Clinical applications of mesenchymal stem cells in chronic diseases

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Clinical applications of mesenchymal stem cells in chronic diseases is …
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P356DOI10.1155/2014/306573
P932PMC publication ID4021690
P698PubMed publication ID24876848
P5875ResearchGate publication ID262734016

P50authorAndrea FariniQ96079880
Mirella MeregalliQ53243014
Clementina SitziaQ64398315
P2093author name stringYvan Torrente
Silvia Erratico
P2860cites workClinical applications of mesenchymal stem cellsQ21198864
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Expansion and redifferentiation of adult human pancreatic islet cellsQ46918992
Defining the risks of mesenchymal stromal cell therapyQ47584701
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Human bone marrow-derived mesenchymal stem cells secrete brain-derived neurotrophic factor which promotes neuronal survival in vitro.Q47894301
Phenotypic and functional comparison of cultures of marrow-derived mesenchymal stem cells (MSCs) and stromal cellsQ48000642
Uneven pattern of dopamine loss in the striatum of patients with idiopathic Parkinson's disease. Pathophysiologic and clinical implicationsQ48088787
Intravenous administration of mesenchymal stem cells derived from bone marrow after contusive spinal cord injury improves functional outcomeQ48198558
Mesenchymal stem cell-secreted superoxide dismutase promotes cerebellar neuronal survivalQ48371412
Bone marrow stromal cells reduce axonal loss in experimental autoimmune encephalomyelitis miceQ48497239
Combining erythropoietin infusion with intramyocardial delivery of bone marrow cells is more effective for cardiac repair.Q50700769
Intracerebral transplantation of adipose-derived mesenchymal stem cells alternatively activates microglia and ameliorates neuropathological deficits in Alzheimer's disease mice.Q50719528
A decreased positivity for CD90 on human mesenchymal stromal cells (MSCs) is associated with a loss of immunosuppressive activity by MSCs.Q50780054
Flk-1+ adipose-derived mesenchymal stem cells differentiate into skeletal muscle satellite cells and ameliorate muscular dystrophy in mdx mice.Q50866492
Treatment of experimental arthritis by inducing immune tolerance with human adipose-derived mesenchymal stem cellsQ83586509
Mesenchymal stromal cellsQ84612117
TLR ligands stimulation protects MSC from NK killingQ86524351
Multilineage potential of adult human mesenchymal stem cellsQ27860737
Stem cell therapy in a caprine model of osteoarthritisQ28191365
Bone marrow cells regenerate infarcted myocardiumQ28210640
Cell therapy using allogeneic bone marrow mesenchymal stem cells prevents tissue damage in collagen-induced arthritisQ28295588
Epithelial-to-Mesenchymal Transition Generates Proliferative Human Islet Precursor CellsQ29541158
Mesenchymal stem cells within tumour stroma promote breast cancer metastasisQ29614303
Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II studyQ29617267
Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cellsQ29618766
Mesenchymal stem cellsQ29619804
Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 productionQ29619807
No Evidence for Mouse Pancreatic  -Cell Epithelial-Mesenchymal Transition In VitroQ30000016
Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing.Q30157916
Skeletal myogenic differentiation of mesenchymal stem cells isolated from human umbilical cord bloodQ30163911
Cell surface antigens on human marrow-derived mesenchymal cells are detected by monoclonal antibodiesQ30195546
Regulatory T cells in CNS injury: the simple, the complex and the confusedQ30424827
Strategies to rescue mesenchymal stem cells (MSCs) and dental pulp stem cells (DPSCs) from NK cell mediated cytotoxicityQ30980207
Mobilized bone marrow cells repair the infarcted heart, improving function and survivalQ31002195
Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypesQ33181775
Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healingQ33326623
Bone-marrow-derived cells that home to acoustic deafened cochlea preserved their hematopoietic identityQ33332228
Why are MSCs therapeutic? New data: new insight.Q33386080
Mesenchymal stromal cells ameliorate experimental autoimmune encephalomyelitis by inhibiting CD4 Th17 T cells in a CC chemokine ligand 2-dependent mannerQ33438830
