A Context-Dependent Role for IL-21 in Modulating the Differentiation, Distribution, and Abundance of Effector and Memory CD8 T Cell Subsets.

scientific article published on 29 January 2016

A Context-Dependent Role for IL-21 in Modulating the Differentiation, Distribution, and Abundance of Effector and Memory CD8 T Cell Subsets. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.1401236
P932PMC publication ID4761492
P698PubMed publication ID26826252

P50authorMaureen CoxQ43166672
Rakesh K BakshiQ87186938
P2093author name stringYuan Tian
Allan J Zajac
Jennifer T Ingram
Shannon M Kahan
P2860cites workInterleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte functionQ24290522
Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesionQ24311291
Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunityQ24604251
Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineagesQ24642180
Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homingQ24646057
Functional classification of memory CD8(+) T cells by CX3CR1 expressionQ27322730
Two subsets of memory T lymphocytes with distinct homing potentials and effector functionsQ28146072
Lineage relationship and protective immunity of memory CD8 T cell subsetsQ28206693
T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cellsQ28268047
Interleukin-21: Basic Biology and Implications for Cancer and AutoimmunityQ29042353
Sensing and alarm function of resident memory CD8⁺ T cellsQ30539038
Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans.Q33361113
Dynamic T cell migration program provides resident memory within intestinal epitheliumQ33730150
Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivoQ33924186
Retinoic acid receptor signaling levels and antigen dose regulate gut homing receptor expression on CD8+ T cells.Q39501097
Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytesQ39912633
Dual functions of fractalkine/CX3C ligand 1 in trafficking of perforin+/granzyme B+ cytotoxic effector lymphocytes that are defined by CX3CR1 expressionQ40726397
Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory developmentQ40760682
T cell memory. Skin-resident memory CD8⁺ T cells trigger a state of tissue-wide pathogen alert.Q41717756
An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cellsQ42139586
A vital role for interleukin-21 in the control of a chronic viral infectionQ42541944
Cutting edge: naive T cells masquerading as memory cellsQ44020264
Ablation of CD8 and CD4 T cell responses by high viral loadsQ44259092
IL-21 promotes CD8+ CTL activity via the transcription factor T-betQ44774282
Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virusQ45385806
IL-21R on T cells is critical for sustained functionality and control of chronic viral infectionQ46697142
Cutting edge: gut microenvironment promotes differentiation of a unique memory CD8 T cell population.Q51985053
Functional properties and lineage relationship of CD8+ T cell subsets identified by expression of IL-7 receptor alpha and CD62L.Q51988630
Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells.Q52004225
Recent immune status determines the source of antigens that drive homeostatic T cell expansionQ81482532
Cutting edge: emergence of CD127high functionally competent memory T cells is compromised by high viral loads and inadequate T cell helpQ81724297
Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cellsQ34003618
Transcriptional control of effector and memory CD8+ T cell differentiationQ34064074
IL-21 Deficiency Influences CD8 T Cell Quality and Recall Responses following an Acute Viral InfectionQ34179921
Immune clearance of highly pathogenic SIV infectionQ34370314
Interleukin-21: a multifunctional regulator of immunity to infectionsQ34388287
Preferential localization of effector memory cells in nonlymphoid tissueQ34514330
Cytokine requirements for acute and Basal homeostatic proliferation of naive and memory CD8+ T cellsQ34524226
T cell memory. A local macrophage chemokine network sustains protective tissue-resident memory CD4 T cellsQ34626234
Intrinsic IL-21 signaling is critical for CD8 T cell survival and memory formation in response to vaccinia viral infectionQ34688226
Differential localization of effector and memory CD8 T cell subsets in lymphoid organs during acute viral infection.Q34712280
Profound early control of highly pathogenic SIV by an effector memory T-cell vaccineQ35009558
Critical role for IL-21 in both primary and memory anti-viral CD8+ T-cell responsesQ35057388
Quantitating the magnitude of the lymphocytic choriomeningitis virus-specific CD8 T-cell response: it is even bigger than we thoughtQ35635463
T cell memory. Resident memory CD8 T cells trigger protective innate and adaptive immune responsesQ35667029
Dengue virus infection elicits highly polarized CX3CR1+ cytotoxic CD4+ T cells associated with protective immunityQ35701686
Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissuesQ35936035
TGF-β signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferationQ36049350
CD8+ T effector memory cells protect against liver-stage malariaQ36055733
Viral antigen and extensive division maintain virus-specific CD8 T cells during chronic infectionQ36229254
IL-21R signaling is critical for induction of spontaneous experimental autoimmune encephalomyelitisQ36266451
Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cellsQ36369731
Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function.Q36402501
A vaccine strategy that protects against genital herpes by establishing local memory T cellsQ36403540
Anti-viral CD8 T cells and the cytokines that they loveQ36634580
IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapyQ36677310
Transcriptional insights into the CD8(+) T cell response to infection and memory T cell formationQ36947052
Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challengeQ37287080
Homeostasis of naive and memory T cellsQ37356053
Low-affinity ligands for the TCR drive proliferation of mature CD8+ T cells in lymphopenic hostsQ37463129
Cutting edge: resident memory CD8 T cells occupy frontline niches in secondary lymphoid organsQ37662759
Selective expression of IL-7 receptor on memory T cells identifies early CD40L-dependent generation of distinct CD8+ memory T cell subsetsQ37682352
Memory T cell subsets, migration patterns, and tissue residenceQ38065191
IL-21 Is Important for Induction of KLRG1+ Effector CD8 T Cells during Acute Intracellular InfectionQ39268381
IL-21 is required to control chronic viral infectionQ39328817
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)2153-2166
P577publication date2016-01-29
P1433published inJournal of ImmunologyQ3521441
P1476titleA Context-Dependent Role for IL-21 in Modulating the Differentiation, Distribution, and Abundance of Effector and Memory CD8 T Cell Subsets
P478volume196

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cites work (P2860)
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