Tolerogenic dendritic cell therapy for rheumatoid arthritis: where are we now?

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Tolerogenic dendritic cell therapy for rheumatoid arthritis: where are we now? is …
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scholarly articleQ13442814

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P356DOI10.1111/CEI.12038
P932PMC publication ID3628318
P698PubMed publication ID23574312
P5875ResearchGate publication ID236190853

P50authorCatharien M. HilkensQ74316716
John D IsaacsQ56408288
P2093author name stringJ D Isaacs
C M U Hilkens
P2860cites workRapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant toleranceQ80358513
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Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunityQ24643886
Resistance to IL-10 inhibition of interferon gamma production and expression of suppressor of cytokine signaling 1 in CD4+ T cells from patients with rheumatoid arthritisQ24798549
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1 Alpha,25-dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activationQ28370605
Dexamethasone inhibits dendritic cell maturation by redirecting differentiation of a subset of cellsQ28378178
A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanismQ29614266
Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acidQ29615586
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Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivoQ30080006
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T-cell priming by type-1 and type-2 polarized dendritic cells: the concept of a third signalQ33774232
Persistence of collagen type II-specific T-cell clones in the synovial membrane of a patient with rheumatoid arthritisQ33832421
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Cutting edge: induction of B7-H4 on APCs through IL-10: novel suppressive mode for regulatory T cellsQ34540019
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A rapid diagnostic test for human regulatory T-cell function to enable regulatory T-cell therapy.Q34634834
Dendritic cell control of tolerogenic responsesQ34982085
Dendritic cells in immunity and tolerance-do they display opposite functions?Q35181775
Tolerogenic dendritic cells and their role in transplantation.Q35341379
Intra-graft expression of genes involved in iron homeostasis predicts the development of operational tolerance in human liver transplantationQ35640630
The formation of immunogenic major histocompatibility complex class II-peptide ligands in lysosomal compartments of dendritic cells is regulated by inflammatory stimuliQ36368355
Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: a novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussiQ36369855
Immunotherapy with dendritic cells directed against tumor antigens shared with normal host cells results in severe autoimmune diseaseQ36375982
Therapeutic effect of exosomes from indoleamine 2,3-dioxygenase-positive dendritic cells in collagen-induced arthritis and delayed-type hypersensitivity disease models.Q36379002
CII-DC-AdTRAIL cell gene therapy inhibits infiltration of CII-reactive T cells and CII-induced arthritisQ36524672
Plasmacytoid dendritic cells mediate oral toleranceQ36534744
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Therapeutic agents for patients with rheumatoid arthritis and an inadequate response to tumour necrosis factor-alpha antagonistsQ37633537
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Functional regulatory immune responses against human cartilage glycoprotein-39 in health vs. proinflammatory responses in rheumatoid arthritis.Q37705125
Developing tolerogenic dendritic cell therapy for rheumatoid arthritis: what can we learn from mouse models?Q37908887
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Tolerogenic dendritic cells: applications for solid organ transplantationQ37974050
The cellular and molecular mechanisms of immuno-suppression by human type 1 regulatory T cellsQ38008355
Prolongation of cardiac allograft survival using dendritic cells treated with NF-kB decoy oligodeoxyribonucleotidesQ38309722
Dendritic cells genetically engineered to express IL-4 inhibit murine collagen-induced arthritisQ39946625
Creation of tolerogenic human dendritic cells via intracellular CTLA4: a novel strategy with potential in clinical immunosuppressionQ40402602
Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donorsQ40532147
Inducible transgenic mice reveal resting dendritic cells as potent inducers of CD8+ T cell tolerance.Q40647086
A novel host-parasite lipid cross-talk. Schistosomal lyso-phosphatidylserine activates toll-like receptor 2 and affects immune polarizationQ40700194
Generation and characterisation of therapeutic tolerogenic dendritic cells for rheumatoid arthritis.Q41180997
Cartilage proteoglycan aggrecan epitopes induce proinflammatory autoreactive T-cell responses in rheumatoid arthritis and osteoarthritisQ41440061
Differential regulation of naïve and memory CD4+ T cells by alternatively activated dendritic cellsQ41754216
High production of proinflammatory and Th1 cytokines by dendritic cells from patients with rheumatoid arthritis, and down regulation upon FcgammaR triggering.Q41987472
