Systemic transplantation of human umbilical cord derived mesenchymal stem cells-educated T regulatory cells improved the impaired cognition in AβPPswe/PS1dE9 transgenic mice

scientific article

Systemic transplantation of human umbilical cord derived mesenchymal stem cells-educated T regulatory cells improved the impaired cognition in AβPPswe/PS1dE9 transgenic mice is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2013PLoSO...869129Y
P356DOI10.1371/JOURNAL.PONE.0069129
P932PMC publication ID3723739
P698PubMed publication ID23935936
P5875ResearchGate publication ID255737097

P2093author name stringHui Yang
Jianzhong Bi
Lifei Wei
Zhaohong Xie
Hongna Yang
P2860cites workReversal of type 1 diabetes via islet β cell regeneration following immune modulation by cord blood-derived multipotent stem cellsQ21245299
Human cord blood stem cell-modulated regulatory T lymphocytes reverse the autoimmune-caused type 1 diabetes in nonobese diabetic (NOD) miceQ21562482
Epidemiology of Alzheimer diseaseQ26865371
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseasesQ28131652
Monitoring lymphocyte proliferation in vitro and in vivo with the intracellular fluorescent dye carboxyfluorescein diacetate succinimidyl esterQ28248444
Morris water maze: procedures for assessing spatial and related forms of learning and memoryQ28296351
Lithium improves hippocampal neurogenesis, neuropathology and cognitive functions in APP mutant miceQ28476571
FOXP3+ regulatory T cells in the human immune systemQ29307487
Mechanisms underlying inflammation in neurodegenerationQ29617977
Regulatory T cells in CNS injury: the simple, the complex and the confusedQ30424827
Immunomodulatory effect of human umbilical cord Wharton's jelly-derived mesenchymal stem cells on lymphocytes.Q34224955
Biogenesis and metabolism of Alzheimer's disease Abeta amyloid peptidesQ34750587
Aire controls mesenchymal stem cell-mediated suppression in chronic colitisQ35665164
Mesenchymal stem cells induce functionally active T-regulatory lymphocytes in a paracrine fashion and ameliorate experimental autoimmune uveitisQ35865438
Microglia: phagocyte and glia cell.Q35894049
Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathologyQ35959633
Immunological applications of stem cells in type 1 diabetesQ36666422
Regulatory T cells - a brief history and perspectiveQ36986732
Regulatory T cells: how do they suppress immune responses?Q37593768
Immunological and regenerative properties of cord blood stem cellsQ37744150
Molecular mechanisms and therapeutic application of NSAIDs and derived compounds in Alzheimer's disease.Q37846242
Immunomodulatory properties and therapeutic application of mesenchymal stem cellsQ37847217
Alzheimer's disease, autoimmunity and inflammation. The good, the bad and the uglyQ37945426
The role of regulatory T cells in neurodegenerative diseasesQ38035240
Review: systemic inflammation and Alzheimer's diseaseQ38050498
Epidemiology of dementias and Alzheimer's disease.Q38060443
Ultraviolet radiation-induced regulatory T cells not only inhibit the induction but can suppress the effector phase of contact hypersensitivityQ38480730
Mesenchymal stem cells inhibit human Th17 cell differentiation and function and induce a T regulatory cell phenotype.Q39698715
The immunomodulatory activity of human umbilical cord blood-derived mesenchymal stem cells in vitro.Q40071382
Vaccination of Alzheimer's model mice with adenovirus vector containing quadrivalent foldable Abeta(1-15) reduces Abeta burden and behavioral impairment without Abeta-specific T cell responseQ40078663
Mesenchymal stromal cells use PGE2 to modulate activation and proliferation of lymphocyte subsets: Combined comparison of adipose tissue, Wharton's Jelly and bone marrow sourcesQ42974571
Immunosuppressive properties of human umbilical cord-derived mesenchymal stem cells: role of B7-H1 and IDO.Q43102091
Human umbilical cord mesenchymal stem cells hUC-MSCs exert immunosuppressive activities through a PGE2-dependent mechanismQ43140862
Inhibition of microglial activation protects hippocampal neurogenesis and improves cognitive deficits in a transgenic mouse model for Alzheimer's diseaseQ48513598
The effect of ageing on neurogenesis and oxidative stress in the APP(swe)/PS1(deltaE9) mouse model of Alzheimer's diseaseQ48615135
Human umbilical cord blood-derived mesenchymal stem cells improve neuropathology and cognitive impairment in an Alzheimer's disease mouse model through modulation of neuroinflammation.Q51053512
Intracerebral transplantation of bone marrow-derived mesenchymal stem cells reduces amyloid-beta deposition and rescues memory deficits in Alzheimer's disease mice by modulation of immune responses.Q51888370
Bone marrow-derived mesenchymal stem cells reduce brain amyloid-beta deposition and accelerate the activation of microglia in an acutely induced Alzheimer's disease mouse model.Q53298716
A review: inflammatory process in Alzheimer's disease, role of cytokines.Q53328528
PD1 Negative and PD1 Positive CD4+ T Regulatory Cells in Mild Cognitive Impairment and Alzheimer's DiseaseQ57997425
Microglia in Alzheimer's diseaseQ58701591
Searching for alternative sources of postnatal human mesenchymal stem cells: candidate MSC-like cells from umbilical cordQ78799982
Mesenchymal cells recruit and regulate T regulatory cellsQ80717999
A novel way to isolate MSCs from umbilical cordsQ84130266
FOXP3 gene expression in multiple sclerosis patients pre- and post mesenchymal stem cell therapyQ84888368
Anti-TNF-α reduces amyloid plaques and tau phosphorylation and induces CD11c-positive dendritic-like cell in the APP/PS1 transgenic mouse brainsQ85246354
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectstem cell transplantationQ65592366
human umbilical cord mesenchymal stem cellQ107296600
P304page(s)e69129
P577publication date2013-07-25
P1433published inPLOS OneQ564954
P1476titleSystemic transplantation of human umbilical cord derived mesenchymal stem cells-educated T regulatory cells improved the impaired cognition in AβPPswe/PS1dE9 transgenic mice
P478volume8

