogeneic grafting of mesenchymal stem cells from dental pulp: A case report
Q37976449Revisiting cardiovascular regeneration with bone marrow-derived angiogenic and vasculogenic cells
Q26825380Role of mesenchymal stem cells in bone regeneration and fracture repair: a review
Q46284858Runx2/Cbfa1-genetically engineered skeletal myoblasts mineralize collagen scaffolds in vitro
Q42689394Safety Profile of Good Manufacturing Practice Manufactured Interferon γ-Primed Mesenchymal Stem/Stromal Cells for Clinical Trials.
Q57289629Secretion of angiogenic proteins by human multipotent mesenchymal stromal cells and their clinical potential in the treatment of avascular osteonecrosis
Q33814461Secretome from mesenchymal stem cells induces angiogenesis via Cyr61
Q37294609Sequential use of human-derived medium supplements favours cardiovascular tissue engineering.
Q43239856Serial in vivo imaging of the porcine heart after percutaneous, intramyocardially injected 111In-labeled human mesenchymal stromal cells
Q34997877Serial transplantation and long-term engraftment of intra-arterially delivered clonally derived mesenchymal stem cells to injured bone marrow.
Q39012336Serum albumin as a local therapeutic agent in cell therapy and tissue engineering.
Q38151905Serum-free media for the production of human mesenchymal stromal cells: a review.
Q50583284Serum-free medium with osteogenic supplements induces adipogenesis in rat bone marrow stromal cells.
Q37368244Serum-free spheroid suspension culture maintains mesenchymal stem cell proliferation and differentiation potential
Q57282139Short-term physiological hypoxia potentiates the therapeutic function of mesenchymal stem cells
Q26778170Skeletal stem cells and their contribution to skeletal fragility: senescence and rejuvenation
Q36159300Skeletal stem cells in regenerative medicine
Q37111537Small molecules affect human dental pulp stem cell properties via multiple signaling pathways
Q36771332Smurf2-mediated degradation of EZH2 enhances neuron differentiation and improves functional recovery after ischaemic stroke
Q35146617Sources of adult mesenchymal stem cells applicable for musculoskeletal applications - a systematic review of the literature
Q43944175Specific lineage-priming of bone marrow mesenchymal stem cells provides the molecular framework for their plasticity.
Q38175402Specific protein markers for stem cell cross-talk with neighboring cells in the environment
Q35982861Spontaneous Differentiation of Human Mesenchymal Stem Cells on Poly-Lactic-Co-Glycolic Acid Nano-Fiber Scaffold
Q33765265Stem Cell Therapy: A New Treatment for Burns?
Q34343825Stem Cells and Regenerative Medicine: Accomplishments to Date and Future Promise
Q34150828Stem cell bioprocess engineering towards cGMP production and clinical applications
Q36990671Stem cell differentiation and expansion for clinical applications of tissue engineering
Q38160451Stem cell horizons in intervertebral disc degeneration
Q36729785Stem cell myths
Q37754873Stem cell therapy for cystic fibrosis: current status and future prospects
Q38331002Stem cell therapy for inflammatory bowel disease
Q36150403Stem cell therapy for osteonecrosis of the femoral head
Q37161090Stem cell therapy for voiding and erectile dysfunction
Q38472909Stem cell transplantation before birth - a realistic option for treatment of osteogenesis imperfecta?
Q37734210Stem cell transplantation in multiple sclerosis: current status and future prospects
Q35568777Stem cell treatment for patients with autoimmune disease by systemic infusion of culture-expanded autologous adipose tissue derived mesenchymal stem cells
Q35923390Stem cell- and growth factor-based regenerative therapies for avascular necrosis of the femoral head
Q38736047Stem cells applications in bone and tooth repair and regeneration: New insights, tools, and hopes
Q37730300Stem cells as vectors for antitumour therapy
Q37143887Stem cells bioprocessing: an important milestone to move regenerative medicine research into the clinical arena
Q34961663Stem cells derived from amniotic fluid: new potentials in regenerative medicine
Q51910330Stem cells genetically modified with the developmental gene MT1-MMP improve regeneration of the supraspinatus tendon-to-bone insertion site.
Q91688583Stem cells in Osteoporosis: From Biology to New Therapeutic Approaches
Q53290264Stromal cell-derived factor-1 mediates changes of bone marrow stem cells during the bone repair process.
