Generation and in vivo evaluation of IL10-treated dendritic cells in a nonhuman primate model of AAV-based gene transfer

scientific article published on 23 July 2014

Generation and in vivo evaluation of IL10-treated dendritic cells in a nonhuman primate model of AAV-based gene transfer is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/MTM.2014.28
P932PMC publication ID4420248
P698PubMed publication ID26015970
P5875ResearchGate publication ID264397751

P50authorOumeya AdjaliQ115599895
Nicolas JaulinQ57387022
P2093author name stringJack-Yves Deschamps
Ignacio Anegon
Philippe Moullier
Gaëlle Tilly
Yan Cherel
Aurélie Moreau
Céline Vandamme
Mercedes Segovia
Maria Cristina Cuturi
Marie Devaux
Mickaël Guilbaud
Johanne Le Duff
P2860cites workTolerogenic dendritic cells and negative vaccination in transplantation: from rodents to clinical trialsQ21131223
Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathwayQ24310325
Transduction of dendritic cells by DNA viral vectors directs the immune response to transgene products in muscle fibersQ33782809
Regulatory dendritic cell infusion prolongs kidney allograft survival in nonhuman primatesQ33804736
AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B.Q34168942
Phase I (safety) study of autologous tolerogenic dendritic cells in type 1 diabetic patients.Q34193317
Sustained alpha-sarcoglycan gene expression after gene transfer in limb-girdle muscular dystrophy, type 2D.Q34266296
Efficacy and long-term safety of alipogene tiparvovec (AAV1-LPLS447X) gene therapy for lipoprotein lipase deficiency: an open-label trialQ34311144
Tolerogenic dendritic cell therapy for rheumatoid arthritis: where are we now?Q34338355
MyD88 signaling in B cells regulates the production of Th1-dependent antibodies to AAVQ36142477
Control of erythropoietin delivery by doxycycline in mice after intramuscular injection of adeno-associated vectorQ77145715
Migration of human dendritic cells after injection in patients with metastatic malignanciesQ77804763
Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant toleranceQ80358513
Donor-specific allograft tolerance by administration of recipient-derived immature dendritic cells and suboptimal immunosuppressionQ81681979
Tolerogenic dendritic cells actively inhibit T cells through heme oxygenase-1 in rodents and in nonhuman primatesQ83779548
Sensitization or tolerance to Mycobacterium leprae antigen by route of injection.Q36337864
Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cellsQ36369028
Safety and efficacy of factor IX gene transfer to skeletal muscle in murine and canine hemophilia B models by adeno-associated viral vector serotype 1.Q36438711
Deficiency in MyD88 Signaling Results in Decreased Antibody Responses to an Adeno-Associated Virus Vector in Murine Pompe DiseaseQ36574550
Tolerogenic dendritic cells and the quest for transplant toleranceQ36879029
Immune responses to AAV vectors: overcoming barriers to successful gene therapyQ36983740
Tolerogenic Donor-Derived Dendritic Cells Risk Sensitization In Vivo owing to Processing and Presentation by Recipient APCs.Q37077325
Protection of islet grafts through transforming growth factor-β-induced tolerogenic dendritic cells.Q37110557
The TLR9-MyD88 pathway is critical for adaptive immune responses to adeno-associated virus gene therapy vectors in miceQ37286686
Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapyQ37364038
Human Treg responses allow sustained recombinant adeno-associated virus-mediated transgene expressionQ37384103
Involvement of suppressive B-lymphocytes in the mechanism of tolerogenic dendritic cell reversal of type 1 diabetes in NOD miceQ37490637
Human tolerogenic DC-10: perspectives for clinical applications.Q38078109
Tolerogenic dendritic cells as a therapy for treating lupusQ38115047
Influence of parenteral administration routes and additional factors on vaccine safety and immunogenicity: a review of recent literature.Q38186768
Lack of immunotoxicity after regional intravenous (RI) delivery of rAAV to nonhuman primate skeletal muscleQ39639059
Lack of an immune response against the tetracycline-dependent transactivator correlates with long-term doxycycline-regulated transgene expression in nonhuman primates after intramuscular injection of recombinant adeno-associated virusQ39685864
