Bisphosphonates: mechanism of action and role in clinical practice

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Bisphosphonates: mechanism of action and role in clinical practice is …
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review articleQ7318358
scholarly articleQ13442814

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P356DOI10.4065/83.9.1032
P3181OpenCitations bibliographic resource ID317634
P932PMC publication ID2667901
P698PubMed publication ID18775204
P5875ResearchGate publication ID23241189

P50authorSundeep KhoslaQ42164143
P2093author name stringMatthew T Drake
Bart L Clarke
P2860cites workBisphosphonate therapy for children and adolescents with secondary osteoporosisQ24243298
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Rho GTPases and the actin cytoskeletonQ27860579
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Narrative [corrected] review: bisphosphonates and osteonecrosis of the jawsQ28240354
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Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosisQ29619487
Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates.Q31841626
Effect of risedronate on the risk of hip fracture in elderly women. Hip Intervention Program Study Group.Q31921266
Microcrack frequency and bone remodeling in postmenopausal osteoporotic women on long-term bisphosphonates: a bone biopsy studyQ33297907
Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitoninQ33902085
Severely suppressed bone turnover: a potential complication of alendronate therapyQ33983792
Effects of teriparatide, alendronate, or both on bone turnover in osteoporotic men.Q33995702
Once-yearly zoledronic acid for treatment of postmenopausal osteoporosisQ34003925
Prolonged bisphosphonate release after treatment in childrenQ79907020
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Zoledronic acid prevents bone loss after allogeneic haemopoietic stem cell transplantationQ80119312
Use of bisphosphonates in multiple myeloma: IMWG response to Mayo Clinic consensus statementQ80120158
Alendronate or alfacalcidol in glucocorticoid-induced osteoporosisQ80129380
The importance of bisphosphonate therapy in maintaining bone mass in men after therapy with teriparatide [human parathyroid hormone(1-34)]Q80156775
Secondary hyperparathyroidism due to hypovitaminosis D affects bone mineral density response to alendronate in elderly women with osteoporosis: a randomized controlled trialQ80307867
Risedronate reduces postoperative bone resorption after cementless total hip arthroplastyQ80442873
Estrogen-dependent increase in bone turnover and bone loss in postmenopausal women with breast cancer treated with anastrozole. Prevention with bisphosphonatesQ80586247
Determinants of persistence with bisphosphonates: a study in women with postmenopausal osteoporosisQ83296260
Osteonecrosis of the jaw in patients with multiple myeloma treated with bisphosphonates: evidence of increased risk after treatment with zoledronic acidQ83938052
Severe hypocalcemia following bisphosphonate treatment in a patient with Paget's disease of boneQ83976296
Transmission of human herpesvirus 8 by blood transfusionQ95814375
Comparative study of alendronate versus etidronate for the treatment of Paget's disease of bone.Q53803388
Alendronate and atrial fibrillation.Q55043822
Individual fracture risk and the cost-effectiveness of bisphosphonates in patients using oral glucocorticoidsQ57086737
Primary prevention of glucocorticoid-induced osteoporosis with intermittent intravenous pamidronate: a randomized trialQ57224477
Factors associated with adherence and persistence to bisphosphonate therapy in osteoporosis: a cross-sectional surveyQ57417197
Alendronate for the Treatment of Osteoporosis in MenQ57450326
Intravenous pamidronate attenuates bone density loss after acute spinal cord injuryQ57711945
A different schedule of zoledronic acid can reduce the risk of the osteonecrosis of the jaw in patients with multiple myelomaQ57786339
Osteonecrosis of the jaws in newly diagnosed multiple myeloma patients treated with zoledronic acid and thalidomide-dexamethasoneQ57904055
Efficacy of Pamidronate in Reducing Skeletal Events in Patients with Advanced Multiple MyelomaQ57905146
Bisphosphonate-Associated Osteonecrosis of the Jaw: Report of a Task Force of the American Society for Bone and Mineral ResearchQ58216587
Efficacy and safety of risedronate 150 mg once a month in the treatment of postmenopausal osteoporosisQ58971133
Yearly zoledronic acid in postmenopausal osteoporosisQ58971184
Intravenous zoledronic acid 5 mg in the treatment of postmenopausal women with low bone density previously treated with alendronateQ58971203
