4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB

scientific article

4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/MCB.18.1.558
P932PMC publication ID121523
P698PubMed publication ID9418902

P2093author name stringThompson CB
Arch RH
P2860cites workThe human OX40 homolog: cDNA structure, expression and chromosomal assignment of the ACT35 antigenQ24305105
A novel RING finger protein interacts with the cytoplasmic domain of CD40Q24306382
Involvement of CRAF1, a relative of TRAF, in CD40 signalingQ24306746
I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transductionQ24313173
ILA, a member of the human nerve growth factor/tumor necrosis factor receptor family, regulates T-lymphocyte proliferation and survivalQ24313254
Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinomaQ24315735
Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cellsQ24317763
A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptorQ24318280
Identification of a human OX-40 ligand, a costimulator of CD4+ T cells with homology to tumor necrosis factorQ24319938
Molecular and biological characterization of human 4-1BB and its ligandQ24320045
A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor familyQ24322784
cDNA sequences of two inducible T-cell genesQ24621040
TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signalingQ24634187
Retracted: Tumor necrosis factor receptor-associated factor (TRAF)-1, TRAF-2, and TRAF-3 interact in vivo with the CD30 cytoplasmic domain; TRAF-2 mediates CD30-induced nuclear factor kappa B activationQ24679579
Basic local alignment search toolQ25938991
The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunitQ27860669
Gene structure and chromosomal localization of the mouse homologue of rat OX40 proteinQ28118387
CD30 contains two binding sites with different specificities for members of the tumor necrosis factor receptor-associated factor family of signal transducing proteinsQ28281794
TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptorQ28282051
Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activationQ28301504
Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic regionQ28511583
Characterization of the MRC OX40 antigen of activated CD4 positive T lymphocytes--a molecule related to nerve growth factor receptorQ28576279
TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40Q28610812
Role of 4-1BB ligand in costimulation of T lymphocyte growth and its upregulation on M12 B lymphomas by cAMP.Q36364613
The T cell-B cell interaction via OX40-OX40L is necessary for the T cell-dependent humoral immune responseQ36365985
The human OX40/gp34 system directly mediates adhesion of activated T cells to vascular endothelial cellsQ36366597
Induction of nuclear factor kappaB by the CD30 receptor is mediated by TRAF1 and TRAF2.Q36566021
Tumor necrosis factor ligand superfamily: involvement in the pathology of malignant lymphomas.Q40544191
Tumor necrosis factor receptor superfamily members and their ligandsQ40626257
Expression of the human OX40 (hOX40) antigen in normal and neoplastic tissuesQ41265266
The v-abl tyrosine kinase negatively regulates NF-kappa B/Rel factors and blocks kappa gene transcription in pre-B lymphocytesQ41481010
75 Assay of transforming activity of tumor virus DNAQ45803657
TANK, a co-inducer with TRAF2 of TNF- and CD 40L-mediated NF-kappaB activationQ48064873
Genomic organization and chromosomal localization of the T-cell antigen 4-1BB.Q48084408
4-1BB is expressed on CD45RAhiROhi transitional T cell in humans.Q52048535
Signals through 4-1BB are costimulatory to previously activated splenic T cells and inhibit activation-induced cell deathQ56908523
Potential role of 4-1BB in T cell activation. Comparison with the costimulatory molecule CD28Q56909347
Expression characteristics of two potential T cell mediator genesQ69208261
Selective depletion of myelin-reactive T cells with the anti-OX-40 antibody ameliorates autoimmune encephalomyelitisQ70934403
OX40 is differentially expressed on activated rat and mouse T cells and is the sole receptor for the OX40 ligandQ71420856
OX-40 antibody enhances for autoantigen specific V beta 8.2+ T cells within the spinal cord of Lewis rats with autoimmune encephalomyelitisQ71609053
Costimulation of CD28- T lymphocytes by 4-1BB ligandQ71968269
Putative cytoplasmic amphiphilic domains in the nerve growth factor/tumour necrosis factor receptor superfamilyQ72872873
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectTumor necrosis factor receptor superfamily, member 4Q14907610
TNF receptor-associated factor 2Q14914363
TNFQ18032037
P304page(s)558-565
P577publication date1998-01-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476title4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB
P478volume18

Reverse relations

cites work (P2860)
Q640536152B4 costimulatory domain enhancing cytotoxic ability of anti-CD5 chimeric antigen receptor engineered natural killer cells against T cell malignancies
Q282175024-1BB (CD137) controls the clonal expansion and survival of CD8 T cells in vivo but does not contribute to the development of cytotoxicity
Q591349554-1BB enhancement of CAR T function requires NF-κB and TRAFs
Q24291798A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells
Q92215112A mathematical model of combined CD8 T cell costimulation by 4-1BB (CD137) and OX40 (CD134) receptors
Q54768658A recombinant vector expressing transgenes for four T-cell costimulatory molecules (OX40L, B7-1, ICAM-1, LFA-3) induces sustained CD4+ and CD8+ T-cell activation, protection from apoptosis, and enhanced cytokine production.
