Progesterone action in endometrial cancer, endometriosis, uterine fibroids, and breast cancer.

scientific article

Progesterone action in endometrial cancer, endometriosis, uterine fibroids, and breast cancer. is …
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scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1210/ER.2012-1043
P932PMC publication ID3565104
P698PubMed publication ID23303565

P50authorSerdar BulunQ22277212
Takeshi KuritaQ56065739
P2093author name stringJ Julie Kim
P2860cites workHormonal therapy in advanced or recurrent endometrial cancerQ24235543
Progesterone receptor regulates Bcl-2 gene expression through direct binding to its promoter region in uterine leiomyoma cellsQ24338931
Retinoid-binding proteins: mediators of retinoid actionQ24532058
The role of oestrogen and progesterone receptors in human mammary development and tumorigenesisQ24542480
Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and BQ24556548
Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (TSC2) geneQ24561849
RANK is essential for osteoclast and lymph node developmentQ24598872
The antiproliferative action of progesterone in uterine epithelium is mediated by Hand2Q24602570
Steroid receptor induction of gene transcription: a two-step modelQ24684065
Transforming growth factor-beta and breast cancer: Mammary gland developmentQ24793194
Cancer of the endometrium: current aspects of diagnostics and treatmentQ24797130
A structural and in vitro characterization of asoprisnil: a selective progesterone receptor modulatorQ27644049
The nuclear receptor superfamily: the second decadeQ27860725
Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trialQ27860743
Estrogen receptor alpha mediates progestin-induced mammary tumor growth by interacting with progesterone receptors at the cyclin D1/MYC promotersQ28116725
Endocrine pharmacological characterization of progesterone antagonists and progesterone receptor modulators with respect to PR-agonistic and antagonistic activityQ28139613
The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland developmentQ28142247
Progesterone antagonists and progesterone receptor modulators: an overviewQ28190655
Classification and pharmacology of progestinsQ28190957
Multicenter phase II study of fertility-sparing treatment with medroxyprogesterone acetate for endometrial carcinoma and atypical hyperplasia in young womenQ28217820
Progesterone receptor messenger ribonucleic acid and protein are overexpressed in human uterine leiomyomasQ72836831
Progesterone receptor regulates decidual prolactin expression in differentiating human endometrial stromal cellsQ73025327
In situ estrogen synthesized by aromatase P450 in uterine leiomyoma cells promotes cell growth probably via an autocrine/intracrine mechanismQ73027724
Prostaglandin E2 stimulates aromatase expression in endometriosis-derived stromal cellsQ73047830
Oral medroxyprogesterone acetate in the treatment of advanced or recurrent endometrial carcinoma: a dose-response study by the Gynecologic Oncology GroupQ73181479
Prediction of pregnancy in infertile women based on the American Society for Reproductive Medicine's revised classification of endometriosisQ73296563
Mammary gland development is mediated by both stromal and epithelial progesterone receptorsQ73386750
Endometriosis-associated pelvic pain: evidence for an association between the stage of disease and a history of chronic pelvic painQ73476608
Progestin treatment of atypical hyperplasia and well-differentiated carcinoma of the endometrium in women under age 40Q73645480
Correlation between shrinkage of uterine leiomyoma treated with buserelin acetate and histopathologic findings of biopsy specimen before treatmentQ73814534
Leiomyoma primary cultures have elevated transcriptional response to estrogen compared with autologous myometrial culturesQ74011770
Subgroup of reproductive functions of progesterone mediated by progesterone receptor-B isoformQ74281193
Immunohistochemical comparison of uterine papillary serous and papillary endometrioid carcinoma: clues to pathogenesisQ74393765
Apoptosis in endometrial glandular and stromal cells in women with and without endometriosisQ74439718
Steroid receptor expression in endometria from women treated with tamoxifenQ77310474
Involvement of cyclin-dependent kinase inhibitor p27Kip1 in growth inhibition of endometrium in the secretory phase and of hyperplastic endometrium treated with progesteroneQ77449008
Deficient 17beta-hydroxysteroid dehydrogenase type 2 expression in endometriosis: failure to metabolize 17beta-estradiolQ77676838
Pattern of distribution of cells positive for estrogen receptor alpha and progesterone receptor in relation to proliferating cells in the mammary glandQ77882685
Murine mammary gland carcinogenesis is critically dependent on progesterone receptor functionQ78257311
Low-dose mifepristone for uterine leiomyomataQ78952409
Progestational agents in the treatment of carcinoma of the endometriumQ79032134
R5020 and RU486 act as progesterone receptor agonists to enhance Sp1/Sp4-dependent gene transcription by an indirect mechanismQ79455934
A randomized, controlled trial of asoprisnil, a novel selective progesterone receptor modulator, in women with uterine leiomyomataQ79791604
The effects of the selective progesterone receptor modulator asoprisnil on the morphology of uterine tissues after 3 months treatment in patients with symptomatic uterine leiomyomataQ79879853
Transcriptional activation of steroidogenic factor-1 by hypomethylation of the 5' CpG island in endometriosisQ80370190
Twelve-month safety and efficacy of low-dose mifepristone for uterine myomasQ81795348
Endometrial stromal sarcoma: analysis of recurrence following adjuvant treatmentQ82692784
EndometriosisQ83187897
Progesterone receptors (PR)-B and -A regulate transcription by different mechanisms: AF-3 exerts regulatory control over coactivator binding to PR-BQ83954270
Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deathsQ28241157
Selective progesterone receptor modulators and progesterone antagonists: mechanisms of action and clinical applicationsQ28241710
Selective progesterone receptor modulator development and use in the treatment of leiomyomata and endometriosisQ28247308
Clinical utility of progesterone receptor modulators and their effect on the endometriumQ28252030
The antagonists RU486 and ZK98299 stimulate progesterone receptor binding to deoxyribonucleic acid in vitro and in vivo, but have distinct effects on receptor conformationQ28266607
