Immune mediators in the tumor microenvironment of prostate cancer

scientific article published on 14 March 2017

Immune mediators in the tumor microenvironment of prostate cancer is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1084253288
P356DOI10.1186/S40880-017-0198-3
P932PMC publication ID5351274
P698PubMed publication ID28292326

P50authorJian ZhangQ95001421
P2093author name stringYi Lu
Evan T Keller
Jinlu Dai
Laurie K McCauley
Hernan Roca
Jill M Keller
P2860cites workOsteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activationQ24311588
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Requirement of ErbB2 for signalling by interleukin-6 in prostate carcinoma cellsQ24317507
RANK is essential for osteoclast and lymph node developmentQ24598872
Myeloid-derived suppressor cells as regulators of the immune systemQ28131637
Interleukin-6 activates phosphatidylinositol-3 kinase, which inhibits apoptosis in human prostate cancer cell linesQ28139004
Identification of a factor that links apoptotic cells to phagocytesQ28217034
Expression of RANKL/RANK/OPG in primary and metastatic human prostate cancer as markers of disease stage and functional regulationQ28575953
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The integrin alpha(v)beta(3-5) ligand MFG-E8 is a p63/p73 target gene in triple-negative breast cancers but exhibits suppressive functions in ER(+) and erbB2(+) breast cancersQ30992805
Host-derived RANKL is responsible for osteolysis in a C4-2 human prostate cancer xenograft model of experimental bone metastasesQ33293423
Clinical and correlative results of SWOG S0354: a phase II trial of CNTO328 (siltuximab), a monoclonal antibody against interleukin-6, in chemotherapy-pretreated patients with castration-resistant prostate cancerQ33389676
CCL2 and interleukin-6 promote survival of human CD11b+ peripheral blood mononuclear cells and induce M2-type macrophage polarizationQ33553562
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In situ vaccination combined with androgen ablation and regulatory T-cell depletion reduces castration-resistant tumor burden in prostate-specific pten knockout miceQ33837085
Shedding of RANKL by tumor-associated MT1-MMP activates Src-dependent prostate cancer cell migration.Q33958982
Osteoprotegerin inhibits prostate cancer-induced osteoclastogenesis and prevents prostate tumor growth in the boneQ39946634
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RANKL acts directly on RANK-expressing prostate tumor cells and mediates migration and expression of tumor metastasis genesQ40050213
CD4+CD25high T cells are enriched in the tumor and peripheral blood of prostate cancer patientsQ40212457
Inhibition of interleukin-6 with CNTO328, an anti-interleukin-6 monoclonal antibody, inhibits conversion of androgen-dependent prostate cancer to an androgen-independent phenotype in orchiectomized miceQ40304139
Osteoprotegerin (OPG) is a survival factor for human prostate cancer cells.Q40742643
Anti-interleukin-6 monoclonal antibody induces regression of human prostate cancer xenografts in nude miceQ40801056
Autocrine effect of androgen on proliferation of an androgen responsive prostatic carcinoma cell line, LNCAP: role of interleukin-6.Q41083320
Immunologic aspects of osteoporosisQ41700884
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Phenotypic analysis of prostate-infiltrating lymphocytes reveals TH17 and Treg skewingQ41953761
Weaning-induced expression of a milk-fat globule protein, MFG-E8, in mouse mammary glands, as demonstrated by the analyses of its mRNA, protein and phosphatidylserine-binding activityQ42156178
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Osteoprotegerin and rank ligand expression in prostate cancerQ42502915
What do we mean when we write "senescence," "apoptosis," "necrosis," or "clearance of dying cells"?Q42854358
Mcl-1 is regulated by IL-6 and mediates the survival activity of the cytokine in a model of late stage prostate carcinomaQ44220344
Peripheral T-cell tolerance associated with prostate cancer is independent from CD4+CD25+ regulatory T cellsQ45874119
The prognostic significance of plasma interleukin-6 levels in patients with metastatic hormone-refractory prostate cancer: results from cancer and leukemia group B 9480.Q46365760
RANKL inhibition is an effective adjuvant for docetaxel in a prostate cancer bone metastases modelQ46715452
Enhanced functionality of CD4+CD25(high)FoxP3+ regulatory T cells in the peripheral blood of patients with prostate cancerQ46748260
Interleukin-6 protects LNCaP cells from apoptosis induced by androgen deprivation through the Stat3 pathwayQ47398934
In vivo real-time imaging of TGF-beta-induced transcriptional activation of the RANK ligand gene promoter in intraosseous prostate cancerQ47816427
Polarization of prostate cancer-associated macrophages is induced by milk fat globule-EGF factor 8 (MFG-E8)-mediated efferocytosisQ34107357
Biology of the RANKL-RANK-OPG System in Immunity, Bone, and BeyondQ34366449
Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitroQ34459310
Denosumab in men receiving androgen-deprivation therapy for prostate cancerQ34570396
CD8+ Foxp3+ regulatory T cells mediate immunosuppression in prostate cancerQ34585720
Prostate carcinoma skeletal metastases: cross-talk between tumor and bone.Q34708745
The first Tianjin, China forum on tumor microenvironmentQ34786304
