| review article | Q7318358 |
| scholarly article | Q13442814 |
| P356 | DOI | 10.1038/NRENDO.2016.71 |
| P8608 | Fatcat ID | release_sqa3ntmocncdhjafveeayejdye |
| P932 | PMC publication ID | 6124897 |
| P698 | PubMed publication ID | 27230951 |
| P50 | author | Teresita M. Bellido | Q54855306 |
| Lilian Plotkin | Q54864466 | ||
| P2860 | cites work | Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST) | Q24290838 |
| Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function | Q24299076 | ||
| A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation | Q24316495 | ||
| The Wnt antagonist secreted frizzled-related protein-1 controls osteoblast and osteocyte apoptosis | Q24321476 | ||
| PLS3 mutations in X-linked osteoporosis with fractures | Q24337600 | ||
| A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait | Q24561917 | ||
| Lrp5 functions in bone to regulate bone mass | Q24615653 | ||
| Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia | Q24623628 | ||
| Effects of PTH on osteocyte function | Q24631082 | ||
| The amazing osteocyte | Q24635849 | ||
| Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist | Q24646652 | ||
| Emerging Therapies for Osteoporosis | Q26782109 | ||
| Osteocytes: master orchestrators of bone | Q27022407 | ||
| Apoptotic osteocytes and the control of targeted bone resorption | Q27023670 | ||
| Regulation of bone-renal mineral and energy metabolism: the PHEX, FGF23, DMP1, MEPE ASARM pathway | Q27026805 | ||
| Control of bone mass and remodeling by PTH receptor signaling in osteocytes | Q27300741 | ||
| High bone mass in mice expressing a mutant LRP5 gene | Q28180741 | ||
| Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity | Q28205398 | ||
| Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling | Q28240767 | ||
| The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment | Q28247505 | ||
| Matrix-embedded cells control osteoclast formation | Q28247746 | ||
| Evidence for osteocyte regulation of bone homeostasis through RANKL expression | Q28247757 | ||
| Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin | Q28261537 | ||
| Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation | Q28269067 | ||
| Role of RANKL in physiological and pathological bone resorption and therapeutics targeting the RANKL-RANK signaling system | Q28283972 | ||
| WNT signaling in bone homeostasis and disease: from human mutations to treatments | Q28285090 | ||
| Sclerostin promotes the apoptosis of human osteoblastic cells: a novel regulation of bone formation | Q28285151 | ||
| Genetic evidence of serum phosphate-independent functions of FGF-23 on bone | Q28473286 | ||
| Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation | Q28505419 | ||
| Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis | Q28507090 | ||
| Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice | Q28507303 | ||
| Cloning and expression of the mouse glomerular podoplanin homologue gp38P | Q28510877 | ||
| Cloning, characterization, and development expression of a rat lung alveolar type I cell gene in embryonic endodermal and neural derivatives | Q28567621 | ||
| Targeted disruption of the osteoblast/osteocyte factor 45 gene (OF45) results in increased bone formation and bone mass | Q28589622 | ||
| Essential role of beta-catenin in postnatal bone acquisition | Q28594492 | ||
| Transduction of cell survival signals by connexin-43 hemichannels | Q30167739 | ||
| Generation and Selection of Novel Fully Human Monoclonal Antibodies That Neutralize Dickkopf-1 (DKK1) Inhibitory Function in Vitro and Increase Bone Mass in Vivo | Q30497635 | ||
| Maternal and offspring pools of osteocalcin influence brain development and functions | Q30559531 | ||
| Osteocytes mediate the anabolic actions of canonical Wnt/β-catenin signaling in bone | Q30619950 | ||
| Isolation of a gene sequence induced later by tumor-promoting 12-O-tetradecanoylphorbol-13-acetate in mouse osteoblastic cells (MC3T3-E1) and expressed constitutively in ras-transformed cells | Q33706868 | ||
| Attachment of osteocyte cell processes to the bone matrix | Q33817347 | ||
| Osteocyte Apoptosis Caused by Hindlimb Unloading is Required to Trigger Osteocyte RANKL Production and Subsequent Resorption of Cortical and Trabecular Bone in Mice Femurs | Q33846076 | ||
| Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone | Q33857424 | ||
| Osteocyte Wnt/beta-catenin signaling is required for normal bone homeostasis | Q33877602 | ||
| Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin | Q33902085 | ||