A membrane receptor for retinol binding protein mediates cellular uptake of vitamin AQ28285192
A novel selective progesterone receptor modulator asoprisnil (J867) inhibits proliferation and induces apoptosis in cultured human uterine leiomyoma cells in the absence of comparable effects on myometrial cellsQ28296171
17 beta-Hydroxysteroid dehydrogenase type 2: chromosomal assignment and progestin regulation of gene expression in human endometriumQ28369073
Genistein effects on stromal cells determines epithelial proliferation in endometrial co-culturesQ28388428
Cellular expression of estrogen and progesterone receptors in mammary glands: regulation by hormones, development and agingQ28506750
Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoformQ28586470
Hepatocyte growth factor is required for progestin-induced epithelial cell proliferation and alveolar-like morphogenesis in serum-free culture of normal mammary epithelial cellsQ28592980
Two domains of the progesterone receptor interact with the estrogen receptor and are required for progesterone activation of the c-Src/Erk pathway in mammalian cellsQ28771752
Retinoid-binding proteins: mediators of retinoid actionQ29038601
Molecular mechanisms of action of steroid/thyroid receptor superfamily membersQ29547540
Nuclear receptor coregulators: cellular and molecular biologyQ29547588
Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progressionQ29614274
Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalitiesQ29615568
Gene regulation by steroid hormonesQ29618291
The role of extranuclear signaling actions of progesterone receptor in mediating progesterone regulation of gene expression and the cell cycleQ30159541
Progesterone receptor contains a proline-rich motif that directly interacts with SH3 domains and activates c-Src family tyrosine kinasesQ30167936
Coordinated regulation of HOX gene expression in myometrium and uterine leiomyomaQ30868227
Management of uterine leiomyomata: what do we really know?Q31094995
17-beta estradiol elicits an autocrine leiomyoma cell proliferation: evidence for a stimulation of protein kinase-dependent pathwayQ31911939
Stromal-epithelial interactions modulate estrogen responsiveness in normal human endometriumQ32023693
Progesterone receptor rapid signaling mediates serine 345 phosphorylation and tethering to specificity protein 1 transcription factorsQ33315228
Estrogen, DNA damage and mutationsQ33538106
The genetics of endometriosisQ33595680
Transcription factor KLF11 integrates progesterone receptor signaling and proliferation in uterine leiomyoma cellsQ33658348
Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland.Q33733718
Retinoic acid: its biosynthesis and metabolismQ33743830
Progesterone: the ultimate endometrial tumor suppressor.Q33773307
Stromal deletion of the APC tumor suppressor in mice triggers development of endometrial cancerQ33833367
Novel mechanisms of progesterone antagonists and progesterone receptorQ33872590
Progesterone is essential for maintenance and growth of uterine leiomyoma.Q33874391
Theories of endometrial carcinogenesis: a multidisciplinary approachQ33886758
Steroid hormone receptor status of mouse mammary stem cellsQ42498451
Transdermal hormone replacement therapy in postmenopausal women with uterine leiomyomas.Q42514799
Interleukin-6 secretion in vitro is up-regulated in ectopic and eutopic endometrial stromal cells from women with endometriosisQ42522100
A gonadotropin-releasing hormone agonist versus a low-dose oral contraceptive for pelvic pain associated with endometriosis.Q42623460
Treatment of recurrent or metastatic low-grade endometrial stromal sarcoma: three case reportsQ42742743
Stromal PRs mediate induction of 17beta-hydroxysteroid dehydrogenase type 2 expression in human endometrial epithelium: a paracrine mechanism for inactivation of E2.Q42823263
Control of mammary stem cell function by steroid hormone signalling.Q43103606
Hormone-responsive model of primary human breast epitheliumQ43236099
Regression of uterine leiomyomata in response to the antiprogesterone RU 486.Q43451349
Breast stroma plays a dominant regulatory role in breast epithelial growth and differentiation: implications for tumor development and progression.Q43540226
Molecular tools to reestablish progestin control of endometrial cancer cell proliferation.Q43575608
Paracrine regulation of apoptosis by steroid hormones in the male and female reproductive systemQ43583220
Differential gene regulation by the two progesterone receptor isoforms in human breast cancer cellsQ43805305
Progesterone inhibits human endometrial cancer cell growth and invasiveness: down-regulation of cellular adhesion molecules through progesterone B receptors.Q43878482
Effect of different doses of progestin on uterine leiomyomas in postmenopausal women.Q43957492
Effectiveness of high-dose progestin and long-term outcomes in young women with early-stage, well-differentiated endometrioid adenocarcinoma of uterine endometriumQ44101817
Proliferative activity of human uterine leiomyoma cells as measured by automatic image analysisQ44104200
Effect of hormone replacement therapy on uterine fibroids in postmenopausal women--a 3-year studyQ44149062
Characterization of uterine leiomyomas in CD-1 mice following developmental exposure to diethylstilbestrol (DES).Q44173042
A novel LacZ reporter mouse reveals complex regulation of the progesterone receptor promoter during mammary gland development.Q44196804
Role of the progesterone receptor (PR) in susceptibility of mouse mammary gland to 7,12-dimethylbenz[a]anthracene-induced hormone-independent preneoplastic lesions in vitroQ44198306
Progestin suppresses matrix metalloproteinase production in endometrial cancerQ44416775
Expression profiling of endometrium from women with endometriosis reveals candidate genes for disease-based implantation failure and infertilityQ44480597
Progesterone receptors A and B differentially affect the growth of estrogen-dependent human breast tumor xenograftsQ44503512
Identification of tamoxifen-DNA adducts in monkeys treated with tamoxifen.Q44542327
Steroid receptor and aromatase expression in baboon endometriotic lesionsQ44593824
Phase II study of medroxyprogesterone acetate plus tamoxifen in advanced endometrial carcinoma: a Gynecologic Oncology Group studyQ44747918
Progesterone down-regulates insulin-like growth factor-I expression in cultured human uterine leiomyoma cellsQ44807399
Reduction of apoptosis and proliferation in endometriosisQ44966171
