Harnessing the immune response to treat cancer

scientific article published on 20 September 2010

Harnessing the immune response to treat cancer is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/ONC.2010.437
P698PubMed publication ID20856204
P5875ResearchGate publication ID46381717

P2093author name stringA K Nowak
R A Lake
B W S Robinson
H J Steer
P2860cites workStressed apoptotic tumor cells stimulate dendritic cells and induce specific cytotoxic T cellsQ78409834
Regulatory CD4+ T cells are crucial for preventing CD8+ T cell-mediated autoimmunityQ81305952
Immunotherapy and chemotherapy--a practical partnershipQ81703535
HLA class I - associated immunodominance affects CTL responsiveness to an ESO recombinant protein tumor antigen vaccineQ83133039
Vaccination with recombinant NY-ESO-1 protein elicits immunodominant HLA-DR52b-restricted CD4+ T cell responses with a conserved T cell receptor repertoireQ84075121
Antigen presentation and T cell stimulation by dendritic cellsQ22255632
The response of autologous T cells to a human melanoma is dominated by mutated neoantigensQ24535034
CD8+ T cell immunity against a tumor/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells.Q24540429
T cell homeostatic proliferation elicits effective antitumor autoimmunityQ24553060
A small-cell lung cancer genome with complex signatures of tobacco exposureQ24600510
A comprehensive catalogue of somatic mutations from a human cancer genomeQ24628532
Secondary replicative function of CD8+ T cells that had developed an effector phenotypeQ24642499
T helper 17 cells promote cytotoxic T cell activation in tumor immunityQ24646584
Characterizing the cancer genome in lung adenocarcinomaQ24649926
Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytesQ24676216
Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activationQ24677534
Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasionQ28131654
Tumor-specific CD4+ T cells have a major "post-licensing" role in CTL mediated anti-tumor immunityQ28138211
Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenaseQ28204166
The danger model: a renewed sense of selfQ28214633
PD-L1/B7H-1 inhibits the effector phase of tumor rejection by T cell receptor (TCR) transgenic CD8+ T cellsQ28243975
Calreticulin exposure dictates the immunogenicity of cancer cell deathQ28280438
Regulatory T cell lineage specification by the forkhead transcription factor foxp3Q28510328
Phagosomes are competent organelles for antigen cross-presentationQ28591811
Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumorsQ29615665
Molecular identification of a danger signal that alerts the immune system to dying cellsQ29619497
Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapyQ29619961
Cognate memory CD4+ T cells generated with dendritic cell priming influence the expansion, trafficking, and differentiation of secondary CD8+ T cells and enhance tumor controlQ30444800
In vivo cross-presentation of a soluble protein antigen: kinetics, distribution, and generation of effector CTL recognizing dominant and subdominant epitopesQ31583375
Transcriptional suppression of interleukin-12 gene expression following phagocytosis of apoptotic cellsQ31813068
Cyclophosphamide chemotherapy sensitizes tumor cells to TRAIL-dependent CD8 T cell-mediated immune attack resulting in suppression of tumor growthQ33502208
Cross-presentation of tumour antigens: evaluation of threshold, duration, distribution and regulation.Q33778847
Phosphatidylserine regulates the maturation of human dendritic cells.Q45025098
Inhibition of CD4(+)25+ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamideQ45182740
Tumor progression can occur despite the induction of very high levels of self/tumor antigen-specific CD8+ T cells in patients with melanomaQ45287769
CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death.Q46028085
Sunitinib mediates reversal of myeloid-derived suppressor cell accumulation in renal cell carcinoma patientsQ46093084
Tumor eradication after cyclophosphamide depends on concurrent depletion of regulatory T cells: a role for cycling TNFR2-expressing effector-suppressor T cells in limiting effective chemotherapyQ46217068
Spatial and mechanistic separation of cross-presentation and endogenous antigen presentationQ46674193
Sorafenib, but not sunitinib, affects function of dendritic cells and induction of primary immune responsesQ46725768
Cancer vaccine enhanced, non-tumor-reactive CD8(+) T cells exhibit a distinct molecular program associated with "division arrest anergy".Q47819013
