RANKL/OPG; Critical role in bone physiology.

scientific article published on 04 January 2015

RANKL/OPG; Critical role in bone physiology. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1042827763
P356DOI10.1007/S11154-014-9308-6
P698PubMed publication ID25557611
P5875ResearchGate publication ID270397557

P50authorNatalie A. SimsQ38324957
P2093author name stringT John Martin
P2860cites workWNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture riskQ21090209
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activationQ24311588
Osteoprotegerin: a novel secreted protein involved in the regulation of bone densityQ24313918
Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesisQ24324701
A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell functionQ24336057
Catabolic effects of continuous human PTH (1--38) in vivo is associated with sustained stimulation of RANKL and inhibition of osteoprotegerin and gene-associated bone formationQ74411385
Cancellous bone remodeling occurs in specialized compartments lined by cells expressing osteoblastic markersQ74488802
RANK is essential for osteoclast and lymph node developmentQ24598872
osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcificationQ24603266
Control of RANKL gene expressionQ24619669
Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in miceQ24642117
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKLQ24682139
Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand familiesQ28137631
Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motifQ28138697
Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient miceQ28140546
Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysisQ28141482
Matrix-embedded cells control osteoclast formationQ28247746
Evidence for osteocyte regulation of bone homeostasis through RANKL expressionQ28247757
The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamilyQ28291317
Denosumab in postmenopausal women with low bone mineral densityQ28298728
Heritable disorders of the RANKL/OPG/RANK signaling pathwayQ28299674
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signalingQ28513445
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesisQ28589430
Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclastsQ29618116
Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosisQ29619487
Cells of bone: proliferation, differentiation, and hormonal regulationQ34182637
Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locusQ34335512
Monocytes induce STAT3 activation in human mesenchymal stem cells to promote osteoblast formationQ34339627
Physiological functions of osteoblast lineage and T cell-derived RANKL in bone homeostasisQ34369482
Kruppel-like factor 4 attenuates osteoblast formation, function, and cross talk with osteoclastsQ34409480
Kruppel-like factor 4 expression in osteoblasts represses osteoblast-dependent osteoclast maturationQ34424720
Transforming growth factor beta inhibits bone resorption in fetal rat long bone culturesQ34560491
A TNF receptor loop peptide mimic blocks RANK ligand-induced signaling, bone resorption, and bone lossQ34567407
Cord blood-derived macrophage-lineage cells rapidly stimulate osteoblastic maturation in mesenchymal stem cells in a glycoprotein-130 dependent mannerQ34998618
Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fracturesQ35360217
Normocalcemia is maintained in mice under conditions of calcium malabsorption by vitamin D-induced inhibition of bone mineralization.Q35913646
Modulation of osteoclast differentiationQ35957509
Activation of resorption in fatigue-loaded bone involves both apoptosis and active pro-osteoclastogenic signaling by distinct osteocyte populationsQ36005508
Osteoclast-derived activity in the coupling of bone formation to resorption.Q36032429
Osteoblasts mediate interleukin 1 stimulation of bone resorption by rat osteoclastsQ36352137
Stimulation of bone formation in cortical bone of mice treated with a receptor activator of nuclear factor-κB ligand (RANKL)-binding peptide that possesses osteoclastogenesis inhibitory activityQ36636031
Vps35 loss promotes hyperresorptive osteoclastogenesis and osteoporosis via sustained RANKL signalingQ36695575
Dissociation between bone resorption and bone formation in osteopenic transgenic miceQ36800774
Commitment to the osteoblast lineage is not required for RANKL gene expressionQ37176364