Serous endometrial cancers that mimic endometrioid adenocarcinomas: a clinicopathologic and immunohistochemical study of a group of problematic casesQ45172178
A novel organotypic culture model for normal human endometrium: regulation of epithelial cell proliferation by estradiol and medroxyprogesterone acetateQ45234417
Hormone receptor patterning plays a critical role in normal lobuloalveolar development and breast cancer progressionQ45248775
A limiting factor mediates the differential activation of promoters by the human progesterone receptor isoformsQ45352912
Sex steroidal modulation of collagen metabolism in uterine leiomyomas.Q46033596
The efficacy of hormonal treatment for residual or recurrent low-grade endometrial stromal sarcoma. A retrospective studyQ46095985
Regression of uterine leiomyomata to the antiprogesterone RU486: dose-response effectQ46198980
Stromal progesterone receptors mediate the inhibitory effects of progesterone on estrogen-induced uterine epithelial cell deoxyribonucleic acid synthesisQ46200500
Gene expression analysis of endometrium reveals progesterone resistance and candidate susceptibility genes in women with endometriosisQ46212864
Treatment of endometriosis with the antiprogesterone mifepristone (RU486)Q46235118
In situ localization of progesterone receptors in normal mouse mammary glands: absence of receptors in the connective and adipose stroma and a heterogeneous distribution in the epitheliumQ46355922
Progesterone receptor isoforms A and B: temporal and spatial differences in expression during murine mammary gland developmentQ46477275
The effect of mifepristone on breast cell proliferation in premenopausal women evaluated through fine needle aspiration cytologyQ46519248
Upregulation of ATP-sensitive potassium channels for estrogen-mediated cell proliferation in human uterine leiomyoma cellsQ46527809
The activation function-1 domain of estrogen receptor alpha in uterine stromal cells is required for mouse but not human uterine epithelial response to estrogen.Q46683753
Progestin treatment induces apoptosis and modulates transforming growth factor-beta in the uterine endometriumQ46694719
Selective progesterone receptor modulator asoprisnil down-regulates collagen synthesis in cultured human uterine leiomyoma cells through up-regulating extracellular matrix metalloproteinase inducerQ46748582
The effect of progesterone, testosterone and synthetic progestogens on growth factor- and estradiol-treated human cancerous and benign breast cellsQ46930093
Significance of p27 as a predicting marker for medroxyprogesterone acetate therapy against endometrial endometrioid adenocarcinomaQ46974271
In vitro culture significantly alters gene expression profiles and reduces differences between myometrial and fibroid smooth muscle cellsQ46981297
Effect of mifepristone for symptomatic leiomyomata on quality of life and uterine size: a randomized controlled trialQ47311848
The nuclear receptor superfamilyQ35049890
Progesterone receptor-B induction of BIRC3 protects endometrial cancer cells from AP1-59-mediated apoptosisQ35097256
Endometriosis expresses a molecular pattern consistent with decreased retinoid uptake, metabolism and action.Q35108292
Mouse primary uterine cell coculture system revisited: ovarian hormones mimic the aspects of in vivo uterine cell proliferationQ35110813
The role of progesterone signaling in the pathogenesis of uterine leiomyomaQ35249360
Uterine leiomyoma in the Eker rat: a unique model for important diseases of women.Q35563119
Stop! In the name of transforming growth factor-beta: keeping estrogen receptor-alpha-positive mammary epithelial cells from proliferatingQ35605773
Effect of infertility treatment and pregnancy-related hormones on breast cell proliferation in vitroQ35620770
Increased activation of the PI3K/AKT pathway compromises decidualization of stromal cells from endometriosis.Q35654201
The role of coactivators and corepressors in the biology and mechanism of action of steroid hormone receptorsQ35671179
Is insulin resistance an essential component of PCOS?: The endometriosis syndromes: a clinical classification in the presence of aetiological confusion and therapeutic anarchyQ35700490
Hormone-induced protection of mammary tumorigenesis in genetically engineered mouse modelsQ35749425
HMGI(Y) expression in human uterine leiomyomata. Involvement of another high-mobility group architectural factor in a benign neoplasmQ35763527
Epithelial progesterone receptor exhibits pleiotropic roles in uterine development and functionQ35787724
Estrogen receptor-positive proliferating cells in the normal and precancerous breast.Q35787982
Systematic review of mifepristone for the treatment of uterine leiomyomataQ35789745
Progesterone receptor distribution in the human endometrium. Analysis using monoclonal antibodies to the human progesterone receptorQ35818398
The biology of progesterone receptor in the normal mammary gland and in breast cancerQ35868802
Hormonal therapy for the management of grade 1 endometrial adenocarcinoma: a literature review.Q35895916
Metastatic or Embolic Endometriosis, due to the Menstrual Dissemination of Endometrial Tissue into the Venous CirculationQ35911329
Opposing effects of retinoic acid on cell growth result from alternate activation of two different nuclear receptorsQ35940872
Breast cancer and atypia among young and middle-aged women: a study of 110 medicolegal autopsiesQ36029584
Reduced progesterone action during endometrial maturation: a potential risk factor for the development of endometriosisQ36062838
A paracrine role for the epithelial progesterone receptor in mammary gland developmentQ36064196
Research resource: Genome-wide profiling of progesterone receptor binding in the mouse uterus.Q36113833
Aromatase, breast cancer and obesity: a complex interactionQ36191587
Stromal estrogen receptors mediate mitogenic effects of estradiol on uterine epitheliumQ36193533
Regulation of aromatase expression in estrogen-responsive breast and uterine disease: from bench to treatment.Q36234570
Function of retinoid nuclear receptors: lessons from genetic and pharmacological dissections of the retinoic acid signaling pathway during mouse embryogenesisQ36364699
Progesterone resistance in endometriosis: link to failure to metabolize estradiolQ36365708
The dose-effect relationship between 'unopposed' oestrogens and endometrial mitotic rate: its central role in explaining and predicting endometrial cancer riskQ36465880