Challenges in Improving the Quality of Osteoporosis Care for Long-term Glucocorticoid UsersQ58974243
Zoledronic Acid Prevents Cancer Treatment–Induced Bone Loss in Premenopausal Women Receiving Adjuvant Endocrine Therapy for Hormone-Responsive Breast Cancer: A Report From the Austrian Breast and Colorectal Cancer Study GroupQ59616816
Suppressed Bone Turnover during Alendronate Therapy for High-Turnover OsteoporosisQ61716195
The influence of pyrophosphate, condensed phosphates, phosphonates and other phosphate compounds on the dissolution of hydroxyapatite in vitro and on bone resorption induced by parathyroid hormone in tissue culture and in thyroparathyroidectomised rQ71646365
Optimal calcium intakeQ71842084
Efficacy of pamidronate in reducing skeletal complications in patients with breast cancer and lytic bone metastases. Protocol 19 Aredia Breast Cancer Study GroupQ71890854
Parathyroid hormone for the prevention of bone loss induced by estrogen deficiencyQ72827947
Alendronate increases bone strength by increasing the mean degree of mineralization of bone tissue in osteoporotic womenQ73150132
Pamidronate prevents skeletal complications and is effective palliative treatment in women with breast carcinoma and osteolytic bone metastases: long term follow-up of two randomized, placebo-controlled trialsQ73504275
Elimination and biochemical responses to intravenous alendronate in postmenopausal osteoporosisQ73794664
Enhancement of bone mass in osteoporotic women with parathyroid hormone followed by alendronateQ73892733
Combination therapy for postmenopausal osteoporosisQ74177997
Efficacy of pamidronate for osteoporosis in patients with cystic fibrosis following lung transplantationQ74316545
Phase II trial evaluating the palliative benefit of second-line zoledronic acid in breast cancer patients with either a skeletal-related event or progressive bone metastases despite first-line bisphosphonate therapyQ79137459
Experience with bisphosphonates in osteogenesis imperfectaQ79856017
Pamidronate reduces bone loss after allogeneic stem cell transplantationQ79885177
Alendronate prevents further bone loss in renal transplant recipients.Q43791666
Alendronate reduces periprosthetic bone loss after uncemented primary total hip arthroplasty: a prospective randomized studyQ43791673
Bone turnover matters: the raloxifene treatment paradox of dramatic decreases in vertebral fractures without commensurate increases in bone densityQ43842242
Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemicQ43968160
The efficacy and tolerability of risedronate once a week for the treatment of postmenopausal osteoporosisQ44042152
Randomized, placebo-controlled trial of clodronate in patients with primary operable breast cancerQ44083704
Severe increase in creatinine with hypocalcaemia in thalidomide-treated myeloma patients receiving zoledronic acid infusionsQ44198095
Two-year results of once-weekly administration of alendronate 70 mg for the treatment of postmenopausal osteoporosisQ44202451
Significant differential effects of alendronate, estrogen, or combination therapy on the rate of bone loss after discontinuation of treatment of postmenopausal osteoporosis. A randomized, double-blind, placebo-controlled trialQ44234273
Randomized controlled trial of zoledronic acid to prevent bone loss in men receiving androgen deprivation therapy for nonmetastatic prostate cancerQ44456773
Alendronate treatment in children with osteogenesis imperfecta.Q44563352
Zoledronic acid delays the onset of skeletal-related events and progression of skeletal disease in patients with advanced renal cell carcinomaQ44564597
Intravenous ibandronate reduces the incidence of skeletal complications in patients with breast cancer and bone metastasesQ44572717
The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosisQ44590934
The Effects of Parathyroid Hormone, Alendronate, or Both in Men with OsteoporosisQ44590937
Compliance with pharmacologic therapy for osteoporosisQ44593075
Prevention of bone loss in renal transplant recipients: a prospective, randomized trial of intravenous pamidronateQ44599938
Renal Failure with the Use of Zoledronic AcidQ44628533
Intermittent intravenous ibandronate injections reduce vertebral fracture risk in corticosteroid-induced osteoporosis: results from a long-term comparative studyQ44650876
Tissue mineralization is increased following 1-year treatment with high doses of bisphosphonates in dogsQ44695650
Ten years' experience with alendronate for osteoporosis in postmenopausal womenQ44804093
Daily and intermittent oral ibandronate normalize bone turnover and provide significant reduction in vertebral fracture risk: results from the BONE studyQ44835560