Reverse relations

cites work (P2860)
Q36326816A Perspective on Roles Played by Innate and Adaptive Immunity in the Pathobiology of Neurodegenerative Disorders
Q93014137Amyloids in Site-Specific Autoimmune Reactions and Inflammatory Responses
Q36018333Breaking immune tolerance by targeting Foxp3(+) regulatory T cells mitigates Alzheimer's disease pathology
Q38543215CD4 + T Cells and Neuroprotection: Relevance to Motoneuron Injury and Disease.
Q30437823Clinical applications of mesenchymal stem cells in chronic diseases
Q92980515Contributions of Age-Related Thymic Involution to Immunosenescence and Inflammaging
Q92699153Decreased Netrin-1 and Correlated Th17/Tregs Balance Disorder in Aβ1-42 Induced Alzheimer's Disease Model Rats
Q47882404Effect of systemic transplantation of bone marrow-derived mesenchymal stem cells on neuropathology markers in APP/PS1 Alzheimer mice
Q89018777Effects of mesenchymal stem cells transplantation on cognitive deficits in animal models of Alzheimer's disease: A systematic review and meta-analysis
Q35837904Effects of stem cell transplantation on cognitive decline in animal models of Alzheimer's disease: A systematic review and meta-analysis.
Q28077869Friend or foe: the dichotomous impact of T cells on neuro-de/re-generation during aging
Q36728537Human Cortical Neural Stem Cells Expressing Insulin-Like Growth Factor-I: A Novel Cellular Therapy for Alzheimer's Disease
Q35548329Human mesenchymal stem cells - current trends and future prospective
Q57041817Human neural stem cell transplantation improves cognition in a murine model of Alzheimer's disease
Q60952623Impact and Challenges of Mesenchymal Stem Cells in Medicine: An Overview of the Current Knowledge
Q36534248Matrine improves cognitive impairment and modulates the balance of Th17/Treg cytokines in a rat model of Aβ1-42-induced Alzheimer's disease
Q38843840Moving from the Dish to the Clinical Practice: A Decade of Lessons and Perspectives from the Pre-Clinical and Clinical Stem Cell Studies for Alzheimer's Disease
Q37688368Neuroprotective effects of CD4+CD25+Foxp3+ regulatory T cells in a 3xTg-AD Alzheimer's disease model
Q57039635Peripheral immune system in aging and Alzheimer's disease
Q38772566Potential for Stem Cells Therapy in Alzheimer's Disease: Do Neurotrophic Factors Play Critical Role?
Q39084950Potential importance of B cells in aging and aging-associated neurodegenerative diseases
Q46297701Secretome released from hydrogel-embedded adipose mesenchymal stem cells protects against the Parkinson's disease related toxin 6-hydroxydopamine
Q44241652Self-assembling nanofibers alter the processing of amyloid precursor protein in a transgenic mouse model of Alzheimer's disease
Q36356181Splenocytes derived from young WT mice prevent AD progression in APPswe/PSENldE9 transgenic mice
Q99579313Stem cell therapy for Alzheimer's disease
Q90627086Stem cell therapy in Alzheimer's disease: possible benefits and limiting drawbacks
Q47602416Systemic immune-checkpoint blockade with anti-PD1 antibodies does not alter cerebral amyloid-β burden in several amyloid transgenic mouse models
Q38274179T-cell-mediated regulation of neuroinflammation involved in neurodegenerative diseases
Q30819335The anti-aging effects of LW-AFC via correcting immune dysfunctions in senescence accelerated mouse resistant 1 (SAMR1) strain
Q39295050The role of regulatory T cells in nervous system pathologies
Q37687257Umbilical cord-derived mesenchymal stem cells reversed the suppressive deficiency of T regulatory cells from peripheral blood of patients with multiple sclerosis in a co-culture - a preliminary study
Q50577170Wharton's Jelly-derived mesenchymal stem cells alleviate memory deficits and reduce amyloid-β deposition in an APP/PS1 transgenic mouse model.

Search more.