Transcription activation by estrogen and progesterone receptorsQ36468309
The regulation and function of the forkhead transcription factor, Forkhead box O1, is dependent on the progesterone receptor in endometrial carcinomaQ36513184
Volume change of uterine myomas during pregnancy: do myomas really grow?Q36589882
Molecular mechanisms involved in progesterone receptor regulation of uterine functionQ36635728
Retinoic acid (RA) regulates 17beta-hydroxysteroid dehydrogenase type 2 expression in endometrium: interaction of RA receptors with specificity protein (SP) 1/SP3 for estradiol metabolismQ36661971
Etiology, symptomatology, and diagnosis of uterine myomasQ36790210
Hormone therapy in advanced and recurrent endometrial cancer: a systematic reviewQ36794868
Progesterone receptors in the mouse mammary duct: distribution and developmental regulation.Q36819985
The emerging picture of the mouse mammary stem cellQ36943334
Decidualization of the human endometrium: mechanisms, functions, and clinical perspectivesQ36981305
Tumor stroma and regulation of cancer developmentQ37014752
Transcriptional response of the murine mammary gland to acute progesterone exposureQ37034915
Serial histologic observation of endometrial adenocarcinoma treated with high-dose progestin until complete disappearance of carcinomatous foci--review of more than 25 biopsies from five patientsQ37064497
Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblastsQ37150735
Progestins activate the AKT pathway in leiomyoma cells and promote survival.Q37198021
Mechanical homeostasis is altered in uterine leiomyomaQ37227767
DNA replication licensing and progenitor numbers are increased by progesterone in normal human breastQ37244666
Progesterone receptor inhibits aromatase and inflammatory response pathways in breast cancer cells via ligand-dependent and ligand-independent mechanismsQ37302387
A novel organotypic model mimics the tumor microenvironmentQ37316568
A low concentration of genistein induces estrogen receptor-alpha and insulin-like growth factor-I receptor interactions and proliferation in uterine leiomyoma cellsQ37323351
Low-grade endometrial stromal sarcoma of the uterus: review of 10 cases.Q37334288
Progesterone receptor action in leiomyoma and endometrial cancerQ37338412
Progestin receptors: isoforms and antihormone actionQ37544485
Modulation of AP-1 activity by the human progesterone receptor in endometrial adenocarcinoma cellsQ37577169
Prolonged conservative treatment of endometrial cancer patients: more than 1 pregnancy can be achievedQ37823119
Endometrial hyperplasiaQ37838975
Cracking the estrogen receptor's posttranslational code in breast tumorsQ37890710
Recent advances in endometrial cancerQ38013633
Global gene profiling in human endometrium during the window of implantationQ38289149
RU486 exerts antiestrogenic activities through a novel progesterone receptor A form-mediated mechanism.Q38308917
Antagonist-occupied human progesterone receptors bound to DNA are functionally switched to transcriptional agonists by cAMP.Q38319428
The progesterone receptor stimulates cell-free transcription by enhancing the formation of a stable preinitiation complexQ38342253
In utero exposures and the incidence of endometriosisQ38476122
Reproductive history and endometriosis among premenopausal womenQ38476734
'Waiting for Godot': a commonsense approach to the medical treatment of endometriosisQ39276875
Progestins for symptomatic endometriosis: a critical analysis of the evidence.Q39453269
Normal endometrial stromal cells regulate survival and apoptosis signaling through PI3K/AKt/Survivin pathway in endometrial adenocarcinoma cells in vitroQ39499928
Up-regulation by progesterone of proliferating cell nuclear antigen and epidermal growth factor expression in human uterine leiomyomaQ47976455
Endometriosis rediscovered?Q48656840
Human 17beta-hydroxysteroid dehydrogenase type 2 messenger ribonucleic acid expression and localization in term placenta and in endometrium during the menstrual cycle.Q50896417
Rapid loss of oestrogen and progesterone receptors in human leiomyoma and myometrial explant cultures.Q50944536
Histologic alterations in endometrial hyperplasia and well-differentiated carcinoma treated with progestins.Q50970377
Increased expression of Bcl-2 protein in human uterine leiomyoma and its up-regulation by progesterone.Q50981405
Effects of sex steroids and growth factors on migration and invasion of endometrial adenocarcinoma SNG-M cells in vitro.Q51031691
Recurrence patterns and prognosis of endometrial stromal sarcoma and the potential of tyrosine kinase-inhibiting therapy.Q51060775
Selective release of follicle-stimulating hormone and luteinizing hormone by 5 alpha-dihydroprogesterone and 3 alpha, 5 alpha-tetrahydroprogesterone in pregnant mare's serum gonadotropin-primed immature rats exposed to constant light.Q51827600
Transcriptional cross talk between the forkhead transcription factor forkhead box O1A and the progesterone receptor coordinates cell cycle regulation and differentiation in human endometrial stromal cells.Q51981689
Dissociation between steroid receptor expression and cell proliferation in the human breast.Q52528046
Altered hormonal responsiveness of proliferation and apoptosis during myometrial maturation and the development of uterine leiomyomas in the rat.Q52541425
Hormone-dependent interaction between the amino- and carboxyl-terminal domains of progesterone receptor in vitro and in vivo.Q52571111
Stromal cells of endometriosis fail to produce paracrine factors that induce epithelial 17beta-hydroxysteroid dehydrogenase type 2 gene and its transcriptional regulator Sp1: a mechanism for defective estradiol metabolism.Q52578119
Identification of tamoxifen-DNA adducts in the endometrium of women treated with tamoxifen.Q53407664
Promoter methylation regulates estrogen receptor 2 in human endometrium and endometriosis.Q53541411
EndometriosisQ55951108
Ultrastructural comparison of uterine leiomyoma cells from the same myoma nodule before and after gonadotropin-releasing hormone agonist treatmentQ57188648
Variation in the Incidence of Uterine Leiomyoma Among Premenopausal Women by Age and RaceQ57751559
Relative overexpression of collagen type I and collagen type III messenger ribonucleic acids by uterine leiomyomas during the proliferative phase of the menstrual cycleQ59650550
Lack of evidence from HPLC 32P-post-labelling for tamoxifenDNA adducts in the human endometriumQ61774306