Long-term efficacy of zoledronic acid for the prevention of skeletal complications in patients with metastatic hormone-refractory prostate cancerQ44918129
Long-term efficacy and safety of zoledronic acid in the treatment of skeletal metastases in patients with nonsmall cell lung carcinoma and other solid tumors: a randomized, Phase III, double-blind, placebo-controlled trialQ44937090
Effects of oral ibandronate administered daily or intermittently on fracture risk in postmenopausal osteoporosis.Q44961457
Maternal and fetal outcome after long-term pamidronate treatment before conception: a report of two casesQ45050162
Oral ibandronate improves bone pain and preserves quality of life in patients with skeletal metastases due to breast cancerQ45056085
Short-term zoledronic acid treatment increases bone mineral density and marrow clonogenic fibroblast progenitors after allogeneic stem cell transplantationQ45152628
Alendronate and risedronate: reports of severe bone, joint, and muscle painQ45264997
Effect of pyrophosphate on hydroxyapatite and its implications in calcium homeostasisQ46288027
Effects of intravenous pamidronate treatment in infants with osteogenesis imperfecta: clinical and histomorphometric outcomeQ46531818
One year of alendronate after one year of parathyroid hormone (1-84) for osteoporosisQ46644468
Daily and cyclic parathyroid hormone in women receiving alendronateQ46644473
Prescription-event monitoring study on 13,164 patients prescribed risedronate in primary care in EnglandQ46679517
Comparison of a single infusion of zoledronic acid with risedronate for Paget's disease.Q46681443
Efficacy of oral alendronate in children with osteogenesis imperfectaQ46732093
Osteonecrosis of the jaw in cancer after treatment with bisphosphonates: incidence and risk factorsQ46825147
Preventive effect of risedronate on bone loss in men receiving androgen-deprivation therapy for prostate cancerQ46884243
Determinants of adherence to osteoporosis treatment in clinical practiceQ46991236
Risedronate in the treatment of Paget's disease of bone: an open label, multicenter studyQ47974874
Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. The Alendronate Phase III Osteoporosis Treatment Study GroupQ48527134
Alendronate prevents bone loss in patients with acute spinal cord injury: a randomized, double-blind, placebo-controlled studyQ51083403
High prevalence of early-onset osteopenia/osteoporosis after allogeneic stem cell transplantation and improvement after bisphosphonate therapy.Q53558015
Intravenous zoledronic acid in postmenopausal women with low bone mineral densityQ34116443
A randomized, placebo-controlled trial of zoledronic acid in patients with hormone-refractory metastatic prostate carcinomaQ34152748
Prolonged, symptomatic hypocalcemia with pamidronate administration and subclinical hypoparathyroidismQ34275146
Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Fracture Intervention Trial Research GroupQ34409983
Two-year clinical trial of oral alendronate versus intravenous pamidronate in children with osteogenesis imperfectaQ34476573
Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures: results from the Fracture Intervention TrialQ34485941
The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugsQ34523564
Osteonecrosis of the jaw--do bisphosphonates pose a risk?Q34572902
Use of bisphosphonates among women and risk of atrial fibrillation and flutter: population based case-control studyQ34589366
Randomized controlled trial of annual zoledronic acid to prevent gonadotropin-releasing hormone agonist-induced bone loss in men with prostate cancer.Q34617892
Zoledronic acid and clinical fractures and mortality after hip fractureQ34689802
Teriparatide or alendronate in glucocorticoid-induced osteoporosisQ34713779
Long-term prevention of skeletal complications of metastatic breast cancer with pamidronate. Protocol 19 Aredia Breast Cancer Study GroupQ34747852
Use of alendronate and risk of incident atrial fibrillation in womenQ34774594
American Society of Clinical Oncology clinical practice guidelines: the role of bisphosphonates in multiple myelomaQ34803386
The effects of intravenous pamidronate on the bone tissue of children and adolescents with osteogenesis imperfectaQ34815287
Modern approach to children with osteogenesis imperfectaQ35065426
Pamidronate-induced nephrotoxic tubular necrosis--a case report.Q35667611
Pharmacokinetics/pharmacodynamics of bisphosphonates: use for optimisation of intermittent therapy for osteoporosisQ36149052
Cancer treatment-related bone loss: a review and synthesis of the literatureQ36410640
Bisphosphonate-induced hypocalcemia: report of 3 cases and review of literatureQ36416668
Adherence to bisphosphonate therapy and fracture rates in osteoporotic women: relationship to vertebral and nonvertebral fractures from 2 US claims databasesQ36561966
