Hematopoietic or Osteoclast-Specific Deletion of Syk Leads to Increased Bone Mass in Experimental Mice

scientific article published on 30 April 2019

Hematopoietic or Osteoclast-Specific Deletion of Syk Leads to Increased Bone Mass in Experimental Mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3389/FIMMU.2019.00937
P932PMC publication ID6524727
P698PubMed publication ID31134061

P50authorZoltán JakusQ59688198
Edina SimonQ114260337
P2093author name stringAttila Mócsai
Petra Aradi
Szilvia Benkő
Dávid S Győri
Csaba Dobó-Nagy
Ahmad Alatshan
Dániel Csete
P2860cites workCoordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeletonQ24293554
Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase SykQ24303475
RANK is essential for osteoclast and lymph node developmentQ24598872
DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic featuresQ24672682
Targeting Syk in Autoimmune Rheumatic DiseasesQ26751042
Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell developmentQ28206720
Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient miceQ28207641
RANKL-RANK signaling in osteoclastogenesis and bone diseaseQ28287091
An Oral Spleen Tyrosine Kinase (Syk) Inhibitor for Rheumatoid ArthritisQ28294375
Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systemsQ28294477
Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cellsQ28505184
Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase FgrQ28507457
Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifsQ28585779
Syk tyrosine kinase required for mouse viability and B-cell developmentQ28586985
Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk.Q28588103
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesisQ28589430
Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorptionQ28592760
A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophagesQ28634082
Osteoclast differentiation and activationQ29547556
Zap70 inhibits Syk-mediated osteoclast functionQ30575570
Bone microenvironment specific roles of ITAM adapter signaling during bone remodeling induced by acute estrogen-deficiencyQ33289959
Spleen tyrosine kinase Syk is critical for sustained leukocyte adhesion during inflammation in vivoQ33307614
Repercussion of Megakaryocyte-Specific Gata1 Loss on Megakaryopoiesis and the Hematopoietic Precursor CompartmentQ33432035
The Syk protein tyrosine kinase is essential for Fcgamma receptor signaling in macrophages and neutrophilsQ33775026
Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatmentQ33896725
Lineage-Specific Analysis of Syk Function in Autoantibody-Induced Arthritis.Q54117883
Conditional deletion of Bmpr1a in differentiated osteoclasts increases osteoblastic bone formation, increasing volume of remodeling bone in mice.Q54357688
Syk-dependent signaling pathways in neutrophils and macrophages are indispensable in the pathogenesis of anti-collagen antibody-induced arthritis.Q54488975
The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor geneQ59092154
Large-scale discovery of mouse transgenic integration sites reveals frequent structural variation and insertional mutagenesisQ64077215
Transgenic mice with hematopoietic and lymphoid specific expression of CreQ78842092
Pathophysiology of bone metastases from solid malignanciesQ88052803
Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclastsQ33939357
Genetic deficiency of Syk protects mice from autoantibody-induced arthritis.Q34275410
Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclastsQ34679499
Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRgamma-Syk-Card9-dependent innate immune activationQ34920323
The phosphoinositide 3-kinase isoform PI3Kβ regulates osteoclast-mediated bone resorption in humans and mice.Q35040987
Evidence for the requirement of ITAM domains but not SLP-76/Gads interaction for integrin signaling in hematopoietic cells.Q35071273
Deletion of Syk in neutrophils prevents immune complex arthritisQ35269028
Phospholipase Cγ2 is required for basal but not oestrogen deficiency-induced bone resorption.Q35697027
Src and Syk kinases: key regulators of phagocytic cell activation.Q36083524
ITAM-based signaling beyond the adaptive immune response.Q36332906
Osteoporosis: now and the futureQ36564425
The SYK tyrosine kinase: a crucial player in diverse biological functionsQ36662082
Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcepsilonRI.Q36689929
Phospholipase Cgamma2 mediates RANKL-stimulated lymph node organogenesis and osteoclastogenesisQ36944827
Immunoreceptor-like signaling by beta 2 and beta 3 integrins.Q36959336
DAP12 couples c-Fms activation to the osteoclast cytoskeleton by recruitment of Syk.Q36977266
RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolismQ37108966
Diverse roles of the tumor necrosis factor family member TRANCE in skeletal physiology revealed by TRANCE deficiency and partial rescue by a lymphocyte-expressed TRANCE transgeneQ37265676
The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinaseQ37647341
Osteoclasts in RA: diverse origins and functionsQ38111507
Osteopetrosis: genetics, treatment and new insights into osteoclast function.Q38123371
PLCgamma2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2.Q38744013
NLRC5 limits the activation of inflammatory pathwaysQ39683163
The signaling adapter protein DAP12 regulates multinucleation during osteoclast developmentQ40589041
The Syk Tyrosine Kinase Is Required for Skin Inflammation in an In Vivo Mouse Model of Epidermolysis Bullosa AcquisitaQ41929292
Syk is required for integrin signaling in neutrophilsQ43968751
G-protein-coupled receptor signaling in Syk-deficient neutrophils and mast cellsQ44280924
Conditional gene targeting in macrophages and granulocytes using LysMcre mice.Q44554898
High dose M-CSF partially rescues the Dap12-/- osteoclast phenotypeQ44660139
Treatment of rheumatoid arthritis with a Syk kinase inhibitor: a twelve-week, randomized, placebo-controlled trialQ46271720
Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasisQ47761859
Osteoimmunology: The Conceptual Framework Unifying the Immune and Skeletal Systems.Q47944184
Bone-Targeted Therapies in Cancer-Induced Bone DiseaseQ48110513
Recent advances in osteoclast biology.Q50215136
Whole-Genome Expression Profiling in Skin Reveals SYK As a Key Regulator of Inflammation in Experimental Epidermolysis Bullosa Acquisita.Q50333828
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P407language of work or nameEnglishQ1860
P921main subjectMiceQ29047609
P304page(s)937
P577publication date2019-04-30
P1433published inFrontiers in ImmunologyQ27723748
P1476titleHematopoietic or Osteoclast-Specific Deletion of Syk Leads to Increased Bone Mass in Experimental Mice
P478volume10

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cites work (P2860)
Q89653987Integrin-associated molecules and signalling cross talking in osteoclast cytoskeleton regulation
Q97423686Osteoclast Signal Transduction During Bone Metastasis Formation

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