| Enhanced osteoclastic resorption and responsiveness to mechanical load in gap junction deficient bone | Q34012735 | ||
| Inhibitors of sclerostin: emerging concepts | Q34069470 | ||
| Bone's mechanostat: A 2003 update | Q34276207 | ||
| Enhanced periosteal and endocortical responses to axial tibial compression loading in conditional connexin43 deficient mice | Q34412279 | ||
| Sclerostin antibody (Scl-Ab) improves osteomalacia phenotype in dentin matrix protein 1(Dmp1) knockout mice with little impact on serum levels of phosphorus and FGF23. | Q36923887 | ||
| Parathyroid hormone (PTH)/PTH-related peptide type 1 receptor (PPR) signaling in osteocytes regulates anabolic and catabolic skeletal responses to PTH. | Q37012357 | ||
| The actions of parathyroid hormone on bone: relation to bone remodeling and turnover, calcium homeostasis, and metabolic bone diseases. II. PTH and bone cells: bone turnover and plasma calcium regulation | Q37047863 | ||
| Wnt signaling control of bone cell apoptosis | Q37062867 | ||
| Hypophosphatemia with elevations in serum fibroblast growth factor 23 in a child with Jansen's metaphyseal chondrodysplasia | Q37072659 | ||
| Demonstration of osteocytic perilacunar/canalicular remodeling in mice during lactation. | Q37163219 | ||
| Resorption controls bone anabolism driven by parathyroid hormone (PTH) receptor signaling in osteocytes | Q37226223 | ||
| Identification of differentially expressed genes between osteoblasts and osteocytes | Q37316190 | ||
| Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone | Q37383855 | ||
| Osteocyte-driven bone remodeling | Q37626024 | ||
| Antagonistic interplay between mechanical forces and glucocorticoids in bone: a tale of kinases | Q37761092 | ||
| Clinical practice. Glucocorticoid-induced bone disease | Q37898140 | ||
| Sclerostin: therapeutic horizons based upon its actions | Q37974871 | ||
| Osteocyte Shape Is Dependent on Actin Filaments and Osteocyte Processes Are Unique Actin-Rich Projections | Q56456127 | ||
| The actions of parathyroid hormone on bone: relation to bone remodeling and turnover, calcium homeostasis, and metabolic bone disease. Part I of IV parts: mechanisms of calcium transfer between blood and bone and their cellular basis: morphological a | Q57105420 | ||
| Sclerostin in Mineralized Matrices and van Buchem Disease | Q57848944 | ||
| Bone adaptation requires oestrogen receptor-α | Q59049437 | ||
| The Osteocyte as a Bone Pump | Q70578287 | ||
| CD44 expression in human bone: a novel marker of osteocytic differentiation | Q71618157 | ||
| Indomethacin has distinct early and late actions on bone formation induced by mechanical stimulation | Q72158600 | ||
| Association of CD44 with OTS-8 in tumor vascular endothelial cells | Q74026223 | ||
| Role for parathyroid hormone in mechanical responsiveness of rat bone | Q74153651 | ||
| Apoptosis of osteocytes in glucocorticoid-induced osteonecrosis of the hip | Q74184826 | ||
| Parathyroid hormone and mechanical usage have a synergistic effect in rat tibial diaphyseal cortical bone | Q74459852 | ||
| In vivo osteocyte death | Q79314689 | ||
| Wnt/beta-catenin signaling is a normal physiological response to mechanical loading in bone | Q80111153 | ||
| The adaptive response of bone to mechanical loading in female transgenic mice is deficient in the absence of oestrogen receptor-alpha and -beta | Q80395475 | ||
| Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction | Q80432871 | ||
| A novel ligand-independent function of the estrogen receptor is essential for osteocyte and osteoblast mechanotransduction | Q80563718 | ||
| Osteopenia and impaired fracture healing in aged EP4 receptor knockout mice | Q81712547 | ||
| A nonprostanoid EP4 receptor selective prostaglandin E2 agonist restores bone mass and strength in aged, ovariectomized rats | Q83104884 | ||
| The role of osteocytes in bone mechanotransduction | Q83599305 | ||
| Denosumab after 8 years | Q86501823 | ||
| Osteocyte regulation of phosphate homeostasis and bone mineralization underlies the pathophysiology of the heritable disorders of rickets and osteomalacia | Q38081019 | ||
| Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT. | Q38319485 | ||
| Mechanical induction of PGE2 in osteocytes blocks glucocorticoid-induced apoptosis through both the β-catenin and PKA pathways | Q38552512 | ||
| Unique roles of phosphorus in endochondral bone formation and osteocyte maturation | Q38552814 | ||
| Monoclonal antibodies - A new era in the treatment of multiple myeloma. | Q38585300 | ||
