Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells

scientific article published in Nature

Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1009213204
P356DOI10.1038/42030
P698PubMed publication ID9285591

P50authorAntonio LanzavecchiaQ4776729
Jean PietersQ18066937
Marina CellaQ55278809
Valérie PinetQ64763847
P2093author name stringEngering A
P2860cites workDendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial productsQ24678867
Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alphaQ28251443
The dendritic cell system and its role in immunogenicityQ29619870
Antigen processing by epidermal Langerhans cells correlates with the level of biosynthesis of major histocompatibility complex class II molecules and expression of invariant chainQ36353782
Dendritic cell loss from nonlymphoid tissues after systemic administration of lipopolysaccharide, tumor necrosis factor, and interleukin 1Q36364968
Related leucine-based cytoplasmic targeting signals in invariant chain and major histocompatibility complex class II molecules control endocytic presentation of distinct determinants in a single proteinQ36376527
Early molecular events in the induction phase of contact sensitivityQ36837916
Class II major histocompatibility complex molecules of murine dendritic cells: synthesis, sialylation of invariant chain, and antigen processing capacity are down-regulated upon cultureQ37472931
Developmental regulation of MHC class II transport in mouse dendritic cells.Q41093187
Antigen presentation mediated by recycling of surface HLA-DR molecules.Q41335304
Irreversible association of peptides with class II MHC molecules in living cells.Q41623807
Processed antigen binds to newly synthesized MHC class II molecules in antigen-specific B lymphocytesQ41661580
Cycling of cell-surface MHC glycoproteins through primaquine-sensitive intracellular compartmentsQ41724706
The biosynthetic pathway of MHC class II but not class I molecules intersects the endocytic routeQ41737562
MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen bindingQ41941589
Disappearance of certain acidic organelles (endosomes and Langerhans cell granules) accompanies loss of antigen processing capacity upon culture of epidermal Langerhans cellsQ42938806
Peptides determine the lifespan of MHC class II molecules in the antigen-presenting cellQ59077649
Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytesQ59098594
P433issue6644
P407language of work or nameEnglishQ1860
P921main subjectinflammationQ101991
dendritic cellQ506253
P304page(s)782-787
P577publication date1997-08-01
P1433published inNatureQ180445
P1476titleInflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells
P478volume388

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Q55289934Nano-scale microfluidics to study 3D chemotaxis at the single cell level.
Q41748252Natural interferon alpha/beta-producing cells link innate and adaptive immunity
Q37921195Natural killer cell activation by dendritic cells: balancing inhibitory and activating signals
Q35014074Natural killer cells and dendritic cells: rendezvous in abused tissues
Q90092691Natural killer cells as participants in pathogenesis of rat experimental autoimmune encephalomyelitis (EAE): lessons from research on rats with distinct age and strain
Q40671984Naturally occurring human IgM antibody that binds B7-DC and potentiates T cell stimulation by dendritic cells
Q84325970Neutralizing antibodies in SIV control: co-impact with T cells
Q42110792Neutrophils mediate immune modulation of dendritic cells through glycosylation-dependent interactions between Mac-1 and DC-SIGN.
Q36375570Nonlymphocyte-derived tumor necrosis factor is required for induction of colitis in recombination activating gene (RAG)2(-/-) mice upon transfer of CD4(+)CD45RB(hi) T cells
Q42944282On the role of the innate immunity in autoimmune disease
Q47616533Opposing Signals from Pathogen-Associated Molecular Patterns and IL-10 Are Critical for Optimal Dendritic Cell Induction of In Vivo Humoral Immunity to Streptococcus pneumoniae
Q36360756Palmitic acid is a toll-like receptor 4 ligand that induces human dendritic cell secretion of IL-1β
Q52015249Peptide-pulsed splenic dendritic cells prime long-lasting CD8(+) T cell memory in the absence of cross-priming by host APC.
Q27025438Periodontal disease immunology: 'double indemnity' in protecting the host
Q33943439Persisting viruses and autoimmunity.
Q33683408Phagocytic antigen processing and effects of microbial products on antigen processing and T-cell responses
Q40367936Phenotype and function of myeloid dendritic cells derived from African green monkey blood monocytes
Q35793849Phenotype and in vitro function of mature MDDC generated from cryopreserved PBMC of cancer patients are equivalent to those from healthy donors
Q34027491Phenotypic and functional abnormalities of bone marrow-derived dendritic cells in systemic lupus erythematosus
Q35312451Phenotypic, ultra-structural, and functional characterization of bovine peripheral blood dendritic cell subsets
Q38271875Plant components for immune modulation targeting dendritic cells: implication for therapy
Q38353384PolyI:C-induced reduction in uptake of soluble antigen is independent of dendritic cell activation
Q33565296Polymeric Materials for Gene Delivery and DNA Vaccination
Q46491194Polysaccharide purified from Ganoderma lucidum induced activation and maturation of human monocyte-derived dendritic cells by the NF-kappaB and p38 mitogen-activated protein kinase pathways.
