CD30 contains two binding sites with different specificities for members of the tumor necrosis factor receptor-associated factor family of signal transducing proteins

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CD30 contains two binding sites with different specificities for members of the tumor necrosis factor receptor-associated factor family of signal transducing proteins is …
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scholarly articleQ13442814

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P356DOI10.1074/JBC.271.22.12852
P698PubMed publication ID8662842
P5875ResearchGate publication ID14537742

P2093author name stringC B Thompson
C S Duckett
J L Van Dongen
M C Gilfillan
R W Gedrich
P2860cites workA novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40Q24306620
Involvement of CRAF1, a relative of TRAF, in CD40 signalingQ24306746
FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosisQ24307362
RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell deathQ24307376
Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinomaQ24315735
Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genesQ24315805
CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNFQ24316162
A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptorQ24318280
The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activationQ24318742
Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin's diseaseQ24324634
The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunitQ27860669
The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteinsQ28117866
Ki-1 (CD30) antigen is released by Ki-1-positive tumor cells in vitro and in vivo. I. Partial characterization of soluble Ki-1 antigen and detection of the antigen in cell culture supernatants and in serum by an enzyme-linked immunosorbent assayQ28251086
The CD40 antigen and its ligandQ28286277
The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor familyQ28307399
TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40Q28610812
CD30-mediated signaling promotes the development of human T helper type 2-like T cellsQ36672795
The two different receptors for tumor necrosis factor mediate distinct cellular responsesQ37609601
Cytokines and STATs: how can signals achieve specificity?Q40451329
Contenders in FasL/TNF death signalingQ40530231
CD30, Th2 cytokines and HIV infection: a complex and fascinating linkQ40611296
Cross-linking of CD30 induces HIV expression in chronically infected T cellsQ41342620
Activation of the B-cell surface receptor CD40 induces A20, a novel zinc finger protein that inhibits apoptosisQ41343773
Identification of the intracytoplasmic region essential for signal transduction through a B cell activation molecule, CD40.Q41727367
CD30 expression by CD8+ T cells producing type 2 helper cytokines. Evidence for large numbers of CD8+CD30+ T cell clones in human immunodeficiency virus infectionQ41779853
Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell deathQ46725238
Production of a monoclonal antibody specific for Hodgkin and Sternberg–Reed cells of Hodgkin's disease and a subset of normal lymphoid cellsQ59090441
P433issue22
P407language of work or nameEnglishQ1860
P304page(s)12852-8
P577publication date1996-05-31
P1433published inJournal of Biological ChemistryQ867727
P1476titleCD30 contains two binding sites with different specificities for members of the tumor necrosis factor receptor-associated factor family of signal transducing proteins
P478volume271