Steroid hormone receptors compete for factors that mediate their enhancer functionQ61818663
The possible influence of temporal factors in androgenic responsiveness of urogenital tissue recombinants from wild-type and androgen-insensitive (Tfm) miceQ67369155
Immunocytochemical analysis of oestrogen receptors and progesterone receptors in the human uterus throughout the menstrual cycle and after the menopauseQ68136434
Estradiol and 20alpha-dihydroprogesterone dehydrogenase activities in human endometrium during the menstrual cycleQ68675945
The effect of progestins on the mitotic activity of uterine fibromyomasQ69954738
Mitotic activity in uterine leiomyomas during the menstrual cycleQ69972772
Steroid receptors and clinical outcome in patients with adenocarcinoma of the endometriumQ70053085
Patterns of growth of uterine leiomyomas during pregnancy. A prospective longitudinal studyQ70195122
Pregnancy success following surgical correction of imperforate hymen and complete transverse vaginal septumQ70354833
An evaluation of the effect of gonadotropin-releasing hormone analogs and medroxyprogesterone acetate on uterine leiomyomata volume by magnetic resonance imaging: a prospective, randomized, double blind, placebo-controlled, crossover trialQ70723071
A prospective, randomized trial of gonadotropin-releasing hormone agonist plus estrogen-progestin or progestin "add-back" regimens for women with leiomyomata uteriQ70735247
Aromatase expression in endometriosisQ70871309
Endometriosis and pelvic pain: relation to disease stage and localizationQ70911703
The effects of hormone replacement therapy on uterine fibroids in postmenopausal womenQ70911730
Morphological changes in uterine leiomyomas treated by GnRH agonist goserelinQ70997857
The subunit structure of human breast cancer progesterone receptors: characterization by chromatography and photoaffinity labelingQ71228918
Tamoxifen-induced DNA adducts in endometrial samples from breast cancer patientsQ71545530
In vitro analysis of the hormonal basis for the sexual dimorphism in the embryonic development of the mouse mammary glandQ71768273
Distribution of progesterone receptor, estradiol dehydrogenase, and 20 alpha-dihydroprogesterone dehydrogenase activities in human endometrial glands and stroma: progestin induction of steroid dehydrogenase activities in vitro is restricted to the gQ72045793
A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancerQ72127267
EndometriosisQ72247288
Antagonist-occupied human progesterone B-receptors activate transcription without binding to progesterone response elements and are dominantly inhibited by A-receptorsQ72281048
Cytosol estrogen and progestin receptor concentrations and 17β-hydroxysteroid dehydrogenase activities in the endometrium and endometriotic tissue: Effects of hormonal treatmentQ72399827
Quantification of messenger ribonucleic acid for epidermal growth factor in human myometrium and leiomyomata using reverse transcriptase polymerase chain reactionQ72404089
Activation of the Src/p21ras/Erk pathway by progesterone receptor via cross-talk with estrogen receptorQ33888599
Progesterone receptor isoform A but not B is expressed in endometriosisQ33914347
Mammary gland growth and development from the postnatal period to postmenopause: ovarian steroid receptor ontogeny and regulation in the mouseQ33923663
The role of mammary stroma in modulating the proliferative response to ovarian hormones in the normal mammary glandQ33923751
Sequential recruitment of steroid receptor coactivator-1 (SRC-1) and p300 enhances progesterone receptor-dependent initiation and reinitiation of transcription from chromatinQ33947754
Polymorphisms in nucleotide excision repair genes and endometrial cancer riskQ33958989
Recurrent endometrial stromal sarcoma: treatment with a progestin and gonadotropin releasing hormone agonistQ33959828
High cumulative incidence of uterine leiomyoma in black and white women: ultrasound evidenceQ33963976
Pregnancy-related changes in the size of uterine leiomyomasQ34000199
Ulipristal acetate versus leuprolide acetate for uterine fibroidsQ34030475
Role of FOXO1A in the regulation of insulin-like growth factor-binding protein-1 in human endometrial cells: interaction with progesterone receptorQ34049545
Role of progesterone in endometrial cancerQ34095034
Genome-wide progesterone receptor binding: cell type-specific and shared mechanisms in T47D breast cancer cells and primary leiomyoma cellsQ34137268
Progestin intrauterine device and GnRH analogue for uterus-sparing treatment of endometrial precancers and well-differentiated early endometrial carcinoma in young womenQ34140562
Breast cancer and hormone-replacement therapy in the Million Women StudyQ34223870
Transactivation of steroidogenic acute regulatory protein in human endometriotic stromalcells is mediated by the prostaglandin EP2 receptorQ34224671
The role of the microenvironment in mammary gland development and cancerQ34241137
Ulipristal acetate versus placebo for fibroid treatment before surgeryQ34251134
Altered retinoid uptake and action contributes to cell survival in endometriosis.Q34262490
Role of stem cells in human uterine leiomyoma growthQ34263429
Targeting RANKL to a specific subset of murine mammary epithelial cells induces ordered branching morphogenesis and alveologenesis in the absence of progesterone receptor expression.Q34281611
Cancer without disease.Q34301350
Treatment of endometriosisQ34320226
Uterine epithelial estrogen receptor α is dispensable for proliferation but essential for complete biological and biochemical responsesQ34320366
Sex steroidal regulation of uterine leiomyoma growth and apoptosisQ34320465
Negative interaction between the RelA(p65) subunit of NF-kappaB and the progesterone receptorQ34378783
Mechanisms of progesterone receptor inhibition of inflammatory responses in cellular models of breast cancerQ34392493
Heregulin induces transcriptional activation of the progesterone receptor by a mechanism that requires functional ErbB-2 and mitogen-activated protein kinase activation in breast cancer cells.Q34463159
Aromatase inhibitors: the next generation of therapeutics for endometriosis?Q34519101
Angiogenic factors in endometriosis.Q34597482
Endometrioid carcinoma of the uterine corpus: a review of its pathology with emphasis on recent advances and problematic aspectsQ34617725
Two pathogenetic types of endometrial carcinomaQ34713298
Health risks and benefits 3 years after stopping randomized treatment with estrogen and progestinQ34758422
