John D Isaacs

researcher

John D Isaacs is …
instance of (P31):
humanQ5

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P6178Dimensions author ID010536430723.39
P2163FAST ID1574531
P213ISNI0000000115878420
P244Library of Congress authority IDn2002152037
P8189National Library of Israel J9U ID987007381385305171
P691NL CR AUT IDxx0256897
P1207NUKAT IDn2011162917
P496ORCID iD0000-0002-6103-7056
P7293PLWABN ID9810685566005606
P1153Scopus author ID25943775400
P214VIAF ID250487127
P10832WorldCat Entities IDE39PBJcgCCH3PTjmb8HPBQPWjC

P734family nameIsaacsQ16871090
IsaacsQ16871090
IsaacsQ16871090
P101field of workmedicineQ11190
immunologyQ101929
rheumatologyQ327657
P735given nameJohnQ4925477
JohnQ4925477
P1412languages spoken, written or signedEnglishQ1860
P106occupationphysicianQ39631
researcherQ1650915
rheumatologistQ5997943
immunologistQ12119633
P5008on focus list of Wikimedia projectWikiProject COVID-19Q87748614
P21sex or gendermaleQ6581097

Reverse relations

author (P50)
Q92931968"Living a normal life": a qualitative study of patients' views of medication withdrawal in rheumatoid arthritis
Q6006197910 years of therapeutic advances in the rheumatic diseases
Q36094049A CD4 T cell gene signature for early rheumatoid arthritis implicates interleukin 6-mediated STAT3 signalling, particularly in anti-citrullinated peptide antibody-negative disease.
Q35875673A Transcriptional Signature of Fatigue Derived from Patients with Primary Sjögren's Syndrome
Q50796127A negative feedback loop mediated by STAT3 limits human Th17 responses.
Q40400372A non-glycosaminoglycan-binding variant of CC chemokine ligand 7 (monocyte chemoattractant protein-3) antagonizes chemokine-mediated inflammation
Q46095815A novel paradigm for dendritic cells as effectors of cartilage destruction.
Q56462138A phase 1 study to address the safety and efficacy of granulocyte colony-stimulating factor for the mobilization of hematopoietic progenitor cells in active rheumatoid arthritis
Q52852039A pilot study of combination anti-cytokine and anti-lymphocyte biological therapy in rheumatoid arthritis.
Q60061989A randomised, controlled, double blinded study of ultrasound guided corticosteroid joint injection in patients with inflammatory arthritis
Q60062004A therapeutic human IgG4 monoclonal antibody that depletes target cells in humans
Q52853353Abnormal T cell differentiation persists in patients with rheumatoid arthritis in clinical remission and predicts relapse.
Q31151181Achieving consensus on minimum data items (including core outcome domains) for a longitudinal observational cohort study in rheumatoid arthritis
Q36293513Adrenal steroidogenesis after B lymphocyte depletion therapy in new-onset Addison's disease
Q60061997Adult Human Fibroblasts Are Potent Immunoregulatory Cells and Functionally Equivalent to Mesenchymal Stem Cells
Q34896371Analysis of Fcgamma receptor haplotypes in rheumatoid arthritis: FCGR3A remains a major susceptibility gene at this locus, with an additional contribution from FCGR3B.
Q60061993Animal models in infection and inflammation - chance and necessity
Q37964318Anti-TNF therapy
Q60061999Anti-TNFα Therapy Modulates the Phenotype of Peripheral Blood CD4+T Cells in Patients with Posterior Segment Intraocular Inflammation
Q37505420Antibody engineering to develop new antirheumatic therapies
Q34184314Application of differential display to immunological research.