LPS activation is required for migratory activity and antigen presentation by tolerogenic dendritic cells.Q42110748
HLA-DR1001 presents "altered-self" peptides derived from joint-associated proteins by accepting citrulline in three of its binding pocketsQ42412117
Gene silencing of IL-12 in dendritic cells inhibits autoimmune arthritis.Q42608288
Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cellsQ42944333
Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapyQ42971266
Response of Th17 cells to a citrullinated arthritogenic aggrecan peptide in patients with rheumatoid arthritisQ43205831
L-selectin-dependent lymphoid occupancy is required to induce alloantigen-specific toleranceQ43874047
Dendritic cells exposed in vitro to TGF-beta1 ameliorate experimental autoimmune myasthenia gravisQ43904319
Risk of tuberculosis in patients treated with tumor necrosis factor antagonists due to incomplete prevention of reactivation of latent infectionQ44422799
The changing face of rheumatoid arthritis: sustained remission for all?Q44508845
Cutting edge: induced indoleamine 2,3 dioxygenase expression in dendritic cell subsets suppresses T cell clonal expansion.Q44539418
T cells signaled by NF-kappa B- dendritic cells are sensitized not anergic to subsequent activationQ44987457
Adenoviral delivery of CTLA4Ig into myeloid dendritic cells promotes their in vitro tolerogenicity and survival in allogeneic recipientsQ45862110
Human myeloid dendritic cells transduced with an adenoviral interleukin-10 gene construct inhibit human skin graft rejection in humanized NOD-scid chimeric miceQ45879284
Targeted lymphoid homing of dendritic cells is required for prolongation of allograft survivalQ46108818
Lymph node occupancy is required for the peripheral development of alloantigen-specific Foxp3+ regulatory T cells.Q46499903
Differential MHC class II-mediated presentation of rheumatoid arthritis autoantigens by human dendritic cells and macrophagesQ47566959
Cutting edge: human CD4+CD25+ T cells restrain the maturation and antigen-presenting function of dendritic cellsQ47810559
Monophosphoryl Lipid A (MPL) as an Adjuvant for Anti-Cancer Vaccines: Clinical ResultsQ50047316
Semi-mature DC are immunogenic and not tolerogenic when inoculated at a high dose in collagen-induced arthritis mice.Q51567175
A pilot study of combination anti-cytokine and anti-lymphocyte biological therapy in rheumatoid arthritis.Q52852039
Corticosteroids inhibit the production of inflammatory mediators in immature monocyte-derived DC and induce the development of tolerogenic DC3.Q52914622
Wnt5a skews dendritic cell differentiation to an unconventional phenotype with tolerogenic features.Q54348864
Synovial autoreactive T cells in rheumatoid arthritis resist IDO-mediated inhibition.Q54570858
Prolongation of rat intestinal allograft survival by administration of donor interleukin-12 p35-silenced bone marrow-derived dendritic cells.Q54655361
Dendritic Cells Matured With TNF can be Further Activated In Vitro and After Subcutaneous Injection In Vivo Which Converts Their Tolerogenicity Into ImmunogenicityQ56689252
"Alternatively activated" dendritic cells preferentially secrete IL-10, expand Foxp3+CD4+ T cells, and induce long-term organ allograft survival in combination with CTLA4-IgQ56901846
CD4(+) and CD8(+) anergic T cells induced by interleukin-10-treated human dendritic cells display antigen-specific suppressor activityQ56904531
Identification of citrullinated vimentin peptides as T cell epitopes in HLAâ DR4â positive patients with rheumatoid arthritisQ58234841
Modulation of established murine collagen-induced arthritis by a single inoculation of short-term lipopolysaccharide-stimulated dendritic cellsQ58234914
Therapeutic effect of tolerogenic dendritic cells in established collagen-induced arthritis is associated with a reduction in Th17 responsesQ60061990
Tumour necrosis factor alpha blockade impairs dendritic cell survival and function in rheumatoid arthritisQ60061992
Stable antigen-specific T-cell hyporesponsiveness induced by tolerogenic dendritic cells from multiple sclerosis patientsQ61656600
Effective treatment of established mouse collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express FasLQ64378360
Effective treatment of established murine collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express IL-4Q64380123
The intrinsic migratory capacity of memory T cells contributes to their accumulation in rheumatoid synoviumQ67466174
Rheumatoid synovium is enriched in mature antigen-presenting dendritic cellsQ71614430
Regulatory dendritic cells protect mice from murine acute graft-versus-host disease and leukemia relapseQ73153290
Dendritic cells genetically engineered to express Fas ligand induce donor-specific hyporesponsiveness and prolong allograft survivalQ73289641
P433issue2
P921main subjectrheumatoid arthritisQ187255
P304page(s)148-157
P577publication date2013-05-01
P1433published inClinical and Experimental ImmunologyQ15716708
P1476titleTolerogenic dendritic cell therapy for rheumatoid arthritis: where are we now?
P478volume172

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