Q30546758Predicting lymph node output efficiency using systems biology
Q38951047Present Yourself! By MHC Class I and MHC Class II Molecules
Q36580586Present and future of lung cancer vaccines
Q28611993Presentation of antigens by MHC class II molecules: getting the most out of them
Q36376648Presentation of exogenous antigens on major histocompatibility complex (MHC) class I and MHC class II molecules is differentially regulated during dendritic cell maturation
Q36514286Presentation of phagocytosed antigens by MHC class I and II.
Q36433065Presentation of type B peptide-MHC complexes from hen egg white lysozyme by TLR ligands and type I IFNs independent of H2-DM regulation
Q34351438Processing and presentation of antigens by dendritic cells: implications for vaccines
Q33815407Processing of bacterial antigens for peptide presentation on MHC class I molecules
Q53664068Production and characterization of clinical grade exosomes derived from dendritic cells.
Q35678201Profiles of carbohydrate ligands associated with adsorbed proteins on self-assembled monolayers of defined chemistries
Q44607345Prostaglandin E2 inhibits TNF production in murine bone marrow-derived dendritic cells
Q37859271Prostaglandin E2 modulates dendritic cell function during chlamydial genital infection
Q35850629Prostanoids and their receptors that modulate dendritic cell-mediated immunity
Q36319176Prostanoids modulate inflammation and alloimmune responses during graft rejection
Q35791420Protease-activated receptor-2 signaling triggers dendritic cell development
Q33885986Proteolysis in MHC class II antigen presentation: who's in charge?
Q64100229Quantitative proteomic changes in LPS-activated monocyte-derived dendritic cells: A SWATH-MS study
Q37361748RNAi-directed inhibition of DC-SIGN by dendritic cells: prospects for HIV-1 therapy
Q47373857Rapid downregulation of antigen processing enzymes in ex vivo generated human monocyte derived dendritic cells occur endogenously in extended cultures
Q34376294Recent developments in adjuvants for vaccines against infectious diseases
Q90751589Regional and functional heterogeneity of antigen presenting cells in the mouse brain and meninges
Q35022580Regulation and function of class II major histocompatibility complex, CD40, and B7 expression in macrophages and microglia: Implications in neurological diseases
Q26797333Regulation of Lipid Specific and Vitamin Specific Non-MHC Restricted T Cells by Antigen Presenting Cells and Their Therapeutic Potentials
Q37303927Regulation of MHC Class II-Peptide Complex Expression by Ubiquitination
Q36037772Regulation of antigen presentation and cross-presentation in the dendritic cell network: facts, hypothesis, and immunological implications.
Q34104329Regulation of antigen presentation by Mycobacterium tuberculosis: a role for Toll-like receptors
Q37765823Regulation of antigen uptake, migration, and lifespan of dendritic cell by Toll-like receptors.
Q74237814Regulation of major histocompatibility complex class II synthesis by interleukin-10
Q36739751Regulatory polymorphisms modulate the expression of HLA class II molecules and promote autoimmunity.
Q40384194Release of IL-1beta via IL-1beta-converting enzyme in a skin dendritic cell line exposed to 2,4-dinitrofluorobenzene
Q36401161Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction of Th1 immunity
Q40943680Revision of the functional analysis and structural features of immortalized dendritic cell lines derived from mice lacking both type I and type II interferon receptors
Q39582614Role of E4 in eliciting CD4 T-cell and B-cell responses to adenovirus vectors delivered to murine and nonhuman primate lungs.
Q33713274Role of dendritic cells in the induction and maintenance of autoimmune diseases
Q37974923Role of immune reactions in drug-induced liver injury (DILI).
Q41578289Route of antigen uptake differentially impacts presentation by dendritic cells and activated monocytes
Q40455669Ryanodine receptor activation by Ca v 1.2 is involved in dendritic cell major histocompatibility complex class II surface expression
Q58800404SH2-domain mutations in STAT3 in hyper-IgE syndrome patients result in impairment of IL-10 function
Q39516857Salmonella enterica serovar typhimurium-induced maturation of bone marrow-derived dendritic cells
Q54445611Selective effect of burn injury on splenic CD11c(+) dendritic cells and CD8alpha(+)CD4(-)CD11c(+) dendritic cell subsets.