Help for cytotoxic-T-cell responses is mediated by CD40 signallingQ47982749
Modifications of CD8+ T Cell Function during In Vivo Memory or Tolerance InductionQ47992203
Infiltration of a mesothelioma by IFN-gamma-producing cells and tumor rejection after depletion of regulatory T cellsQ51919478
The critical role of Th1-dominant immunity in tumor immunology.Q52025034
Imatinib mesylate inhibits antigen-specific memory CD8 T cell responses in vivoQ53573167
Immunosurveillance is active in colorectal cancer as downregulation but not complete loss of MHC class I expression correlates with a poor prognosis.Q53851520
Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patientsQ57220173
Cell-Associated Ovalbumin Is Cross-Presented Much More Efficiently than Soluble Ovalbumin In VivoQ57227930
Tumor-Infiltrating FOXP3+ T Regulatory Cells Show Strong Prognostic Significance in Colorectal CancerQ57254166
Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cellsQ57275942
NOX2 Controls Phagosomal pH to Regulate Antigen Processing during Crosspresentation by Dendritic CellsQ58007061
Tumor progression despite efficient tumor antigen cross-presentation and effective "arming" of tumor antigen-specific CTLQ61466188
CD4 + CD25 + Cells Controlling a Pathogenic CD4 Response Inhibit Cytokine Differentiation, CXCR-3 Expression, and Tissue InvasionQ63346582
Combination of p53 cancer vaccine with chemotherapy in patients with extensive stage small cell lung cancerQ64378051
The risk of autoimmunity associated with tumor immunotherapyQ74434052
Endocytosis mechanisms and the cell biology of antigen presentationQ37076774
Systemic blockade of transforming growth factor-beta signaling augments the efficacy of immunogene therapyQ37087603
Multiple roles for CD4+ T cells in anti-tumor immune responsesQ37118150
Human regulatory T cells and autoimmunityQ37131908
Inhibitory B7-family molecules in the tumour microenvironmentQ37171804
Specificity in cancer immunotherapyQ37236636
The mechanism of anti-CTLA-4 activity and the negative regulation of T-cell activationQ37322936
Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells.Q37418499
Inhibitors of indoleamine-2,3-dioxygenase for cancer therapy: can we see the wood for the trees?Q37492248
Clinical use of anti-CD25 antibody daclizumab to enhance immune responses to tumor antigen vaccination by targeting regulatory T cellsQ37600964
Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasiaQ39296306
Tumor-mediated liver X receptor-alpha activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responsesQ39758426
Immunogenic death of colon cancer cells treated with oxaliplatinQ39780621
Chemotherapy induces ATP release from tumor cellsQ39783670
Cutting edge: Necrosis activates the NLRP3 inflammasomeQ39825783
Vaccination with a recombinant protein encoding the tumor-specific antigen NY-ESO-1 elicits an A2/157-165-specific CTL repertoire structurally distinct and of reduced tumor reactivity than that elicited by spontaneous immune responses to NY-ESO-1-exQ39880448
Deliberately provoking local inflammation drives tumors to become their own protective vaccine site.Q39934421
The co-translocation of ERp57 and calreticulin determines the immunogenicity of cell deathQ39984426
Targeting the effector site with IFN-alphabeta-inducing TLR ligands reactivates tumor-resident CD8 T cell responses to eradicate established solid tumorsQ40022319
Different immune correlates associated with tumor progression and regression: implications for prevention and treatment of cancerQ40026321
Expression of tumor-associated differentiation antigens, MUC1 glycoforms and CEA, in human thymic epithelial cells: implications for self-tolerance and tumor therapyQ40222466
Reinstalling antitumor immunity by inhibiting tumor-derived immunosuppressive molecule IDO through RNA interferenceQ40224792
Chemotherapy pretreatment sensitizes solid tumor-derived cell lines to V alpha 24+ NKT cell-mediated cytotoxicityQ40286194
Functional endogenous cytotoxic T lymphocytes are generated to multiple antigens co-expressed by progressing tumors; after intra-tumoral IL-2 therapy these effector cells eradicate established tumorsQ40352199
Gemcitabine selectively eliminates splenic Gr-1+/CD11b+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activityQ40372686
Partial, but not complete, tumor-debulking surgery promotes protective antitumor memory when combined with chemotherapy and adjuvant immunotherapy.Q40377919
Cutting edge: tumor-specific CTL are constitutively cross-armed in draining lymph nodes and transiently disseminate to mediate tumor regression following systemic CD40 activationQ40495409
