MHC class II-restricted antigen processing and presentation

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MHC class II-restricted antigen processing and presentation is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/S0065-2776(00)75004-8
P698PubMed publication ID10879284

P2093author name stringPieters J
P2860cites workHLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptidesQ24294751
Structure of the human class I histocompatibility antigen, HLA-A2Q24297966
The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3Q24303524
An essential role for HLA-DM in antigen presentation by class II major histocompatibility moleculesQ24309308
A dendritic-cell-derived C-C chemokine that preferentially attracts naive T cellsQ24311809
AP-3: an adaptor-like protein complex with ubiquitous expressionQ24315945
Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)Q24317711
HLA-DM induces clip dissociation from MHC class II αβ dimers and facilitates peptide loadingQ24318038
Characterization of the adaptor-related protein complex, AP-3Q24321479
Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destructionQ24324602
Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loadingQ24328923
The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptidesQ24339477
Clathrin coats at 21 A resolution: a cellular assembly designed to recycle multiple membrane receptorsQ24533303
Pool sequencing of natural HLA-DR, DQ, and DP ligands reveals detailed peptide motifs, constraints of processing, and general rulesQ72271969
Molecular requirements for the interaction of class II major histocompatibility complex molecules and invariant chain with calnexinQ72536368
The B-cell antigen receptor complex: structure and signal transductionQ72768322
Proteases, processing, and thymic selectionQ74516573
Genetic susceptibility to systemic lupus erythematosusQ74578130
Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null miceQ74595052
Signal transduction of phagocytosisQ75294630
Phagocytosis of microbes: insights and prospectsQ75294681
Mechanisms of protein sorting and coat assembly: insights from the clathrin-coated vesicle pathwayQ77159594
Transport vesicles: coats of many coloursQ77316060
MHC class II and invariant chain biosynthesis and transport during maturation of human precursor dendritic cellsQ77658986
Mice lacking the transcription factor CIITA--a second lookQ77786394
AutoimmunityQ95444134
HLA-DR associates with specific stress proteins and is retained in the endoplasmic reticulum in invariant chain negative cellsQ24675139
Major histocompatibility complex class II-associated p41 invariant chain fragment is a strong inhibitor of lysosomal cathepsin LQ24678337
B lymphocytes secrete antigen-presenting vesiclesQ24678522
Invariant chain trimers are sequestered in the rough endoplasmic reticulum in the absence of association with HLA class II antigensQ24678747
Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial productsQ24678867
Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distributionQ24679240
Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myelomaQ24681545
Crystal structures of two viral peptides in complex with murine MHC class I H-2KbQ27642080
Specificity pockets for the side chains of peptide antigens in HLA-Aw68Q27700642
Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptideQ27731272
Atomic structure of clathrin: a beta propeller terminal domain joins an alpha zigzag linkerQ27766075
Dendritic cells and the control of immunityQ27860918
A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chainsQ27913878
A new human HLA class II-related locus, DMQ28235428
MHC class II-deficient combined immunodeficiency: a disease of gene regulationQ28247076
HLA-DMA and -DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cellsQ28251133
Limited polymorphism in HLA-DM does not involve the peptide binding grooveQ28255697
The serum mannose-binding protein and the macrophage mannose receptor are pattern recognition molecules that link innate and adaptive immunityQ28287631
Interaction of tyrosine-based sorting signals with clathrin-associated proteinsQ28290076
DM enhances peptide binding to class II MHC by release of invariant chain-derived peptideQ28295795
A novel DNA-binding regulatory factor is mutated in primary MHC class II deficiency (bare lymphocyte syndrome)Q28301107
Uptake of Pneumocystis carinii mediated by the macrophage mannose receptorQ28301754
Sequence analysis of peptides bound to MHC class II moleculesQ28303686
Altered antigen presentation in mice lacking H2-OQ28504672
H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selectionQ28504958
Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathwayQ28507891
The MHC class II molecule H2-M is targeted to an endosomal compartment by a tyrosine-based targeting motifQ28585954
