The ins and outs of MHC class II-mediated antigen processing and presentation

scientific article published on 27 February 2015

The ins and outs of MHC class II-mediated antigen processing and presentation is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1002326549
P356DOI10.1038/NRI3818
P932PMC publication ID6314495
P698PubMed publication ID25720354

P2093author name stringKazuyuki Furuta
Paul A Roche
P2860cites workA Genome-wide multidimensional RNAi screen reveals pathways controlling MHC class II antigen presentationQ24298726
Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteinsQ24304937
Interleukin-10-induced MARCH1 mediates intracellular sequestration of MHC class II in monocytesQ24317219
MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulationQ24318499
Cell surface HLA-DR-invariant chain complexes are targeted to endosomes by rapid internalizationQ24561527
The induction of tolerance by dendritic cells that have captured apoptotic cellsQ24671078
Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial productsQ24678867
MHC class II association with lipid rafts on the antigen presenting cell surfaceQ27008954
Inhibition of MHC class II expression and immune responses by c-MIRQ28247142
Achieving stability through editing and chaperoning: regulation of MHC class II peptide binding and expressionQ28273723
ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cellsQ28506676
Dynamics of major histocompatibility complex class II compartments during B cell receptor-mediated cell activationQ28585845
Novel regulation of MHC class II function in B cellsQ28586416
Discrete domains of MARCH1 mediate its localization, functional interactions, and posttranscriptional control of expressionQ28589598
Phagosomes are competent organelles for antigen cross-presentationQ28591811
Macroautophagy substrates are loaded onto MHC class II of medullary thymic epithelial cells for central toleranceQ28593303
Cathepsin S required for normal MHC class II peptide loading and germinal center developmentQ28611850
Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophagesQ29547420
Immunobiology of dendritic cellsQ29547465
Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomesQ29619437
Syk-dependent actin dynamics regulate endocytic trafficking and processing of antigens internalized through the B-cell receptorQ30479947
Human immunodeficiency virus type 1 nef expression prevents AP-2-mediated internalization of the major histocompatibility complex class II-associated invariant chain.Q39966059
Dendritic cells regulate exposure of MHC class II at their plasma membrane by oligoubiquitinationQ40194881
Location of major histocompatibility complex class II molecules in rafts on dendritic cells enhances the efficiency of T-cell activation and proliferationQ40332851
AP2 clathrin adaptor complex, but not AP1, controls the access of the major histocompatibility complex (MHC) class II to endosomes.Q40450171
Epstein-Barr virus gp42 is posttranslationally modified to produce soluble gp42 that mediates HLA class II immune evasion.Q40478188
Endogenous MHC class II processing of a viral nuclear antigen after autophagy.Q40481959
MHC class II molecules traffic into lipid rafts during intracellular transportQ40512665
Asparagine endopeptidase can initiate the removal of the MHC class II invariant chain chaperone.Q40653773
Differential role of actin, clathrin, and dynamin in Fc gamma receptor-mediated endocytosis and phagocytosisQ40691199
Mature dendritic cells use endocytic receptors to capture and present antigensQ30493720
Autophagy proteins stabilize pathogen-containing phagosomes for prolonged MHC II antigen processing.Q30559146
TLR-dependent phagosome tubulation in dendritic cells promotes phagosome cross-talk to optimize MHC-II antigen presentationQ30596786
Tetraspan microdomains distinct from lipid rafts enrich select peptide-MHC class II complexesQ30778649
Pathways of antigen processingQ33631854
Human immunodeficiency virus-1 Nef expression induces intracellular accumulation of multivesicular bodies and major histocompatibility complex class II complexes: potential role of phosphatidylinositol 3-kinaseQ33763110
Involvement of clathrin and AP-2 in the trafficking of MHC class II molecules to antigen-processing compartmentsQ33833534
A coat protein on phagosomes involved in the intracellular survival of mycobacteriaQ33862936
Regulation of B lymphocyte responses to foreign and self-antigens by the CD19/CD21 complexQ33932719