Intravenous administration of mesenchymal stem cells exerts therapeutic effects on parkinsonian model of rats: focusing on neuroprotective effects of stromal cell-derived factor-1alphaQ33564990
IL-6-dependent PGE2 secretion by mesenchymal stem cells inhibits local inflammation in experimental arthritisQ33769303
Transplantation of human bone marrow mesenchymal stem cell ameliorates the autoimmune pathogenesis in MRL/lpr miceQ33811436
Cardiomyocytes can be generated from marrow stromal cells in vitroQ33843659
Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfectaQ33855709
Human leukocyte antigen-G5 secretion by human mesenchymal stem cells is required to suppress T lymphocyte and natural killer function and to induce CD4+CD25highFOXP3+ regulatory T cells.Q34007524
Marrow stromal cells form guiding strands in the injured spinal cord and promote recoveryQ34012747
Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: Implications for cell therapy of boneQ34066339
Bone marrow mesenchymal stem cell transplantation in patients with multiple sclerosis: a pilot studyQ34132522
SHED: stem cells from human exfoliated deciduous teeth.Q34193093
Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trialQ34332467
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Potential of rat bone marrow-derived mesenchymal stem cells as vehicles for delivery of neurotrophins to the Parkinsonian rat brainQ39664348
Immunosuppressive effects of mesenchymal stem cells in collagen-induced mouse arthritisQ39797982
The effect of continued hypoxia on rat pulmonary arterial circulation. An ultrastructural studyQ39844907
Lentiviral delivery of LMX1a enhances dopaminergic phenotype in differentiated human bone marrow mesenchymal stem cellsQ39993972
Dopaminergic differentiation of human mesenchymal stem cells--utilization of bioassay for tyrosine hydroxylase expressionQ40138132
Allogeneic mesenchymal stem cell and mesenchymal stem cell-differentiated chondrocyte suppress the responses of type II collagen-reactive T cells in rheumatoid arthritisQ40144569
Mobilization of endothelial progenitor cells into the circulation in burned patientsQ40183091
Efficient transduction of liver and muscle after in utero injection of lentiviral vectors with different pseudotypesQ40574948
Phenotypic determination and characterization of nestin-positive precursors derived from human fetal pancreas.Q40594090
Discrepancy between the in vitro and in vivo effects of murine mesenchymal stem cells on T-cell proliferation and collagen-induced arthritisQ40727194
Importance of the SDF-1:CXCR4 axis in myocardial repairQ42570987
Modeling familial Alzheimer's disease with induced pluripotent stem cellsQ42817521
Human mesenchymal stem cells infiltrate the spinal cord, reduce demyelination, and localize to white matter lesions in experimental autoimmune encephalomyelitis.Q43578851
The dynamic in vivo distribution of bone marrow-derived mesenchymal stem cells after infusion.Q43599448
Mesenchymal stem cell-derived molecules directly modulate hepatocellular death and regeneration in vitro and in vivoQ44124588
Neutrophils do not contribute to local tissue damage, but play a key role in skeletal muscle regeneration, in mice injected with Bothrops asper snake venomQ44594506
Mesenchymal stem cells from adult human bone marrow differentiate into a cardiomyocyte phenotype in vitro.Q44960426
Human umbilical cord blood cells differentiate into muscle in sjl muscular dystrophy miceQ45145866
Mesenchymal stem cells contribute to the renal repair of acute tubular epithelial injury.Q45152925
Human mesenchymal stem cells ectopically expressing full-length dystrophin can complement Duchenne muscular dystrophy myotubes by cell fusion.Q45888978
Involvement of the CXCL12/CXCR4 pathway in the recovery of skin following burnsQ45889492
Improvement of liver function in liver cirrhosis patients after autologous mesenchymal stem cell injection: a phase I-II clinical trial.Q46004819
Experimental study on influence of bone marrow mesenchymal stem cells on activation and function of mouse peritoneal macrophagesQ46180763
Enhanced expression of the CXCl12/SDF-1 chemokine receptor CXCR7 after cerebral ischemia in the rat brainQ46566592
Dynamic distribution of bone marrow-derived mesenchymal stromal cells and change of pathology after infusing into mdx miceQ46639962