Q57323704Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NF B signalling pathways
Q42564764Association of FCGR2A and FCGR2A-FCGR3A haplotypes with susceptibility to giant cell arteritis
Q37054390Association of HLA-DRB1 haplotypes with rheumatoid arthritis severity, mortality, and treatment response
Q64109926Association of response to TNF inhibitors in rheumatoid arthritis with quantitative trait loci for and CD39
Q37000109Association of rheumatoid factor and anti-cyclic citrullinated peptide positivity, but not carriage of shared epitope or PTPN22 susceptibility variants, with anti-tumour necrosis factor response in rheumatoid arthritis
Q57306851Association of the tumour necrosis factor-308 variant with differential response to anti-TNF agents in the treatment of rheumatoid arthritis
Q37517575Atacicept, a novel B cell-targeting biological therapy for the treatment of rheumatoid arthritis.
Q37604510Autologous tolerogenic dendritic cells for rheumatoid and inflammatory arthritis
Q36085007Baseline serum MMP-3 levels in patients with Rheumatoid Arthritis are still independently predictive of radiographic progression in a longitudinal observational cohort at 8 years follow up
Q60061978Bcl-3 in CD4+ T Cell-Mediated Rheumatoid Arthritis Pathogenesis: Comment on the Article by Meguro et al
Q92974083Between a ROC and a hard place: Teaching prevalence plots to understand real world biomarker performance in the clinic
Q56975651Biologic refractory disease in rheumatoid arthritis: results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis
Q37909907Biologic therapies in non-rheumatic diseases: lessons for rheumatologists?
Q36694805Biologic therapies in rheumatology: lessons learned, future directions
Q38592363Biosimilars in immune-mediated inflammatory diseases: initial lessons from the first approved biosimilar anti-tumour necrosis factor monoclonal antibody.
Q49376742CD4+ and B Lymphocyte Expression Quantitative Traits at Rheumatoid Arthritis Risk Loci in Patients With Untreated Early Arthritis: Implications for Causal Gene Identification.
Q57173903CD4+CD25+ T-regulatory cells are decreased in patients with autoimmune polyendocrinopathy candidiasis ectodermal dystrophy
Q36665428CMV seropositivity and T-cell senescence predict increased cardiovascular mortality in octogenarians: results from the Newcastle 85+ study
Q28109583Capture Hi-C identifies a novel causal gene, IL20RA, in the pan-autoimmune genetic susceptibility region 6q23
Q34454531Changes in serum creatinine in patients with active rheumatoid arthritis treated with tofacitinib: results from clinical trials
Q48092147Clinical trials of biosimilars should become more similar
Q36832755Clinical utility of random anti-tumor necrosis factor drug-level testing and measurement of antidrug antibodies on the long-term treatment response in rheumatoid arthritis
Q41447431Clinical utility of random anti-tumour necrosis factor drug testing and measurement of anti-drug antibodies on long-term treatment response in rheumatoid arthritis.
Q31112066Components of treatment delay in rheumatoid arthritis differ according to autoantibody status: validation of a single-centre observation using national audit data.
Q52844225Confirmation of association of FCGR3B but not FCGR3A copy number with susceptibility to autoantibody positive rheumatoid arthritis.
Q36633196Correlation of C-reactive protein haplotypes with serum C-reactive protein level and response to anti-tumor necrosis factor therapy in UK rheumatoid arthritis patients: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study S
Q37398076Current concepts in the pathogenesis of early rheumatoid arthritis
Q38666239Cytokines in rheumatoid arthritis - shaping the immunological landscape
Q35242453Defective removal of ribonucleotides from DNA promotes systemic autoimmunity.
Q55089799Defective removal of ribonucleotides from DNA promotes systemic lupus erythematosus.
Q91823360Design of experiments and the virtual PCR simulator: An online game for pharmaceutical scientists and biotechnologists
Q34006506Detection of Mycobacterium tuberculosis group organisms in human and mouse joint tissue by reverse transcriptase PCR: prevalence in diseased synovial tissue suggests lack of specific association with rheumatoid arthritis
Q37383419Detection of anti-drug antibodies using a bridging ELISA compared with radioimmunoassay in adalimumab-treated rheumatoid arthritis patients with random drug levels.