Superiority of bone marrow-derived dendritic cells over monocyte-derived ones for the expansion of regulatory T cells in the macaqueQ40092510
Generation and characterisation of therapeutic tolerogenic dendritic cells for rheumatoid arthritis.Q41180997
Comparative study of clinical grade human tolerogenic dendritic cellsQ42836981
Cell therapy with autologous tolerogenic dendritic cells induces allograft tolerance through interferon-gamma and epstein-barr virus-induced gene 3.Q43544645
Long-term pharmacologically regulated expression of erythropoietin in primates following AAV-mediated gene transfer.Q43727676
Immediate and long-term safety of recombinant adeno-associated virus injection into the nonhuman primate muscleQ44474527
Antigen-bearing immature dendritic cells induce peptide-specific CD8(+) regulatory T cells in vivo in humansQ45221904
A phase I trial of adeno-associated virus serotype 1-γ-sarcoglycan gene therapy for limb girdle muscular dystrophy type 2C.Q45360452
Adeno-associated virus capsid structure drives CD4-dependent CD8+ T cell response to vector encoded proteinsQ45384856
Phase I trial of intramuscular injection of a recombinant adeno-associated virus serotype 2 alphal-antitrypsin (AAT) vector in AAT-deficient adultsQ45409947
Correction of feline lipoprotein lipase deficiency with adeno-associated virus serotype 1-mediated gene transfer of the lipoprotein lipase S447X beneficial mutationQ45416450
Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vectorQ45855552
Erythropoietin gene therapy leads to autoimmune anemia in macaquesQ45871284
Autoimmune anemia in macaques following erythropoietin gene therapyQ45871935
Muscle-directed gene transfer and transient immune suppression result in sustained partial correction of canine hemophilia B caused by a null mutationQ45879591
Risk and prevention of anti-factor IX formation in AAV-mediated gene transfer in the context of a large deletion of F9.Q45879597
Major role of local immune responses in antibody formation to factor IX in AAV gene transferQ45883516
Infusion of stably immature monocyte-derived dendritic cells plus CTLA4Ig modulates alloimmune reactivity in rhesus macaques.Q50946765
Prolongation of heart allograft survival by immature dendritic cells generated from recipient type bone marrow progenitors.Q53874628
Safety and Efficacy of Regional Intravenous (RI) Versus Intramuscular (IM) Delivery of rAAV1 and rAAV8 to Nonhuman Primate Skeletal Muscle.Q54457954
Heme oxygenase-1 expression inhibits dendritic cell maturation and proinflammatory function but conserves IL-10 expressionQ56975206
Effective migration of antigen-pulsed dendritic cells to lymph nodes in melanoma patients is determined by their maturation stateQ57779701
Interleukin‐10 differentially regulates B7‐1 (CD80) and B7‐2 (CD86) expression on human peripheral blood dendritic cellsQ71815204
Mammalian and viral IL-10 enhance C-C chemokine receptor 5 but down-regulate C-C chemokine receptor 7 expression by myeloid dendritic cells: impact on chemotactic responses and in vivo homing abilityQ73966632
P921main subjectdendritic cellQ506253
P304page(s)14028
P577publication date2014-07-23
P1433published inMolecular Therapy. Methods & Clinical DevelopmentQ27725341
P1476titleGeneration and in vivo evaluation of IL10-treated dendritic cells in a nonhuman primate model of AAV-based gene transfer
P478volume1

Reverse relations

cites work (P2860)
Q91938979Five Years of Successful Inducible Transgene Expression Following Locoregional Adeno-Associated Virus Delivery in Nonhuman Primates with No Detectable Immunity
Q90529882Generation and functional assessment of nonhuman primate regulatory dendritic cells and their therapeutic efficacy in renal transplantation
Q40184422IL-21/anti-Tim1/CD40 ligand promotes B10 activity in vitro and alleviates bone loss in experimental periodontitis in vivo
Q26752803Production and clinical development of nanoparticles for gene delivery
Q52665595Tolerogenic Dendritic Cells in Solid Organ Transplantation: Where Do We Stand?
Q39013872Tolerogenic dendritic cell therapy in organ transplantation

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