Viral subversion of the immune systemQ33932763
Cell biology of antigen processing in vitro and in vivoQ33985828
Dendritic cells continue to capture and present antigens after maturation in vivoQ34084191
Early events in B cell activationQ34101385
Epstein-Barr virus evades CD4+ T cell responses in lytic cycle through BZLF1-mediated downregulation of CD74 and the cooperation of vBcl-2.Q34116845
Indirect activation of naïve CD4+ T cells by dendritic cell-derived exosomesQ34158527
Francisella tularensis elicits IL-10 via a PGE₂-inducible factor, to drive macrophage MARCH1 expression and class II down-regulationQ34277992
Inhibition of HLA-DR assembly, transport, and loading by human cytomegalovirus glycoprotein US3: a novel mechanism for evading major histocompatibility complex class II antigen presentationQ34349848
In vivo requirement for Atg5 in antigen presentation by dendritic cellsQ34376166
Ubiquitination regulates MHC class II-peptide complex retention and degradation in dendritic cellsQ34377531
Dendritic Cell Activation Prevents MHC Class II Ubiquitination and Promotes MHC Class II Survival Regardless of the Activation StimulusQ34438938
CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10-driven MARCH1-mediated ubiquitination and degradation.Q34501441
Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomesQ34593324
Ubiquitin-mediated regulation of CD86 protein expression by the ubiquitin ligase membrane-associated RING-CH-1 (MARCH1).Q35423428
Autophagy in antigen-presenting cells results in presentation of citrullinated peptides to CD4 T cellsQ35627649
Association of MHC class II-peptide complexes with plasma membrane lipid microdomainsQ35634044
Ubiquitination of CD86 is a key mechanism in regulating antigen presentation by dendritic cellsQ35832131
Adaptor protein-3 in dendritic cells facilitates phagosomal toll-like receptor signaling and antigen presentation to CD4(+) T cellsQ35991964
MHC class II distribution in dendritic cells and B cells is determined by ubiquitin chain lengthQ36061581
The actin-based motor protein myosin II regulates MHC class II trafficking and BCR-driven antigen presentation.Q36118069
Phagocytosis: elegant complexityQ36127867
Dendritic cell preactivation impairs MHC class II presentation of vaccines and endogenous viral antigensQ36140598
Endocytosis and the recycling of plasma membraneQ36206544
Autonomous phagosomal degradation and antigen presentation in dendritic cellsQ36221894
Viral modulation of antigen presentation: manipulation of cellular targets in the ER and beyondQ36266461
Human resident langerhans cells display a lysosomal compartment enriched in MHC class IIQ72727651
Transport of peptide-MHC class II complexes in developing dendritic cellsQ73698434
Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null miceQ74595052
CIIV, MIIC and other compartments for MHC class II loadingQ77844640
Inflammatory stimuli recruit cathepsin activity to late endosomal compartments in human dendritic cellsQ78516497
The pathway of antigen uptake and processing dictates MHC class II-mediated B cell survival and activationQ81300353
CD83 localization in a recycling compartment of immature human monocyte-derived dendritic cellsQ81475154
SWAP-70 regulates RhoA/RhoB-dependent MHCII surface localization in dendritic cellsQ81995305
Autoregulation of MARCH1 expression by dimerization and autoubiquitinationQ83906899
Internalization and endosomal degradation of receptor-bound antigens regulate the efficiency of cross presentation by human dendritic cellsQ84569562
Antibody modulation of antigen presentation: positive and negative effects on presentation of the tetanus toxin antigen via the murine B cell isoform of FcgammaRII.Q40752702
Concentration of MHC class II molecules in lipid rafts facilitates antigen presentationQ40820913
Follicular dendritic cells carry MHC class II-expressing microvesicles at their surfaceQ40867441
Invariant chain structure and MHC class II functionQ40968427
Cutting edge: signals from the B lymphocyte antigen receptor regulate MHC class II containing late endosomes.Q41038581
Developmental regulation of MHC class II transport in mouse dendritic cells.Q41093187
MHC class II compartments and the kinetics of antigen presentation in activated mouse spleen dendritic cellsQ41339121
Regulation of MHC class II expression by interferon-gamma mediated by the transactivator gene CIITA.Q41457392