Q36995849Determination of thymic function directly from peripheral blood: a validated modification to an established method.
Q37701864Development of dendritic cell-based immunotherapy for autoimmunity
Q37023870Differential Methylation as a Biomarker of Response to Etanercept in Patients With Rheumatoid Arthritis
Q41754216Differential regulation of naïve and memory CD4+ T cells by alternatively activated dendritic cells
Q36907659Disease activity and cognition in rheumatoid arthritis: an open label pilot study
Q50585017Dissection of the FCGR3A association with RA: increased association in men and with autoantibody positive disease.
Q37705181Drug breakthrough offers hope to arthritis sufferers: qualitative analysis of medical research in UK newspapers.
Q52009888Dysregulated lymphocyte proliferation and differentiation in patients with rheumatoid arthritis.
Q96171120EULAR provisional recommendations for the management of rheumatic and musculoskeletal diseases in the context of SARS-CoV-2
Q46068649Effect of baseline rheumatoid factor and anticitrullinated peptide antibody serotype on rituximab clinical response: a meta-analysis
Q37689966Effect of tocilizumab on haematological markers implicates interleukin-6 signalling in the anaemia of rheumatoid arthritis
Q46467386Efficacy and safety of secukinumab, a fully human anti-interleukin-17A monoclonal antibody, in patients with moderate-to-severe psoriatic arthritis: a 24-week, randomised, double-blind, placebo-controlled, phase II proof-of-concept trial
Q60061986Efficacy of a single ultrasound-guided injection for the treatment of hip osteoarthritis
Q56420714Elucidation of the relationship between synovitis and bone damage: A randomized magnetic resonance imaging study of individual joints in patients with early rheumatoid arthritis
Q38188862Emerging immunotherapies for rheumatoid arthritis.
Q45370040Epstein-Barr virus-driven lymphoproliferative disorder post-CAMPATH-1H (alemtuzumab) in refractory polymyositis
Q35654020Evaluation of the effect of tofacitinib on measured glomerular filtration rate in patients with active rheumatoid arthritis: results from a randomised controlled trial
Q50980583Evidence of NLRP3-inflammasome activation in rheumatoid arthritis (RA); genetic variants within the NLRP3-inflammasome complex in relation to susceptibility to RA and response to anti-TNF treatment.
Q47784149Fc gamma receptors are critical modulators of inflammation within the synovium: comment on the article by Blom et al.
Q73092745Fcgamma receptor type IIIA is associated with rheumatoid arthritis in two distinct ethnic groups
Q34123499FcγRIIIa expression on monocytes in rheumatoid arthritis: role in immune-complex stimulated TNF production and non-response to methotrexate therapy
Q47666819Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: cross-sectional findings from the Newcastle 85+ Study.
Q41180997Generation and characterisation of therapeutic tolerogenic dendritic cells for rheumatoid arthritis.
Q34134975Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients
Q28489093Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis
Q24628710Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls
Q34886162Genome-wide association study of genetic predictors of anti-tumor necrosis factor treatment efficacy in rheumatoid arthritis identifies associations with polymorphisms at seven loci
Q60061980Genotyping in rheumatoid arthritis: a game changer in clinical management?
Q37604498High frequency of antidrug antibodies and association of random drug levels with efficacy in certolizumab pegol-treated patients with rheumatoid arthritis: results from the BRAGGSS cohort
Q59042851High-dose cyclophosphamide with stem cell rescue for severe rheumatoid arthritis: Short-term efficacy correlates with reduction of macroscopic and histologic synovitis
Q34518941Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells.