Q36254865Activation of NF-kappaB by HTLV-I and implications for cell transformation
Q28138697Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif
Q36696891Activation of NF-kappaB1 by OX40 contributes to antigen-driven T cell expansion and survival
Q34358363Activation of OX40 Augments Th17 Cytokine Expression and Antigen-Specific Uveitis
Q35427446Agonist antibodies to TNFR molecules that costimulate T and NK cells
Q34577189Altered T cell responses in children with autism
Q84675386Altered expression of TNFSF4 and TRAF2 mRNAs in peripheral blood mononuclear cells in patients with systemic lupus erythematosus: association with atherosclerotic symptoms and lupus nephritis
Q35717963An alternative signal 3: CD8⁺ T cell memory independent of IL-12 and type I IFN is dependent on CD27/OX40 signaling
Q40746656Anoxia-induced apoptosis occurs through a mitochondria-dependent pathway in lung epithelial cells
Q34325097Anti-CD137 antibodies in the treatment of autoimmune disease and cancer
Q34582700Antigen-independent signalosome of CARMA1, PKCθ, and TNF receptor-associated factor 2 (TRAF2) determines NF-κB signaling in T cells
Q35008690Arabidopsis thaliana BTB/ POZ-MATH proteins interact with members of the ERF/AP2 transcription factor family
Q36851678Assembling OX40 aptamers on a molecular scaffold to create a receptor-activating aptamer
Q35925874Assembly of post-receptor signaling complexes for the tumor necrosis factor receptor superfamily
Q48112970Augmentation of CD134 (OX40)-dependent NK anti-tumour activity is dependent on antibody cross-linking
Q36718807BK Virus Load Associated with Serum Levels of sCD30 in Renal Transplant Recipients
Q82542679Blockade of OX40-ligand after initial triggering of the T helper 2 response inhibits mercuric chloride-induced autoimmunity
Q59800859CD137 (4-1BB) Signalosome: Complexity Is a Matter of TRAFs
Q91737659CD137 Co-Stimulation Improves The Antitumor Effect Of LMP1-Specific Chimeric Antigen Receptor T Cells In Vitro And In Vivo
Q48340513CD137 Plays Both Pathogenic and Protective Roles in Type 1 Diabetes Development in NOD Mice
Q34582338CD137 signaling enhances tight junction resistance in intestinal epithelial cells
Q24647213CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand
Q22253249Caspase-induced inactivation of the anti-apoptotic TRAF1 during Fas ligand-mediated apoptosis
Q42631651Characterization and expression analysis of TNFR-associated factor 1 (TRAF1) in grass carp Ctenopharyngodon idella
Q97424540Chimeric antigen receptor signaling: Functional consequences and design implications
Q28207052Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?
Q39313794Comparative Analysis of Immune Checkpoint Molecules and Their Potential Role in the Transmissible Tasmanian Devil Facial Tumor Disease.
Q38919438Comparison of the peptide binding preferences of three closely related TRAF paralogs: TRAF2, TRAF3, and TRAF5
Q33899607Control of immunity by the TNFR-related molecule OX40 (CD134)
Q33212786Costimulation by CD137/4-1BB inhibits T cell apoptosis and induces Bcl-xL and c-FLIP(short) via phosphatidylinositol 3-kinase and AKT/protein kinase B.
Q35145627Costimulation of T cells by OX40, 4-1BB, and CD27.
Q58741753Cryptic sequence features in the active postmortem transcriptome
Q47292379Crystal structure of murine 4-1BB and its interaction with 4-1BBL support a role for galectin-9 in 4-1BB signaling.
Q59980503Crystal structure of the m4-1BB/4-1BBL complex reveals an unusual dimeric ligand that undergoes structural changes upon 4-1BB receptor binding
Q38698632Deciphering CD137 (4-1BB) signaling in T-cell costimulation for translation into successful cancer immunotherapy
Q38498718Differential DNA methylation status between human preadipocytes and mature adipocytes
Q37657776Distinct functions of HTLV-1 Tax1 from HTLV-2 Tax2 contribute key roles to viral pathogenesis
Q43085782Effects of tumour necrosis factor-alpha on developing cerebellar granule and Purkinje neurons in vitro
Q48010492Enhanced immune-modulatory effects of thalidomide and dexamethasone co-treatment on T cell subsets.
