LTβR and CD40: working together in dendritic cells to optimize immune responses.

scientific article

LTβR and CD40: working together in dendritic cells to optimize immune responses. is …
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scholarly articleQ13442814

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P356DOI10.1111/J.1600-065X.2011.01056.X
P698PubMed publication ID22017433

P50authorJennifer L GommermanQ56987206
P2093author name stringLeslie Summers deLuca
P2860cites workCharacterization of receptors for human tumour necrosis factor and their regulation by gamma-interferonQ24294921
TRAF3 controls activation of the canonical and alternative NFkappaB by the lymphotoxin beta receptorQ24300996
Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activityQ24301401
LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediatorQ24308657
CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cellsQ24310570
A lymphotoxin-beta-specific receptorQ24312186
A fourth IkappaB protein within the NF-kappaB signaling moduleQ24676472
Different roles for L3T4+ and Lyt 2+ T cell subsets in the control of an acute herpes simplex virus infection of the skin and nervous systemQ43977064
Targeted depletion of lymphotoxin-alpha-expressing TH1 and TH17 cells inhibits autoimmune diseaseQ44118287
Lymphotoxins and cytomegalovirus cooperatively induce interferon-beta, establishing host-virus détente.Q44130049
Cross-priming of CD8+ T cells stimulated by virus-induced type I interferonQ44860628
Type I IFNs control antigen retention and survival of CD8α(+) dendritic cells after uptake of tumor apoptotic cells leading to cross-primingQ45397464
CD8 T cells specific for lymphocytic choriomeningitis virus require type I IFN receptor for clonal expansionQ45418190
Lymphotoxin alpha-/- mice develop functionally impaired CD8+ T cell responses and fail to contain virus infection of the central nervous systemQ45739093
Reversal of virus-induced systemic shock and respiratory failure by blockade of the lymphotoxin pathwayQ45745997
Intrinsic lymphotoxin-beta receptor requirement for homeostasis of lymphoid tissue dendritic cells.Q46496003
Lymphtoxin beta receptor-Ig ameliorates TNBS-induced colitis via blocking LIGHT/HVEM signalingQ46518707
IL-21R on T cells is critical for sustained functionality and control of chronic viral infectionQ46697142
Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody productionQ46892881
Cooperation between helper T cells and cytotoxic T lymphocyte precursorsQ46908739
Sustained IL-12 signaling is required for Th1 developmentQ47305582
Lymph node genesis is induced by signaling through the lymphotoxin beta receptorQ47713223
The lymphotoxin beta receptor controls organogenesis and affinity maturation in peripheral lymphoid tissuesQ47713235
Systemic administration of antigen-loaded CD40-deficient dendritic cells mimics soluble antigen administrationQ47867764
Blocking lymphotoxin-beta receptor activation diminishes inflammation via reduced mucosal addressin cell adhesion molecule-1 (MAdCAM-1) expression and leucocyte margination in chronic DSS-induced colitisQ47927327
The lymphotoxin beta receptor is critically involved in controlling infections with the intracellular pathogens Mycobacterium tuberculosis and Listeria monocytogenesQ47929660
T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactionsQ47982736
Help for cytotoxic-T-cell responses is mediated by CD40 signallingQ47982749
A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cellQ47982760
Monocyte-derived IL12, CD86 (B7-2) and CD40L expression in relapsing and progressive multiple sclerosisQ47997496
Both the lymphotoxin and tumor necrosis factor pathways are involved in experimental murine models of colitisQ48709458
Lymphotoxin-alpha-deficient mice make delayed, but effective, T and B cell responses to influenza.Q51700316
CD40 on APCs is needed for optimal programming, maintenance, and recall of CD8+ T cell memory even in the absence of CD4+ T cell help.Q51966220
Innate inflammatory signals induced by various pathogens differentially dictate the IFN-I dependence of CD8 T cells for clonal expansion and memory formation.Q51980899
Contrasting the roles of costimulation and the natural adjuvant lipopolysaccharide during the induction of T cell immunity.Q52013235
Affinity maturation without germinal centres in lymphotoxin-alpha-deficient mice.Q52047087
Gene expression profiling of minor salivary glands clearly distinguishes primary Sjögren's syndrome patients from healthy control subjects.Q54664601
Lymphocyte Cytotoxicity in vitro: Activation and Release of a Cytotoxic FactorQ59095839
Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activationQ24677534
Coordination between NF-kappaB family members p50 and p52 is essential for mediating LTbetaR signals in the development and organization of secondary lymphoid tissuesQ24685416
Dendritic cells and the control of immunityQ27860918
Expression of the lymphotoxin beta receptor on follicular stromal cells in human lymphoid tissuesQ28141400
Molecular and biological characterization of a murine ligand for CD40Q28186605
A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cellsQ28187669
Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosisQ28207830
Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathwayQ28214369
Tumor necrosis factor receptor-associated factor 2 (TRAF2)-deficient B lymphocytes reveal novel roles for TRAF2 in CD40 signalingQ28511980
Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activationQ28584897
Distinct roles in lymphoid organogenesis for lymphotoxins alpha and beta revealed in lymphotoxin beta-deficient miceQ28587819
In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigensQ29615098
Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophagesQ29618421
Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient miceQ29618716
TRAF2 plays a key, nonredundant role in LIGHT-lymphotoxin beta receptor signalingQ33707599
Regulation of the IL-12/IL-12R axis: a critical step in T-helper cell differentiation and effector functionQ33776116
Lymphotoxin-alpha-deficient mice can clear a productive infection with murine gammaherpesvirus 68 but fail to develop splenomegaly or lymphocytosisQ33800151
TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-kappaB pathway by TRAF-binding TNFRsQ33864629
Allosteric regulation of the ubiquitin:NIK and ubiquitin:TRAF3 E3 ligases by the lymphotoxin-beta receptorQ33883378
Dendritic cells are sufficient to cross-present self-antigens to CD8 T cells in vivoQ33931653
Inflammatory cytokines as a third signal for T cell activationQ33936084
Gene regulation and chromatin remodeling by IL-12 and type I IFN in programming for CD8 T cell effector function and memoryQ33946269
Lymphotoxin beta receptor induces sequential activation of distinct NF-kappa B factors via separate signaling pathwaysQ34173731