Fibroblast precursors in normal and irradiated mouse hematopoietic organsQ34474362
Human Thymus Mesenchymal Stromal Cells Augment Force Production in Self-Organized Cardiac TissueQ34495019
Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosisQ34564111
Systemic transplantation of human umbilical cord derived mesenchymal stem cells-educated T regulatory cells improved the impaired cognition in AβPPswe/PS1dE9 transgenic miceQ34919216
In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusionQ34967985
Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effectsQ35168236
Cell therapy for bone disease: a review of current statusQ35216533
Mesenchymal stem cells enhance autophagy and increase β-amyloid clearance in Alzheimer disease models.Q35319897
Islet transplantation: immunological perspectivesQ35538149
Cord blood in regenerative medicine: do we need immune suppression?Q35633105
Mesenchymal stem/stromal cells (MSCs): role as guardians of inflammationQ35665181
Mesenchymal stem cells: clinical applications and biological characterization.Q35686355
Mesenchymal stem cells: isolation and therapeuticsQ35877577
Surviving the butterfly and the wolf: mortality trends in systemic lupus erythematosusQ35879759
Autologous haematopoietic-stem-cell transplantation for multiple sclerosisQ35994389
Mesenchymal stem cells: progress toward promiseQ36205474
Identification of a novel population of muscle stem cells in mice: potential for muscle regenerationQ36324366
Skeletal muscle repair by adult human mesenchymal stem cells from synovial membrane.Q36325014
Mesenchymal stem cells: isolation, in vitro expansion and characterizationQ36349210
Parkinson's disease: pathophysiologyQ36495393
Multipotent stromal cells are activated to reduce apoptosis in part by upregulation and secretion of stanniocalcin-1.Q36547021
Immune regulation by mesenchymal stem cells: two sides to the coinQ36703067
Mesenchymal stem cells: a new strategy for immunosuppression?Q36776872
Modulation of immune responses by mesenchymal stem cellsQ36795173
Differentiation potential of multipotent progenitor cells derived from war-traumatized muscle tissueQ37132476
Inflammation and tumor microenvironments: defining the migratory itinerary of mesenchymal stem cellsQ37134013
Direct muscle delivery of GDNF with human mesenchymal stem cells improves motor neuron survival and function in a rat model of familial ALSQ37183861
Mesenchymal stem cell homing: the devil is in the detailsQ37407769
Mesenchymal stem cells: immunobiology and role in immunomodulation and tissue regenerationQ37537193
Biomolecular strategies of bone augmentation in spinal surgeryQ37825049
Role of adult stem/progenitor cells in osseointegration and implant looseningQ37861558
Bioreactor systems for bone tissue engineeringQ37865539
Recent preclinical evidence advancing cell therapy for Alzheimer's disease.Q38024220
T cells out of control--impaired immune regulation in the inflamed jointQ38079816
Tissue-engineered approach for the treatment of steroid-induced osteonecrosis of the femoral head: transplantation of autologous mesenchymal stem cells cultured with beta-tricalcium phosphate ceramics and free vascularized fibula.Q51092429
Healos and bone marrow aspirate used for lumbar spine fusion: a case controlled study comparing healos with autograft.Q51144517
CNS microvascular pericytes exhibit multipotential stem cell activity.Q51285884
Transplantation of mesenchymal stem cells improves cardiac function in a rat model of dilated cardiomyopathy.Q51371194
Reversal of the immunosuppressive properties of mesenchymal stem cells by tumor necrosis factor alpha in collagen-induced arthritis.Q51474101
Intravenous administration of mesenchymal stem cells improves cardiac function in rats with acute myocardial infarction through angiogenesis and myogenesis.Q51638429
Phase 1 trial of autologous bone marrow mesenchymal stem cell transplantation in patients with decompensated liver cirrhosis.Q51898878
Human heart, spleen, and perirenal fat-derived mesenchymal stem cells have immunomodulatory capacities.Q51972063
Widespread distribution and muscle differentiation of human fetal mesenchymal stem cells after intrauterine transplantation in dystrophic mdx mouse.Q51998594
