Lipopolysaccharide increases IL-6 secretion via activation of the ERK1/2 signaling pathway to up-regulate RANKL gene expression in MLO-Y4 cells.

scientific article published on 24 October 2016

Lipopolysaccharide increases IL-6 secretion via activation of the ERK1/2 signaling pathway to up-regulate RANKL gene expression in MLO-Y4 cells. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/CBIN.10696
P698PubMed publication ID27778412

P2093author name stringHang Wang
Xiaoyu Li
Yuanyuan Ma
Ke Yu
Jiefei Shen
Xiangnan Wu
Xianxian Li
Wenjia Liu
P2860cites workMolecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathwayQ24305237
RANK is essential for osteoclast and lymph node developmentQ24598872
Bone resorption by osteoclastsQ28145169
Evidence for osteocyte regulation of bone homeostasis through RANKL expressionQ28247757
Transcriptional regulation by the MAP kinase signaling cascadesQ28679148
Transcriptional responses to polypeptide ligands: the JAK-STAT pathwayQ29620287
Gene expression of osteoclast differentiation factor is induced by lipopolysaccharide in mouse osteoblasts via Toll-like receptorsQ32024958
Osteonecrosis induced by a single administration of low-dose lipopolysaccharide in rabbitsQ33337844
Osteocyte Wnt/beta-catenin signaling is required for normal bone homeostasisQ33877602
Physiological functions of osteoblast lineage and T cell-derived RANKL in bone homeostasisQ34369482
Cytokine production in whole blood cell cultures of patients with rheumatoid arthritisQ35546993
IL-6, RANKL, TNF-alpha/IL-1: interrelations in bone resorption pathophysiologyQ35640443
Mechanosensation and Transduction in OsteocytesQ35741903
Activation of resorption in fatigue-loaded bone involves both apoptosis and active pro-osteoclastogenic signaling by distinct osteocyte populationsQ36005508
Osteocyte RANKL: new insights into the control of bone remodelingQ36253514
Immune response: the key to bone resorption in periodontal diseaseQ36309235
Osteoblast Lineage Cells Play an Essential Role in Periodontal Bone Loss Through Activation of Nuclear Factor-Kappa BQ36370991
The role of the interleukin-6/gp130 signaling pathway in bone metabolismQ36617113
Functions of RANKL/RANK/OPG in bone modeling and remodelingQ36700779
Regulation of cortical and trabecular bone mass by communication between osteoblasts, osteocytes and osteoclastsQ38215896
RANKL/OPG; Critical role in bone physiology.Q38306944
Glutathione, N-acetylcysteine and lipoic acid down-regulate starvation-induced apoptosis, RANKL/OPG ratio and sclerostin in osteocytes: involvement of JNK and ERK1/2 signallingQ38912068
Concomitant activation of the PI3K/Akt and ERK1/2 signalling is involved in cyclic compressive force-induced IL-6 secretion in MLO-Y4 cellsQ39038707
Serotonin acts as a novel regulator of interleukin-6 secretion in osteocytes through the activation of the 5-HT(2B) receptor and the ERK1/2 signalling pathwayQ39065170
Oral administration of prostaglandin E(2)-specific receptor 4 antagonist inhibits lipopolysaccharide-induced osteoclastogenesis in rat periodontal tissueQ39475508
ERK1/2 is involved in cyclic compressive force-induced IL-6 secretion in MLO-Y4 cellsQ39654612
Gene expression patterns of osteocyte-like MLO-Y4 cells in response to cyclic compressive force stimulationQ39756270
Cross-talk between the interleukin-6 and prostaglandin E(2) signaling systems results in enhancement of osteoclastogenesis through effects on the osteoprotegerin/receptor activator of nuclear factor-{kappa}B (RANK) ligand/RANK system.Q40477297
STAT3 activation in stromal/osteoblastic cells is required for induction of the receptor activator of NF-kappaB ligand and stimulation of osteoclastogenesis by gp130-utilizing cytokines or interleukin-1 but not 1,25-dihydroxyvitamin D3 or parathyroiQ40945774
Defective nuclear factor-κB-inducing kinase in aly/aly mice prevents bone resorption induced by local injection of lipopolysaccharide.Q42484433
Transcriptional control of receptor activator of nuclear factor-kappaB ligand by the protein kinase A activator forskolin and the transmembrane glycoprotein 130-activating cytokine, oncostatin M, is exerted through multiple distal enhancersQ42503028
IL-6, leukemia inhibitory factor, and oncostatin M stimulate bone resorption and regulate the expression of receptor activator of NF-kappa B ligand, osteoprotegerin, and receptor activator of NF-kappa B in mouse calvariaeQ44129538
Locally administered T cells from mice immunized with lipopolysaccharide (LPS) accelerate LPS-induced bone resorptionQ47814012
P433issue1
P921main subjectlipopolysaccharideQ421804
P304page(s)84-92
P577publication date2016-10-24
P1433published inCell Biology InternationalQ1254690
P1476titleLipopolysaccharide increases IL-6 secretion via activation of the ERK1/2 signaling pathway to up-regulate RANKL gene expression in MLO-Y4 cells.
P478volume41

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cites work (P2860)
Q64275098Bone function, dysfunction and its role in diseases including critical illness
Q28817148Osteocyte Alterations Induce Osteoclastogenesis in an In Vitro Model of Gaucher Disease
Q90152411S100A9 Increases IL-6 and RANKL Expressions through MAPKs and STAT3 Signaling Pathways in Osteocyte-Like Cells
Q64106454The Osteocyte as a Novel Key Player in Understanding Periodontitis Through its Expression of RANKL and Sclerostin: a Review
Q47132574Tumor Acidosis and Hypoxia Differently Modulate the Inflammatory Program: Measurements In Vitro and In Vivo

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