Q78759402Expression and costimulatory effects of the TNF receptor superfamily members CD134 (OX40) and CD137 (4-1BB), and their role in the generation of anti-tumor immune responses
Q34095134Expression and function of TRAF-3 splice-variant isoforms in human lymphoma cell lines
Q54076273Expression of CD134 (0X-40) on T cells during the first 100 days following allogeneic bone marrow transplantation as a marker for lymphocyte activation and therapy-resistant graft-versus-host disease.
Q40560816Fc Engineering Approaches to Enhance the Agonism and Effector Functions of an Anti-OX40 Antibody.
Q36232655Function of tumor necrosis factor receptor family members on regulatory T-cells
Q35745563Gene expression profiling in an in vitro model of angiogenesis
Q38957340Genetic markers as therapeutic target in rheumatoid arthritis: A game changer in clinical therapy?
Q35718485Genome-wide expression profiling implicates a MAST3-regulated gene set in colonic mucosal inflammation of ulcerative colitis patients
Q38770814Harnessing co-stimulatory TNF receptors for cancer immunotherapy: Current approaches and future opportunities
Q92432857Immunization with mannosylated nanovaccines and inhibition of the immune-suppressing microenvironment sensitizes melanoma to immune checkpoint modulators
Q92710342Induction of NKG2D ligand expression on tumor cells by CD8+ T-cell engagement-mediated activation of nuclear factor-kappa B and p300/CBP-associated factor
Q34851737Intrinsic TNF/TNFR2 interactions fine-tune the CD8 T cell response to respiratory influenza virus infection in mice
Q24314418Isolation and characterization of two novel metalloproteinase genes linked to the Cdc2L locus on human chromosome 1p36.3
Q35679587Loss of the signaling adaptor TRAF1 causes CD8+ T cell dysregulation during human and murine chronic infection
Q22254016MIP-T3, a novel protein linking tumor necrosis factor receptor-associated factor 3 to the microtubule network
Q94683589NF-κB in the New Era of Cancer Therapy
Q92453577NK cells for cancer immunotherapy
Q94552595New pathways in immune stimulation: targeting OX40
Q48326988Novel CD137 Gene Polymorphisms and Susceptibility to Ischemic Stroke in the Northern Chinese Han Population.
Q39598751OX40 complexes with phosphoinositide 3-kinase and protein kinase B (PKB) to augment TCR-dependent PKB signaling
Q28188488OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells
Q42227779Opposing roles for TRAF1 in the alternative versus classical NF-κB pathway in T cells
Q39939828Optimising anti-tumour CD8 T-cell responses using combinations of immunomodulatory antibodies.
Q41140315PKC-ѳ is dispensable for OX40L-induced TCR-independent Treg proliferation but contributes by enabling IL-2 production from effector T-cells
Q51973286Potent costimulation of human CD8 T cells by anti-4-1BB and anti-CD28 on synthetic artificial antigen presenting cells.
Q37368594Proteomic characterization of HIV-modulated membrane receptors, kinases and signaling proteins involved in novel angiogenic pathways.
Q34996759Reactive oxygen intermediates in TNF signaling
Q28137640Receptor activator of NF-kappaB recruits multiple TRAF family adaptors and activates c-Jun N-terminal kinase
Q40739297Recombinant glucocorticoid induced tumor necrosis factor receptor (rGITR) induces NOS in murine macrophage.
Q64990463Regulation of Interleukin-6 Receptor Signaling by TNF Receptor-Associated Factor 2 and 5 During Differentiation of Inflammatory CD4+ T Cells.
Q35990308Regulation of the PKCθ-NF-κB Axis in T Lymphocytes by the Tumor Necrosis Factor Receptor Family Member OX40
Q38224322Regulatory tone and mucosal immunity in asthma
Q78028326Relative abilities of 4-1BB (CD137) and CD28 to co-stimulate the response of cytokine deflected Th1 and Th2 cells
Q58580426Role of TRAFs in Signaling Pathways Controlling T Follicular Helper Cell Differentiation and T Cell-Dependent Antibody Responses
Q48666974Role of Thalidomide on the Expression of OX40, 4-1BB, and GITR in T Cell Subsets
Q38179139Roles for TNF-receptor associated factor 3 (TRAF3) in lymphocyte functions
Q36380507Roles of OX40 in the pathogenesis and the control of diseases
Q26853280Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functions
Q36487245SA-4-1BBL as a novel adjuvant for the development of therapeutic cancer vaccines
Q35049033SUMOylation is required for optimal TRAF3 signaling capacity
Q40553282Secretions of MMP-9 by soluble glucocorticoid-induced tumor necrosis factor receptor (sGITR) mediated by protein kinase C (PKC)delta and phospholipase D (PLD) in murine macrophage
Q36370648Selective activation of the c-Jun NH2-terminal protein kinase signaling pathway by stimulatory KIR in the absence of KARAP/DAP12 in CD4+ T cells
Q24291496Sequence analysis identifies TTRAP, a protein that associates with CD40 and TNF receptor-associated factors, as a member of a superfamily of divalent cation-dependent phosphodiesterases
Q46036396Signaling through OX40 (CD134) breaks peripheral T-cell tolerance.