Antigen presentation and T cell development in H2-M-deficient miceQ28587240
Antigen processing for presentation by class II major histocompatibility complex requires cleavage by cathepsin EQ28589161
Cathepsin S required for normal MHC class II peptide loading and germinal center developmentQ28611850
MHC class II-associated invariant chain contains a sorting signal for endosomal compartmentsQ28612553
Negative regulation by HLA-DO of MHC class II-restricted antigen processingQ28613199
Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymusQ28613227
Inhibition of invariant chain (Ii)-calnexin interaction results in enhanced degradation of Ii but does not prevent the assembly of alpha beta Ii complexesQ36365643
Related leucine-based cytoplasmic targeting signals in invariant chain and major histocompatibility complex class II molecules control endocytic presentation of distinct determinants in a single proteinQ36376527
Dendritic cells are recruited into the airway epithelium during the inflammatory response to a broad spectrum of stimuliQ36377468
Degradation of mouse invariant chain: roles of cathepsins S and D and the influence of major histocompatibility complex polymorphismQ36380525
A lysosomal targeting signal in the cytoplasmic tail of the beta chain directs HLA-DM to MHC class II compartments.Q36382769
Sorting signals in the MHC class II invariant chain cytoplasmic tail and transmembrane region determine trafficking to an endocytic processing compartmentQ36382892
Type II and III receptors for immunoglobulin G (IgG) control the presentation of different T cell epitopes from single IgG-complexed antigensQ36400334
Complement receptors and phagocytosisQ36499115
Bacterial entry into eukaryotic cellsQ37342351
MHC class-II molecules and autoimmunityQ37357888
Receptor-mediated antigen uptake and its effect on antigen presentation to class II-restricted T lymphocytesQ37925555
Protein degradation in the endoplasmic reticulumQ37947738
The role of N-linked oligosaccharides of MHC class II antigens in T cell stimulationQ38307334
New class II-like genes in the murine MHC.Q38332928
MHC class II invariant chains in antigen processing and presentationQ38735747
Protein oligomerization in the endoplasmic reticulumQ38737584
Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in sizeQ39229154
Acidification of the endocytic and exocytic pathwaysQ39459758
The immune response genes of the major histocompatibility complexQ39475236
Constitutive and regulated secretion of proteinsQ39683816
Genetics and expression of mouse Ia antigensQ39849787
Histocompatibility-linked immune response genesQ39866999
Role of MHC gene products in immune regulationQ40100288
The class II molecules of the human and murine major histocompatibility complex.Q40108949
Quality control in the secretory pathwayQ40380586
The cell biology of CTL killingQ40404856
HLA-DM: an in vivo facilitator of MHC class II peptide loadingQ40410057
The endocytic activity of dendritic cells.Q40457008
MHC molecules as peptide receptorsQ40485460
Dominance and crypticity of T cell antigenic determinantsQ40486347
Immunoglobulin E-binding structures on antigen-presenting cells present in skin and bloodQ40518123
PhagocytosisQ40523944
Chemistry of peptides associated with MHC class I and class II moleculesQ40540085
Molecular basis of Fc receptor functionQ40602173
The role of clathrin, adaptors and dynamin in endocytosisQ40647427
Biology of animal lectinsQ40800560
Positive selection of lymphocytesQ40807424
MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activationQ40807437
The mouse B-cell antigen receptor: definition and assembly of the core receptor of the five immunoglobulin isotypesQ40833862
Peptides naturally presented by MHC class I moleculesQ40898177
Origin, maturation and antigen presenting function of dendritic cells.Q40906220
Regulation of MHC class II gene expression.Q40928426
Invariant chain structure and MHC class II functionQ40968427
The cell biology of infection by intracellular bacterial pathogens.Q41020962
How MHC class II molecules acquire peptide cargo: biosynthesis and trafficking through the endocytic pathwayQ41020969
Detection of a common polypeptide chain in I-A and I-E sub-region immunoprecipitatesQ41048783
Developing and shedding inhibitions: how MHC class II molecules reach maturityQ41053707
HLA-DO is a negative modulator of HLA-DM-mediated MHC class II peptide loadingQ41064461
Distinct antigen MHC class II complexes generated by separate processing pathways.Q41079003
Developmental regulation of MHC class II transport in mouse dendritic cells.Q41093187
Antigen endocytosis and presentation mediated by human membrane IgG1 in the absence of the Ig(alpha)/Ig(beta) dimerQ41101974
The alpha chain gene of H-2O has an unexpected location in the major histocompatibility complexQ36231627