Two processing pathways for the MHC class II-restricted presentation of exogenous influenza virus antigenQ41467922
Invariant chain association with HLA-DR molecules inhibits immunogenic peptide bindingQ41731115
Early endosomes and a late endocytic compartment generate different peptide-class II MHC complexes via distinct processing mechanisms.Q41929057
Epitope-specific enhancement of antigen presentation by invariant chainQ41937027
Reorganization of multivesicular bodies regulates MHC class II antigen presentation by dendritic cellsQ42132231
The lymph as a pool of self-antigensQ42672113
Endosomally stored MHC class II does not contribute to antigen presentation by dendritic cells at inflammatory conditions.Q42811453
TRIF-GEFH1-RhoB pathway is involved in MHCII expression on dendritic cells that is critical for CD4 T-cell activationQ43101212
MHC II in dendritic cells is targeted to lysosomes or T cell-induced exosomes via distinct multivesicular body pathways.Q43645305
Destructive processing by asparagine endopeptidase limits presentation of a dominant T cell epitope in MBP.Q43867716
Activation of lysosomal function during dendritic cell maturationQ44333919
A cytosolic pathway for MHC class II-restricted antigen processing that is proteasome and TAP dependentQ44791801
Differential lysosomal proteolysis in antigen-presenting cells determines antigen fateQ45345585
Exploring the MHC-peptide matrix of central tolerance in the human thymus.Q45929502
Sorting of MHC class II molecules into exosomes through a ubiquitin-independent pathway.Q45946092
The small GTPase Rac2 controls phagosomal alkalinization and antigen crosspresentation selectively in CD8(+) dendritic cellsQ46071205
Interleukin-10 down-regulates MHC class II alphabeta peptide complexes at the plasma membrane of monocytes by affecting arrival and recycling.Q46299578
Regulation of phagosome maturation by signals from toll-like receptorsQ47604798
Developmental control of endocytosis in dendritic cells by Cdc42.Q50119612
Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membraneQ50335826
Dendritic cells constitutively present self antigens in their immature state in vivo and regulate antigen presentation by controlling the rates of MHC class II synthesis and endocytosis.Q52004514
T-cell engagement of dendritic cells rapidly rearranges MHC class II transport.Q54026692
Polarized secretion of lysosomes at the B cell synapse couples antigen extraction to processing and presentation.Q54569550
MHC class II expression is differentially regulated in plasmacytoid and conventional dendritic cells.Q54705034
Human cytomegalovirus protein pp65 mediates accumulation of HLA-DR in lysosomes and destruction of the HLA-DR alpha-chain.Q54786854
Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for toleranceQ56701390
Differential MHC class II synthesis and ubiquitination confers distinct antigen-presenting properties on conventional and plasmacytoid dendritic cellsQ57134111
Enhanced Dendritic Cell Antigen Capture via Toll-Like Receptor-Induced Actin RemodelingQ57204114
ICAM-1 on exosomes from mature dendritic cells is critical for efficient naive T-cell primingQ57267744
Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cellsQ57275942
Capture of cell-derived microvesicles (exosomes and apoptotic bodies) by human plasmacytoid dendritic cellsQ58198307
Toll-dependent selection of microbial antigens for presentation by dendritic cellsQ59063722
Surface expression of MHC class II in dendritic cells is controlled by regulated ubiquitinationQ59077373
Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytesQ59098594
TLR signalling and phagosome maturation: an alternative viewpointQ60343837
Cytomegalovirus US2 destroys two components of the MHC class II pathway, preventing recognition by CD4+ T cellsQ62735441
Extensive trafficking of MHC class II-invariant chain complexes in the endocytic pathway and appearance of peptide-loaded class II in multiple compartmentsQ71843540
Control of MHC class II antigen presentation in dendritic cells: a balance between creative and destructive forces.Q36266484
Right place, right time, right peptide: DO keeps DM focusedQ36266508
Regulation of MHC class II gene expression by the class II transactivatorQ36274925
Antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptorsQ36349536
Phagocytosis of antigens by Langerhans cells in vitroQ36362124