Requirement for CD4 T Cell Help in Generating Functional CD8 T Cell MemoryQ34190038
Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxinQ34258651
Role of lymphotoxin alpha in T-cell responses during an acute viral infection.Q34336955
Compromised influenza virus-specific CD8(+)-T-cell memory in CD4(+)-T-cell-deficient miceQ34359535
Impairment of antigen-specific T-cell priming in mice lacking CD40 ligandQ34367466
LTβR signaling in dendritic cells induces a type I IFN response that is required for optimal clonal expansion of CD8+ T cellsQ34549822
Effector and memory CTL differentiationQ34584974
Blockade of LIGHT/LTbeta and CD40 signaling induces allospecific T cell anergy, preventing graft-versus-host diseaseQ34788330
Lymphotoxin/light, lymphoid microenvironments and autoimmune diseaseQ35219029
A role for surface lymphotoxin in experimental autoimmune encephalomyelitis independent of LIGHT.Q35679191
CD40/CD154 interactions at the interface of tolerance and immunityQ35698455
Effector T-cell differentiation during viral and bacterial infections: Role of direct IL-12 signals for cell fate decision of CD8(+) T cellsQ39834545
A novel mechanism for TNFR-associated factor 6-dependent CD40 signalingQ40078976
CD8 T Cell Clonal Expansion and Development of Effector Function Require Prolonged Exposure to Antigen, Costimulation, and Signal 3 CytokineQ40618314
Inhibition of phosphatidylinositol 3-kinase- and ERK MAPK-regulated protein synthesis reveals the pro-apoptotic properties of CD40 ligation in carcinoma cellsQ40622324
CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytesQ40669542
The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathwaysQ40696432
Interleukin-12 and its role in the generation of TH1 cellsQ40712406
CD40-mediated activation of NF-kappa B in airway epithelial cellsQ40717817
The TNF superfamily members LIGHT and CD154 (CD40 ligand) costimulate induction of dendritic cell maturation and elicit specific CTL activityQ40785578
High-affinity interactions of tumor necrosis factor receptor-associated factors (TRAFs) and CD40 require TRAF trimerization and CD40 multimerizationQ40937646
Rapid induction of a novel costimulatory activity on B cells by CD40 ligand.Q41275876
Functions of CD40 on B cells, dendritic cells and other cellsQ41514641
Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cellsQ41564337
Lymphotoxin-beta-deficient mice show defective antiviral immunity.Q41679119
Expression of lymphotoxin-alphabeta on antigen-specific T cells is required for DC functionQ41905092
CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerizationQ42060069
A vital role for interleukin-21 in the control of a chronic viral infectionQ42541944
Defective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell HelpQ42642562
CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signalQ42834238
Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signalingQ43142702
A lymphotoxin-IFN-beta axis essential for lymphocyte survival revealed during cytomegalovirus infectionQ43511891
Elimination of colonic patches with lymphotoxin beta receptor-Ig prevents Th2 cell-type colitisQ43710164
A fail-safe mechanism for maintaining self-toleranceQ36231679
Cytotoxicity mediated by soluble antigen and lymphocytes in delayed hypersensitivity. I. Characterization of the phenomenonQ36269434
Cooperation between cytotoxic and helper T lymphocytes in protection against lethal Sendai virus infection. Protection by T cells is MHC-restricted and MHC-regulated; a model for MHC-disease associationsQ36352807
High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10.Q36367196
Progressive loss of CD8+ T cell-mediated control of a gamma-herpesvirus in the absence of CD4+ T cellsQ36367286
Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo.Q36367475
CD4+ but not CD8+ cells are essential for allorejectionQ36367566
The formation of immunogenic major histocompatibility complex class II-peptide ligands in lysosomal compartments of dendritic cells is regulated by inflammatory stimuliQ36368355
Reversal of spontaneous autoimmune insulitis in nonobese diabetic mice by soluble lymphotoxin receptorQ36369174
Uncoupling of proliferative potential and gain of effector function by CD8(+) T cells responding to self-antigens.Q36370873
Signal 3 determines tolerance versus full activation of naive CD8 T cells: dissociating proliferation and development of effector functionQ36370978
Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell toleranceQ36376611
Induction of a CD8+ cytotoxic T lymphocyte response by cross-priming requires cognate CD4+ T cell helpQ36380318
TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factorQ36380989
Combined TLR and CD40 triggering induces potent CD8+ T cell expansion with variable dependence on type I IFNQ36402326
Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infectionQ36402851
Requirement for TRAF3 in signaling by LMP1 but not CD40 in B lymphocytesQ36403897
Prospect of targeting the CD40 pathway for cancer therapyQ36743436
TRAF3 and its biological functionQ36882586
TRAF proteins in CD40 signalingQ36882612
Targeting lymphocyte activation through the lymphotoxin and LIGHT pathwaysQ37036159
Programming for CD8 T cell memory development requires IL-12 or type I IFNQ37110371
Blockade of lymphotoxin-beta receptor signaling reduces aspects of Sjögren's syndrome in salivary glands of non-obese diabetic miceQ37207114
The role of positive costimulatory molecules in transplantation and toleranceQ37236949
Lymphotoxin-mediated crosstalk between B cells and splenic stroma promotes the initial type I interferon response to cytomegalovirusQ37243919
The inhibitory HVEM-BTLA pathway counter regulates lymphotoxin receptor signaling to achieve homeostasis of dendritic cellsQ37262669
ICOS, CD40, and lymphotoxin beta receptors signal sequentially and interdependently to initiate a germinal center reactionQ37326558
Secondary lymphoid organs: responding to genetic and environmental cues in ontogeny and the immune responseQ37397090
The CD160, BTLA, LIGHT/HVEM pathway: a bidirectional switch regulating T-cell activationQ37474948
The role of CD40 and CD154/CD40L in dendritic cellsQ37518524
Targeted disruption of LIGHT causes defects in costimulatory T cell activation and reveals cooperation with lymphotoxin beta in mesenteric lymph node genesisQ38288045
IFN-alpha beta promote priming of antigen-specific CD8+ and CD4+ T lymphocytes by immunostimulatory DNA-based vaccinesQ38289507
Upregulation of TRAF-3 by shear stress blocks CD40-mediated endothelial activationQ38294592
IL-21 is required to control chronic viral infectionQ39328817
P433issue1
P921main subjectdendritic cellQ506253
P304page(s)85-98
P577publication date2011-11-01
P1433published inImmunological ReviewsQ15724582
P1476titleLTβR and CD40: working together in dendritic cells to optimize immune responses
P478volume244