Phagocytic chimeric receptors require both transmembrane and cytoplasmic domains from the mannose receptorQ36232139
Efficient endosomal localization of major histocompatibility complex class II-invariant chain complexes requires multimerization of the invariant chain targeting sequenceQ36235619
Isoforms of the invariant chain regulate transport of MHC class II molecules to antigen processing compartmentsQ36236708
Protein targeting by tyrosine- and di-leucine-based signals: evidence for distinct saturable componentsQ36237576
Demonstration of structural polymorphism among HLA-DR light chains by two-dimensional gel electrophoresisQ36343209
Dendritic cells are accessory cells for the development of anti-trinitrophenyl cytotoxic T lymphocytesQ36344044
Antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptorsQ36349536
Cell surface expression of class II histocompatibility antigens occurs in the absence of the invariant chainQ36353070
Tyrosine phosphorylation is required for Fc receptor-mediated phagocytosis in mouse macrophagesQ36361230
Specificity and promiscuity among naturally processed peptides bound to HLA-DR allelesQ36361966
Dendritic cell progenitors phagocytose particulates, including bacillus Calmette-Guerin organisms, and sensitize mice to mycobacterial antigens in vivoQ36362128
Determinant capture as a possible mechanism of protection afforded by major histocompatibility complex class II molecules in autoimmune diseaseQ36362580
The requirement for DM in class II-restricted antigen presentation and SDS-stable dimer formation is allele and species dependent.Q36364225
Binding of major histocompatibility complex class II to the invariant chain-derived peptide, CLIP, is regulated by allelic polymorphism in class II.Q36364390
Confrontation between intracellular bacteria and the immune system.Q43459073
Fc receptorsQ44298973
Two-dimensional gel analysis of the polypeptides precipitated by a polymorphic HLA-DR1,2,w6 monoclonal antibody: evidence for a third locusQ44827228
Isolation and analysis of naturally processed viral peptides as recognized by cytotoxic T cellsQ45007765
Two forms of the Ia antigen-associated invariant chain result from alternative initiations at two in-phase AUGsQ45200339
Sequestration from immune CD4+ T cells of mycobacteria growing in human macrophagesQ45222064
Intracellular transport of class II MHC molecules directed by invariant chain.Q45941447
A novel class II MHC molecule with unusual tissue distributionQ45998244
Invariant chain distinguishes between the exogenous and endogenous antigen presentation pathwaysQ46424023
Clathrin coats--threads laid bareQ46487428
Characterization of a naturally processed MHC class II-restricted T-cell determinant of hen egg lysozymeQ46739108
Developmental regulation of invariant chain proteolysis controls MHC class II trafficking in mouse dendritic cells.Q47872621
Secretory lysosomes - a special mechanism of regulated secretion in haemopoietic cellsQ47986701
Nomenclature for factors of the HLA system, 1996.Q48775755
Transient aggregation of major histocompatibility complex class II chains during assembly in normal spleen cells.Q49164800
Antigen presentation by memory B cells: the sting is in the tail.Q52043159
Some recollections of Peter Gorer and his work on this fiftieth anniversary of his discovery of H-2.Q52404001
The repertoire of T cells shaped by a single MHC/peptide ligand.Q52887226
The role of complement and complement receptors in induction and regulation of immunity.Q53992218
Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC moleculesQ55042699
Antigen receptor tail clue.Q55060334
Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system.Q55061347
The mannose receptor functions as a high capacity and broad specificity antigen receptor in human dendritic cellsQ57275938
Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cellsQ57275942
Mannose receptor mediated antigen uptake and presentation in human dendritic cellsQ57275947
The mannose 6-phosphate receptor and the biogenesis of lysosomesQ57960197
Immunology Inside the gearbox of the dendritic cellQ58323381
Antigen processing and class II MHC peptide-loading compartments in human B-lymphoblastoid cellsQ58323390
Lymphocytes recognize human vascular endothelial and dermal fibroblast Ia antigens induced by recombinant immune interferonQ59063739
Antigen-specific interaction between T and B cellsQ59063745
Binding of immunogenic peptides to Ia histocompatibility moleculesQ59070314
Association of class I major histocompatibility heavy and light chains induced by viral peptidesQ59072754
Reversal of fortune for nascent proteinsQ59072797
Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytesQ59098594
Cytotoxic T cells recognize fragments of the influenza nucleoproteinQ61761274
