The Role of Osteoprotegerin and Its Ligands in Vascular Function

journal article from 'International Journal of Molecular Sciences' published in 2019

The Role of Osteoprotegerin and Its Ligands in Vascular Function is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.3390/IJMS20030705
P953full work available at URLhttps://www.mdpi.com/1422-0067/20/3/705
P932PMC publication ID6387017
P698PubMed publication ID30736365

P50authorYves CottinQ57304161
P2093author name stringYves Cottin
Catherine Vergely
Eve Rigal
Marianne Zeller
Luc Rochette
Alexandre Meloux
P2860cites workOsteoprotegerin: a novel secreted protein involved in the regulation of bone densityQ24313918
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Osteoprotegerin Is an αvβ3-induced, NF-κB-dependent Survival Factor for Endothelial CellsQ56964366
Osteoprotegerin increases leukocyte adhesion to endothelial cells both in vitro and in vivoQ59225172
Exosomes secreted by endothelial progenitor cells accelerate bone regeneration during distraction osteogenesis by stimulating angiogenesisQ60912265
The Interplay of SIRT1 and Wnt Signaling in Vascular CalcificationQ60949633
Smoking and FOS expression from blood leukocyte transcripts in patients with coronary artery diseaseQ61849091
Role of alphav integrin in osteoprotegerin-induced endothelial cell migration and proliferationQ64126438
PDGF induces osteoprotegerin expression in vascular smooth muscle cells by multiple signal pathwaysQ74308465
Activation of the cardiac proteasome during pressure overload promotes ventricular hypertrophyQ79249946
Osteoprotegerin expression in dendritic cells increases with maturation and is NF-kappaB-dependentQ79435466
Osteoprotegerin inactivation accelerates advanced atherosclerotic lesion progression and calcification in older ApoE-/- miceQ79903873
Dysregulated osteoprotegerin/RANK ligand/RANK axis in clinical and experimental heart failureQ81730161
Low concentrations of phospholipids and plasma HDL cholesterol subclasses in asymptomatic subjects with high coronary calcium scoresQ86364990
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CD73 as a potential opportunity for cancer immunotherapyQ90580312
TLR2 Promotes Vascular Smooth Muscle Cell Chondrogenic Differentiation and Consequent Calcification via the Concerted Actions of Osteoprotegerin Suppression and IL-6-Mediated RANKL InductionQ90967417
Osteoblasts Regulate Angiogenesis in Response to Mechanical UnloadingQ93345668
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Osteoprotegerin Is a New Regulator of Inflammation and Angiogenesis in Proliferative Diabetic RetinopathyQ50203941
Lung pericyte-like cells are functional interstitial immune sentinel cells.Q51141682
Functional dissection of osteoprotegerin and its interaction with receptor activator of NF-kappaB ligand.Q52661548
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Plasma osteoprotegerin, its correlates, and risk of heart failure: a prospective cohort studyQ30314414
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OPG/RANKL/RANK axis is a critical inflammatory signaling system in ischemic brain in miceQ33730470
A systems biology strategy for predicting similarities and differences of drug effects: evidence for drug-specific modulation of inflammation in atherosclerosisQ33991958
Biology of the RANKL-RANK-OPG System in Immunity, Bone, and BeyondQ34366449
Cardiac endothelial-myocardial signaling: its role in cardiac growth, contractile performance, and rhythmicityQ35035923
A variant in the osteoprotegerin gene is associated with coronary atherosclerosis in patients with rheumatoid arthritis: results from a candidate gene studyQ35139150
Endothelial cell metabolism in normal and diseased vasculatureQ35234625
Osteoprotegerin, pericytes and bone-like vascular calcification are associated with carotid plaque stabilityQ35279609
Fatty acid carbon is essential for dNTP synthesis in endothelial cellsQ35548351
