Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif

scientific article (publication date: 19 March 1999)

Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.274.12.7724
P3181OpenCitations bibliographic resource ID1332966
P698PubMed publication ID10075662
P5875ResearchGate publication ID13214593

P2093author name stringJ Ni
P A Moore
B B Aggarwal
B G Darnay
P2860cites workTRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factorQ36380989
Induction of nuclear factor kappaB by the CD30 receptor is mediated by TRAF1 and TRAF2.Q36566021
The p60 tumor necrosis factor (TNF) receptor-associated kinase (TRAK) binds residues 344-397 within the cytoplasmic domain involved in TNF signalingQ41333986
NF-kappaB-inducing kinase and IkappaB kinase participate in human T-cell leukemia virus I Tax-mediated NF-kappaB activationQ45754430
IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signalingQ24309107
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activationQ24311588
TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cellsQ24315251
IKAP is a scaffold protein of the IkappaB kinase complexQ24316436
A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptorQ24318280
NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176Q24319941
ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5Q24321707
Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1Q24323286
A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell functionQ24336057
4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaBQ24533857
Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2Q24642851
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKLQ24682139
Eukaryotic proteins expressed in Escherichia coli: An improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferaseQ28131695
Binding sites of cytoplasmic effectors TRAF1, 2, and 3 on CD30 and other members of the TNF receptor superfamilyQ28239398
Identification and characterization of an IkappaB kinaseQ28245341
CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinaseQ28270530
Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinaseQ28278061
Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting [...]Q28280257
TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptorQ28282051
The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptorQ28285539
TRAF6 is a signal transducer for interleukin-1Q28291934
MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1Q28302936
Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic regionQ28511583
Tumor necrosis factor receptor-associated factors (TRAFs)--a family of adapter proteins that regulates life and deathQ28609905
MyD88: an adapter that recruits IRAK to the IL-1 receptor complexQ28611795
Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell deathQ29620021
Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinasesQ33777633
Interaction of tumor necrosis factor receptor-associated factor signaling proteins with the latent membrane protein 1 PXQXT motif is essential for induction of epidermal growth factor receptor expressionQ33786551
Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1Q36004058
JNK or IKK, AP-1 or NF-kappaB, which are the targets for MEK kinase 1 action?Q36070075
Epstein-Barr virus-transforming protein latent infection membrane protein 1 activates transcription factor NF-kappaB through a pathway that includes the NF-kappaB-inducing kinase and the IkappaB kinases IKKalpha and IKKbetaQ36285724
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectNF-κBQ411114
P304page(s)7724-31
P577publication date1999-03-19
P1433published inJournal of Biological ChemistryQ867727
P1476titleActivation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif
P478volume274

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cites work (P2860)
Q356436233-Formylchromone interacts with cysteine 38 in p65 protein and with cysteine 179 in IκBα kinase, leading to down-regulation of nuclear factor-κB (NF-κB)-regulated gene products and sensitization of tumor cells
Q90124747A TRAF6 genetic variant is associated with low bone mineral density in rheumatoid arthritis
Q27919649A functional interaction between the p75 neurotrophin receptor interacting factors, TRAF6 and NRIF.
Q41831683A novel splice variant of mouse interleukin-1-receptor-associated kinase-1 (IRAK-1) activates nuclear factor-kappaB (NF-kappaB) and c-Jun N-terminal kinase (JNK)
Q24292059A novel zinc finger protein that inhibits osteoclastogenesis and the function of tumor necrosis factor receptor-associated factor 6
Q53364532A unique domain in RANK is required for Gab2 and PLCgamma2 binding to establish osteoclastogenic signals.
Q44329387Adenosine suppresses activation of nuclear factor-kappaB selectively induced by tumor necrosis factor in different cell types
Q93046970Administration of SB239063 Ameliorates Ovariectomy-Induced Bone Loss via Suppressing Osteoclastogenesis in Mice
Q89848783Amaranthus mangostanus Inhibits the Differentiation of Osteoclasts and Prevents Ovariectomy-Induced Bone Loss
Q30993599Analysis of expressed sequence tags from Maize mosaic rhabdovirus-infected gut tissues of Peregrinus maidis reveals the presence of key components of insect innate immunity
Q40871220Anethole blocks both early and late cellular responses transduced by tumor necrosis factor: effect on NF-kappaB, AP-1, JNK, MAPKK and apoptosis
Q50770025Apolipoprotein E inhibits osteoclast differentiation via regulation of c-Fos, NFATc1 and NF-κB.