Emerging principles for the recognition of peptide antigens by MHC class I moleculesQ67494475
Exact prediction of a natural T cell epitopeQ67702861
Map of the human MHCQ67848204
HL-A, immune-response genes, and diseaseQ70017187
Biochemical characterization of an invariant polypeptide associated with Ia antigens in human and mouseQ70903774
Mice lacking the MHC class II transactivator (CIITA) show tissue-specific impairment of MHC class II expressionQ71066478
The gene encoding the human class II antigen-associated gamma chain is located on chromosome 5Q71429361
Receptor-mediated pinocytosis of mannose glycoconjugates by macrophages: characterization and evidence for receptor recyclingQ71494370
Potent effects of low levels of MHC class II-associated invariant chain on CD4+ T cell developmentQ71727590
Reconstitution of invariant chain function in transgenic mice in vivo by individual p31 and p41 isoformsQ71727595
Major histocompatibility class II peptide occupancy, antigen presentation, and CD4+ T cell function in mice lacking the p41 isoform of invariant chainQ71727600
Destructive proteolysis by cysteine proteases in antigen presentation of ovalbuminQ71918543
Cathepsin D, but not cathepsin B, releases T cell stimulatory fragments from lysozyme that are functional in the context of multiple murine class II MHC moleculesQ72194431
Peptide motifs of HLA-B51, -B52 and -B78 molecules, and implications for Behćet's diseaseQ72201949
Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPasesQ29614245
The proteasome: paradigm of a self-compartmentalizing proteaseQ29615187
Intracellular Aspects of the Process of Protein SynthesisQ29615237
Endocytosis and molecular sortingQ29616706
Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPaseQ29617355
The biogenesis of lysosomesQ29617860
The ubiquitin systemQ29618565
The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosolQ29618773
Response of cultured macrophages to Mycobacterium tuberculosis, with observations on fusion of lysosomes with phagosomesQ31154479
Mechanism of Shigella entry into epithelial cellsQ33536573
Impact of intracellular location of and antigen display by intracellular bacteria: implications for vaccine developmentQ33538300
A coat protein on phagosomes involved in the intracellular survival of mycobacteriaQ33862936
Dileucine-based sorting signals bind to the beta chain of AP-1 at a site distinct and regulated differently from the tyrosine-based motif-binding siteQ33888654
The mannose receptor mediates uptake of pathogenic and nonpathogenic mycobacteria and bypasses bactericidal responses in human macrophagesQ34000130
Localization of the HLA class II-associated invariant chain gene to human chromosome band 5q32.Q34167283
Molecular characterization of the human macrophage mannose receptor: demonstration of multiple carbohydrate recognition-like domains and phagocytosis of yeasts in Cos-1 cellsQ34269349
Membrane insertion and oligomeric assembly of HLA-DR histocompatibility antigensQ34273916
The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processingQ34310837
Assembly, transport, and function of MHC class II moleculesQ34328789
Isolation and characterization of the intracellular MHC class II compartment.Q34340778
Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1.Q34350288
The chondroitin sulfate form of invariant chain can enhance stimulation of T cell responses through interaction with CD44.Q34352008
Initiation and processing of signals from the B cell antigen receptorQ34425416
Host-pathogen interactions during entry and actin-based movement of Listeria monocytogenesQ34453738
Mechanisms of MHC class I--restricted antigen processingQ34468834
An asparaginyl endopeptidase processes a microbial antigen for class II MHC presentation.Q34485526
The trans Golgi network: sorting at the exit site of the Golgi complex.Q34562583
L. monocytogenes-induced actin assembly requires the actA gene product, a surface proteinQ34614282
Immunological surveillance against altered self components by sensitised T lymphocytes in lymphocytes choriomeningitisQ34699212
The mannose receptor and other macrophage lectinsQ35228669
Chemistry and functional role of the invariant chainQ35228677
Immunological aspects of demyelinating diseasesQ35319665
The immunogenetics of rheumatoid arthritisQ35532736
Protein antigens of Chlamydia psittaci present in infected cells but not detected in the infectious elementary bodyQ35771161
Complexity in the major histocompatibility complexQ36022934
Transfer of proteins across membranes. II. Reconstitution of functional rough microsomes from heterologous componentsQ36204254
Tails from the hall of infection: actin-based motility of pathogens.Q41104075
Role of B cell receptor Ig alpha and Ig beta subunits in MHC class II-restricted antigen presentationQ41306022