Q60062009Humanised monoclonal antibody therapy for rheumatoid arthritis
Q36577401IL-6-driven STAT signalling in circulating CD4+ lymphocytes is a marker for early anticitrullinated peptide antibody-negative rheumatoid arthritis
Q37518302Immune reconstitution 20 years after treatment with alemtuzumab in a rheumatoid arthritis cohort: implications for lymphocyte depleting therapies
Q50960730Immunity 12 years after alemtuzumab in RA: CD5⁺ B-cell depletion, thymus-dependent T-cell reconstitution and normal vaccine responses.
Q35881647Immunotherapy of rheumatoid arthritis.
Q35102134Impact of inadequate adherence on response to subcutaneously administered anti-tumour necrosis factor drugs: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort
Q34130318Impact of psychological factors on subjective disease activity assessments in patients with severe rheumatoid arthritis
Q95833967In search of pathobiological endotypes: a systems approach to early rheumatoid arthritis
Q35311054Incidence of corneal melting in association with systemic disease in the Yorkshire Region, 1995-7
Q41994013Inhibition of macropinocytosis blocks antigen presentation of type II collagen in vitro and in vivo in HLA-DR1 transgenic mice.
Q35840716Integrated safety in tocilizumab clinical trials
Q36439978Investigating CD11c expression as a potential genomic biomarker of response to TNF inhibitor biologics in whole blood rheumatoid arthritis samples
Q51785508Investigation of genetic variants within candidate genes of the TNFRSF1B signalling pathway on the response to anti-TNF agents in a UK cohort of rheumatoid arthritis patients.
Q24310184Investigation of rheumatoid arthritis susceptibility genes identifies association of AFF3 and CD226 variants with response to anti-tumour necrosis factor treatment
Q42110748LPS activation is required for migratory activity and antigen presentation by tolerogenic dendritic cells.
Q96016711Latent class trajectory modelling of 2-components-DAS28 identifies multiple rheumatoid arthritis phenotypes of response to biologic disease modifying anti-rheumatic drugs
Q60061976Lessons learnt from a discontinued randomised controlled trial: adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica (Subcutaneous Injection of Adalimumab Trial compared with Control: SCIATiC)
Q48171918Let's not fool ourselves. In RA, the ACR/EULAR remission criteria are not perfect!
Q60062002Local bioactive tumour necrosis factor (TNF) in corneal allotransplantation
Q60062007Long-term remission of intractable systemic vasculitis with monoclonal antibody therapy
Q38617064Lost in space: design of experiments and scientific exploration in a Hogarth Universe
Q39338146Low-strength T-cell activation promotes Th17 responses.
Q60061998Management of rheumatoid arthritis in primary care—an educational need?
Q38991972Mechanism of action of methotrexate in rheumatoid arthritis, and the search for biomarkers.
Q39775657Mechanism of first-dose cytokine-release syndrome by CAMPATH 1-H: involvement of CD16 (FcgammaRIII) and CD11a/CD18 (LFA-1) on NK cells
Q60062010Mesangial IgA Disease with Crescent Formation During Pregnancy: Postpartum Treatment with Immunosuppression
Q49403463Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization
Q28596281Minimum information about tolerogenic antigen-presenting cells (MITAP): a first step towards reproducibility and standardisation of cellular therapies
Q39713867Monoclonal antibody therapy of chronic intraocular inflammation using Campath-1H.
Q37073761Morbidity and mortality in rheumatoid arthritis patients with prolonged therapy-induced lymphopenia: twelve-year outcomes
Q47343514Neutralizing tumor necrosis factor activity leads to remission in patients with refractory noninfectious posterior uveitis
Q38126008Novel immunotherapies for rheumatoid arthritis.
Q53131122Novel therapies for immune-mediated inflammatory diseases: What can we learn from their use in rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus, psoriasis, Crohn's disease and ulcerative colitis?
Q35552816Overexpression of transcripts containing LINE-1 in the synovia of patients with rheumatoid arthritis.