Q24539054Stress-induced decrease in TRAF2 stability is mediated by Siah2
Q27617947Structural basis for self-association and receptor recognition of human TRAF2
Q44818468Structural mapping of CD134 residues critical for interaction with feline immunodeficiency virus
Q57823195Synthetic immunology: T-cell engineering and adoptive immunotherapy
Q38086114T cell co-stimulatory molecules: a co-conspirator in the pathogenesis of eosinophilic esophagitis?
Q35021163T cell-NF-κB activation is required for tumor control in vivo
Q38168010T-cell costimulatory blockade in organ transplantation
Q37948129T-cell intrinsic effects of GITR and 4-1BB during viral infection and cancer immunotherapy
Q89467763THEMIS-SHP1 Recruitment by 4-1BB Tunes LCK-Mediated Priming of Chimeric Antigen Receptor-Redirected T Cells
Q30578474TNF receptor associated factors in cytokine signaling.
Q35534271TNF superfamily protein-protein interactions: feasibility of small- molecule modulation
Q37266849TNF superfamily: costimulation and clinical applications
Q40644972TNF-related weak inducer of apoptosis receptor, a TNF receptor superfamily member, activates NF-kappa B through TNF receptor-associated factors
Q38778362TNFR-Associated Factors 2 and 5 Differentially Regulate the Instructive IL-6 Receptor Signaling Required for Th17 Development.
Q40184385TNFSF9 exerts an inhibitory effect on hepatocellular carcinoma
Q28142929TRAF-3 interacts with p62 nucleoporin, a component of the nuclear pore central plug that binds classical NLS-containing import complexes
Q33876001TRAF-3 mRNA splice-deletion variants encode isoforms that induce NF-kappaB activation
Q37769438TRAF-mediated regulation of immune and inflammatory responses
Q28138885TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis
Q50792035TRAF3 forms heterotrimers with TRAF2 and modulates its ability to mediate NF-{kappa}B activation.
Q28512952TROY, a newly identified member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair follicles
Q38120535Targeting of the tumor necrosis factor receptor superfamily for cancer immunotherapy
Q81999267Targeting the CD134-CD134L interaction using anti-CD134 and/or rhCD134 fusion protein as a possible strategy to prevent lupus nephritis
Q53542645The 4-1BB ligand and 4-1BB expressed on osteoclast precursors enhance RANKL-induced osteoclastogenesis via bi-directional signaling.
Q40677513The Fn14 cytoplasmic tail binds tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5 and mediates nuclear factor-kappaB activation
Q37062139The IKK-neutralizing compound Bay11 kills supereffector CD8 T cells by altering caspase-dependent activation-induced cell death
Q38073762The TNF receptor-ligands 4-1BB-4-1BBL and GITR-GITRL in NK cell responses
Q28198125The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators
Q33940420The adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells by antagonizing signaling via the receptor for IL-6.
Q38541019The pharmacology of second-generation chimeric antigen receptors.
Q37524064The role of OX40-mediated co-stimulation in T-cell activation and survival
Q35145613The signaling adaptors and pathways activated by TNF superfamily
Q34979946The significance of OX40 and OX40L to T-cell biology and immune disease.
Q27619945The structural basis for the recognition of diverse receptor sequences by TRAF2
Q36370712The transcriptional repressor Gfi1 affects development of early, uncommitted c-Kit+ T cell progenitors and CD4/CD8 lineage decision in the thymus
Q35192167Thermodynamic characterization of the interaction between TRAF2 and tumor necrosis factor receptor peptides by isothermal titration calorimetry
Q44503926Thyroid hormone induces the expression of 4-1BB and activation of caspases in a thyroid hormone receptor-dependent manner
Q88922346Toward Small-Molecule Inhibition of Protein-Protein Interactions: General Aspects and Recent Progress in Targeting Costimulatory and Coinhibitory (Immune Checkpoint) Interactions
Q39690697Triple expression of B7-1, B7-2 and 4-1BBL enhanced antitumor immune response against mouse H22 hepatocellular carcinoma
Q40321861Tumor necrosis factor receptor (TNFR)-associated factor 5 is a critical intermediate of costimulatory signaling pathways triggered by glucocorticoid-induced TNFR in T cells
Q34135071Tumor necrosis factor receptor-associated factor (TRAF) 2 and its role in TNF signaling.
Q28178466Tumor necrosis factor receptor-associated factor (TRAF) 4 is a new binding partner for the p70S6 serine/threonine kinase
Q28199382Tumor necrosis factor receptor-associated factors (TRAFs)

Search more.