Q34614799Stromal cell-derived factor-1β mediates cell survival through enhancing autophagy in bone marrow-derived mesenchymal stem cells.
Q90733778Suitability and limitations of mesenchymal stem cells to elucidate human bone illness
Q36905079Suppression of androgen receptor enhances the self-renewal of mesenchymal stem cells through elevated expression of EGFR.
Q51545691Suppression of human peripheral blood lymphocyte proliferation by immortalized mesenchymal stem cells derived from bone marrow of Banna Minipig inbred-line.
Q38982780Sustained expression of coagulation factor IX by modified cord blood-derived mesenchymal stromal cells
Q33864378Synovium fragment-derived cells exhibit characteristics similar to those of dissociated multipotent cells in synovial fluid of the temporomandibular joint
Q51349416Synthetic vascular prosthesis impregnated with genetically modified bone marrow cells produced recombinant proteins.
Q36808571Systemic Mesenchymal Stromal Cell Transplantation Prevents Functional Bone Loss in a Mouse Model of Age-Related Osteoporosis
Q37692465Systemic administration of mesenchymal stem cells combined with parathyroid hormone therapy synergistically regenerates multiple rib fractures.
Q37307155TGF-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formation
Q56574797THIS ARTICLE HAS BEEN RETRACTED Periurethral injection of autologous adipose‐derived stem cells for the treatment of stress urinary incontinence in patients undergoing radical prostatectomy: Report of two initial cases
Q30449821Targets and delivery methods for therapeutic angiogenesis in peripheral artery disease
Q39898293Telomerase immortalized human amnion- and adipose-derived mesenchymal stem cells: maintenance of differentiation and immunomodulatory characteristics.
Q37071096The CD34-like protein PODXL and alpha6-integrin (CD49f) identify early progenitor MSCs with increased clonogenicity and migration to infarcted heart in mice
Q34760856The Cdc42 guanine nucleotide exchange factor FGD1 regulates osteogenesis in human mesenchymal stem cells
Q47224539The Components of Bone and What They Can Teach Us about Regeneration
Q52661742The Effects of Photobiomodulation of 808 nm Diode Laser Therapy at Higher Fluence on the in Vitro Osteogenic Differentiation of Bone Marrow Stromal Cells.
Q26773017The Modulatory Effects of Mesenchymal Stem Cells on Osteoclastogenesis
Q37758303The Oncogenic Potential of Mesenchymal Stem Cells in the Treatment of Cancer: Directions for Future Research
Q89623527The Potential of Mesenchymal Stem Cells to Treat Systemic Inflammation in Horses
Q56837269The Safety of Non-Expanded Multipotential Stromal Cell Therapies
Q36804648The concept of mesenchymal stem cells
Q81434774The controversial and changing role of haematopoietic cell transplantation for lysosomal storage disorders: an update
Q42124688The effect of in vivo mobilization of bone marrow stem cells on the pancreas of diabetic albino rats (a histological & immunohistochemical study).
Q33941513The effects of axial displacement on fracture callus morphology and MSC homing depend on the timing of application
Q33630408The efficacy of human placenta-derived mesenchymal stem cells on radiation enteropathy along with proteomic biomarkers predicting a favorable response
Q35940531The elusive nature and function of mesenchymal stem cells
Q33454406The establishment of a bank of stored clinical bone marrow stromal cell products
Q45876004The fate of mesenchymal stem cells transplanted into immunocompetent neonatal mice: implications for skeletal gene therapy via stem cells
Q37310625The immune boundaries for stem cell based therapies: problems and prospective solutions.
Q36715937The impact of cell source, culture methodology, culture location, and individual donors on gene expression profiles of bone marrow-derived and adipose-derived stromal cells.
Q37720654The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine
Q37567542The possible use of stem cells in regenerative medicine: dream or reality?
Q37790311The potential of adipose stem cells in regenerative medicine.
Q36054671The potential of mesenchymal stromal cells as a novel cellular therapy for multiple sclerosis
Q45222224The role of bone marrow-derived cells during the bone healing process in the GFP mouse bone marrow transplantation model.