Reverse relations

cites work (P2860)
Q21133637Acetylcorynoline impairs the maturation of mouse bone marrow-derived dendritic cells via suppression of IκB kinase and mitogen-activated protein kinase activities
Q34488528CD40-mediated amplification of local immunity by epithelial cells is impaired by HPV.
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Q39193752Dendritic Cell KLF2 Expression Regulates T Cell Activation and Proatherogenic Immune Responses
Q54353561Dryocrassin suppresses immunostimulatory function of dendritic cells and prolongs skin allograft survival.
Q37138965Immunotherapeutic targeting of LIGHT/LTβR/HVEM pathway fully recapitulates the reduced cytotoxic phenotype of LIGHT-deficient T cells
Q38874554Involvement of the cytoplasmic cysteine-238 of CD40 in its up-regulation of CD23 expression and its enhancement of TLR4-triggered responses
Q83409279Lymphotoxin and the amazing technicolor circus of intestinal homeostasis
Q38113962Regulation of PI-3-Kinase and Akt Signaling in T Lymphocytes and Other Cells by TNFR Family Molecules
Q37576573Role of the Lymphotoxin/LIGHT System in the Development and Maintenance of Reticular Networks and Vasculature in Lymphoid Tissues
Q89168207Safety testing of monoclonal antibodies in non-human primates: Case studies highlighting their impact on human risk assessment
Q38746598T Cell Cancer Therapy Requires CD40-CD40L Activation of Tumor Necrosis Factor and Inducible Nitric-Oxide-Synthase-Producing Dendritic Cells
Q38129083The contextual role of TNFR family members in CD8(+) T-cell control of viral infections

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