Q42971765Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites
Q43821766Signaling from epithelial to dendritic cells of the thyroid gland: evidence for thyrocyte-derived factors controlling the survival, multiplication, and endocytic activity of dendritic cells
Q52574350Simvastatin inhibits the MHC class II pathway of antigen presentation by impairing Ras superfamily GTPases.
Q33258637Small organic compounds enhance antigen loading of class II major histocompatibility complex proteins by targeting the polymorphic P1 pocket
Q46674193Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation
Q34632056Spinning molecular immunology into successful immunotherapy
Q59640222Strategies for improved antigen delivery into dendritic cells
Q57198394Strategies to Stimulate Innate Immunity for Designing Effective Vaccine Adjuvants
Q55488025Streptococcus suis Serotype 2 Infection Impairs Interleukin-12 Production and the MHC-II-Restricted Antigen Presentation Capacity of Dendritic Cells.
Q51837303Studying MHC class II transport in dendritic cells.
Q44294573Superoxide anions induce the maturation of human dendritic cells
Q41921184Surface expression of HLA-DM on dendritic cells derived from CD34-positive bone marrow haematopoietic stem cells
Q59077373Surface expression of MHC class II in dendritic cells is controlled by regulated ubiquitination
Q39787577Susceptibility of immature and mature Langerhans cell-type dendritic cells to infection and immunomodulation by human cytomegalovirus
Q36024310Sustained antigen presentation can promote an immunogenic T cell response, like dendritic cell activation.
Q45264704Systemic activation of dendritic cells by Toll-like receptor ligands or malaria infection impairs cross-presentation and antiviral immunity
Q36400665T helper 1 (Th1) and Th2 characteristics start to develop during T cell priming and are associated with an immediate ability to induce immunoglobulin class switching
Q77174567T-cell-independent antiviral antibody responses
Q40227414TLR and nucleotide-binding oligomerization domain-like receptor signals differentially regulate exogenous antigen presentation
Q34533668TNF activates calcium-nuclear factor of activated T cells (NFAT)c1 signaling pathways in human macrophages
Q36990604Taming cancer by inducing immunity via dendritic cells
Q90290687Targeting Regulatory T Cells by Addressing Tumor Necrosis Factor and Its Receptors in Allogeneic Hematopoietic Cell Transplantation and Cancer
Q77383438Targeting the function of mature dendritic cells by human cytomegalovirus: a multilayered viral defense strategy
Q36548512Tetherin/BST-2 promotes dendritic cell activation and function during acute retrovirus infection.
Q30385433Tetherin/BST-2: Restriction Factor or Immunomodulator?
Q45208367The MHC class II transactivator (CIITA) mRNA stability is critical for the HLA class II gene expression in myelomonocytic cells.
Q26784452The Role of Dendritic Cells in Fibrosis Progression in Nonalcoholic Fatty Liver Disease
Q26776548The Timing of T Cell Priming and Cycling
Q73361348The Toll-Like Receptor 5 Stimulus Bacterial Flagellin Induces Maturation and Chemokine Production in Human Dendritic Cells
Q34612325The cell biology of MHC class I antigen presentation.
Q34129335The cell biology of antigen presentation in dendritic cells.
Q28384138The dendritic cell response to classic, emerging, and homeostatic danger signals. Implications for autoimmunity
Q82385519The effect of azithromycin on the maturation and function of murine bone marrow-derived dendritic cells
Q35821240The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules
Q36368355The formation of immunogenic major histocompatibility complex class II-peptide ligands in lysosomal compartments of dendritic cells is regulated by inflammatory stimuli
Q34145128The heat shock protein gp96: a receptor-targeted cross-priming carrier and activator of dendritic cells
Q35210456The history, evolution, and clinical use of dendritic cell-based immunization strategies in the therapy of brain tumors
Q30472498The immune response to dermatophytes
Q34378402The immune system and gene expression microarrays--new answers to old questions
Q36238108The impact of DM on MHC class II-restricted antigen presentation can be altered by manipulation of MHC-peptide kinetic stability
Q78616722The impact of a low dose, low volume, multi-site immunization on the production of therapeutic antivenoms in Thailand
Q36128812The impact of eicosanoids on the crosstalk between innate and adaptive immunity: the key roles of dendritic cells
Q28142443The impact of the non-classical MHC proteins HLA-DM and HLA-DO on loading of MHC class II molecules
Q24671078The induction of tolerance by dendritic cells that have captured apoptotic cells
Q33814962The initiation of autoimmune diabetes
Q38365560The ins and outs of MHC class II-mediated antigen processing and presentation
Q21195249The instructive role of dendritic cells on T-cell responses
Q46328514The periodontal war: microbes and immunity.