Q35925874Assembly of post-receptor signaling complexes for the tumor necrosis factor receptor superfamily
Q37496714Attenuation of RANKL-induced Osteoclast Formation via p38-mediated NFATc1 Signaling Pathways by Extract of Euphorbia Lathyris L.
Q36369124Attenuation of colon inflammation through activators of the retinoid X receptor (RXR)/peroxisome proliferator-activated receptor gamma (PPARgamma) heterodimer. A basis for new therapeutic strategies
Q35853244Autophagy regulator BECN1 suppresses mammary tumorigenesis driven by WNT1 activation and following parity
Q93053543BANK1 interacts with TRAF6 and MyD88 in innate immune signaling in B cells
Q35415849Bharangin, a diterpenoid quinonemethide, abolishes constitutive and inducible nuclear factor-κB (NF-κB) activation by modifying p65 on cysteine 38 residue and reducing inhibitor of nuclear factor-κB α kinase activation, leading to suppression of NF-
Q34366449Biology of the RANKL-RANK-OPG System in Immunity, Bone, and Beyond
Q35145622Biology of the TRANCE axis
Q92704323Bone Regeneration, Reconstruction and Use of Osteogenic Cells; from Basic Knowledge, Animal Models to Clinical Trials
Q35995710C-Src-mediated RANKL-induced breast cancer cell migration by activation of the ERK and Akt pathway
Q39855419CD40/CD40L interaction induces Abeta production and increases gamma-secretase activity independently of tumor necrosis factor receptor associated factor (TRAF) signaling
Q44301311Calagualine inhibits nuclear transcription factors-kappaB activated by various inflammatory and tumor promoting agents
Q52956230Castalagin Exerts Inhibitory Effects on Osteoclastogenesis Through Blocking a Broad Range of Signaling Pathways with Low Cytotoxicity.
Q35173015Caveolin-1 regulates osteoclastogenesis and bone metabolism in a sex-dependent manner
Q90278559Caveolin‑1 enhances RANKL‑induced gastric cancer cell migration
Q41990475Characterization and Mechanistic Studies of a Novel Melanoma-Targeting Construct Containing IκBa for Specific Inhibition of Nuclear Factor-κB Activity
Q28186559Characterization of a cascade of protein interactions initiated at the IL-1 receptor
Q37464897Chemical and Biochemical Basis of Cell-Bone Matrix Interaction in Health and Disease
Q52942810Cobalt protoporphyrin represses osteoclastogenesis through blocking multiple signaling pathways.
Q34225114Control of osteoclastogenesis and bone resorption by members of the TNF family of receptors and ligands
Q39929790Coronarin D, a labdane diterpene, inhibits both constitutive and inducible nuclear factor-kappa B pathway activation, leading to potentiation of apoptosis, inhibition of invasion, and suppression of osteoclastogenesis
Q34094406Crotepoxide chemosensitizes tumor cells through inhibition of expression of proliferation, invasion, and angiogenic proteins linked to proinflammatory pathway
Q43830972Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines
Q40582077Decoy receptor 3 (DcR3) induces osteoclast formation from monocyte/macrophage lineage precursor cells
Q48058406Development of 1-Amino-4-(phenylamino)anthraquinone-2-sulfonate Sodium Derivatives as a New Class of Inhibitors of RANKL-Induced Osteoclastogenesis
Q33738074Development of cell-based high-throughput assays for the identification of inhibitors of receptor activator of nuclear factor-kappa B signaling.
Q24302174Distinct molecular mechanism for initiating TRAF6 signalling
Q28546890Disulfiram attenuates osteoclast differentiation in vitro: a potential antiresorptive agent
Q36739991Early estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesis
Q36953281Effects of a GSK-3β inhibitor on the renal expression levels of RANK, RANKL and NF-κB in a rat model of diabetic nephropathy
Q28207648Effects of the NIK aly mutation on NF-kappaB activation by the Epstein-Barr virus latent infection membrane protein, lymphotoxin beta receptor, and CD40
Q47146522Effects of triethylene glycol dimethacrylate (TEGDMA) on the odontoclastic differentiation ability of human dental pulp cells.