Denosumab and bone metastasis-free survival in men with nonmetastatic castration-resistant prostate cancer: exploratory analyses by baseline prostate-specific antigen doubling timeQ37227675
Coupling the activities of bone formation and resorption: a multitude of signals within the basic multicellular unitQ37506724
Advances in the biology of bone metastasis: how the skeleton affects tumor behaviorQ37774077
Osteoclast-derived coupling factors in bone remodelingQ38108750
Transforming growth factor beta affects osteoclast differentiation via direct and indirect actions.Q38296222
Sustained RANKL response to parathyroid hormone in oncostatin M receptor-deficient osteoblasts converts anabolic treatment to a catabolic effect in vivoQ38329281
Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerinQ39116155
The pathobiology of the osteoclastQ39492910
Biochemical Characterization with Parathormone and Calcitonin of Isolated Bone Cells: Provisional Identification of Osteoclasts and OsteoblastsQ40007256
Cell proliferation and specialization during endochondral osteogenesis in young ratsQ41043295
Role of osteoblasts in hormonal control of bone resorption—A hypothesisQ41551873
Structural requirements for the action of parathyroid hormone-related protein (PTHrP) on bone resorption by isolated osteoclasts.Q41700823
Cloning of an osteoblastic cell line involved in the formation of osteoclast-like cellsQ41713781
Osteoprotegerin-deficient male mice as a model for severe alveolar bone loss: comparison with RANKL-overexpressing transgenic male miceQ43493548
Tumor necrosis factors alpha and beta induce osteoblastic cells to stimulate osteoclastic bone resorption.Q43597885
Osteoprotegerin Regulates Bone Formation through a Coupling Mechanism with Bone ResorptionQ44590734
Bisphosphonate therapy ameliorates hearing loss in mice lacking osteoprotegerinQ44639831
Familial expansile osteolysisQ45287088
Increased presence of capillaries next to remodeling sites in adult human cancellous bone.Q45881370
EphrinB2 signaling in osteoblasts promotes bone mineralization by preventing apoptosis.Q46284330
Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasisQ47761859
Evaluation of pharmaceuticals with a novel 50-hour animal model of bone loss.Q51788770
Localization of RANKL (receptor activator of NF kappa B ligand) mRNA and protein in skeletal and extraskeletal tissues.Q52172979
Osteoclast-like cell formation in fetal and newborn long-term baboon marrow cultures is more sensitive to 1,25-dihydroxyvitamin D3 than adult long-term marrow cultures.Q52255684
Osteoblastic cells are involved in osteoclast formation.Q54374668
EphrinB2/EphB4 inhibition in the osteoblast lineage modifies the anabolic response to parathyroid hormone.Q54470749
Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis.Q54528928
RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-βQ57675150
c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodelingQ58326943
Investigation of cell lineage in bone using a chimaera of chick and quail embryonic tissueQ59094872
Randomized Active-Controlled Phase II Study of Denosumab Efficacy and Safety in Patients With Breast Cancer-Related Bone MetastasesQ62392239
Bone Resorption Restored in Osteopetrotic Mice by Transplants of Normal Bone Marrow and Spleen CellsQ66903767
The osteoclast: review of ultrastructure, origin, and structure-function relationshipQ67832252
Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow culturesQ68274092
Osteoblast-like cells in the presence of parathyroid hormone release soluble factor that stimulates osteoclastic bone resorptionQ68737372
The bone marrow-derived stromal cell lines MC3T3-G2/PA6 and ST2 support osteoclast-like cell differentiation in cocultures with mouse spleen cellsQ69541163
The cellular basis of bone resorptionQ71328791
Role of osteoblasts in hormonal control of bone resorption - a hypothesisQ71614035
Activated T lymphocytes support osteoclast formation in vitroQ73149439
Osteoprotegerin produced by osteoblasts is an important regulator in osteoclast development and functionQ74244387
P433issue2
P921main subjectphysiologyQ521
P304page(s)131-139
P577publication date2015-06-01
P1433published inReviews in Endocrine and Metabolic DisordersQ15766899
P1476titleRANKL/OPG; Critical role in bone physiology
P478volume16

Reverse relations

cites work (P2860)
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