Losartan increases bone mass and accelerates chondrocyte hypertrophy in developing skeletonQ35588952
Osteoprotegerin upregulates endothelial cell adhesion molecule response to tumor necrosis factor-alpha associated with induction of angiopoietin-2.Q36248821
Osteoprotegerin mediates tumor-promoting effects of Interleukin-1beta in breast cancer cellsQ36265801
Human pericytes for ischemic heart repairQ36609495
Immunology of Osteoporosis: A Mini-ReviewQ36766801
Design of a RANK-Mimetic Peptide Inhibitor of Osteoclastogenesis with Enhanced RANKL-Binding AffinityQ36835372
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Energy metabolism in heart failure and remodellingQ37090565
GDF11 decreases bone mass by stimulating osteoclastogenesis and inhibiting osteoblast differentiationQ37282297
The ubiquitin-proteasome pathway and endothelial (dys)functionQ37600516
TLR2 elicits IL-17-mediated RANKL expression, IL-17, and OPG production in neutrophils from arthritic miceQ37686619
Capillary endothelial fatty acid binding proteins 4 and 5 play a critical role in fatty acid uptake in heart and skeletal muscle.Q37691786
The regulatory role of nitric oxide in proinflammatory cytokine expression during the induction and resolution of inflammationQ37784328
Molecular mechanisms of triggering, amplifying and targeting RANK signaling in osteoclastsQ38074961
Vascular calcification: an update on mechanisms and challenges in treatmentQ38086058
Nitric oxide synthase inhibition and oxidative stress in cardiovascular diseases: possible therapeutic targets?Q38122012
Cardiac metabolism and its interactions with contraction, growth, and survival of cardiomyocytesQ38129182
Diabetes, oxidative stress and therapeutic strategiesQ38218198
Heparan sulphate as a regulator of leukocyte recruitment in inflammation.Q38360333
Tumor Necrosis Factor Related Apoptosis Inducing Ligand (Trail) in endothelial response to biomechanical and biochemical stresses in arteriesQ38479846
Growth and differentiation factor 11 (GDF11): Functions in the regulation of erythropoiesis and cardiac regenerationQ38622247
Shear stress inhibits IL-17A-mediated induction of osteoclastogenesis via osteocyte pathwaysQ38707465
Exogenous GDF11 induces cardiac and skeletal muscle dysfunction and wasting.Q38710240
The beneficial pleiotropic effects of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) within the vasculature: A review of the evidenceQ38734032
The A3 adenosine receptor (A3AR): therapeutic target and predictive biological marker in rheumatoid arthritisQ38737178
Association Between Vascular Cell Adhesion Molecule 1 and Atrial FibrillationQ38738095
Vascular calcification in type-2 diabetes and cardiovascular disease: Integrative roles for OPG, RANKL and TRAIL.Q38754124
Distinct roles of TNF-related apoptosis-inducing ligand (TRAIL) in viral and bacterial infections: from pathogenesis to pathogen clearanceQ38760809
Binding Studies of TNF Receptor Superfamily (TNFRSF) Receptors on Intact CellsQ38771001
Identification of novel therapeutic targets in the secretome of ionizing radiation‑induced senescent tumor cellsQ38807943
Endothelial Mechanosignaling: Does One Sensor Fit All?Q38888511
Skeletal and cardiac muscle pericytes: Functions and therapeutic potentialQ38946672
Angiotensin receptor 1 blockade reduces secretion of inflammation associated cytokines from cultured human carotid atheroma and vascular cells in association with reduced extracellular signal regulated kinase expression and activationQ38947765
Mitral valve endothelial cells with osteogenic differentiation potential.Q38978261
The Link Between Angiogenesis and Endothelial MetabolismQ39043297
Vascular ageing: Underlying mechanisms and clinical implications.Q39380015
IL-1β Inhibition in Cardiovascular Complications Associated to Diabetes MellitusQ39403443
Vascular endothelial growth factor B controls endothelial fatty acid uptake.Q39727853