Q53019890Endoplasmic reticulum stress response and bone loss in experimental periodontitis in mice.
Q41981419Epstein-Barr virus latent membrane protein 1 modulates distinctive NF- kappaB pathways through C-terminus-activating region 1 to regulate epidermal growth factor receptor expression
Q37396119Estrogen inhibits RANKL-stimulated osteoclastic differentiation of human monocytes through estrogen and RANKL-regulated interaction of estrogen receptor-alpha with BCAR1 and Traf6.
Q40235625Evidence that TNF-TNFR1-TRADD-TRAF2-RIP-TAK1-IKK pathway mediates constitutive NF-kappaB activation and proliferation in human head and neck squamous cell carcinoma
Q57533748Expression of functional RANK on mature rat and human osteoclasts
Q38462802Expression of the tumor necrosis factor receptor-associated factors (TRAFs) 1 and 2 is a characteristic feature of Hodgkin and Reed-Sternberg cells
Q43000284Functional analysis of the interleukin-1-receptor-associated kinase (IRAK-1) in interleukin-1 beta-stimulated nuclear factor kappa B (NF-kappa B) pathway activation: IRAK-1 associates with the NF-kappa B essential modulator (NEMO) upon receptor stim
Q35079256Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members
Q24678660Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-kappaB signaling pathway
Q29617421Genetic regulation of osteoclast development and function
Q35105452Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2
Q90463796Global long terminal repeat activation participates in establishing the unique gene expression programme of classical Hodgkin lymphoma
Q35839884Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta-activated kinase-1-mediated NF-kappaB activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of osteoclastogenesis.
Q47595585Gα12 regulates osteoclastogenesis by modulating NFATc1 expression
Q40883179Human chorionic gonadotropin suppresses activation of nuclear transcription factor-kappa B and activator protein-1 induced by tumor necrosis factor
Q64262538I-BET151 suppresses osteoclast formation and inflammatory cytokines secretion by targetting BRD4 in multiple myeloma
Q36806362IL-17 mediates estrogen-deficient osteoporosis in an Act1-dependent manner.
Q36251949Identification and application of anti-inflammatory compounds screening system based on RAW264.7 cells stably expressing NF-κB-dependent SEAP reporter gene
Q35763320Identification of functionally distinct TRAF proinflammatory and phosphatidylinositol 3-kinase/mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (PI3K/MEK) transforming activities emanating from RET/PTC fusion oncoprotein
Q53584487Identification of novel RANK polymorphisms and their putative association with low BMD among postmenopausal women.
Q36924500Identification of novel human receptor activator of nuclear factor-kB isoforms generated through alternative splicing: implications in breast cancer cell survival and migration
Q39085876Identification of small molecule inhibitors of RANKL and TNF signalling as anti-inflammatory and antiresorptive agents in mice
Q93041137Inhibitory Effect of Probenecid on Osteoclast Formation via JNK, ROS and COX-2
Q39251233Inhibitory effects of tert-butylhydroquinone on osteoclast differentiation via up-regulation of heme oxygenase-1 and down-regulation of HMGB1 release and NFATc1 expression
Q39919544Interleukin-1 receptor type 1 is a substrate for gamma-secretase-dependent regulated intramembrane proteolysis.
Q44754181Investigation of osteoclastogenic signalling of the RANKL substitute LIGHT.
Q64065423KBTBD11, a novel BTB-Kelch protein, is a negative regulator of osteoclastogenesis through controlling Cullin3-mediated ubiquitination of NFATc1
Q36770410Kinsenoside prevents ovariectomy-induced bone loss and suppresses osteoclastogenesis by regulating classical NF-κB pathways
Q40752073Lack of requirement of STAT1 for activation of nuclear factor-kappaB, c-Jun NH2-terminal protein kinase, and apoptosis by tumor necrosis factor-alpha
Q35913362Lycorine suppresses RANKL-induced osteoclastogenesis in vitro and prevents ovariectomy-induced osteoporosis and titanium particle-induced osteolysis in vivo
Q44508743Mechanism of cytosine arabinoside-mediated apoptosis: role of Rel A (p65) dephosphorylation
Q52578848Mechanisms involved in normal and pathological osteoclastogenesis.
Q37146973Mechanisms of tooth eruption and orthodontic tooth movement
Q38442845Microarray gene expression during early healing of GBR-treated calvarial critical size defects.