The two novel MHC class II transactivators RFX5 and CIITA both control expression of HLA-DM genesQ41322316
Mediation by HLA-DM of dissociation of peptides from HLA-DRQ41333614
Antigen presentation mediated by recycling of surface HLA-DR molecules.Q41335304
Regulation of transcription of MHC class II genesQ41353021
MHC class II restricted antigen presentationQ41353041
Inter-relationship among macrophages, natural killer cells and neutrophils in early stages of Listeria resistanceQ41353064
How HLA-DM edits the MHC class II peptide repertoire: survival of the fittest?Q41370585
Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cellsQ41440525
Regulation of MHC class II expression by interferon-gamma mediated by the transactivator gene CIITA.Q41457392
A segment of the MHC class II beta chain plays a critical role in targeting class II molecules to the endocytic pathwayQ41458842
Fc receptor biologyQ41464279
Capture and processing of exogenous antigens for presentation on MHC molecules.Q41464375
Biogenesis of phagolysosomes proceeds through a sequential series of interactions with the endocytic apparatusQ41483433
Signal transduction in the mammalian cell during bacterial attachment and entryQ41502909
Linking cargo to vesicle formation: receptor tail interactions with coat proteins.Q41566699
Structure of the murine Ia-associated invariant (Ii) chain as deduced from a cDNA clone.Q41569267
Invariant chain peptides in most HLA-DR molecules of an antigen-processing mutantQ41589934
Antigen presentation enhanced by the alternatively spliced invariant chain gene product p41.Q41619054
Endosomal proteases and antigen processingQ41633118
Formation of a nine-subunit complex by HLA class II glycoproteins and the invariant chainQ41653246
Intracellular transport and localization of major histocompatibility complex class II molecules and associated invariant chainQ41653697
Peptide selection by MHC class I moleculesQ41687117
Microbial immunology: a new mechanism for immune subversionQ41690560
Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartmentsQ41695026
Isolation of an endogenously processed immunodominant viral peptide from the class I H–2Kb moleculeQ41714857
Antigen processing: HLA-DO--a hitchhiking inhibitor of HLA-DM.Q41720786
Toxoplasma gondii: fusion competence of parasitophorous vacuoles in Fc receptor-transfected fibroblastsQ41725157
Empty MHC class I molecules come out in the coldQ41725383
Role of B-cell and Fc receptors in the selection of T-cell epitopesQ41729828
Endosomal proteolysis and MHC class II functionQ41729834
Invariant chain association with HLA-DR molecules inhibits immunogenic peptide bindingQ41731115
Viral strategies of immune evasionQ41735903
Defective processing and presentation of exogenous antigens in mutants with normal HLA class II genesQ41944480
Class II transactivator regulates the expression of multiple genes involved in antigen presentationQ41944761
A role of Ia-associated invariant chains in antigen processing and presentation.Q41946241
Antigen capture and major histocompatibility class II compartments of freshly isolated and cultured human blood dendritic cellsQ41946843
Keratinocyte-Derived Monocyte Chemoattractant Protein 1 (MCP-1): Analysis in a Transgenic Model Demonstrates MCP-1 Can Recruit Dendritic and Langerhans Cells to SkinQ42479824
Immunocytochemical characterization of the endocytic and phagolysosomal compartments in peritoneal macrophagesQ42545057
Acceleration of intracellular targeting of antigen by the B-cell antigen receptor: importance depends on the nature of the antigen-antibody interaction.Q42594655
Transport properties of free and MHC class II-associated oligomers containing different isoforms of human invariant chainQ42605882
A macrophage invasion mechanism of pathogenic mycobacteriaQ42662108
Distinct intracellular compartments involved in invariant chain degradation and antigenic peptide loading of major histocompatibility complex (MHC) class II moleculesQ42796320
Colocalization of F-actin and talin during Fc receptor-mediated phagocytosis in mouse macrophagesQ42938886
A 15 amino acid fragment of influenza nucleoprotein synthesized in the cytoplasm is presented to class I-restricted cytotoxic T lymphocytesQ42939778
Suppressive effect of antibody on processing of T cell epitopesQ42941954
Characterization of the Mycobacterium tuberculosis phagosome and evidence that phagosomal maturation is inhibitedQ42942760
T cell responses affected by aminopeptidase N (CD13)-mediated trimming of major histocompatibility complex class II-bound peptidesQ42943610
P304page(s)159-208
P577publication date2000-01-01
P1433published inAdvances in ImmunologyQ15752932
P1476titleMHC class II-restricted antigen processing and presentation
P478volume75