Mesenchymal stem cells overexpressing interleukin-10 attenuate collagen-induced arthritis in mice.Q53532396
Islet-derived fibroblast-like cells are not derived via epithelial-mesenchymal transition from Pdx-1 or insulin-positive cells.Q53587915
Cytokines produced by bone marrow cells can contribute to functional improvement of the infarcted heart by protecting cardiomyocytes from ischemic injury.Q53628210
Mesenchymal stem cell-natural killer cell interactions: evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL-2-induced NK-cell proliferation.Q53652498
Marrow stromal stem cells.Q54130286
Stromal cell-derived factor 1/CXCR4 signaling is critical for the recruitment of mesenchymal stem cells to the fracture site during skeletal repair in a mouse model.Q54493066
Effective treatment of collagen-induced arthritis by adoptive transfer of CD25+ regulatory T cells.Q54656483
Pretransplant infusion of mesenchymal stem cells prolongs the survival of a semiallogeneic heart transplant through the generation of regulatory T cellsQ57702376
Pretransplant Infusion of Mesenchymal Stem Cells Prolongs the Survival of a Semiallogeneic Heart Transplant through the Generation of Regulatory T CellsQ57702466
PD1 Negative and PD1 Positive CD4+ T Regulatory Cells in Mild Cognitive Impairment and Alzheimer's DiseaseQ57997425
Interleukin-10 inhibition of the progression of established collagen-induced arthritisQ58479922
Mesenchymal Stem Cell-Mediated Immunosuppression Occurs via Concerted Action of Chemokines and Nitric OxideQ61645540
Immunosuppressive effect of mesenchymal stem cells favors tumor growth in allogeneic animalsQ62083511
Mesenchymal Stem Cells for Treatment of Therapy-Resistant Graft-versus-Host DiseaseQ63197317
Ex vivo expansion and subsequent infusion of human bone marrow-derived stromal progenitor cells (mesenchymal progenitor cells): implications for therapeutic useQ70803151
In vivo cardiovasculogenesis by direct injection of isolated adult mesenchymal stem cellsQ73702569
Intra-bone marrow injection of allogeneic bone marrow cells: a powerful new strategy for treatment of intractable autoimmune diseases in MRL/lpr miceQ73850247
Mesenchymal stem cell implantation in a swine myocardial infarct model: engraftment and functional effectsQ74341231
Abnormality of bone marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosusQ80082586
Abnormal surface markers expression on bone marrow CD34+ cells and correlation with disease activity in patients with systemic lupus erythematosusQ80188870
Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarctionQ80246358
[Cell based therapy for the treatment of femoral head necrosis]Q80265662
Immunosuppression by placental indoleamine 2,3-dioxygenase: a role for mesenchymal stem cellsQ80832925
Prospective identification of myogenic endothelial cells in human skeletal muscleQ80982228
Activated CD4+CD25+ regulatory T cells inhibit osteoclastogenesis and collagen-induced arthritisQ81277810
Interaction between human NK cells and bone marrow stromal cells induces NK cell triggering: role of NKp30 and NKG2D receptorsQ81447005
A critical role of IFNgamma in priming MSC-mediated suppression of T cell proliferation through up-regulation of B7-H1Q81596726
Leukemia inhibitory factor: Role in human mesenchymal stem cells mediated immunosuppressionQ81667319
Transcoronary transplantation of autologous mesenchymal stem cells and endothelial progenitors into infarcted human myocardiumQ81845589
[Clinical study of lumbar fusion by hybrid construct of stem cells technique and biodegradable material]Q81953551
Immunosuppressive properties of mesenchymal stem cells derived from bone marrow of patients with chronic myeloid leukemiaQ82095655
Flk-1+ mesenchymal stem cells aggravate collagen-induced arthritis by up-regulating interleukin-6Q82209428
Human bone marrow-derived mesenchymal cells differentiate and mature into endocrine pancreatic lineage in vivoQ82253464
Generation of glucose-responsive, insulin-producing cells from human umbilical cord blood-derived mesenchymal stem cellsQ83126621
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P921main subjectmesenchymal stem cellQ1922379
P304page(s)306573
P577publication date2014-04-30
P1433published inStem Cells InternationalQ26842114
P1476titleClinical applications of mesenchymal stem cells in chronic diseases
P478volume2014