Mayo clinic consensus statement for the use of bisphosphonates in multiple myelomaQ36561970
Markers of bone turnover for the management of patients with bone metastases from prostate cancerQ36641310
Oral ibandronate reduces the risk of skeletal complications in breast cancer patients with metastatic bone disease: results from two randomised, placebo-controlled phase III studiesQ36694734
Consensus and controversy regarding osteoporosis in the pediatric populationQ36943010
Effects of continuing or stopping alendronate after 5 years of treatment: the Fracture Intervention Trial Long-term Extension (FLEX): a randomized trialQ38400853
Bisphosphonates and estrogens inhibit osteocyte apoptosis via distinct molecular mechanisms downstream of extracellular signal-regulated kinase activation.Q40482310
Zoledronic acid versus pamidronate in the treatment of skeletal metastases in patients with breast cancer or osteolytic lesions of multiple myeloma: a phase III, double-blind, comparative trialQ40593773
Perspectives: a practical guide to the use of pamidronate in the treatment of Paget's diseaseQ40756461
Bisphosphonates: a review of their pharmacokinetic propertiesQ41132404
Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis: a randomized controlled trial. Vertebral Efficacy With Risedronate Therapy (VERT) Study GroupQ41697049
Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras.Q42543174
Zoledronic acid reduces skeletal-related events in patients with osteolytic metastasesQ43563141
Intravenous pamidronate as treatment for osteoporosis after heart transplantation: a prospective studyQ43575868
Effect of ibandronate on bone loss and renal function after kidney transplantation.Q43652008
Pamidronate to prevent bone loss during androgen-deprivation therapy for prostate cancerQ43749401
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)1032-1045
P577publication date2008-09-01
P1433published inMayo Clin ProcQ6538184
P1476titleBisphosphonates: mechanism of action and role in clinical practice
P478volume83

Reverse relations

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Q64084531Immune Modulation by Transplanted Calcium Phosphate Biomaterials and Human Mesenchymal Stromal Cells in Bone Regeneration
Q90599028Immunohistochemical Femoral Nerve Study Following Bisphosphonates Administration
Q64120300Immunoregulation of macrophages by dynamic ligand presentation via ligand-cation coordination
Q36594973Impact and risk factors of post-stroke bone fracture
Q37354985In vitro potency, in vitro and in vivo efficacy of liposomal alendronate in combination with γδ T cell immunotherapy in mice.
Q50691033In vivo distribution of zoledronic acid in a bisphosphonate-metal complex-based nanoparticle formulation synthesized by a reverse microemulsion method.
Q57295723Indirect Evaluation of Bone Saturation with Zoledronic Acid After Long-Term Dosing
Q34599958Inhibition of osteoclastogenesis and inflammatory bone resorption by targeting BET proteins and epigenetic regulation
Q39199332Insights into Pathomechanisms and Treatment Development in Heritable Ectopic Mineralization Disorders: Summary of the PXE International Biennial Research Symposium-2016.
Q48262033Interactions between Clinically Used Bisphosphonates and Bone Mineral: from Coordination Chemistry to Biomedical Applications and Beyond.
Q38766431Interventions to prevent and treat corticosteroid-induced osteoporosis and prevent osteoporotic fractures in Duchenne muscular dystrophy.
Q24198280Interventions to prevent steroid-induced osteoporosis and osteoporotic fractures in Duchenne muscular dystrophy
Q37603941Intra-tumor delivery of zoledronate mitigates metastasis-induced osteolysis superior to systemic administration.
Q84074575Is ¹⁵³Samarium-ethylene-diamine-tetramethyl-phosphonate (EDTMP) bone uptake influenced by bisphosphonates in patients with castration-resistant prostate cancer?
Q48023175La(iii) biodistribution profiles from intravenous and oral dosing of two lanthanum complexes, La(dpp)3 and La(XT), and evaluation as treatments for bone resorption disorders
Q38617388Long-Term Bisphosphonate Therapy in Osteogenesis Imperfecta
Q61797341Low-dose zoledronate for the treatment of bone metastasis secondary to prostate cancer
Q36027214Management of atypical femoral fracture: a scoping review and comprehensive algorithm
Q37337113Management of osteoporosis in the aging male: focus on zoledronic acid
Q41196623Managing bisphosphonate-related osteonecrosis of the jaws with xenografts: a case report
Q34106431Managing osteoporosis in postmenopausal women
Q35400080Mandibular inferior cortical bone thickness on panoramic radiographs in patients using bisphosphonates.