CD4+CD25+ regulatory T cells suppress tumor immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumors to be curativeQ40591372
IL-2 intratumoral immunotherapy enhances CD8+ T cells that mediate destruction of tumor cells and tumor-associated vasculature: a novel mechanism for IL-2.Q40618350
Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLsQ41057373
How many mutations in a cancer?Q41834410
A ras-mutated peptide targeted by CTL infiltrating a human melanoma lesionQ42674919
Immunology. Ex uno pluraQ42732716
Delayed clearance of apoptotic lymphoma cells allows cross-presentation of intracellular antigens by mature dendritic cells.Q42811987
Modeling the repertoire of true tumor-specific MHC I epitopes in a human tumorQ43102307
Locally administered TLR7 agonists drive systemic antitumor immune responses that are enhanced by anti-CD40 immunotherapyQ43705031
Induction of tumor cell apoptosis in vivo increases tumor antigen cross-presentation, cross-priming rather than cross-tolerizing host tumor-specific CD8 T cellsQ44432115
Success or failure of vaccination for HPV16-positive vulvar lesions correlates with kinetics and phenotype of induced T-cell responsesQ33977826
Building better vaccines: how apoptotic cell death can induce inflammation and activate innate and adaptive immunityQ34046869
Death by design: apoptosis, necrosis and autophagyQ34365753
Recognition of a new ARTC1 peptide ligand uniquely expressed in tumor cells by antigen-specific CD4+ regulatory T cellsQ34397184
Regulatory T cells in cancerQ34550248
CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefitQ34601772
Distinct pathways of antigen uptake and intracellular routing in CD4 and CD8 T cell activation.Q34623431
Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environmentsQ34983123
T helper lymphocytes rescue CTL from activation-induced cell deathQ35073666
Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapyQ35540109
Danger signals: a time and space continuum.Q35791962
Pathways of apoptotic and non-apoptotic death in tumour cellsQ35852309
Innate immune recognition of nucleic acidsQ35868815
CD4+ CD25+ T cells responding to serologically defined autoantigens suppress antitumor immune responsesQ35978636
Role of transforming growth factor Beta in human cancerQ36073421
Mechanisms of suppression by suppressor T cellsQ36078047
The controversial abscopal effectQ36143531
Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway.Q36228158
CD8(+) T cell tolerance to a tumor-associated antigen is maintained at the level of expansion rather than effector functionQ36369713
Cranking the immunologic engine with chemotherapy: using context to drive tumor antigen cross-presentation towards useful antitumor immunity.Q36372880
Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cellsQ36399149
Tumor cells convert immature myeloid dendritic cells into TGF-beta-secreting cells inducing CD4+CD25+ regulatory T cell proliferationQ36403539
Receptor-mediated uptake of antigen/heat shock protein complexes results in major histocompatibility complex class I antigen presentation via two distinct processing pathwaysQ36404658
Loss of functional beta 2-microglobulin in metastatic melanomas from five patients receiving immunotherapyQ36470726
Immune suppression in the tumor microenvironmentQ36478177
Combined chemoimmunotherapy of solid tumours: improving vaccines?Q36605604
Activation-induced non-responsiveness (anergy) limits CD8 T cell responses to tumorsQ36893068
Structure and function: heat shock proteins and adaptive immunity.Q36901412
TGF-beta 1 attenuates the acquisition and expression of effector function by tumor antigen-specific human memory CD8 T cellsQ36924688
Cytotoxic T-lymphocyte-associated antigen-4.Q36944367
Molecular determinants of immunogenic cell death: surface exposure of calreticulin makes the differenceQ36949870
Imatinib mesylate inhibits CD4+ CD25+ regulatory T cell activity and enhances active immunotherapy against BCR-ABL- tumorsQ36965879
The interaction between HMGB1 and TLR4 dictates the outcome of anticancer chemotherapy and radiotherapyQ36990578
Immunological aspects of cancer chemotherapyQ37039588
P433issue48
P407language of work or nameEnglishQ1860
P304page(s)6301-6313
P577publication date2010-09-20
P1433published inOncogeneQ1568657
P1476titleHarnessing the immune response to treat cancer
P478volume29

Reverse relations

cites work (P2860)
Q52731753A bispecific nanobody approach to leverage the potent and widely applicable tumor cytolytic capacity of Vγ9Vδ2-T cells.