Q37856146Pathophysiology of rheumatoid arthritis
Q40407272Patient and researcher perspectives on facilitating patient and public involvement in rheumatology research
Q101124613Pharmacogenetics of TNF inhibitor response in rheumatoid arthritis utilizing the two-component disease activity score
Q55344794Phenotypic and Transcriptomic Analysis of Peripheral Blood Plasmacytoid and Conventional Dendritic Cells in Early Drug Naïve Rheumatoid Arthritis.
Q53335115Polymorphisms spanning the TNFR2 and TACE genes do not contribute towards variable anti-TNF treatment response.
Q37690108Predicting persistent inflammatory arthritis amongst early arthritis clinic patients in the UK: is musculoskeletal ultrasound required?
Q37067150Pregnancy Outcomes in the Tofacitinib Safety Databases for Rheumatoid Arthritis and Psoriasis.
Q60061987Prevalence and diagnostic outcome relating to vitamin D deficiency in new patients presenting to an early arthritis clinic over 12 months
Q60062005Prevention of immune-mediated corneal graft destruction with the anti-lymphocyte monoclonal antibody, CAMPATH-1H
Q37200651Previously reported PDE3A-SLCO1C1 genetic variant does not correlate with anti-TNF response in a large UK rheumatoid arthritis cohort
Q43696497Profound invariant natural killer T-cell deficiency in inflammatory arthritis.
Q47748916Progression-seeking bias and rational optimism in research and development
Q40565049Prospective study of anti-tumour necrosis factor receptor superfamily 1B fusion protein, and case study of anti-tumour necrosis factor receptor superfamily 1A fusion protein, in tumour necrosis factor receptor associated periodic syndrome (TRAPS): c
Q27318199Prospects for therapeutic tolerance in humans
Q38261841R&D productivity rides again?
Q35998928RITPBC: B-cell depleting therapy (rituximab) as a treatment for fatigue in primary biliary cirrhosis: study protocol for a randomised controlled trial
Q21256663Real-time PCR based on SYBR-Green I fluorescence: an alternative to the TaqMan assay for a relative quantification of gene rearrangements, gene amplifications and micro gene deletions
Q37471303Regulatory T cells and autoimmunity
Q36189976Replication of association of the PTPRC gene with response to anti-tumor necrosis factor therapy in a large UK cohort
Q60061981Retrospective analysis of the role of serum vitamin D in early rheumatic disease
Q35544546Rheumatoid arthritis response to treatment across IgG1 allotype - anti-TNF incompatibility: a case-only study
Q36839197Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy
Q36011107Rheumatoid arthritis synovial T cells regulate transcription of several genes associated with antigen-induced anergy
Q38373629Rheumatoid arthritis: an evolutionary force in biologics
Q39084894Rheumatoid arthritis: from palliation to remission in two decades
Q60061985Rheumatology Conference Highlights
Q112291812Robust optimization of SWATH-MS workflow for human blood serum proteome analysis using a quality by design approach
Q39998781Safety, tolerability, pharmacokinetics, pharmacodynamics and efficacy of the monoclonal antibody ASK8007 blocking osteopontin in patients with rheumatoid arthritis: a randomised, placebo controlled, proof-of-concept study.
Q38284201Seronegative rheumatoid arthritis: pathogenetic and therapeutic aspects.
Q60061988Serotyping for an extended anti-citrullinated peptide autoantibody panel does not add value to CCP2 testing for diagnosing RA in an early undifferentiated arthritis cohort
Q96302073Smart battles: immunosuppression versus immunomodulation in the inflammatory RMDs
Q35859428Stem cell transplantation for autoimmune disorders. Immune reconstitution
Q47235759Subcutaneous Injection of Adalimumab Trial compared with Control (SCIATiC): a randomised controlled trial of adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica.
Q40891825Synovial CD4+ T-cell-derived GM-CSF supports the differentiation of an inflammatory dendritic cell population in rheumatoid arthritis.