Q51183940Material properties of bone in the femoral head treated with ibandronate and BMP-2 following ischemic osteonecrosis.
Q46451867Mathematical Model of Bone Remodeling Captures the Antiresorptive and Anabolic Actions of Various Therapies
Q64953317Mechanism of CK2.3, a Novel Mimetic Peptide of Bone Morphogenetic Protein Receptor Type IA, Mediated Osteogenesis.
Q64985581Mechanisms of Cellular Internalization of Quantum Dot® Conjugated Bone Formation Mimetic Peptide CK2.3.
Q64276494Medication-related osteonecrosis of the jaw after long-term bisphosphonate treatment in a cat
Q39700905Medication-related osteonecrosis of the jaw. Introduction of a new modified experimental model.
Q91212184Medication-related osteonecrosis: Patients with a hidden risk of MRONJ
Q58885355Microwave-driven Synthesis of Iron Oxide Nanoparticles for Fast Detection of Atherosclerosis
Q56985914Microwave-driven synthesis of bisphosphonate nanoparticles allows in vivo visualisation of atherosclerotic plaque
Q53743085Models for anti-tumor activity of bisphosphonates using refined topochemical descriptors.
Q94397831Molecular pathogenesis and therapeutic strategies of human osteosarcoma
Q38763133Monomethyl Auristatin E Phosphate Inhibits Human Prostate Cancer Growth
Q41855288Multiple fractures, pain, and severe disability in a patient with adult-onset hypophosphatasia
Q34038854Multiple myeloma mesenchymal stromal cells: Contribution to myeloma bone disease and therapeutics
Q50053775Nano-confinement-driven enhanced magnetic relaxivity of SPIONs for targeted tumor bioimaging.
Q39198933Nephrotoxicity of anticancer treatment
Q47710981Neuropeptide Y Y2 antagonist treated ovariectomized mice exhibit greater bone mineral density.
Q60922830Nitrogen Containing Bisphosphonates Impair the Release of Bone Homeostasis Mediators and Matrix Production by Human Primary Pre-Osteoblasts
Q48101911Non-complex reconstructive techniques in the management of BRONJ: a case series of patient-related outcomes
Q89187407Nonsurgical Management of Medication-Related Osteonecrosis of the Jaws Using Local Wound Care
Q36240108Novel applications of statins for bone regeneration
Q35899482Nur77 prevents excessive osteoclastogenesis by inducing ubiquitin ligase Cbl-b to mediate NFATc1 self-limitation.
Q55237271Observational study of the bisphosphonate-related osteonecrosis of jaws.
Q35229899Oral bisphosphonates and risk of subtrochanteric or diaphyseal femur fractures in a population-based cohort
Q52655586Osteogenesis imperfecta and therapeutics.
Q43479103Osteonecrosis of the jaw in patients with metastatic breast cancer: ethnic and socio-economic aspects
Q34178759Osteoporosis and gastrointestinal disease
Q88900139Osteoporosis following heart transplantation and immunosuppressive therapy
Q35173349Osteoporosis in chronic obstructive pulmonary disease
Q40290624Osteoporosis treatment with zoledronic acid in pediatric population at a university hospital in Western Saudi Arabia. A 13-year experience
Q39255870Osteoporosis, bone mineral density and CKD-MBD: treatment considerations.
Q90729095Osteoporosis: Mechanism, Molecular Target, and Current Status on Drug Development
Q37791155Pharmacogenetics of Osteoporosis-Related Bone Fractures: Moving Towards the Harmonization and Validation of Polymorphism Diagnostic Tools
Q90487338Pitavastatin slows tumor progression and alters urine-derived volatile organic compounds through the mevalonate pathway
Q89483219Positive effect of alendronate on bone turnover in ovariectomised rats' osteoporosis: comparison of transdermal lipid-based delivery with conventional oral administration
Q35480967Prevalence, pathophysiology, screening and management of osteoporosis in gastric cancer patients
Q52687655Prevention of ovariectomy-induced osteoporosis in rats : Comparative study of zoledronic acid, parathyroid hormone (1-34) and strontium ranelate.
Q26852821Prevention of steroid-induced low bone mineral density in children with renal diseases: a systematic review
Q36687880Primary brain calcification in patients undergoing treatment with the biphosphanate alendronate
Q46276532Primary cilium is required for the stimulating effect of icaritin on osteogenic differentiation and mineralization of osteoblasts in vitro.