The formation of immunogenic major histocompatibility complex class II-peptide ligands in lysosomal compartments of dendritic cells is regulated by inflammatory stimuliQ36368355
Processing of Mycobacterium tuberculosis antigen 85B involves intraphagosomal formation of peptide-major histocompatibility complex II complexes and is inhibited by live bacilli that decrease phagosome maturationQ36370092
In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccinationQ36402359
Encounter with antigen-specific primed CD4 T cells promotes MHC class II degradation in dendritic cellsQ36436748
T cell-induced secretion of MHC class II-peptide complexes on B cell exosomesQ36439289
Class II MHC molecules are present in macrophage lysosomes and phagolysosomes that function in the phagocytic processing of Listeria monocytogenes for presentation to T cellsQ36532094
Robust T-cell stimulation by Epstein-Barr virus-transformed B cells after antigen targeting to DEC-205.Q36654119
Major histocompatibility complex (MHC) class II-peptide complexes arrive at the plasma membrane in cholesterol-rich microclustersQ36832560
MARCH1-mediated MHCII ubiquitination promotes dendritic cell selection of natural regulatory T cellsQ36907903
MHC class II molecules on the move for successful antigen presentationQ37018661
Pathogenic CD4⁺ T cells recognizing an unstable peptide of insulin are directly recruited into islets bypassing local lymph nodes.Q37246540
Antigen-presentation properties of plasmacytoid dendritic cellsQ37272231
Salmonella regulates polyubiquitination and surface expression of MHC class II antigensQ37291725
Tumour-derived exosomes as antigen delivery carriers in dendritic cell-based immunotherapy for malignant mesotheliomaQ37295688
Internalizing MHC class II-peptide complexes are ubiquitinated in early endosomes and targeted for lysosomal degradationQ37394995
Francisella tularensis induces ubiquitin-dependent major histocompatibility complex class II degradation in activated macrophagesQ37410355
Virus entry by macropinocytosisQ37464753
Dendritic cell-derived exosomes for cancer immunotherapy: what's next?Q37690060
Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritisQ37700775
Autophagy and adaptive immunityQ37768484
Macropinocytosis: an endocytic pathway for internalising large gulpsQ37855532
Ubiquitin and membrane protein turnover: from cradle to graveQ37992157
Cross-presentation by dendritic cellsQ38025870
Association of major histocompatibility complex II with cholesterol- and sphingolipid-rich membranes precedes peptide loadingQ38340325
Membrane transfer from tumor cells overcomes deficient phagocytic ability of plasmacytoid dendritic cells for the acquisition and presentation of tumor antigensQ39043478
Identification of a novel motif that affects the conformation and activity of the MARCH1 E3 ubiquitin ligaseQ39221350
Mass spectrometry analysis and quantitation of peptides presented on the MHC II molecules of mouse spleen dendritic cellsQ39474621
LAMP-2-deficient human B cells exhibit altered MHC class II presentation of exogenous antigensQ39697429
The herpes simplex virus-1 encoded glycoprotein B diverts HLA-DR into the exosome pathwayQ39769129
P433issue4
P304page(s)203-216
P577publication date2015-02-27
P1433published inNature Reviews ImmunologyQ43355
P1476titleThe ins and outs of MHC class II-mediated antigen processing and presentation
P478volume15

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Q64118744The Antidepressant Mirtazapine Inhibits Hepatic Innate Immune Networks to Attenuate Immune-Mediated Liver Injury in Mice
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Q39711277The Human Thymus Is Enriched for Autoreactive B Cells.
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Q60944020The Phosphoinositide Kinase PIKfyve Promotes Cathepsin-S-Mediated Major Histocompatibility Complex Class II Antigen Presentation
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Q39084138The elucidation of non-classical MHC class II antigen processing through the study of viral antigens
Q57165421The immunobiology of ubiquitin-dependent B cell receptor functions
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Q40975860The prognostic impact of programmed cell death ligand 1 and human leukocyte antigen class I in pancreatic cancer
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Q52884764[Autophagy, autoimmunity and autoimmune diseases].
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