Q39431367Synovial tissue research: a state-of-the-art review
Q59041025Synovial tissue research: a state-of-the-art review
Q36870412T cell immunomodulation--the Holy Grail of therapeutic tolerance
Q41856587T cell responses to a non-glycosylated epitope predominate in type II collagen-immunised HLA-DRB1*0101 transgenic mice
Q40095092Targeting of tolerogenic dendritic cells towards heat shock proteins: a novel therapeutic strategy for autoimmune diseases?
Q40331977Teaching examples for the design of experiments: geographical sensitivity and the self-fulfilling prophecy
Q50467012Testing the role of vitamin D in response to antitumour necrosis factor α therapy in a UK cohort: a Mendelian randomisation approach.
Q60061983The 2013 BSR and BHPR guideline for the use of intravenous tocilizumab in the treatment of adult patients with rheumatoid arthritis
Q52839665The 2013 BSR and BHPR guideline for the use of intravenous tocilizumab in the treatment of adult patients with rheumatoid arthritis.
Q34042702The Darwin Awards: sex differences in idiotic behaviour
Q47355032The RA-MAP Consortium: a working model for academia-industry collaboration.
Q44508845The changing face of rheumatoid arthritis: sustained remission for all?
Q60061995The clinical utility of a rule for predicting rheumatoid arthritis in patients with early undifferentiated arthritis: Comment on the article by van der Helm-van Mil et al
Q46919820The impact of glycosylation on HLA-DR1-restricted T cell recognition of type II collagen in a mouse model.
Q47427257The interferon gene signature is increased in patients with early treatment-naive rheumatoid arthritis and predicts a poorer response to initial therapy.
Q57753442The need for personalised medicine for rheumatoid arthritis
Q33731299The predictive value of serum S100A9 and response to etanercept is not confirmed in a large UK rheumatoid arthritis cohort
Q56420835The relationship between pityriasis rubra pilaris and inflammatory arthritis: Case report and response of the arthritis to anti-tumor necrosis factor immunotherapy
Q38068691The role of biosimilars in the treatment of rheumatic diseases
Q52851165The value of synovial cytokine expression in predicting the clinical response to TNF antagonist therapy (infliximab).
Q37173126Therapeutic T-cell manipulation in rheumatoid arthritis: past, present and future.
Q37633537Therapeutic agents for patients with rheumatoid arthritis and an inadequate response to tumour necrosis factor-alpha antagonists
Q60061990Therapeutic effect of tolerogenic dendritic cells in established collagen-induced arthritis is associated with a reduction in Th17 responses
Q60061996Thymic function and immune senescence in juvenile idiopathic arthritis: Comment on the article by Prelog et al
Q60061984Tofacitinib in Combination With Nonbiologic Disease-Modifying Antirheumatic Drugs in Patients With Active Rheumatoid Arthritis
Q34338355Tolerogenic dendritic cell therapy for rheumatoid arthritis: where are we now?
Q38800903Tolerogenic dendritic cells generated with dexamethasone and vitamin D3 regulate rheumatoid arthritis CD4+ T cells partly via transforming growth factor-β1.
Q38674722Traceless Cleavage of Protein-Biotin Conjugates under Biologically Compatible Conditions
Q49151897Transient increase in symptoms associated with cytokine release in patients with multiple sclerosis
Q60061991Translating cutting edge science into novel and effective therapies
Q37781916Treating to re-establish tolerance in inflammatory arthritis - lessons from other diseases
Q30494071Treatment of stiff person syndrome with rituximab.
Q38124277Treg cells in rheumatoid arthritis: an update
Q60061992Tumour necrosis factor alpha blockade impairs dendritic cell survival and function in rheumatoid arthritis
Q38975794Unique TCR beta-subunit variable gene haplotypes in Africans
Q41535327What can rheumatologists learn from translational cancer therapy?
Q60061982Why is it hard to terminate failing projects in pharmaceutical R&D?
Q37588725Will treatment of rheumatoid arthritis with an IL-6R inhibitor help facilitate the 'age of remission'?

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