Q33571981A mathematical model for pancreatic cancer growth and treatments
Q56898024An immune-active tumor microenvironment favors clinical response to ipilimumab
Q36085104Analysis of CD8+ Treg cells in patients with ovarian cancer: a possible mechanism for immune impairment
Q30637447AntiCD3Fv fused to human interleukin-3 deletion variant redirected T cells against human acute myeloid leukemic stem cells
Q38869740Antigen-specific impairment of adoptive T-cell therapy against cancer: players, mechanisms, solutions and a hypothesis
Q38734506Antitumor Effects of Orally and Intraperitoneally Administered Chitosan Oligosaccharides (COSs) on S180-Bearing/Residual Mouse
Q36541076C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation
Q57462232CD8 T-Cell Density Imaging with Cu-Labeled Cys-Diabody Informs Immunotherapy Protocols
Q38223355Chemokines in cancer development and progression and their potential as targeting molecules for cancer treatment
Q37950700Chemokines in tumor development and progression.
Q34226903Chemotherapy enhances cross-presentation of nuclear tumor antigens
Q33889105Combination GITR targeting/PD-1 blockade with vaccination drives robust antigen-specific antitumor immunity
Q36395752CpG expedites regression of local and systemic tumors when combined with activatable nanodelivery
Q37588227Elevated neutrophil-to-lymphocyte ratio is an independent poor prognostic factor in patients with intrahepatic cholangiocarcinoma
Q36177023Enhancing Dendritic Cell-based Immunotherapy with IL-2/Monoclonal Antibody Complexes for Control of Established Tumors.
Q39534587Epothilone B enhances Class I HLA and HLA-A2 surface molecule expression in ovarian cancer cells
Q38975033Evaluation of anti-cancer and immunomodulatory effects of carnosol in a Balb/c WEHI-164 fibrosarcoma model.
Q39232427Examining T Cells at Vaccine Sites of Tumor-bearing Hosts Provides Insights to Dysfunctional T-Cell Immunity
Q44503506HLA-E/β2 microglobulin overexpression in colorectal cancer is associated with recruitment of inhibitory immune cells and tumor progression
Q37295663IFN-α potentiates the direct and immune-mediated antitumor effects of epigenetic drugs on both metastatic and stem cells of colorectal cancer
Q43916071Increased tumor-infiltrating CD8+Foxp3+ T lymphocytes are associated with tumor progression in human gastric cancer
Q35955224Increasing vaccine potency through exosome antigen targeting
Q40268002Inducible TAP1 Negatively Regulates the Antiviral Innate Immune Response by Targeting the TAK1 Complex.
Q36038385Infiltrating CTLs are bothered by HLA-E on tumors
Q37997202Non-steroidal anti-inflammatory drugs, tumour immunity and immunotherapy
Q30360210Priming is key to effective incorporation of image-guided thermal ablation into immunotherapy protocols.
Q38096411Redirection of T-cell effector functions for cancer therapy: bispecific antibodies and chimeric antigen receptors
Q58122935Regulatory T-cell-mediated inhibition of antitumor immune responses is associated with clinical outcome in patients with liver metastasis from colorectal cancer
Q28081582T Helper Lymphocyte Subsets and Plasticity in Autoimmunity and Cancer: An Overview
Q37222202TLR4-mediated immunomodulatory properties of the bacterial metalloprotease arazyme in preclinical tumor models
Q27022348Targeting regulatory T cells in cancer
Q38847321The Future of Immunotherapy in the Treatment of Small Cell Lung Cancer
Q51065862Transcriptional profiling of peripheral blood in pancreatic adenocarcinoma patients identifies diagnostic biomarkers
Q42109061Tumor Necrosis Factor (TNF) and Chemokines in Colitis-Associated Cancer
Q64979554Urothelial bladder cancer may suppress perforin expression in CD8+ T cells by an ICAM-1/TGFβ2 mediated pathway.
Q39499046pDNA-lipoplexes engrafted with flagellin-related peptide induce potent immunity and anti-tumour effects

Search more.