Breast cancer after use of estrogen plus progestin in postmenopausal womenQ34938322
COX-2 inhibitors and their role in gynecologyQ35006858
Mechanism of action of progesterone antagonistsQ35027291
Tissue interaction in androgen response of embryonic mammary rudiment of mouse: identification of target tissue for testosteroneQ35035898
Forkhead transcription factor FOXO1 is a direct target of progestin to inhibit endometrial epithelial cell growthQ39623809
Steroid hormones and endometrial cancerQ39773771
High concentrations of progesterone and mifepristone mutually reinforce cell cycle retardation and induction of apoptosis.Q39857096
Early effects of high concentrations of progesterone and mifepristone A gene expression study of endometrial cancer cells (Ishikawa).Q39896392
Induction of Human Endometrial Estradiol Dehydrogenase by ProgestinsQ39962020
Gene expression in endometrial cancer cells (Ishikawa) after short time high dose exposure to progesteroneQ40045161
Progestin effects on breast cancer cell proliferation, proteases activation, and in vivo development of metastatic phenotype all depend on progesterone receptor capacity to activate cytoplasmic signaling pathways.Q40144666
Histone deacetylase inhibition and progesterone act synergistically to stimulate baboon glycodelin gene expressionQ40163029
Prevention of Brca1-mediated mammary tumorigenesis in mice by a progesterone antagonistQ40202330
Histone deacetylase inhibitors stimulate cell migration in human endometrial adenocarcinoma cells through up-regulation of glycodelin.Q40215090
Growth regulation and transcriptional activities of estrogen and progesterone in human endometrial cancer cellsQ40323481
Up-regulation of the progesterone receptor (PR)-C isoform in laboring myometrium by activation of nuclear factor-kappaB may contribute to the onset of labor through inhibition of PR function.Q40341667
Histone deacetylase inhibitors induce differentiation of human endometrial adenocarcinoma cells through up-regulation of glycodelinQ40381321
The effects of progesterone, medroxyprogesterone acetate, and norethisterone on growth factor- and estradiol-treated human cancerous and noncancerous breast cellsQ40394641
Progesterone-independent effects of human progesterone receptors (PRs) in estrogen receptor-positive breast cancer: PR isoform-specific gene regulation and tumor biology.Q40488240
RU486: pharmacology and potential use in the treatment of endometriosis and leiomyomata uteri.Q40675975
Distinct functional differences of human progesterone receptors A and B on gene expression and growth regulation in two endometrial carcinoma cell linesQ40679032
Effect of normal endometrial stroma on growth and differentiation in Ishikawa endometrial adenocarcinoma cellsQ40758221
Hysterectomy in the United States, 1988-1990.Q41037526
Biphasic regulation of breast cancer cell growth by progesterone: role of the cyclin-dependent kinase inhibitors, p21 and p27(Kip1).Q41084288
Abnormal ribosome assembly in a mutant of Escherichia coliQ41129147
Progestin alone as primary treatment of endometrial carcinoma in premenopausal women. Report of seven cases and review of the literatureQ41331490
Endometrial cancer: incidence, prognostic factors, diagnosis, and treatmentQ41358328
RU486 (mifepristone): mechanisms of action and clinical usesQ41360492
Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B functionQ41523742
Role of co-activators and co-repressors in the mechanism of steroid/thyroid receptor actionQ41546396
Physiological action of progesterone in target tissuesQ41574892
Does disruption of immune and endocrine systems by environmental toxins contribute to development of endometriosis?Q41651724
Oestrogen receptor (ER)-alpha and ER-beta isoforms in normal endometrial and endometriosis-derived stromal cellsQ41674994
Paracrine regulation of epithelial progesterone receptor and lactoferrin by progesterone in the mouse uterusQ41726031
Longitudinal evaluation of uterine myoma growth during pregnancy. A sonographic studyQ42032538
Progesterone induces adult mammary stem cell expansionQ42471079
The human progesterone receptor A-form functions as a transcriptional modulator of mineralocorticoid receptor transcriptional activityQ72413179
The predisposing gene of the Eker rat inherited cancer syndrome is tightly linked to the tuberous sclerosis (TSC2) geneQ72692517
Use of progestational agents in the management of endometrial cancerQ72727579
Estrogen receptor expression of benign breast epithelium and its association with breast cancerQ72785661
P433issue1
P921main subjectendometriosisQ205764
uterine fibroidQ556281
endometrial cancerQ944777
P304page(s)130-162
P577publication date2013-01-09
P1433published inEndocrine ReviewsQ3054007
P1476titleProgesterone action in endometrial cancer, endometriosis, uterine fibroids, and breast cancer
P478volume34

Reverse relations

cites work (P2860)
Q91655319A calcium-dependent phospholipase A2 (cPLA2) expression is regulated by MIG-6 during endometrial tumorigenesis
Q47119285A network pharmacology approach to investigate the pharmacological effects of Guizhi Fuling Wan on uterine fibroids
Q91619806A-Kinase Anchoring Protein 13 (AKAP13) Augments Progesterone Signaling in Uterine Fibroid Cells
Q37225222ARID1A mutations and PI3K/AKT pathway alterations in endometriosis and endometriosis-associated ovarian carcinomas
Q53224664ATM may be a protective factor in endometrial carcinogenesis with the progesterone pathway.
Q34664105Altered gene expression patterns during the initiation and promotion stages of neonatally diethylstilbestrol-induced hyperplasia/dysplasia/neoplasia in the hamster uterus
Q47824474Androgens Upregulate Endometrial Epithelial Progesterone Receptor Expression: Potential Implications for Endometriosis.
Q26749272Aromatase expression and regulation in breast and endometrial cancer
Q49787688Assessing tumor molecular profiling to guide treatments for patients with advanced female genital tract malignancy
Q37001517Association between the CYP11 family and six cancer types
Q90134710Baicalein Is a Phytohormone that Signals Through the Progesterone and Glucocorticoid Receptors
Q37685866Benign breast and gynecologic conditions, reproductive and hormonal factors, and risk of thyroid cancer
Q34568706Bioinformatic analysis of cis-regulatory interactions between progesterone and estrogen receptors in breast cancer.
Q52683168Bisphenol A impairs decidualization of human uterine stromal fibroblasts.