| Role of the Parathyroid Hormone Type 1 Receptor (PTH1R) as a Mechanosensor in Osteocyte Survival | Q38926507 | ||
| FGF23-regulated production of Fetuin-A (AHSG) in osteocytes | Q38952487 | ||
| Osteocytic osteolysis | Q39891592 | ||
| Mechanical stimulation prevents osteocyte apoptosis: requirement of integrins, Src kinases, and ERKs | Q40426618 | ||
| Mechanical strain and estrogen activate estrogen receptor alpha in bone cells | Q40800951 | ||
| Establishment of an osteocyte-like cell line, MLO-Y4. | Q41072892 | ||
| Increased bone formation in osteocalcin-deficient mice. | Q41182577 | ||
| Severe Spinal Cord Injury Causes Immediate Multi-cellular Dysfunction at the Chondro-Osseous Junction | Q41476589 | ||
| Regulation of osteoclast function | Q41486748 | ||
| The structure of bone tissues and the cellular control of their deposition | Q41515011 | ||
| Does osteocyte formation cause the nonlinear refilling of osteons? | Q41711456 | ||
| A novel way to statistically analyze morphologic changes in Dmp1-null osteocytes | Q41786832 | ||
| DMP1 and MEPE expression are elevated in osteocytes after mechanical loading in vivo: theoretical role in controlling mineral quality in the perilacunar matrix. | Q42175723 | ||
| Glucocorticoids induce osteocyte apoptosis by blocking focal adhesion kinase-mediated survival. Evidence for inside-out signaling leading to anoikis | Q42514385 | ||
| Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia | Q42801302 | ||
| Loss of sclerostin promotes osteoarthritis in mice via β-catenin-dependent and -independent Wnt pathways. | Q43182431 | ||
| Effect of parathyroid hormone on cortical bone response to in vivo external loading of the rat tibia | Q43669945 | ||
| Mechanical loading enhances the anabolic effects of intermittent parathyroid hormone (1-34) on trabecular and cortical bone in mice | Q43822707 | ||
| Reversal of bone loss in mice by nongenotropic signaling of sex steroids | Q44193903 | ||
| Mechanical loading: biphasic osteocyte survival and targeting of osteoclasts for bone destruction in rat cortical bone. | Q44245985 | ||
| Parathyroid hormone enhances mechanically induced bone formation, possibly involving L-type voltage-sensitive calcium channels | Q44363915 | ||
| Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts. A putative explanation for why intermittent administration is needed for bone anabolism | Q44605245 | ||
| Pharmacological inhibition of fibroblast growth factor (FGF) receptor signaling ameliorates FGF23-mediated hypophosphatemic rickets. | Q45020373 | ||
| A rate-limiting role for Dickkopf-1 in bone formation and the remediation of bone loss in mouse and primate models of postmenopausal osteoporosis by an experimental therapeutic antibody | Q45122407 | ||
| Sclerostin is expressed in articular cartilage but loss or inhibition does not affect cartilage remodeling during aging or following mechanical injury | Q45393385 | ||
| Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength | Q46186977 | ||
| Estrogen protects primary osteocytes against glucocorticoid-induced apoptosis | Q46503262 | ||
| Stretch-induced PTH-related protein gene expression in osteoblasts | Q46592948 | ||
| Therapeutic effects of anti-FGF23 antibodies in hypophosphatemic rickets/osteomalacia | Q47871507 | ||
| Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling | Q47871615 | ||
| Terminal differentiation of osteoblasts to osteocytes is accompanied by dramatic changes in the distribution of actin-binding proteins. | Q47893383 | ||
| CD44 regulates dendrite morphogenesis through Src tyrosine kinase-dependent positioning of the Golgi. | Q48491440 | ||
| Romosozumab in postmenopausal women with low bone mineral density. | Q50481558 | ||
| Novel EP4 receptor agonist-bisphosphonate conjugate drug (C1) promotes bone formation and improves vertebral mechanical properties in the ovariectomized rat model of postmenopausal bone loss. | Q51108931 | ||
| Age and distance from the surface but not menopause reduce osteocyte density in human cancellous bone. | Q52035580 | ||
| The metalloproteinase MT1-MMP is required for normal development and maintenance of osteocyte processes in bone. | Q52561730 | ||
| Identification of signal peptide domain SOST mutations in autosomal dominant craniodiaphyseal dysplasia. | Q53443331 | ||
| Role for beta1 integrins in cortical osteocytes during acute musculoskeletal disuse. | Q53466905 | ||
| Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss. | Q53628612 | ||
| Bone "mass" and the "mechanostat": a proposal. | Q53710331 | ||
