A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells

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A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells is …
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scholarly articleQ13442814

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P356DOI10.1084/JEM.194.8.1111
P3181OpenCitations bibliographic resource ID1840951
P932PMC publication ID2193511
P698PubMed publication ID11602640
P5875ResearchGate publication ID275108472

P50authorMarco ColonnaQ37377244
Marina CellaQ55278809
P2093author name stringC Hernández-Munain
A Bouchon
P2860cites workHuman myeloid cells express an activating ILT receptor (ILT1) that associates with Fc receptor gamma-chainQ77787435
Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cellsQ22003745
NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamilyQ22008826
An activating immunoreceptor complex formed by NKG2D and DAP10Q22010441
Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytesQ22254042
Association of signal-regulatory proteins beta with KARAP/DAP-12Q24273419
Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cellsQ24315619
A family of proteins that inhibit signalling through tyrosine kinase receptorsQ24336010
A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell functionQ24336057
4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaBQ24533857
Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activationQ24677534
Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cellsQ27860599
Phosphorylation meets ubiquitination: the control of NF-[kappa]B activityQ27860643
Dendritic cells and the control of immunityQ27860918
NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responsesQ27861101
The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodesQ28140140
Toll-like receptors in the induction of the innate immune responseQ28144797
Regulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinaseQ28145921
TREM-1 amplifies inflammation and is a crucial mediator of septic shockQ28185818
Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alphaQ28251443
Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activationQ28263653
Association of DAP12 with activating CD94/NKG2C NK cell receptorsQ28275848
EBI1/CCR7 is a new member of dendritic cell chemokine receptor that is up-regulated upon maturationQ28282903
NF-kappa B RelA-deficient lymphocytes: normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responsesQ28505819
Gene structure, expression pattern, and biological activity of mouse killer cell activating receptor-associated protein (KARAP)/DAP-12Q28570776
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesisQ28589430
CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organsQ28594485
Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cellsQ28609671
DAP12-mediated signal transduction in natural killer cells. A dominant role for the Syk protein-tyrosine kinaseQ28610866
Activation of NF-kappa B requires proteolysis of the inhibitor I kappa B-alpha: signal-induced phosphorylation of I kappa B-alpha alone does not release active NF-kappa BQ28615810
BCL-2 family members and the mitochondria in apoptosisQ29614427
IgG Fc receptorsQ29615378
Chemokines: a new classification system and their role in immunityQ29615663
A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometryQ29617253
The Bcl-2 protein family: arbiters of cell survivalQ29618158
Innate immunityQ29618949
Signal-regulatory protein alpha (SIRPalpha) but not SIRPbeta is involved in T-cell activation, binds to CD47 with high affinity, and is expressed on immature CD34(+)CD38(-) hematopoietic cells.Q30649377
Cloning and characterization of a novel mouse myeloid DAP12-associated receptor familyQ30657557
A critical role for p38 mitogen-activated protein kinase in the maturation of human blood-derived dendritic cells induced by lipopolysaccharide, TNF-alpha, and contact sensitizersQ32133166
Fc receptor signaling and trafficking: a connection for antigen processingQ33815451
Leukocyte migration: scent of the T zoneQ33830297
Natural adjuvants: endogenous activators of dendritic cellsQ33878894
Apoptotic pathways: paper wraps stone blunts scissorsQ33993406
Series introduction: the transcription factor NF-kappaB and human diseaseQ34116362
BH3-Only proteins-essential initiators of apoptotic cell deathQ34117362
Differential requirements for survival and proliferation of CD8 naïve or memory T cellsQ34430192
Signaling through human killer cell activating receptors triggers tyrosine phosphorylation of an associated protein complexQ34461855
Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleenQ34488105
Myeloma based expression system for production of large mammalian proteinsQ35289817
T cell-dependent induction of NF-kappa B in B cellsQ36361506
