The formation of immunogenic major histocompatibility complex class II-peptide ligands in lysosomal compartments of dendritic cells is regulated by inflammatory stimuli

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The formation of immunogenic major histocompatibility complex class II-peptide ligands in lysosomal compartments of dendritic cells is regulated by inflammatory stimuli is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1084/JEM.191.6.927
P932PMC publication ID2193115
P698PubMed publication ID10727455
P5875ResearchGate publication ID12589442

P50authorRalph SteinmanQ105494
P2093author name stringI Mellman
S Turley
K Inaba
C Reis e Sousa
R N Germain
F Yamaide
S Shimoyama
T Iyoda
P2860cites workEssential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loadingQ24328923
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Invariant chain association with HLA-DR molecules inhibits immunogenic peptide bindingQ41731115
Antigen capture and major histocompatibility class II compartments of freshly isolated and cultured human blood dendritic cellsQ41946843
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Developmental regulation of invariant chain proteolysis controls MHC class II trafficking in mouse dendritic cells.Q47872621
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The duration of antigenic stimulation determines the fate of naive and effector T cells.Q51099389
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Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cellsQ57275942
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An improved isolation method for murine migratory cutaneous dendritic cellsQ71217258
Both dendritic cells and memory T lymphocytes emigrate from organ cultures of human skin and form distinctive dendritic-T-cell conjugatesQ72353140
Transport of peptide-MHC class II complexes in developing dendritic cellsQ73698434
Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cellsQ74310288
Entry into afferent lymphatics and maturation in situ of migrating murine cutaneous dendritic cellsQ74440382
Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturationQ77353738
Class I-restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8(+) T cellsQ24653129
Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activationQ24677534
Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial productsQ24678867
Dendritic cells and the control of immunityQ27860918
EBI1/CCR7 is a new member of dendritic cell chemokine receptor that is up-regulated upon maturationQ28282903
The invariant chain is required for intracellular transport and function of major histocompatibility complex class II moleculesQ28585584
MHC class II-associated invariant chain contains a sorting signal for endosomal compartmentsQ28612553
Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factorQ29619247
Generation of large numbers of fully mature and stable dendritic cells from leukapheresis products for clinical applicationQ33536357
Production, specificity, and functionality of monoclonal antibodies to specific peptide-major histocompatibility complex class II complexes formed by processing of exogenous proteinQ33731623
Rapid generation of broad T-cell immunity in humans after a single injection of mature dendritic cells.Q33855405
Isolation and characterization of the intracellular MHC class II compartment.Q34340778
Antigen processing by epidermal Langerhans cells correlates with the level of biosynthesis of major histocompatibility complex class II molecules and expression of invariant chainQ36353782
Migration and maturation of Langerhans cells in skin transplants and explantsQ36353813
Presentation of exogenous protein antigens by dendritic cells to T cell clones. Intact protein is presented best by immature, epidermal Langerhans cellsQ36356239
Phagocytosis of antigens by Langerhans cells in vitroQ36362124
Dendritic cell progenitors phagocytose particulates, including bacillus Calmette-Guerin organisms, and sensitize mice to mycobacterial antigens in vivoQ36362128
B7 but not intercellular adhesion molecule-1 costimulation prevents the induction of human alloantigen-specific toleranceQ36362561
Resting and anergic B cells are defective in CD28-dependent costimulation of naive CD4+ T cells.Q36363106
The CLIP region of invariant chain plays a critical role in regulating major histocompatibility complex class II folding, transport, and peptide occupancyQ36363714
The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitroQ36363984
B70/B7-2 is identical to CD86 and is the major functional ligand for CD28 expressed on human dendritic cellsQ36364036
High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10.Q36367196
Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo.Q36367475
Vaccination with mage-3A1 peptide-pulsed mature, monocyte-derived dendritic cells expands specific cytotoxic T cells and induces regression of some metastases in advanced stage IV melanomaQ36375683
Related leucine-based cytoplasmic targeting signals in invariant chain and major histocompatibility complex class II molecules control endocytic presentation of distinct determinants in a single proteinQ36376527
Maturation stages of mouse dendritic cells in growth factor-dependent long-term culturesQ36376739
High levels of a major histocompatibility complex II-self peptide complex on dendritic cells from the T cell areas of lymph nodesQ36380488
Antigen-unspecific B cells and lymphoid dendritic cells both show extensive surface expression of processed antigen-major histocompatibility complex class II complexes after soluble protein exposure in vivo or in vitro.Q36380500
Efficient presentation of phagocytosed cellular fragments on the major histocompatibility complex class II products of dendritic cellsQ36401207
Co-localization of molecules involved in antigen processing and presentation in an early endocytic compartmentQ38138330
Origin, maturation and antigen presenting function of dendritic cells.Q40906220
How MHC class II molecules acquire peptide cargo: biosynthesis and trafficking through the endocytic pathwayQ41020969
Developmental regulation of MHC class II transport in mouse dendritic cells.Q41093187
HLA-DM is localized to conventional and unconventional MHC class II-containing endocytic compartments.Q41224482
Accumulation of HLA-DM, a regulator of antigen presentation, in MHC class II compartmentsQ41412265
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectdendritic cellQ506253
inflammationQ101991
P304page(s)927-936
P577publication date2000-03-01
P1433published inJournal of Experimental MedicineQ3186912
P1476titleThe formation of immunogenic major histocompatibility complex class II-peptide ligands in lysosomal compartments of dendritic cells is regulated by inflammatory stimuli
P478volume191

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