Q34285044Modification of Cysteine 179 of IκBα Kinase by Nimbolide Leads to Down-regulation of NF-κB-regulated Cell Survival and Proliferative Proteins and Sensitization of Tumor Cells to Chemotherapeutic Agents
Q90275102Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation
Q42642070Molecular biology of bone remodelling
Q40698580NF-kappaB inhibits transcription of the H(+)-K(+)-ATPase alpha(2)-subunit gene: role of histone deacetylases
Q41907549NF-kappaB signal triggering and termination by tumor necrosis factor receptor 2.
Q35208356NIK signaling in dendritic cells but not in T cells is required for the development of effector T cells and cell-mediated immune responses
Q90397955New Selective Progesterone Receptor Modulators and Their Impact on the RANK/RANKL Complex Activity
Q24619151New insights into the mechanisms of green tea catechins in the chemoprevention of prostate cancer
Q37748586New knowledge on critical osteoclast formation and activation pathways from study of rare genetic diseases of osteoclasts: focus on the RANK/RANKL axis.
Q39703528Novel derivative of benzofuran induces cell death mostly by G2/M cell cycle arrest through p53-dependent pathway but partially by inhibition of NF-kappaB.
Q35175282Nuclear transcription factor-kappaB in Hodgkin's disease
Q38000081Nutritional factors and bone homeostasis: synergistic effect with zinc and genistein in osteogenesis
Q40617978Oleandrin suppresses activation of nuclear transcription factor-κB and activator protein-1 and potentiates apoptosis induced by ceramide
Q73211247Osteoblasts/stromal cells stimulate osteoclast activation through expression of osteoclast differentiation factor/RANKL but not macrophage colony-stimulating factor: receptor activator of NF-kappa B ligand
Q35755039Osteoclasts: New Insights
Q40673196Pathologic Findings in NEMO Deficiency: A Surgical and Autopsy Survey
Q33961554Pathway-based association analyses identified TRAIL pathway for osteoporotic fractures
Q28208696Pleiotropic signal transduction mediated by human CD30: a member of the tumor necrosis factor receptor (TNFR) family
Q73731212Protein tyrosine kinase p56lck is required for ceramide-induced but not tumor necrosis factor-induced activation of NF-kappa B, AP-1, JNK, and apoptosis
Q38866853Punicalagin attenuates osteoclast differentiation by impairing NFATc1 expression and blocking Akt- and JNK-dependent pathways
Q24598872RANK is essential for osteoclast and lymph node development
Q37108966RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism
Q26747442RANK-RANKL signalling in cancer
Q41107411RANK-mediated amplification of TRAF6 signaling leads to NFATc1 induction during osteoclastogenesis.
Q39590554RANKL increases migration of human lung cancer cells through intercellular adhesion molecule-1 up-regulation
Q38306944RANKL/OPG; Critical role in bone physiology.
Q58776864Rab GTPases in Osteoclastic Endomembrane Systems
Q38695357Rab44, a novel large Rab GTPase, negatively regulates osteoclast differentiation by modulating intracellular calcium levels followed by NFATc1 activation
Q34333628Receptor Activator of NF-κB (RANK) Cytoplasmic IVVY535–538 Motif Plays an Essential Role in Tumor Necrosis Factor-α (TNF)-mediated Osteoclastogenesis
Q40633180Receptor Activator of NF-κB Ligand Stimulates Recruitment of SHP-1 to the Complex Containing TNFR-Associated Factor 6 That Regulates Osteoclastogenesis
Q24537518Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6
Q34086847Receptor activator of nuclear factor-kappaB ligand and osteoprotegerin: potential implications for the pathogenesis and treatment of malignant bone diseases
Q37217673Recurrent mutation of the gene encoding sequestosome 1 (SQSTM1/p62) in Paget disease of bone
Q38113962Regulation of PI-3-Kinase and Akt Signaling in T Lymphocytes and Other Cells by TNFR Family Molecules
Q36702425Regulation of neurite growth by tumour necrosis superfamily member RANKL.
Q34269354Regulation of proliferation, survival and apoptosis by members of the TNF superfamily
Q34728971Regulatory mechanisms of osteoblast and osteoclast differentiation
Q24311417Role of the A20-TRAF6 axis in lipopolysaccharide-mediated osteoclastogenesis
Q24295323SASH1 is a scaffold molecule in endothelial TLR4 signaling
Q60933379SPA0355 prevents ovariectomy-induced bone loss in mice
Q34090842Selective targeting of RANK signaling pathways as new therapeutic strategies for osteoporosis.