Q33938242The role of TLR2, TRL3, TRL4, and TRL9 signaling in the pathogenesis of autoimmune disease in a retinal autoimmunity model
Q34268029The role of antigen presenting cells in multiple sclerosis
Q42094703The role of aquaporins in dendritic cell macropinocytosis
Q38072995The role of cysteine proteinases and their inhibitors in the host-pathogen cross talk
Q34712656The role of dendritic cells during Salmonella infection
Q33711401The role of dendritic cells in the induction and regulation of immunity to microbial infection.
Q33887435The role of dendritic cells in the innate immune system.
Q82758762The role of dendritic cells in the mechanism of action of a peptide that ameliorates lupus in murine models
Q47927773The role of endosomes and lysosomes in MHC class II functioning
Q48291060The small heat shock protein alpha B-crystallin as key autoantigen in multiple sclerosis
Q35575949The tetraspanin CD9 mediates lateral association of MHC class II molecules on the dendritic cell surface
Q41660538Therapeutic Effect of Exogenous Truncated IK Protein in Inflammatory Arthritis
Q36181313Therapeutic potential of dendritic-based vaccines
Q34601931Toll-like receptor 2 is required for inflammatory responses to Francisella tularensis LVS
Q34091293Towards a molecular understanding of dendritic cell immunobiology
Q34029353Towards a systems understanding of MHC class I and MHC class II antigen presentation.
Q35192195Transcutaneous immunization and immunostimulant strategies: capitalizing on the immunocompetence of the skin
Q27319941Transport of Streptococcus pneumoniae capsular polysaccharide in MHC Class II tubules
Q38754861Tregitopes and impaired antigen presentation: Drivers of the immunomodulatory effects of IVIg?
Q35039049Triptolide, a constituent of immunosuppressive Chinese herbal medicine, is a potent suppressor of dendritic-cell maturation and trafficking
Q37428687Tubulation of endosomal structures in human dendritic cells by Toll-like receptor ligation and lymphocyte contact accompanies antigen cross-presentation.
Q33713257Tumor necrosis factor-alpha and the progression of diabetes in non-obese diabetic mice
Q34650772Tuning immune responses: diversity and adaptation of the immunological synapse.
Q61628136Turning the immune system on
Q51786001Two-sided effect of Cordyceps sinensis on dendritic cells in different physiological stages.
Q42568916Type I IFN drives a distinctive dendritic cell maturation phenotype that allows continued class II MHC synthesis and antigen processing
Q36949908Ubiquitin-mediated fluctuations in MHC class II facilitate efficient germinal center B cell responses
Q35990017Ubiquitination by March-I prevents MHC class II recycling and promotes MHC class II turnover in antigen-presenting cells
Q34377531Ubiquitination regulates MHC class II-peptide complex retention and degradation in dendritic cells
Q73158574Umbilical cord blood dendritic cells are a rich source of soluble HLA-DR: synergistic effect of exosomes and dendritic cells on autologous or allogeneic T-Cell proliferation
Q35189424Understanding the cell biology of antigen presentation: the dendritic cell contribution.
Q35139857Understanding the function of CD1-restricted T cells
Q36432026Unopposed production of granulocyte-macrophage colony-stimulating factor by tumors inhibits CD8+ T cell responses by dysregulating antigen-presenting cell maturation.
Q38806402Using Visualization of t-Distributed Stochastic Neighbor Embedding To Identify Immune Cell Subsets in Mouse Tumors
Q36375683Vaccination with mage-3A1 peptide-pulsed mature, monocyte-derived dendritic cells expands specific cytotoxic T cells and induces regression of some metastases in advanced stage IV melanoma
Q36198632Vaccines in cancer: GVAX, a GM-CSF gene vaccine
Q39742020Varicella-zoster virus productively infects mature dendritic cells and alters their immune function
Q40613990Viral targeting of hematopoietic progenitors and inhibition of DC maturation as a dual strategy for immune subversion
Q35883106Virally infected and matured human dendritic cells activate natural killer cells via cooperative activity of plasma membrane-bound TNF and IL-15.
Q36193523Zinc finger transcription factor zDC is a negative regulator required to prevent activation of classical dendritic cells in the steady state
Q74309792[Dendritic cells and the control of the immune response]
Q34646735p38 Mitogen-Activated Protein Kinase in beryllium-induced dendritic cell activation