High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10.Q36367196
Fcgamma receptor-mediated induction of dendritic cell maturation and major histocompatibility complex class I-restricted antigen presentation after immune complex internalizationQ36367948
TRANCE, a tumor necrosis factor family member critical for CD40 ligand-independent T helper cell activationQ36368029
Impairment of antigen-presenting cell function in mice lacking expression of OX40 ligandQ36375697
Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cellsQ36375909
TRANCE, a tumor necrosis factor family member, enhances the longevity and adjuvant properties of dendritic cells in vivoQ36375923
Dissociation of cytokine-induced phosphorylation of Bad and activation of PKB/akt: involvement of MEK upstream of Bad phosphorylationQ36490362
Regulation of the T-cell receptor delta enhancer by functional cooperation between c-Myb and core-binding factorsQ38312442
CD40L: a multi-functional ligandQ40386990
Two distinct regions of FC gamma RI initiate separate signalling pathways involved in endocytosis and phagocytosisQ40805605
Combined natural killer cell and dendritic cell functional deficiency in KARAP/DAP12 loss-of-function mutant mice.Q40850965
Interaction of Ly-49D+ NK cells with H-2Dd target cells leads to Dap-12 phosphorylation and IFN-gamma secretionQ40908098
syk protein tyrosine kinase regulates Fc receptor gamma-chain-mediated transport to lysosomesQ41015817
Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localizationQ42064511
Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responsesQ42488424
Ox40-ligand has a critical costimulatory role in dendritic cell:T cell interactionsQ42806821
Dendritic cell survival and maturation are regulated by different signaling pathways.Q42971737
Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sitesQ42971765
DAP12-deficient mice fail to develop autoimmunity due to impaired antigen primingQ46091534
Differential regulation of chemokine receptors during dendritic cell maturation: a model for their trafficking properties.Q47757468
Ly-49D and Ly-49H associate with mouse DAP12 and form activating receptorsQ47910176
Cloning and characterization of a novel activating Ly49 closely related to Ly49A.Q47918540
Immunology. Licence to killQ47982772
A novel mutant gene involved in T-lymphocyte-specific homing into peripheral lymphoid organs on mouse chromosome 4.Q52039534
Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood.Q54451826
Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells.Q55066427
Signaling through human killer cell activating receptors triggers tyrosine phosphorylation of an associated protein complexQ57200936
Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cellsQ57275942
Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expressionQ62817899
Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cellsQ72191659
Human killer cell activatory receptors for MHC class I molecules are included in a multimeric complex expressed by natural killer cellsQ73369937
Interleukin-18 activates NF-kappaB in murine T helper type 1 cellsQ73401336
Granulocyte-macrophage colony-stimulating factor delays neutrophil constitutive apoptosis through phosphoinositide 3-kinase and extracellular signal-regulated kinase pathwaysQ73644532
TREM-1: a new regulator of innate immunity in sepsis syndromeQ73820244
Expression and function of OX40 ligand on human dendritic cellsQ73900124
The PI3 kinase, p38 SAP kinase, and NF-kappaB signal transduction pathways are involved in the survival and maturation of lipopolysaccharide-stimulated human monocyte-derived dendritic cellsQ74055104
Cutting edge: secondary lymphoid-tissue chemokine (SLC) and CC chemokine receptor 7 (CCR7) participate in the emigration pathway of mature dendritic cells from the skin to regional lymph nodesQ74595801
Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturationQ77353738
IkappaB-NF-kappaB structures: at the interface of inflammation controlQ77726306
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectnegative regulation of protein localization to plasma membraneQ21106417
positive regulation of protein localization to plasma membraneQ21106669
regulation of protein localization to plasma membraneQ21112181
positive regulation of C-C chemokine receptor CCR7 signaling pathwayQ21173954
positive regulation of CD40 signaling pathwayQ21173955
dendritic cellQ506253
regulation of C-C chemokine receptor CCR7 signaling pathwayQ22303707
negative regulation of C-C chemokine receptor CCR7 signaling pathwayQ22303708
P304page(s)1111-22
P577publication date2001-10-15
P1433published inJournal of Experimental MedicineQ3186912
P1476titleA DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells
P478volume194