Q33957047Sesamin manifests chemopreventive effects through the suppression of NF-kappa B-regulated cell survival, proliferation, invasion, and angiogenic gene products
Q36043987Signal peptide mutations in RANK prevent downstream activation of NF-κB.
Q24534564Signal transducers and activators of transcription 3 (STAT3) inhibits transcription of the inducible nitric oxide synthase gene by interacting with nuclear factor kappaB
Q33782305Signal transduction by tumour necrosis factor and tumour necrosis factor related ligands and their receptors
Q29616428Signalling pathways of the TNF superfamily: a double-edged sword
Q24321363Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation
Q28066288Smad-dependent mechanisms of inflammatory bone destruction
Q36949929Staphylococcus aureus induces expression of receptor activator of NF-kappaB ligand and prostaglandin E2 in infected murine osteoblasts
Q54352725Structure of the TRAF4 TRAF domain with a coiled-coil domain and its implications for the TRAF4 signalling pathway.
Q38743328Suppression of Host Innate Immune Response by Hepatitis C Virus via Induction of Autophagic Degradation of TRAF6.
Q24324222TAK1-dependent signaling requires functional interaction with TAB2/TAB3
Q39698378TRAF6 is autoinhibited by an intramolecular interaction which is counteracted by trans-ubiquitination
Q33416004TRAF6 is required for generation of the B-1a B cell compartment as well as T cell-dependent and -independent humoral immune responses
Q40119268TRAF6 ubiquitin ligase is essential for RANKL signaling and osteoclast differentiation
Q28142620TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src
Q22253885TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation
Q40641517TWEAK mediates signal transduction and differentiation of RAW264.7 cells in the absence of Fn14/TweakR. Evidence for a second TWEAK receptor
Q39092456Taurine exerts anti-osteoclastogenesis activity via inhibiting ROS generation, JNK phosphorylation and COX-2 expression in RAW264.7 cells
Q36520887The NFκB-inducing kinase is essential for the developmental programming of skin-resident and IL-17-producing γδ T cells.
Q24654977The RING domain and first zinc finger of TRAF6 coordinate signaling by interleukin-1, lipopolysaccharide, and RANKL
Q33976649The Ran-binding protein RanBPM can depress the NF-κB pathway by interacting with TRAF6.
Q28198125The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators
Q37973113The adaptor protein p62/SQSTM1 in osteoclast signaling pathways
Q38719373The dental resin monomers HEMA and TEGDMA have inhibitory effects on osteoclast differentiation with low cytotoxicity
Q24683018The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games
Q37520235The prognostic role of RANK SNP rs34945627 in breast cancer patients with bone metastases.
Q24805207The role of TNF-receptor family members and other TRAF-dependent receptors in bone resorption.
Q27619945The structural basis for the recognition of diverse receptor sequences by TRAF2
Q38931685The structure function of the death domain of human IRAK-M.
Q24308947The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner
Q37185295Trolox prevents osteoclastogenesis by suppressing RANKL expression and signaling
Q33886695Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction
Q34135071Tumor necrosis factor receptor-associated factor (TRAF) 2 and its role in TNF signaling.
Q35592741Tumor necrosis factor-alpha: molecular and cellular mechanisms in skeletal pathology
Q33307880Ubiquitin-mediated signalling and Paget's disease of bone
Q38303038VP4 differentially regulates TRAF2 signaling, disengaging JNK activation while directing NF-kappa B to effect rotavirus-specific cellular responses
Q81344654Water solution of onion crude powder inhibits RANKL-induced osteoclastogenesis through ERK, p38 and NF-kappaB pathways
Q36202827Wound healing is impaired in MyD88-deficient mice: a role for MyD88 in the regulation of wound healing by adenosine A2A receptors.
Q44546925alpha-Melanocyte-stimulating hormone induces cell death in mast cells: involvement of NF-kappaB.
Q40624157alpha-Melanocyte-stimulating hormone inhibits lipopolysaccharide-induced biological responses by downregulating CD14 from macrophages
Q40552100beta-D-Glucoside suppresses tumor necrosis factor-induced activation of nuclear transcription factor kappaB but potentiates apoptosis

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