Combination GITR targeting/PD-1 blockade with vaccination drives robust antigen-specific antitumor immunity

scientific article

Combination GITR targeting/PD-1 blockade with vaccination drives robust antigen-specific antitumor immunity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.18632/ONCOTARGET.16605
P932PMC publication ID5503599
P698PubMed publication ID28388572

P2093author name stringMelissa A Smith
Daniel O Villarreal
Linda A Snyder
Diana Chin
Leopoldo L Luistro
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GITR agonist enhances vaccination responses in lung cancerQ30279074
Agonist anti-GITR monoclonal antibody induces melanoma tumor immunity in mice by altering regulatory T cell stability and intra-tumor accumulationQ33573450
Combined PD-1 blockade and GITR triggering induce a potent antitumor immunity in murine cancer models and synergizes with chemotherapeutic drugsQ33926200
Features of responding T cells in cancer and chronic infection.Q33941340
TGF-β downregulates KLRG1 expression in mouse and human CD8(+) T cellsQ40899436
Biological behavior of malignant melanoma cells correlated to their survival in vivoQ41067629
Tumor-infiltrating, interleukin-33-producing effector-memory CD8(+) T cells in resected hepatocellular carcinoma prolong patient survivalQ41489558
Contribution of Pulmonary KLRG1high and KLRG1low CD8 T Cells to Effector and Memory Responses during Influenza Virus InfectionQ41719095
Generation of antitumor immunity by cytotoxic T lymphocyte epitope peptide vaccination, CpG-oligodeoxynucleotide adjuvant, and CTLA-4 blockade.Q44480757
Vaccine-induced effector-memory CD8+ T cell responses predict therapeutic efficacy against tumors.Q45343706
Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cellsQ52004225
Dual blockade of PD-1 and CTLA-4 combined with tumor vaccine effectively restores T-cell rejection function in tumors--responseQ56897109
Adjuvant Combination and Antigen Targeting as a Strategy to Induce Polyfunctional and High-Avidity T-Cell Responses against Poorly Immunogenic TumorsQ61851543
Dendritic cells in antitumor immune responses. I. Defective antigen presentation in tumor-bearing hostsQ71148644
The GITR-GITRL interaction: co-stimulation or contrasuppression of regulatory activity?Q79990209
Solid tumors "melt" from the inside after successful CD8 T cell attackQ82133126
Tumor antigen expression in melanoma varies according to antigen and stageQ82506715
CD8⁺ cytotoxic T cell and FOXP3⁺ regulatory T cell infiltration in relation to breast cancer survival and molecular subtypesQ84474625
The Alarmin HMGN1 contributes to antitumor immunity and is a potent immunoadjuvantQ85282087
Multicolor flow cytometric analysis of immune cell subsets in tumor-bearing miceQ86426765
Alarmin IL-33 acts as an immunoadjuvant to enhance antigen-specific tumor immunityQ34033407
Transcriptional control of effector and memory CD8+ T cell differentiationQ34064074
Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impairedQ34080914
Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+ T cell dysfunction in melanoma patientsQ34161579
Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunityQ34554995
GITR/GITRL: more than an effector T cell co-stimulatory system.Q34615533
KLRG1+NKG2A+ CD8 T Cells Mediate Protection and Participate in Memory Responses during γ-Herpesvirus InfectionQ35157498
Similarities and differences in CD4+ and CD8+ effector and memory T cell generationQ35207085
Molecular regulation of effector and memory T cell differentiationQ35283304
Combination of alphavirus replicon particle-based vaccination with immunomodulatory antibodies: therapeutic activity in the B16 melanoma mouse model and immune correlates.Q35527105
Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humansQ35669097
In vivo imaging of cytotoxic T cell infiltration and elimination of a solid tumorQ36229738
Disease-associated bias in T helper type 1 (Th1)/Th2 CD4(+) T cell responses against MAGE-6 in HLA-DRB10401(+) patients with renal cell carcinoma or melanomaQ36371068
Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells.Q36403529
Ligation of the OX40 co-stimulatory receptor reverses self-Ag and tumor-induced CD8 T-cell anergy in vivoQ36433183
Agonist anti-GITR antibody enhances vaccine-induced CD8(+) T-cell responses and tumor immunityQ36459336
Immune resistance orchestrated by the tumor microenvironmentQ36593747
Persistent antigen at vaccination sites induces tumor-specific CD8⁺ T cell sequestration, dysfunction and deletionQ36745336
Ubiquitin-like Molecule ISG15 Acts as an Immune Adjuvant to Enhance Antigen-specific CD8 T-cell Tumor ImmunityQ36757129
Effector-like CD8+ T Cells in the Memory Population Mediate Potent Protective ImmunityQ36988106
Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodiesQ37125759
The ratios of CD8+ T cells to CD4+CD25+ FOXP3+ and FOXP3- T cells correlate with poor clinical outcome in human serous ovarian cancer.Q37308863
Safety, efficacy, and biomarkers of nivolumab with vaccine in ipilimumab-refractory or -naive melanomaQ37333645
Memory CD8+ T cells exhibit increased antigen threshold requirements for recall proliferationQ37576718
Harnessing the immune response to treat cancerQ37790599
Key roles of adjuvants in modern vaccinesQ38169040
Targeting tumor-necrosis factor receptor pathways for tumor immunotherapyQ38214095
Trafficking of T cells into tumorsQ38283501
Evolving synergistic combinations of targeted immunotherapies to combat cancer.Q38553010
Dual Roles for Regulatory T-cell Depletion and Costimulatory Signaling in Agonistic GITR Targeting for Tumor ImmunotherapyQ38719468
Intratumoral CD4+ T lymphodepletion sensitizes poorly immunogenic melanomas to immunotherapy with an OX40 agonistQ39030036
A Novel Murine GITR Ligand Fusion Protein Induces Antitumor Activity as a Monotherapy That Is Further Enhanced in Combination with an OX40 AgonistQ39030631
IL-21 Is Important for Induction of KLRG1+ Effector CD8 T Cells during Acute Intracellular InfectionQ39268381
CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cellsQ40266751
Glucocorticoid-induced TNF receptor family related gene activation overcomes tolerance/ignorance to melanoma differentiation antigens and enhances antitumor immunity.Q40278217
P433issue24
P407language of work or nameEnglishQ1860
P304page(s)39117-39130
P577publication date2017-03-27
P1433published inOncotargetQ1573155
P1476titleCombination GITR targeting/PD-1 blockade with vaccination drives robust antigen-specific antitumor immunity
P478volume8

Reverse relations

cites work (P2860)
Q57191719Anti-glucocorticoid-induced Tumor Necrosis Factor-Related Protein (GITR) Therapy Overcomes Radiation-Induced Treg Immunosuppression and Drives Abscopal Effects
Q45064262TNF-receptor superfamily agonists as molecular adjuvants for cancer vaccines
Q47185561Targeting of CD122 enhances antitumor immunity by altering the tumor immune environment
Q55712193The Imbalance of FOXP3/GATA3 in Regulatory T Cells from the Peripheral Blood of Asthmatic Patients.
Q61811648Vaccine Strategies to Improve Anti-cancer Cellular Immune Responses

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