Q39267549Progress in tumor-associated macrophage (TAM)-targeted therapeutics
Q39143187Proline modulates the effect of bisphosphonate on calcium levels and adenosine triphosphate production in cell lines derived from bovine Echinococcus granulosus protoscoleces.
Q90866188Protein and bone health across the lifespan
Q103034302Quantification of the bisphosphonate alendronate using capillary electrophoresis mass spectrometry with dynamic pH barrage junction focusing
Q35228787RANK/RANKL/OPG signaling pathways in necrotic jaw bone from bisphosphonate-treated subjects
Q89838580Real-world use of denosumab and bisphosphonates in patients with solid tumours and bone metastases in Germany
Q36259554Removal of pamidronate from bone in rats using systemic and local chelation
Q64294389Response to Zoledronic Acid in Patients with Active Paget's Disease of Bone: A Retrospective Study
Q38187901Review: epidemiology and pathophysiology of atypical femur fractures
Q36820214Risk of cardiac valvulopathy with use of bisphosphonates: a population-based, multi-country case-control study
Q40100089Risk of long-term infection-related death in clinical osteoporotic vertebral fractures: A hospital-based analysis
Q35068631Risk of osteonecrosis in patients taking bisphosphonates for prevention of osteoporosis: a systematic review and meta-analysis
Q44747076Risks and benefits of long-term bisphosphonate therapy
Q64911041Role of bisphosphonates in the management of acute Charcot foot.
Q48294628Role of microcracks in the pathogenesis of bisphosphonate-related osteonecrosis of the jaw.
Q37475161SEOM Clinical Guideline for bone metastases from solid tumours (2016).
Q51342272Self-assembling bisphosphonates into nanofibers to enhance their inhibitory capacity on bone resorption.
Q50061495Self-healing hydrogels formed by complexation between calcium ions and bisphosphonate-functionalized star-shaped polymers.
Q45963261Serum levels of RANKL and OPG, and the RANKL/OPG ratio in bisphosphonate-related osteonecrosis of the jaw: Are they useful biomarkers for the advanced stages of osteonecrosis?
Q90182098Severe bilateral Legg-Calvé-Perthes resolved with pamidronate in combination with casts, physiotherapy and adductor tenotomy: a pictorial essay over 11 years
Q38218704Sex disparities in neuro-ophthalmologic disorders
Q42910875Short‐term zoledronic acid reduces trabecular bone remodeling in dogs
Q34753158Should bisphosphonates be used for long-term treatment of glucocorticoid-induced osteoporosis?
Q37615260Skeletal Site-specific Effects of Zoledronate on in vivo Bone Remodeling and in vitro BMSCs Osteogenic Activity
Q89280856Skeletal accumulation of fluorescently tagged zoledronate is higher in animals with early stage chronic kidney disease
Q37354085Skeletal metastasis: treatments, mouse models, and the Wnt signaling
Q64254391Skeletal-Related Events in Patients With Multiple Myeloma and Prostate Cancer Who Receive Standard vs Extended-Interval Bisphosphonate Dosing
Q41008310Soluble activin type IIB receptor improves fracture healing in a closed tibial fracture mouse model.
Q40973749Standardized classification unsuitable for spontaneous reporting: the example of osteonecrosis of the jaw.
Q39569410Stiffness and strength of bone in osteoporotic patients treated with varying durations of oral bisphosphonates
Q41036893Strontium ranelate treatment in a postmenopausal woman with osteonecrosis of the jaw after long-term oral bisphosphonate administration: a case report
Q36152236Successful conservative treatment: multiple atypical fractures in osteoporotic patients after bisphosphate medication: a unique case report
Q35867314Surgical management of bisphosphonate-related osteonecrosis of the jaws: literature review.
Q45587240Synthesis and biological evaluation of bisphosphonate compound labeled with (99m)Tc(CO)3(+).
Q28829845Synthesis of composite magnetic nanoparticles Fe3O4 with alendronate for osteoporosis treatment
Q46396656Synthesis, preclinical, and pharmacokinetic evaluation of a new zoledronate derivative as a promising antiosteoporotic candidate using radiolabeling technique.