Q35614080Breast cancer in the setting of fertility-sparing treatment for endometrial cancer
Q33776694COUP-TFI modifies CXCL12 and CXCR4 expression by activating EGF signaling and stimulates breast cancer cell migration
Q92500366Chronic Exposure of Mice to Bisphenol-A Alters Uterine Fibroblast Growth Factor Signaling and Leads to Aberrant Epithelial Proliferation
Q29248520Chronic exposure to bisphenol a impairs progesterone receptor-mediated signaling in the uterus during early pregnancy
Q37596751Combination of Diane-35 and Metformin to Treat Early Endometrial Carcinoma in PCOS Women with Insulin Resistance
Q47911011Conditional Ablation of Progesterone Receptor Membrane Component 2 Causes Female Premature Reproductive Senescence
Q37353846Continuous Combined Estrogen Plus Progestin and Endometrial Cancer: The Women's Health Initiative Randomized Trial
Q38892949Correlation Between the Clinical Parameters and Tissue Phenotype in Patients Affected by Deep-Infiltrating Endometriosis
Q92237242Curcumin and endometrial carcinoma: an old spice as a novel agent
Q33711732Deep sequencing reveals new aspects of progesterone receptor signaling in breast cancer cells
Q36528223Deficiency in DGCR8-dependent canonical microRNAs causes infertility due to multiple abnormalities during uterine development in mice.
Q92702753Development of A 3D Tissue Slice Culture Model for the Study of Human Endometrial Repair and Regeneration
Q53440345Development of a technique to detect the activated form of the progesterone receptor and correlation with clinical and histopathological characteristics of endometrioid adenocarcinoma of the uterine corpus.
Q33675285Direct effects of metformin in the endometrium: a hypothetical mechanism for the treatment of women with PCOS and endometrial carcinoma.
Q38663754Does dienogest influence the inflammatory response of endometriotic cells? A systematic review.
Q46019835Effects of noncavity-distorting fibroids on endometrial gene expression and function.
Q36525065Endocrinology of uterine fibroids: steroid hormones, stem cells, and genetic contribution.
Q30353001Endometrial Expression of Steroidogenic Factor 1 Promotes Cystic Glandular Morphogenesis.
Q37567264Endometrial progesterone resistance and PCOS.
Q40290088Endometriosis and risk of ovarian and endometrial cancers in a large prospective cohort of U.S. nurses
Q40645330Endometriosis and risks for ovarian, endometrial and breast cancers: A nationwide cohort study.
Q35944399Epidemiological and genetic clues for molecular mechanisms involved in uterine leiomyoma development and growth.
Q38788210Epidemiology of Endometrial Carcinoma: Etiologic Importance of Hormonal and Metabolic Influences
Q92702483Epigenetic Dysregulation at the Crossroad of Women's Cancer
Q64964271Epithelial to Mesenchymal Transition and Cell Biology of Molecular Regulation in Endometrial Carcinogenesis.
Q34776859Establishment of human patient-derived endometrial cancer xenografts in NOD scid gamma mice for the study of invasion and metastasis
Q36267111Estrogen Receptor β Modulates Apoptosis Complexes and the Inflammasome to Drive the Pathogenesis of Endometriosis
Q34395170Fenretinide: a novel treatment for endometrial cancer
Q49250031Gefitinib enhances sensitivity of endometrial cancer cells to progestin therapy via dual-specificity phosphatase 1.
Q58604035Generation of Progesterone-Responsive Endometrial Stromal Fibroblasts from Human Induced Pluripotent Stem Cells: Role of the WNT/CTNNB1 Pathway
Q37016586Growth of poorly differentiated endometrial carcinoma is inhibited by combined action of medroxyprogesterone acetate and the Ras inhibitor Salirasib
Q28294446HRT optimization, using transdermal estradiol plus micronized progesterone, a safer HRT
Q36054376History of uterine leiomyomata and incidence of breast cancer
Q64064494Hormonal therapy in uterine sarcomas
Q30370194Hyperplasia and fibrosis in mice with conditional loss of the TSC2 tumor suppressor in Müllerian duct mesenchyme-derived myometria.
Q28292646Hypomethylation of ETS transcription factor binding sites and upregulation of PARP1 expression in endometrial cancer
Q34876165Identification and characterization of progesterone- and estrogen-regulated MicroRNAs in mouse endometrial epithelial cells.
Q41815158Imiquimod Induces Apoptosis in Human Endometrial Cancer Cells In vitro and Prevents Tumor Progression In vivo
Q36723027Immunoexpression of Steroid Hormone Receptors and Proliferation Markers in Uterine Leiomyoma and Normal Myometrial Tissues from the Miniature Pig, Sus scrofa
Q38648524Impact of oestrogen and progesterone receptor expression in the cancer cells and myometrium on survival of patients with endometrial cancer.
Q40170713In silico, in vitro and in vivo analysis identifies a potential role for steroid hormone regulation of FOXD3 in endometriosis-associated genes
Q35617565Influence of AKT on progesterone action in endometrial diseases
Q52751765Inhibiting Nuclear Phospho-Progesterone Receptor Enhances Antitumor Activity of Onapristone in Uterine Cancer.
Q34504377Innovations in classical hormonal targets for endometriosis
Q30381117Insulin/IGF and sex hormone axes in human endometrium and associations with endometrial cancer risk factors.
Q28260010Kaempferol Exhibits Progestogenic Effects in Ovariectomized Rats
Q36324375Lack of cyclical fluctuations of endometrial GLUT4 expression in women with polycystic ovary syndrome: Evidence for direct regulation of GLUT4 by steroid hormones
Q33826091Loss of CDH1 and Pten accelerates cellular invasiveness and angiogenesis in the mouse uterus.
Q36000984Loss of Cdh1 and Trp53 in the uterus induces chronic inflammation with modification of tumor microenvironment
Q47634931MIG-6 negatively regulates STAT3 phosphorylation in uterine epithelial cells
Q40045531Menopausal Hormone Therapy and Long-term All-Cause and Cause-Specific Mortality: The Women's Health Initiative Randomized Trials
Q37658616Menopausal hormone therapy and health outcomes during the intervention and extended poststopping phases of the Women's Health Initiative randomized trials
Q26472029Metformin for endometrial hyperplasia
Q36105494Metformin for endometrial hyperplasia: a Cochrane protocol
Q51648368Metformin targeting autophagy overcomes progesterone resistance in endometrial carcinoma.
Q51290637Mig-6 Mouse Model of Endometrial Cancer.
Q33631557Minireview: Progesterone Regulation of Proliferation in the Normal Human Breast and in Breast Cancer: A Tale of Two Scenarios?