| Low peak bone mass and attenuated anabolic response to parathyroid hormone in mice with an osteoblast-specific deletion of connexin43. | Q54580289 | ||
| A bisphosphonate that does not affect osteoclasts prevents osteoblast and osteocyte apoptosis and the loss of bone strength induced by glucocorticoids in mice | Q34441705 | ||
| Prostaglandin E(2) receptors in bone formation | Q34641986 | ||
| Endocrine regulation of male fertility by the skeleton | Q34642934 | ||
| Disruption of Lrp4 function by genetic deletion or pharmacological blockade increases bone mass and serum sclerostin levels | Q34661015 | ||
| E11/gp38 selective expression in osteocytes: regulation by mechanical strain and role in dendrite elongation | Q34718158 | ||
| Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids | Q35058081 | ||
| Anabolic agents and bone quality | Q35078764 | ||
| Prevention of glucocorticoid induced-apoptosis of osteoblasts and osteocytes by protecting against endoplasmic reticulum (ER) stress in vitro and in vivo in female mice | Q35108990 | ||
| Osteocyte and osteoblast apoptosis and excessive bone deposition accompany failure of collagenase cleavage of collagen | Q35127462 | ||
| Parathyroid hormone (PTH)-induced bone gain is blunted in SOST overexpressing and deficient mice | Q35156214 | ||
| Cx43 and mechanotransduction in bone. | Q35163731 | ||
| Parathyroid hormone receptor signaling in osteocytes increases the expression of fibroblast growth factor-23 in vitro and in vivo | Q35196515 | ||
| Connexin43 interacts with βarrestin: a pre-requisite for osteoblast survival induced by parathyroid hormone | Q35228320 | ||
| PTH receptor signaling in osteocytes governs periosteal bone formation and intracortical remodeling. | Q35229920 | ||
| High Bone Mass-Causing Mutant LRP5 Receptors Are Resistant to Endogenous Inhibitors In Vivo | Q35586766 | ||
| Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading. | Q35635751 | ||
| Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism. | Q35728669 | ||
| Cell autonomous requirement of connexin 43 for osteocyte survival: consequences for endocortical resorption and periosteal bone formation. | Q35729489 | ||
| Prolonged Correction of Serum Phosphorus in Adults With X-Linked Hypophosphatemia Using Monthly Doses of KRN23. | Q35829300 | ||
| Clinical development of anti-RANKL therapy | Q35901092 | ||
| Inhibition of osteocyte apoptosis prevents the increase in osteocytic receptor activator of nuclear factor κB ligand (RANKL) but does not stop bone resorption or the loss of bone induced by unloading | Q35905296 | ||
| A model for the role of integrins in flow induced mechanotransduction in osteocytes | Q36023747 | ||
| Meox2Cre-mediated disruption of CSF-1 leads to osteopetrosis and osteocyte defects | Q36029570 | ||
| The chicken or the egg: PHEX, FGF23 and SIBLINGs unscrambled | Q36074718 | ||
| Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2(-/-) mice | Q36119294 | ||
| Parathyroid hormone-related protein: an update | Q36201545 | ||
| Defective cancellous bone structure and abnormal response to PTH in cortical bone of mice lacking Cx43 cytoplasmic C-terminus domain. | Q36269032 | ||
| Aberrant Phex function in osteoblasts and osteocytes alone underlies murine X-linked hypophosphatemia | Q36303697 | ||
| Beyond gap junctions: Connexin43 and bone cell signaling | Q36442344 | ||
| PTH Signaling During Exercise Contributes to Bone Adaptation | Q36525466 | ||
| Crosstalk between caveolin-1/extracellular signal-regulated kinase (ERK) and β-catenin survival pathways in osteocyte mechanotransduction | Q36708516 | ||
| Characterization and cloning of the E11 antigen, a marker expressed by rat osteoblasts and osteocytes | Q36822732 | ||
| Absence of Cx43 selectively from osteocytes enhances responsiveness to mechanical force in mice | Q36874711 | ||
| A paradigm of integrative physiology, the crosstalk between bone and energy metabolisms | Q36886615 | ||
| The mechanism of transduction of mechanical strains into biological signals at the bone cellular level. | Q36912338 | ||
| P2507 | corrigendum / erratum | Erratum: Osteocytic signalling pathways as therapeutic targets for bone fragility | Q88016889 |
| P433 | issue | 10 | |
| P304 | page(s) | 593-605 | |
| P577 | publication date | 2016-05-27 | |
| P1433 | published in | Nature Reviews Endocrinology | Q2079257 |
| P1476 | title | Osteocytic signalling pathways as therapeutic targets for bone fragility | |
| P478 | volume | 12 |
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