CD4+CD25+ regulatory T cells suppress tumor immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumors to be curative

scientific article published on February 2004

CD4+CD25+ regulatory T cells suppress tumor immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumors to be curative is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/EJI.200324181
P698PubMed publication ID14768038
P5875ResearchGate publication ID8881859

P50authorFrançois GhiringhelliQ40399221
Bruno ChauffertQ40457597
François MartinQ41019017
Eric SolaryQ41021747
P2093author name stringCarmen Garrido
François Ghiringhelli
Bruno Chauffert
Bernard Bonnotte
Nicolas Larmonier
Arnaud Parcellier
Elise Schmitt
Dominique Cathelin
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectimmunotherapyQ1427096
P304page(s)336-344
P577publication date2004-02-01
P1433published inEuropean Journal of ImmunologyQ5412727
P1476titleCD4+CD25+ regulatory T cells suppress tumor immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumors to be curative
P478volume34

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Q39418860Regulatory T cells inhibit Fas ligand-induced innate and adaptive tumour immunity.
Q36430144Regulatory T cells, tumour immunity and immunotherapy
Q36911411Regulatory T cells--the renaissance of the suppressor T cells.
Q38023842Regulatory T-cell modulation using cyclophosphamide in vaccine approaches: a current perspective
Q26795598Relevance of tumor-infiltrating lymphocytes in breast cancer
Q38926803Renal cancer treatment with recipient lymphocyte infusion enhanced the antitumor effect of nonmyeloablative allogeneic stem cell transplantation
Q94340437Reply: Forkhead box P3-positive regulatory T cells in immune surveillance and cancer
Q41132577Reversal of gastrointestinal carcinoma-induced immunosuppression and induction of antitumoural immunity by a combination of cyclophosphamide and gene transfer of IL-12.
Q36609898Review article: immune suppression and colorectal cancer
Q41991396Role of Interferon Regulatory Factor 1 in Governing Treg Depletion, Th1 Polarization, Inflammasome Activation and Antitumor Efficacy of Cyclophosphamide.
Q37864686Role of immune responses in the pathogenesis of low-risk MDS and high-risk MDS: implications for immunotherapy
Q37965750Role of myeloid-derived suppressor cells in tumor immunotherapy
Q57461797Sensitivity of CD3/CD28-stimulated versus non-stimulated lymphocytes to ionizing radiation and genotoxic anticancer drugs: key role of ATM in the differential radiation response
Q36432030Sensitization of B16 tumor cells with a CXCR4 antagonist increases the efficacy of immunotherapy for established lung metastases.
Q48328578Serial immunological parameters in a phase II trial of exemestane and low-dose oral cyclophosphamide in advanced hormone receptor-positive breast cancer
Q27335748Serial low doses of sorafenib enhance therapeutic efficacy of adoptive T cell therapy in a murine model by improving tumor microenvironment
Q55362771Single nucleotide polymorphisms of casitas B-lineage lymphoma proto-oncogene-b predict outcomes of patients with advanced non-small cell lung cancer after first-line platinum based doublet chemotherapy.
Q37043725Special regulatory T-cell review: A rose by any other name: from suppressor T cells to Tregs, approbation to unbridled enthusiasm
Q34697795Stimulation of anti-tumor immunity by photodynamic therapy
Q38065786Strategies for optimizing the clinical impact of immunotherapeutic agents such as sipuleucel-T in prostate cancer.
Q37017023Substantially modified ratios of effector to regulatory T cells during chemotherapy in ovarian cancer patients return to pre-treatment levels at completion: implications for immunotherapy.
Q27026151Suppression, subversion and escape: the role of regulatory T cells in cancer progression
Q84979126Surgically Unresectable Regional Melanoma Metastases in a Patient With Renal Failure and Peripheral Vascular Disease: Are There Safe and Potentially Effective Treatments?
Q37514733Synergistic antitumor efficacy of antibacterial helvolic acid from Cordyceps taii and cyclophosphamide in a tumor mouse model.
Q36476394Synergy of topical toll-like receptor 7 agonist with radiation and low-dose cyclophosphamide in a mouse model of cutaneous breast cancer
Q49822317T cell modulation by cyclophosphamide for tumour therapy.
Q37800935T regulatory cells in cancer: recent advances and therapeutic potential
Q35459820T regulatory cells: aid or hindrance in the clearance of disease?
Q92534116T-Regulatory Cells In Tumor Progression And Therapy
Q37454346T-regulatory cell modulation: the future of cancer immunotherapy?
Q38006901T-regulatory cells: key players in tumor immune escape and angiogenesis
Q37671730Targeting Carcinoembryonic Antigen with DNA Vaccination: On-Target Adverse Events Link with Immunologic and Clinical Outcomes.
Q56888810Targeting Immunosupportive Cancer Therapies: Accentuate the Positive, Eliminate the Negative
Q27009348Targeting and utilizing primary tumors as live vaccines: changing strategies
Q37259608Targeting cytochrome P450 CYP1B1 with a therapeutic cancer vaccine
