Identification and characterization of anti-osteoclastogenic peptides derived from the cytoplasmic tail of receptor activator of nuclear factor kappa B

scientific article published on 28 April 2012

Identification and characterization of anti-osteoclastogenic peptides derived from the cytoplasmic tail of receptor activator of nuclear factor kappa B is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S00774-012-0353-5
P698PubMed publication ID22543819

P2093author name stringJin Gohda
Jun-Ichiro Inoue
Yuu Taguchi
Yoko Kiga
P2860cites workCLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choiceQ24286950
TAK1 is a ubiquitin-dependent kinase of MKK and IKKQ24291454
The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesisQ24297505
A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexesQ24299311
Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1Q24300916
Central control of fever and female body temperature by RANKL/RANKQ24321735
The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytesQ24338639
Genetic applications of an inverse polymerase chain reactionQ24532247
Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6Q24537518
RANK is essential for osteoclast and lymph node developmentQ24598872
Bisphosphonates: mechanism of action and role in clinical practiceQ24644708
Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40Q24676338
Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient miceQ28140546
The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland developmentQ28142247
Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chainQ28142613
Bisphosphonates: from bench to bedsideQ28251212
Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systemsQ28294477
Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic regionQ28511583
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signalingQ28513445
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesisQ28589430
Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclastsQ29618116
Arginine-rich peptides. An abundant source of membrane-permeable peptides having potential as carriers for intracellular protein deliveryQ31577177
Therapeutic approaches to bone diseasesQ34021178
NFATc1 regulation of the human beta3 integrin promoter in osteoclast differentiationQ34565548
Retrovirus-mediated gene transfer and expression cloning: powerful tools in functional genomicsQ35571380
Tat peptide-mediated cellular delivery: back to basicsQ36049561
TRANCE, a tumor necrosis factor family member, enhances the longevity and adjuvant properties of dendritic cells in vivoQ36375923
Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axisQ36402845
Selective inhibition of RANK blocks osteoclast maturation and function and prevents bone loss in miceQ37143375
Characterization of the mouse tartrate-resistant acid phosphatase (trap) gene promoterQ38297200
Large scale gene expression analysis of osteoclastogenesis in vitro and elucidation of NFAT2 as a key regulatorQ38363724
PLCgamma2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2.Q38744013
Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesisQ39714931
Two mechanistically and temporally distinct NF-kappaB activation pathways in IL-1 signalingQ39785295
Gene expression elicited by NFAT in the presence or absence of cooperative recruitment of Fos and Jun.Q40370662
Tissue-specific and ubiquitous promoters direct the expression of alternatively spliced transcripts from the calcitonin receptor geneQ40811962
Identification and characterization of the new osteoclast progenitor with macrophage phenotypes being able to differentiate into mature osteoclastsQ40862968
RANK-mediated amplification of TRAF6 signaling leads to NFATc1 induction during osteoclastogenesis.Q41107411
Autoamplification of NFATc1 expression determines its essential role in bone homeostasisQ42972503
Renal Failure with the Use of Zoledronic AcidQ44628533
Alendronate and risedronate: reports of severe bone, joint, and muscle painQ45264997
Contribution of nuclear factor of activated T cells c1 to the transcriptional control of immunoreceptor osteoclast-associated receptor but not triggering receptor expressed by myeloid cells-2 during osteoclastogenesisQ46620740
Cellular internalization and distribution of arginine-rich peptides as a function of extracellular peptide concentration, serum, and plasma membrane associated proteoglycansQ46758321
Osteoclast differentiation requires TAK1 and MKK6 for NFATc1 induction and NF-kappaB transactivation by RANKL.Q46960866
Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasisQ47761859
The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.Q51949099
A unique domain in RANK is required for Gab2 and PLCgamma2 binding to establish osteoclastogenic signals.Q53364532
Possible involvement of IkappaB kinase 2 and MKK7 in osteoclastogenesis induced by receptor activator of nuclear factor kappaB ligandQ64378984
A randomized controlled trial to assess alendronate-associated injury of the upper gastrointestinal tractQ73166731
Involvement of p38 mitogen-activated protein kinase signaling pathway in osteoclastogenesis mediated by receptor activator of NF-kappa B ligand (RANKL)Q73907464
Dendritic cell development and survival require distinct NF-kappaB subunitsQ77704364
CD40 ligation stimulates MCP-1 and IL-8 production, TRAF6 recruitment, and MAPK activation in proximal tubule cellsQ78068575
Constructing recombinant DNA molecules by PCRQ80674300
A novel receptor activator of NF-kappaB (RANK) cytoplasmic motif plays an essential role in osteoclastogenesis by committing macrophages to the osteoclast lineageQ82062490
P433issue5
P304page(s)543-553
P577publication date2012-04-28
P1433published inJournal of Bone and Mineral MetabolismQ15767236
P1476titleIdentification and characterization of anti-osteoclastogenic peptides derived from the cytoplasmic tail of receptor activator of nuclear factor kappa B
P478volume30