Q38150244The role of mesenchymal stem cells in bone repair and regeneration
Q38788475The role of mesenchymal stem cells in oncology and regenerative medicine
Q36268038The role of recipient T cells in mesenchymal stem cell-based tissue regeneration
Q39852962The small molecule phenamil induces osteoblast differentiation and mineralization
Q37677911The therapeutic potential of mesenchymal stem cell transplantation as a treatment for multiple sclerosis: consensus report of the International MSCT Study Group
Q36897375The therapeutic potential of mesenchymal stem cells. Cell- & tissue-based therapy
Q89769517Therapeutic Mesenchymal Stromal Cells for Immunotherapy and for Gene and Drug Delivery
Q37142832Therapeutic angiogenesis in critical limb ischemia.
Q38057676Therapeutic application of mesenchymal stem cells in bone and joint diseases
Q30319123Therapeutic application of mesenchymal stromal cells in autoimmune disease: rationale and initial clinical experience
Q38213836Therapeutic cell carriers: a potential road to cure glioma
Q34159047Therapeutic potential of adult bone marrow-derived mesenchymal stem cells in diseases of the skeleton
Q34137317Therapeutic potential of genetically modified adult stem cells for osteopenia
Q36737833Therapeutic potential of mesenchymal stem cells in regenerative medicine
Q35726548Therapeutic potential of stem cells in orthopedics
Q46643273Therapeutic superiority for cartilage repair by CD271-positive marrow stromal cell transplantation
Q37669198Tissue Engineering with Nano-Fibrous Scaffolds
Q51094994Tissue engineering using adult stem cells.
Q80568647Tissue repair using allogeneic mesenchymal stem cells for hemorrhagic cystitis, pneumomediastinum and perforated colon
Q37164045Tolerance strategies for stem-cell-based therapies.
Q34652682Total body irradiation is permissive for mesenchymal stem cell-mediated new bone formation following local transplantation.
Q38127722Toward the use of endometrial and menstrual blood mesenchymal stem cells for cell-based therapies.
Q36183143Transcription factor ZNF25 is associated with osteoblast differentiation of human skeletal stem cells
Q33952249Transformation of human mesenchymal cells and skin fibroblasts into hematopoietic cells
Q34557484Translating research into clinical scale manufacturing of mesenchymal stromal cells
Q60912266Transplantation of bone marrow mesenchymal stromal cells attenuates liver fibrosis in mice by regulating macrophage subtypes
Q36206449Transplanted bone marrow mononuclear cells and MSCs impart clinical benefit to children with osteogenesis imperfecta through different mechanisms.
Q36915154Transplanted murine long-term repopulating hematopoietic cells can differentiate to osteoblasts in the marrow stem cell niche
Q36656538Treatment of children with osteogenesis imperfecta
Q26853357Treatment of osteogenesis imperfecta in adults
Q37194001Treatment of systemic sclerosis: potential role for stem cell transplantation.
Q58752199Treatment options for osteogenesis imperfecta
Q42596943True autologous approach in cell therapy. - Using your own serum for cell culture -.
Q50215039UV-activated 7-dehydrocholesterol-coated titanium implants promote differentiation of human umbilical cord mesenchymal stem cells into osteoblasts
Q37721514Unrelated donor allogeneic hematopoietic stem cell transplantation for patients with hemoglobinopathies using a reduced-intensity conditioning regimen and third-party mesenchymal stromal cells
Q38924988Use of Pig as a Model for Mesenchymal Stem Cell Therapies for Bone Regeneration.
Q26747035Using Stem Cells to Grow Artificial Tissue for Peripheral Nerve Repair
Q26777025Using mesenchymal stem cells as a therapy for bone regeneration and repairing
Q47401296VEGF secreted by mesenchymal stem cells mediates the differentiation of endothelial progenitor cells into endothelial cells via paracrine mechanisms
Q38293045Virus-based scaffolds for tissue engineering applications
Q37542905Wnt and PPARgamma signaling in osteoblastogenesis and adipogenesis
Q36728535Xeno-Free Extraction, Culture, and Cryopreservation of Human Adipose-Derived Mesenchymal Stem Cells
Q42577722Xeno-free chondrogenesis of bone marrow mesenchymal stromal cells: towards clinical-grade chondrocyte production.
Q80988331[Bone harvesting from the iliac crest]
Q88040135[Mesenchymal stem/stroma cells : Therapeutic potential in the treatment of autoimmune diseases]
Q83514683[Mesenchymal stromal cells: Biological properties and clinical prospects]
Q80357363[The hopes of the mesenchymal stem cells in regenerative medicine]
Q50464926hTERT- and hCTLA4Ig-expressing human bone marrow-derived mesenchymal stem cells: in vitro and in vivo characterization and osteogenic differentiation.

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