Q38970585Targeting the Bone Marrow Microenvironment.
Q38289041Targeting the bone marrow microenvironment in multiple myeloma.
Q38805897Targeting the tumor microenvironment: removing obstruction to anticancer immune responses and immunotherapy
Q35814814Th-1 lymphocytes induce dendritic cell tumor killing activity by an IFN-γ-dependent mechanism
Q36975757The 'kiss of death' by dendritic cells to cancer cells
Q49322680The Different Functional Distribution of "Not Effector" T Cells (Treg/Tnull) in Colorectal Cancer.
Q59210075The Effect of Light Exposure at Night (LAN) on Carcinogenesis via Decreased Nocturnal Melatonin Synthesis
Q36677608The anticancer immune response: indispensable for therapeutic success?
Q37959968The dendritic cell-regulatory T lymphocyte crosstalk contributes to tumor-induced tolerance
Q64273734The effect of everolimus and low-dose cyclophosphamide on immune cell subsets in patients with metastatic renal cell carcinoma: results from a phase I clinical trial
Q95936578The future of cancer immunotherapy: microenvironment-targeting combinations
Q36249962The immunotherapy of prostate and bladder cancer.
Q38995979The importance of correctly timing cancer immunotherapy
Q35841503The influence of gut microbiota on drug metabolism and toxicity.
Q31144277The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide
Q38059581The mechanism of the anticancer function of M1 macrophages and their use in the clinic
Q36161201The potential of exosomes in immunotherapy
Q33631986The role of regulatory T cells in cancer
Q36652214The role of regulatory T cells in the control of natural killer cells: relevance during tumor progression
Q31105891The safety profile of cyclophosphamide in multiple sclerosis therapy
Q35871559The tumor microenvironment expression of p-STAT3 influences the efficacy of cyclophosphamide with WP1066 in murine melanoma models.
Q36593753The tumor-draining lymph node as an immune-privileged site
Q39935569Therapeutic vaccines in metastatic castration-resistant prostate cancer: principles in clinical trial design.
Q37474385Timed sequential treatment with cyclophosphamide, doxorubicin, and an allogeneic granulocyte-macrophage colony-stimulating factor-secreting breast tumor vaccine: a chemotherapy dose-ranging factorial study of safety and immune activation
Q91639441Timing of changing therapy from gemcitabine and cisplatin chemotherapy based on real-world data of advanced urothelial carcinoma
Q35207161Toll-like receptor 4 single-nucleotide polymorphisms Asp299Gly and Thr399Ile in head and neck squamous cell carcinomas
Q36350565Towards a therapeutic breast cancer vaccine: the next steps
Q34795354Transduction of an HLA-DP4-restricted NY-ESO-1-specific TCR into primary human CD4+ lymphocytes
Q35849686Transferred melanoma-specific CD8+ T cells persist, mediate tumor regression, and acquire central memory phenotype
Q91642619Treatment of Metastatic or High-Risk Solid Cancer Patients by Targeting the Immune System and/or Tumor Burden: Six Cases Reports
Q37419728Treatment of lymphoma with adoptively transferred T cells.
Q51799863Treg cells as potential cellular targets for functionalized nanoparticles in cancer therapy.
Q39937711Treg suppress CTL responses upon immunization with HSP gp96.
Q56892924Trial Watch: Immunostimulation with recombinant cytokines for cancer therapy
Q34210664Tumor antigen cross-presentation and the dendritic cell: where it all begins?
Q36403539Tumor cells convert immature myeloid dendritic cells into TGF-beta-secreting cells inducing CD4+CD25+ regulatory T cell proliferation
Q27007772Tumor microenvironment: regulatory cells and immunosuppressive cytokines
Q36997144Tumor stress, cell death and the ensuing immune response.
Q35889643Tumor-infiltrating lymphocytes predict response to anthracycline-based chemotherapy in estrogen receptor-negative breast cancer.
Q35986612Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning
Q33943553Tumour-infiltrating T-cell subpopulations in glioblastomas
Q64108546Turning the Tide Against Regulatory T Cells
Q34170003Unexpected high response rate to traditional therapy after dendritic cell-based vaccine in advanced melanoma: update of clinical outcome and subgroup analysis
Q28076497Update on immune checkpoint inhibitors in gynecological cancers
Q54710399VEGFR2 is selectively expressed by FOXP3high CD4+ Treg.
Q36490759Vaccination for treatment and prevention of cancer in animal models.
Q39043404Vaccine strategies for the treatment of lymphoma: preclinical progress and clinical trial update
Q36907746Y27, a novel derivative of 4-hydroxyquinoline-3-formamide, prevents the development of murine systemic lupus erythematosus-like diseases in MRL/lpr autoimmune mice and BDF1 hybrid mice
Q38439138Zonal difference and prognostic significance of foxp3 regulatory T cell infiltration in breast cancer
Q34025664mTOR signaling inhibition modulates macrophage/microglia-mediated neuroinflammation and secondary injury via regulatory T cells after focal ischemia

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