Q92589455Synthetic Calcium Phosphate Ceramics as a Potential Treatment for Bisphosphonate-Related Osteonecrosis of the Jaw
Q37524684Systematic review on the incidence of bisphosphonate related osteonecrosis of the jaw in children diagnosed with osteogenesis imperfecta.
Q58117324Targeted Nanomedicine to Treat Bone Metastasis
Q27030812Targeted microbubbles: a novel application for the treatment of kidney stones
Q38698660Targeting collagen for diagnostic imaging and therapeutic delivery
Q82413764Targeting osteoclast-osteoblast communication
Q38626370The Characteristics of Bone Metastasis in Patients with Colorectal Cancer: A Long-Term Report from a Single Institution.
Q52690066The Effect of Inhalant Organic Dust on Bone Health.
Q61796517The Effect of Polydeoxyribonucleotide Extracted from Salmon Sperm on the Restoration of Bisphosphonate-Related Osteonecrosis of the Jaw
Q89884796The Effectiveness of the Low-Level Laser, Antibiotic and Surgical Therapy in the Treatment of Medication-Related Osteonecrosis of the Jaws: A Case Report
Q47134813The Potential of microRNAs for Stem Cell-based Therapy for Degenerative Skeletal Diseases.
Q36743799The Role of KV7.3 in Regulating Osteoblast Maturation and Mineralization
Q64080243The Role of Tocotrienol in Preventing Male Osteoporosis-A Review of Current Evidence
Q31156585The effect of medications which cause inflammation of the gastro-oesophageal tract on cancer risk: a nested case-control study of routine Scottish data.
Q47729932The effects of atorvastatin on the prevention of osteoporosis and dyslipidemia in the high-fat-fed ovariectomized rats
Q48794992The most frequent electrolyte disorders in the emergency department : what must be done immediately?
Q38717986The role of radiotherapy in bone metastases: A critical review of current literature
Q90470510The use of bisphosphonates after joint arthroplasty is associated with lower implant revision rate
Q90290365Therapeutic Irradiation: Consequences for Bone and Bone Marrow Adipose Tissue
Q36147288Thiocolchicoside suppresses osteoclastogenesis induced by RANKL and cancer cells through inhibition of inflammatory pathways: a new use for an old drug.
Q53565333Time and labor costs associated with administration of intravenous bisphosphonates for breast or prostate cancer patients with metastatic bone disease: a time and motion study.
Q90015665Tissue engineered models of healthy and malignant human bone marrow
Q48875320Tissue-Engineered Model of Human Osteolytic Bone Tumor
Q89142853Tissue-Nonspecific Alkaline Phosphatase Is Required for MC3T3 Osteoblast-Mediated Protection of Acute Myeloid Leukemia Cells from Apoptosis
Q35191865Tooth alterations in areas of bisphosphonate-induced osteonecrosis
Q33577356Total hip arthroplasty in patients with Paget's disease of bone: A systematic review
Q57110556Translational models of prostate cancer bone metastasis
Q91672626Treatment of Calciphylaxis in CKD: A Systematic Review and Meta-analysis
Q37987820Treatment of acute Charcot foot with bisphosphonates: a systematic review of the literature
Q38050104Treatment of complex regional pain syndrome in adults: a systematic review of randomized controlled trials published from June 2000 to February 2012.
Q57346992Unprecedented Control of Selectivity in Nickel-Catalyzed Hydrophosphorylation of Alkynes: Efficient Route to Mono- and Bisphosphonates
Q37812617Use of medications and risk of revision after primary total hip arthroplasty
Q33958113Validation of diagnostic codes for subtrochanteric, diaphyseal, and atypical femoral fractures using administrative claims data.
Q36729340Variations in nanomechanical properties and tissue composition within trabeculae from an ovine model of osteoporosis and treatment
Q83588890Wnt signaling as a therapeutic target for bone diseases
Q98463617Zoledronate and SPIO dual-targeting nanoparticles loaded with ICG for photothermal therapy of breast cancer tibial metastasis
Q40613636Zoledronate as effective treatment for minimal trauma fractures in a child with STAT3 deficiency and osteonecrosis of the hip.
Q34025648Zoledronic acid directly suppresses cell proliferation and induces apoptosis in highly tumorigenic prostate and breast cancers
Q42786117Zoledronic acid in myeloma: MRC Myeloma IX.
Q47139370Zoledronic acid in pediatric metabolic bone disorders
Q37688626Zoledronic acid is an effective radiosensitizer in the treatment of osteosarcoma

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