Cardiovascular risk assessment in osteoporotic patients using osteoprotegerin as a reliable predictive biochemical marker.Q40067017
Association between serum alkaline phosphatase and coronary artery calcification in a sample of primary cardiovascular prevention patients.Q40260672
Osteoprotegerin is Associated With Endothelial Function and Predicts Early Carotid Atherosclerosis in Patients With Coronary Artery DiseaseQ40343176
Induction of bone-type alkaline phosphatase in human vascular smooth muscle cells: roles of tumor necrosis factor-alpha and oncostatin M derived from macrophagesQ40718834
A Jak1/2 inhibitor, baricitinib, inhibits osteoclastogenesis by suppressing RANKL expression in osteoblasts in vitroQ41017658
Mitral valve endothelial cells secrete osteoprotegerin during endothelial mesenchymal transitionQ41112182
Adipose-derived stem cell-released osteoprotegerin protects cardiomyocytes from reactive oxygen species-induced cell deathQ41718620
Coupling of angiogenesis and osteogenesis by a specific vessel subtype in boneQ41881171
Energy turnover of vascular endothelial cellsQ42442529
Osteoprotegerin induces cytoskeletal reorganization and activates FAK, Src, and ERK signaling in endothelial cells.Q43120907
Mechanistic study of the proangiogenic effect of osteoprotegerinQ43938558
Molecular pathways: osteoclast-dependent and osteoclast-independent roles of the RANKL/RANK/OPG pathway in tumorigenesis and metastasisQ44486779
Vascular endothelial growth factor up-regulates expression of receptor activator of NF-kappa B (RANK) in endothelial cells. Concomitant increase of angiogenic responses to RANK ligandQ44534331
The relationship between oxidized LDL and other cardiovascular risk factors and subclinical CVD in different ethnic groups: the Multi-Ethnic Study of Atherosclerosis (MESA).Q44574510
NF-kappaB-dependent induction of osteoprotegerin by Porphyromonas gingivalis in endothelial cellsQ44794854
Osteoprotegerin causes apoptosis of endothelial progenitor cells by induction of oxidative stressQ44937839
RANKL increases vascular smooth muscle cell calcification through a RANK-BMP4-dependent pathwayQ46072800
Thrombospondin 1 protects pancreatic β-cells from lipotoxicity via the PERK-NRF2 pathway.Q46371926
Predictive ability of circulating osteoprotegerin as a novel biomarker for early detection of acute kidney injury induced by sepsisQ46412957
Association of osteoprotegerin with human abdominal aortic aneurysm progressionQ46531394
Human osteoblast precursors produce extracellular adenosine, which modulates their secretion of IL-6 and osteoprotegerinQ46898246
Oxidized low density lipoprotein increases RANKL level in human vascular cells. Involvement of oxidative stressQ46989920
The anti-tumor effect of RANKL inhibition in malignant solid tumors - A systematic review.Q47386961
Unraveling Binding Interactions between Human RANKL and Its Decoy Receptor OsteoprotegerinQ47636814
Fibroblast growth factor 21 attenuates calcification of vascular smooth muscle cells in vitro.Q47694388
The role of osteoprotegerin in the crosstalk between vessels and bone: Its potential utility as a marker of cardiometabolic diseasesQ47862783
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
membrane proteinQ423042
circulatory systemQ11068
tissueQ40397
vascular diseaseQ1266890
cell surface receptorQ2476074
P304page(s)705
P577publication date2019-01-01
2019-02-06
P1433published inInternational Journal of Molecular SciencesQ3153277
P1476titleThe Role of Osteoprotegerin and Its Ligands in Vascular Function
P478volume20

Reverse relations

cites work (P2860)
Q92277957Comprehensive assessment of tissue and serum parameters of bone metabolism in a series of orthopaedic patients
Q99587324Osteoprotegerin SNP associations with coronary artery disease and ischemic stroke risk: a meta-analysis
Q100490869Vascular density with optical coherence tomography angiography and systemic biomarkers in low and high cardiovascular risk patients

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