IL-6 promotes prostate tumorigenesis and progression through autocrine cross-activation of IGF-IR.Q35037290
Roles of bone marrow cells in skeletal metastases: no longer bystandersQ35603122
Crosstalk between cancer cells and bone microenvironment in bone metastasisQ36032072
Interleukin-6 regulation of prostate cancer cell growthQ36101905
Cyclophosphamide creates a receptive microenvironment for prostate cancer skeletal metastasis.Q36278280
Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapyQ36378276
Myeloid-derived suppressor cells expand during breast cancer progression and promote tumor-induced bone destructionQ36476085
Osteocyte control of osteoclastogenesisQ36514172
Bone marrow macrophages support prostate cancer growth in boneQ36546464
A multicenter, retrospective epidemiologic survey of the clinical features and management of bone metastatic disease in ChinaQ36836736
Circulating prediagnostic interleukin-6 and C-reactive protein and prostate cancer incidence and mortalityQ37155349
Induction of proinflammatory response in prostate cancer epithelial cells by activated macrophagesQ37199013
A destructive cascade mediated by CCL2 facilitates prostate cancer growth in bone.Q37233535
Inflammation and prostate cancer.Q37298650
Differentiation and heterogeneity in the mononuclear phagocyte systemQ37349749
Stroma-epithelium crosstalk in prostate cancerQ37355741
Macrophage cathepsin K promotes prostate tumor progression in boneQ37554550
Biology and clinical observations of regulatory T cells in cancer immunologyQ37761674
TAM receptor signaling and autoimmune diseaseQ37804572
Denosumab: in cancer treatment-induced bone lossQ37806196
Infection, inflammation and prostate carcinogenesisQ37852301
Interleukin-6: a multifunctional targetable cytokine in human prostate cancerQ37888027
Review: milk fat globule-EGF factor 8 expression, function and plausible signal transduction in resolving inflammationQ37929022
Th17 Cells in Protection from Tumor or Promotion of Tumor ProgressionQ38907336
Regulatory T cells: balancing protection versus pathologyQ38920427
Macrophages induce neuroendocrine differentiation of prostate cancer cells via BMP6-IL6 LoopQ39581495
The prognostic impact of M-CSF, CSF-1 receptor, CD68 and CD3 in prostatic carcinomaQ39847976
Pigment epithelium-derived factor and interleukin-6 control prostate neuroendocrine differentiation via feed-forward mechanism.Q39905772
Randomized phase II trial of denosumab in patients with bone metastases from prostate cancer, breast cancer, or other neoplasms after intravenous bisphosphonates.Q51803777
LuCaP 35: A new model of prostate cancer progression to androgen independenceQ52832790
Peritoneal macrophages are distinct from monocytes and adherent macrophages.Q53214170
Pretreatment frequency of circulating IL-17+CD4+T-cells, but not Tregs, correlates with clinical response to whole-cell vaccination in prostate cancer patientsQ56986771
Prognostic value of IL-6 in localized prostatic cancerQ61197642
Expression of osteoclast differentiation signals by stromal elements of giant cell tumorsQ73711524
Osteoprotegerin blocks bone cancer-induced skeletal destruction, skeletal pain and pain-related neurochemical reorganization of the spinal cordQ73766127
Osteoprotegerin diminishes advanced bone cancer painQ73893976
Tumor associated macrophages in human prostate cancer: relation to clinicopathological variables and survivalQ74153839
Characterization of the role of IL-6 in the progression of prostate cancerQ74587530
Soluble receptor activator of nuclear factor kappaB Fc diminishes prostate cancer progression in boneQ79317200
Induction of hsp70-mediated Th17 autoimmunity can be exploited as immunotherapy for metastatic prostate cancerQ80224497
Receptor activator of nuclear factor-kappaB ligand (RANKL) as a novel prognostic marker in prostate carcinomaQ80954384
Infiltration of tumour-associated macrophages in prostate biopsy specimens is predictive of disease progression after hormonal therapy for prostate cancerQ82278667
Cutting edge: depletion of Foxp3+ cells leads to induction of autoimmunity by specific ablation of regulatory T cells in genetically targeted miceQ84925181
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectprostate cancerQ181257
tumor microenvironmentQ1786433
prostate neoplasmQ56014511
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)29
P577publication date2017-03-14
P1433published inChinese Journal of CancerQ15760211
P1476titleImmune mediators in the tumor microenvironment of prostate cancer
P478volume36

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cites work (P2860)
Q64253447A Rich Array of Prostate Cancer Molecular Biomarkers: Opportunities and Challenges
Q90216342CTHRC1 and PD‑1/PD‑L1 expression predicts tumor recurrence in prostate cancer
Q42367488Cancer metastasis: issues and challenges
Q90070057Mass cytometry reveals species-specific differences and a new level of complexity for immune cells in the prostate
Q94564120Prognostic Value of Preoperative Systemic Immune-Inflammation Index in Breast Cancer: A Propensity Score-Matching Study
Q41152020Prognostic value of systemic immune-inflammation index in patients with gastric cancer
Q48333900Systemic immune-inflammation index predicts the combined clinical outcome after sequential therapy with abiraterone and docetaxel for metastatic castration-resistant prostate cancer patients.

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