IL-21 Is Important for Induction of KLRG1+ Effector CD8 T Cells during Acute Intracellular Infection

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IL-21 Is Important for Induction of KLRG1+ Effector CD8 T Cells during Acute Intracellular Infection is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.1501258
P932PMC publication ID4959448
P698PubMed publication ID26597007
P5875ResearchGate publication ID284713764

P50authorImtiaz A KhanQ88040189
P2093author name stringMagali M Moretto
P2860cites workIL-21 up-regulates the expression of genes associated with innate immunity and Th1 responseQ24307467
Interleukin-21-producing HIV-1-specific CD8 T cells are preferentially seen in elite controllersQ24629567
Microsporidiosis: an emerging and opportunistic infection in humans and animalsQ28240542
T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cellsQ28268047
CD4+ T cell regulation of CD25 expression controls development of short-lived effector CD8+ T cells in primary and secondary responsesQ33591684
Absence of both IL-7 and IL-15 severely impairs the development of CD8 T cell response against Toxoplasma gondiiQ33592970
Tracking the total CD8 T cell response to infection reveals substantial discordance in magnitude and kinetics between inbred and outbred hostsQ33596976
Intrinsic TGF-β signaling promotes age-dependent CD8+ T cell polyfunctionality attrition.Q33685895
Optimal CD8 T-cell response against Encephalitozoon cuniculi is mediated by Toll-like receptor 4 upregulation by dendritic cellsQ33963213
Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cellsQ34003618
The role of interleukin-2 during homeostasis and activation of the immune systemQ34255232
The biology of interleukin-2.Q34585827
IL-21 is pivotal in determining age-dependent effectiveness of immune responses in a mouse model of human hepatitis B.Q34627115
Effector and memory T-cell differentiation: implications for vaccine developmentQ34632071
Latent Microsporidiosis Caused by Encephalitozoon cuniculi in Immunocompetent Hosts: A Murine Model Demonstrating the Ineffectiveness of the Immune System and Treatment with AlbendazoleQ34674383
Intrinsic IL-21 Signaling Is Critical for CD8 T Cell Survival and Memory Formation in Response to Vaccinia Viral InfectionQ34688226
Induction of a rapid and strong antigen-specific intraepithelial lymphocyte response during oral Encephalitozoon cuniculi infectionQ34909495
Microsporidiosis: current status.Q35029765
Critical role for IL-21 in both primary and memory anti-viral CD8+ T-cell responsesQ35057388
Helping the CD8(+) T-cell responseQ35852274
Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function.Q36402501
Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and productionQ36547664
IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapyQ36677310
Transcriptional repressor Blimp-1 promotes CD8(+) T cell terminal differentiation and represses the acquisition of central memory T cell propertiesQ37439855
Interleukin-21 is a critical regulator of CD4 and CD8 T cell survival during priming under Interleukin-2 deprivation conditionsQ37458914
IL-12 and type I interferon prolong the division of activated CD8 T cells by maintaining high-affinity IL-2 signaling in vivoQ37483123
Interleukin-21: a double-edged sword with therapeutic potentialQ38206058
IL-21 is required to control chronic viral infectionQ39328817
Pharmacologic inhibition of MEK-ERK signaling enhances Th17 differentiation.Q39753984
IL-21 synergizes with IL-7 to augment expansion and anti-tumor function of cytotoxic T cellsQ40075794
IL-2 induction of Blimp-1 is a key in vivo signal for CD8+ short-lived effector T cell differentiationQ42206468
A vital role for interleukin-21 in the control of a chronic viral infectionQ42541944
Decreased levels of circulating IL-21 in HIV-infected AIDS patients: correlation with CD4+ T-cell countsQ43557466
IL-21 Promotes CD8+ CTL Activity via the Transcription Factor T-betQ44774282
IL-21 inhibits T cell IL-2 production and impairs Treg homeostasis.Q45951121
IL-21R on T cells is critical for sustained functionality and control of chronic viral infectionQ46697142
Prolonged interleukin-2Ralpha expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivoQ51887589
Cutting edge: CD4+ T cell-derived IL-2 is essential for help-dependent primary CD8+ T cell responsesQ51960590
IL-21 induces apoptosis of antigen-specific CD8+ T lymphocytesQ53530408
Albendazole for Treatment and Prophylaxis of Microsporidiosis Due toEncephalitozoon intestinalisin Patients with AIDS: A Randomized Double‐Blind Controlled TrialQ53954531
Treatment of HIV-1-associated microsporidiosis and cryptosporidiosis with combination antiretroviral therapyQ54148024
CD8+ CTLs are essential for protective immunity against Encephalitozoon cuniculi infectionQ77404893
IL-21 promotes differentiation of naive CD8 T cells to a unique effector phenotypeQ80427899
IL-21 promotes T lymphocyte survival by activating the phosphatidylinositol-3 kinase signaling cascadeQ80441560
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)375-384
P577publication date2015-11-23
P1433published inJournal of ImmunologyQ3521441
P1476titleIL-21 Is Important for Induction of KLRG1+ Effector CD8 T Cells during Acute Intracellular Infection
P478volume196

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cites work (P2860)
Q36600988A Context-Dependent Role for IL-21 in Modulating the Differentiation, Distribution, and Abundance of Effector and Memory CD8 T Cell Subsets.
Q33889105Combination GITR targeting/PD-1 blockade with vaccination drives robust antigen-specific antitumor immunity
Q46165473Downregulated IL-21 Response and T Follicular Helper Cell Exhaustion Correlate with Compromised CD8 T Cell Immunity during Chronic Toxoplasmosis
Q38869063Environmental cues orchestrate regional immune surveillance and protection by pulmonary CTLs
Q38889721IL-21 and T Cell Differentiation: Consider the Context
Q97518718Innate and Adaptive Immune Responses Against Microsporidia Infection in Mammals
Q92190807Interleukin (IL)-21 in Inflammation and Immunity During Parasitic Diseases
Q88910076Interleukin-21 Induces Short-Lived Effector CD8+ T Cells but Does Not Inhibit Their Exhaustion after Mycobacterium bovis BCG Infection in Mice

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