Q38103751Model of tumor-associated epigenetic changes of HER2, ER, and PgR expression in invasive breast cancer phenotypes
Q28076023Molecular Targets and Emerging Therapeutic Options for Uterine Leiomyosarcoma
Q33734466Natural and synthetic progestins enrich cancer stem cell-like cells in hormone-responsive human breast cancer cell populations in vitro
Q36107514Neonatal Progesterone Programs Adult Uterine Responses to Progesterone and Susceptibility to Uterine Dysfunction
Q41634189Niclosamide As a Potential Nonsteroidal Therapy for Endometriosis That Preserves Reproductive Function in an Experimental Mouse Model.
Q37316692Oestrogen-induced angiogenesis and implantation contribute to the development of parasitic myomas after laparoscopic morcellation
Q34437666Ovarian steroids, stem cells and uterine leiomyoma: therapeutic implications.
Q37516309PCOS and obesity: insulin resistance might be a common etiology for the development of type I endometrial carcinoma
Q53092574PRL-3 Is Involved in Estrogen- and IL-6-Induced Migration of Endometrial Stromal Cells From Ectopic Endometrium.
Q33779337Patients with uterine leiomyoma exhibit a high incidence but low mortality rate for breast cancer.
Q47282567Pharmacokinetic drug evaluation of ulipristal acetate for the treatment of uterine fibroids.
Q57286101Phase I study of onapristone, a type I antiprogestin, in female patients with previously treated recurrent or metastatic progesterone receptor-expressing cancers
Q28550351Prediction of Candidate Drugs for Treating Pancreatic Cancer by Using a Combined Approach
Q36791086Primary extraosseous Ewing sarcoma of the lung in children
Q35108906Progesterone action in breast, uterine, and ovarian cancers
Q88032097Progesterone activation of zebrafish mineralocorticoid receptor may influence growth of some transplanted tumors
Q90073087Progesterone and Breast Cancer
Q35974555Progesterone antagonizes the positive influence of estrogen on Chlamydia trachomatis serovar E in an Ishikawa/SHT-290 co-culture model
Q40799076Progesterone levels in letrozole associated controlled ovarian stimulation for fertility preservation in breast cancer patients.
Q49487934Progesterone modulates microtubule dynamics and epiboly progression during zebrafish gastrulation.
Q37718405Progesterone potentiates the growth inhibitory effects of calcitriol in endometrial cancer via suppression of CYP24A1.
Q90412314Progesterone receptor integrates the effects of mutated MED12 and altered DNA methylation to stimulate RANKL expression and stem cell proliferation in uterine leiomyoma
Q37406760Progesterone receptor isoforms A and B: new insights into the mechanism of progesterone resistance for the treatment of endometrial carcinoma
Q36844266Progesterone receptor membrane component 1 promotes survival of human breast cancer cells and the growth of xenograft tumors
Q35551056Progesterone receptor signaling in the initiation of pregnancy and preservation of a healthy uterus
Q51616209Progesterone-induced miR-133a inhibits the proliferation of endometrial epithelial cells.
Q30836342Progesterone-targeted magnetic resonance imaging probes
Q60044628Prognostic value of progesterone receptor in solid pseudopapillary neoplasm of the pancreas: evaluation of a pooled case series
Q36250770Promising clinical practices of metformin in women with PCOS and early-stage endometrial cancer.
Q42371820Pterostilbene, a natural phenolic compound, synergizes the antineoplastic effects of megestrol acetate in endometrial cancer
Q37725437RNPC1 enhances progesterone receptor functions by regulating its mRNA stability in breast cancer
Q33852886Recent Advances in Uterine Fibroid Etiology
Q36352719Regulation of Androgen Receptor Expression Alters AMPK Phosphorylation in the Endometrium: In Vivo and In Vitro Studies in Women with Polycystic Ovary Syndrome
Q38184989Regulation of voltage-gated sodium channel expression in cancer: hormones, growth factors and auto-regulation
Q48074431Renovated (nondual) approach to endometrial cancer typing: endocrine and inflammatory issues
Q64914914Role of erythropoietin and its receptor in the development of endometriosis in rats
Q34448400Role of nuclear progesterone receptor isoforms in uterine pathophysiology
Q37361130Role of nuclear receptors in blastocyst implantation.
Q36447481Role of the steroidogenic acute regulatory protein in health and disease
Q35855640Signaling Pathways in Leiomyoma: Understanding Pathobiology and Implications for Therapy
Q29247892Strain-Specific Induction of Endometrial Periglandular Fibrosis in Mice Exposed During Adulthood to the Endocrine Disrupting Chemical Bisphenol A
Q91779264TRPM7 is involved in acid-induced necrotic cell death in a manner sensitive to progesterone in human cervical cancer cells
Q35921030Targeting female hormone receptors as cervical cancer therapy
Q37621100Targeting nuclear receptors with marine natural products
Q26853244The Krüppel-like factors in female reproductive system pathologies
Q52799875The allosteric AKT inhibitor, MK2206, decreases tumor growth and invasion in patient derived xenografts of endometrial cancer.
Q92324480The cost-effective, but forgotten, medical endometriosis therapy: a prospective, quasi-randomized study on progestin therapy
Q33926671The hormonal composition of follicular fluid and its implications for ovarian cancer pathogenesis
Q59046724Theories on the pathogenesis of endometriosis
Q33888331Treatment with bazedoxifene and conjugated estrogens results in regression of endometriosis in a murine model
Q54330083Tumour and cellular distribution of activated forms of PR in breast cancers: a novel immunohistochemical analysis of a large clinical cohort.
Q36742639Unremitting cell proliferation in the secretory phase of eutopic endometriosis: involvement of pAkt and pGSK3β
Q35662059Use of depot medroxyprogesterone acetate and prevalent leiomyoma in young African American women
Q53078772Uterine function in the mouse requires speckle-type poz protein.
Q30490853Vaginal estrogen: a dual-edged sword in postoperative healing of the vaginal wall.
Q90559037Water-Soluble Nanoconjugate for Enhanced Cellular Delivery of Receptor-Targeted Magnetic Resonance Contrast Agents
Q34590328Women with endometriosis have a higher DNA repair capacity and diminished breast cancer risk

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