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cites work (P2860)
Q4109498712-O-tetradecanoylphorbol-13-acetate (TPA) downregulates expression of CD30 in erythroleukemia cell line K562.
Q245338574-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB
Q24291050A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains
Q102054075A novel model of alternative NF-κB pathway activation in anaplastic large cell lymphoma
Q42165830A regulatory role for TRAF1 in antigen-induced apoptosis of T cells.
Q39392332AP-1 mediated relief of repressive activity of the CD30 promoter microsatellite in Hodgkin and Reed-Sternberg cells
Q28263653Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation
Q40813696Activation of c-Jun N-terminal kinase in the absence of NFkappaB function prior to induction of NK cell death triggered by a combination of anti-class I and anti-CD16 antibodies
Q48528844Anaplastic large cell lymphoma: pathology, genetics, and clinical aspects.
Q33699315Antigen presenting cells integrate opposing signals from CD4+ and CD8+ regulatory T lymphocytes to arbitrate the outcomes of immune responses
Q35925874Assembly of post-receptor signaling complexes for the tumor necrosis factor receptor superfamily
Q36718807BK Virus Load Associated with Serum Levels of sCD30 in Renal Transplant Recipients
Q24647213CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand
Q40177590CD30 activates both the canonical and alternative NF-kappaB pathways in anaplastic large cell lymphoma cells
Q35996947CD30 induction of human immunodeficiency virus gene transcription is mediated by TRAF2
Q33747241CD30 ligand (CD30L)-expressing acute myeloid leukemias: a new model of paracrine interactions for the regulation of blast cells proliferation.
Q24605401CD30-dependent degradation of TRAF2: implications for negative regulation of TRAF signaling and the control of cell survival
Q42631651Characterization and expression analysis of TNFR-associated factor 1 (TRAF1) in grass carp Ctenopharyngodon idella
Q39879963Characterization of LMP-1's association with TRAF1, TRAF2, and TRAF3.
Q40733134Cytoplasmic aggregation of TRAF2 and TRAF5 proteins in the Hodgkin-Reed-Sternberg cells
Q42441496Differential expression and function of A20 and TRAF1 in Hodgkin lymphoma and anaplastic large cell lymphoma and their induction by CD30 stimulation
Q36004058Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1
Q41682745Differential requirements for tumor necrosis factor receptor-associated factor family proteins in CD40-mediated induction of NF-kappaB and Jun N-terminal kinase activation.
Q34428468Distinct motifs in the intracellular domain of human CD30 differentially activate canonical and alternative transcription factor NF-κB signaling
Q28255713Dominant negative mutants of TRAF3 reveal an important role for the coiled coil domains in cell death signaling by the lymphotoxin-beta receptor
Q29618716Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice
Q34095134Expression and function of TRAF-3 splice-variant isoforms in human lymphoma cell lines
Q35788035Frequent expression of the variant CD30 in human malignant myeloid and lymphoid neoplasms
Q38331230Galectin-1-mediated cell death is increased by CD30-induced signaling in anaplastic large cell lymphoma cells but not in Hodgkin lymphoma cells
Q33713375Gene targeting in the analysis of mammalian apoptosis and TNF receptor superfamily signaling
Q28207526Hodgkin's lymphoma and CD30 signal transduction
Q28245341Identification and characterization of an IkappaB kinase
Q73980580Identification and characterization of two CD40-inducible enhancers in the mouse TRAF1 gene locus
Q28280342Identification and functional characterization of DR6, a novel death domain-containing TNF receptor
Q36566021Induction of nuclear factor kappaB by the CD30 receptor is mediated by TRAF1 and TRAF2.
Q33786551Interaction of tumor necrosis factor receptor-associated factor signaling proteins with the latent membrane protein 1 PXQXT motif is essential for induction of epidermal growth factor receptor expression
Q40736248Ligand-independent signaling by overexpressed CD30 drives NF-kappaB activation in Hodgkin-Reed-Sternberg cells
Q36959865Lymphoma microenvironment: culprit or innocent?
Q24564927Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB
Q42807549Murine Siva-1 and Siva-2, alternate splice forms of the mouse Siva gene, both bind to CD27 but differentially transduce apoptosis
Q57203665NF-κB as an emerging target in atopy
Q33919859Neurotrophin receptor structure and interactions
Q74746971Neurotrophin receptors: mediators of life and death
Q28208696Pleiotropic signal transduction mediated by human CD30: a member of the tumor necrosis factor receptor (TNFR) family
Q34996759Reactive oxygen intermediates in TNF signaling
Q28137640Receptor activator of NF-kappaB recruits multiple TRAF family adaptors and activates c-Jun N-terminal kinase
Q42775424Regulation of CD30 antigen expression and its potential significance for human disease
Q78631997Regulation of lymphocyte clustering by CD30-mediated ICAM-1 up-regulation
Q24679579Retracted: Tumor necrosis factor receptor-associated factor (TRAF)-1, TRAF-2, and TRAF-3 interact in vivo with the CD30 cytoplasmic domain; TRAF-2 mediates CD30-induced nuclear factor kappa B activation
Q39550436Role of cellular tumor necrosis factor receptor-associated factors in NF-kappaB activation and lymphocyte transformation by herpesvirus Saimiri STP.
Q31927630Structure of the Hodgkin's lymphoma-associated human CD30 gene and the influence of a microsatellite region on its expression in CD30(+) cell lines.
Q40027786Sub-megabase resolution tiling (SMRT) array-based comparative genomic hybridization profiling reveals novel gains and losses of chromosomal regions in Hodgkin Lymphoma and Anaplastic Large Cell Lymphoma cell lines
Q35183220Systemic and primary cutaneous anaplastic large cell lymphomas
Q30578474TNF receptor associated factors in cytokine signaling.
Q37266849TNF superfamily: costimulation and clinical applications
Q28142929TRAF-3 interacts with p62 nucleoporin, a component of the nuclear pore central plug that binds classical NLS-containing import complexes
Q33876001TRAF-3 mRNA splice-deletion variants encode isoforms that induce NF-kappaB activation
Q24313308TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation
Q28138885TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis
Q73925277TRAF2 is essential for JNK but not NF-kappaB activation and regulates lymphocyte proliferation and survival
Q35125212TRAF2 recruitment via T61 in CD30 drives NFκB activation and enhances hESC survival and proliferation
Q57492396TRAF3 as a Multifaceted Regulator of B Lymphocyte Survival and Activation
Q22253885TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation
Q52522634Targeted disruption of TRAF3 leads to postnatal lethality and defective T-dependent immune responses.
Q40850973The CD28 and CTLA-4 receptors associate with the serine/threonine phosphatase PP2A.
Q35997566The Epstein-Barr virus LMP1 amino acid sequence that engages tumor necrosis factor receptor associated factors is critical for primary B lymphocyte growth transformation
Q28589608The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2
Q95789811The collagen repeat sequence is a determinant of the degree of herpesvirus saimiri STP transforming activity
Q35850668The in vivo function of a noncanonical TRAF2-binding domain in the C-terminus of CD40 in driving B-cell growth and differentiation
Q22254032The prodomain of caspase-1 enhances Fas-mediated apoptosis through facilitation of caspase-8 activation
Q35145613The signaling adaptors and pathways activated by TNF superfamily
Q27619945The structural basis for the recognition of diverse receptor sequences by TRAF2
Q40905330The tyrosine kinase NPM-ALK, associated with anaplastic large cell lymphoma, binds the intracellular domain of the surface receptor CD30 but is not activated by CD30 stimulation
Q35192167Thermodynamic characterization of the interaction between TRAF2 and tumor necrosis factor receptor peptides by isothermal titration calorimetry
Q41343487Trans-signaling by cytokine and growth factor receptors
Q40375572Transactivation of the ICAM-1 gene by CD30 in Hodgkin's lymphoma
Q24642851Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2
Q41056335Tumor necrosis factor receptor (TNFR)-associated factor 2A (TRAF2A), a TRAF2 splice variant with an extended RING finger domain that inhibits TNFR2-mediated NF-kappaB activation
Q28301504Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation
Q36400170Tumor necrosis factor receptor-associated factor 6 (TRAF6) stimulates extracellular signal-regulated kinase (ERK) activity in CD40 signaling along a ras-independent pathway.
Q28199382Tumor necrosis factor receptor-associated factors (TRAFs)
Q24676338Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40
Q24304221VIAF, a conserved inhibitor of apoptosis (IAP)-interacting factor that modulates caspase activation

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