| scholarly article | Q13442814 |
| P356 | DOI | 10.1016/0092-8674(94)90505-3 |
| P698 | PubMed publication ID | 8124708 |
| P50 | author | Susumu Tonegawa | Q108602 |
| Rolf M. Zinkernagel | Q116064 | ||
| Luc Van Kaer | Q37839914 | ||
| P2093 | author name string | P G Ashton-Rickardt | |
| A Bandeira | |||
| J R Delaney | |||
| H P Pircher | |||
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| Lower receptor avidity required for thymic clonal deletion than for effector T-cell function | Q59093837 | ||
| Tolerance induction by clonal deletion of CD4+8+ thymocytes in vitro does not require dedicated antigen-presenting cells | Q61454446 | ||
| Assembly of MHC class I molecules analyzed in vitro | Q61761268 | ||
| Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus | Q63363368 | ||
| Emerging principles for the recognition of peptide antigens by MHC class I molecules | Q67494475 | ||
| Identity of cells that imprint H-2-restricted T-cell specificity in the thymus | Q69989585 | ||
| TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selective | Q72873502 | ||
| It is easier for a camel to pass the needle's eye | Q80506162 | ||
| P433 | issue | 4 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 651-663 | |
| P577 | publication date | 1994-02-01 | |
| P1433 | published in | Cell | Q655814 |
| P1476 | title | Evidence for a differential avidity model of T cell selection in the thymus | |
| P478 | volume | 76 |
| Q35834589 | A T cell receptor-specific blockade of positive selection |
| Q77372675 | A caspase inhibitor protects thymocytes from diverse signal-mediated apoptosis but not from clonal deletion in fetal thymus organ culture |
| Q34666349 | A discrete affinity-driven elevation of ZAP-70 kinase activity initiates negative selection |
| Q37528668 | A discrete computer model of the immune system reveals competitive interactions between the humoral and cellular branch and between cross-reacting memory and naïve responses. |
| Q36369989 | A kinetic threshold between negative and positive selection based on the longevity of the T cell receptor-ligand complex |
| Q56922218 | A little of what you fancy . . |
| Q36380664 | A mechanism for the major histocompatibility complex-linked resistance to autoimmunity |
| Q41326884 | A model for developmentally acquired thymus-dependent tolerance to central and peripheral antigens |
| Q36369498 | A naturally processed mitochondrial self-peptide in complex with thymic MHC molecules functions as a selecting ligand for a viral-specific T cell receptor |
| Q36367304 | A single T cell receptor recognizes structurally distinct MHC/peptide complexes with high specificity |
| Q39285418 | A single peptide-MHC complex positively selects a diverse and specific CD8 T cell repertoire |
| Q37461924 | A single-amino-acid variant of the H60 CD8 epitope generates specific immunity with diverse TCR recruitment |
| Q33857220 | Aberrant prostaglandin synthase 2 expression defines an antigen-presenting cell defect for insulin-dependent diabetes mellitus |
| Q38170501 | Adoptive immunotherapy with genetically modified lymphocytes in allogeneic stem cell transplantation |
| Q52165633 | Affinity of thymic self-peptides for the TCR determines the selection of CD8(+) T lymphocytes in the thymus. |
| Q33639952 | Affinity-based selection of regulatory T cells occurs independent of agonist-mediated induction of Foxp3 expression |
| Q40438837 | Altered MHC class I expression: A role for transplantation and IDDM autoimmunity |
| Q36171567 | Altered peptide ligands induce quantitatively but not qualitatively different intracellular signals in primary thymocytes |
| Q34982958 | Altered positive selection due to corecognition of floppy peptide/MHC II conformers supports an integrative model of thymic selection |
| Q33596728 | Altered thymic positive selection and intracellular signals in Cbl-deficient mice |
| Q35729215 | An alternative to current thinking about positive selection, negative selection and activation of T cells |
| Q36402496 | An antagonist peptide mediates positive selection and CD4 lineage commitment of MHC class II-restricted T cells in the absence of CD4 |
| Q36401332 | Analysis of the role of variation of major histocompatibility complex class II expression on nonobese diabetic (NOD) peripheral T cell response |
| Q36401775 | Antagonist peptide selects thymocytes expressing a class II major histocompatibility complex-restricted T cell receptor into the CD8 lineage |
| Q60730845 | Anti-alpha4 integrin antibody induces apoptosis in murine thymocytes and staphylococcal enterotoxin B-activated lymph node T cells |
| Q37638193 | Antigen presentation in the thymus for positive selection and central tolerance induction |
| Q35092544 | Antigen-induced regulatory T cells in autoimmunity |
| Q41202687 | Antigen-specific T-cell receptors and their reactions with complexes formed by peptides with major histocompatibility complex proteins |
| Q36304701 | Antigen-specific inhibition of CD4(+) T-cell responses to β-lactoglobulin by its single amino acid-substituted mutant form through T-cell receptor antagonism |
| Q40956043 | Apoptosis of thymic lymphoma clones by thymic epithelial cells: a putative model for 'death by neglect'. |
| Q40615110 | Are MHC-bound peptides a nuisance for positive selection? |
| Q37689611 | Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires |
| Q41053752 | Biophysical studies of T-cell receptors and their ligands |
| Q41063816 | Block of T lymphocyte differentiation by activation of the cAMP-dependent signal transduction pathway |
| Q44021531 | Bystander suppression induced by oral tolerance |
| Q36370736 | CD1d-expressing dendritic cells but not thymic epithelial cells can mediate negative selection of NKT cells |
| Q36400625 | CD3 ligation on immature thymocytes generates antagonist-like signals appropriate for CD8 lineage commitment, independently of T cell receptor specificity |
| Q71118162 | CD3-induced apoptosis of CD4+CD8+ thymocytes in the absence of clonotypic T cell antigen receptor |
| Q74299648 | CD4 regulates the efficiency of an endogenous superantigen-induced clonal deletion of TCRV beta 11+ cells in the periphery |
| Q35769448 | CD4/CD8 coreceptors in thymocyte development, selection, and lineage commitment: analysis of the CD4/CD8 lineage decision |
| Q73468032 | CD45 enhances positive selection and is expressed at a high level in large, cycling, positively selected CD4+CD8+ thymocytes |
| Q35202754 | CD4⁺CD25⁺Foxp3⁺ regulatory T cell formation requires more specific recognition of a self-peptide than thymocyte deletion |
| Q73101489 | CD8 T cells from major histocompatibility complex class II-deficient mice respond vigorously to class II molecules in a primary mixed lymphocyte reaction |
| Q41706471 | CD8+TCR+ and CD8+TCR- cells in whole bone marrow facilitate the engraftment of hematopoietic stem cells across allogeneic barriers |
| Q48065352 | CTX, a novel molecule specifically expressed on the surface of cortical thymocytes in Xenopus. |
| Q39679218 | Calcineurin B1 is essential for positive but not negative selection during thymocyte development |
| Q40855145 | Cellular and molecular aspects of thymic T-cell education in neuroendocrine self principles. Implications for autoimmunity. |
| Q37241773 | Cellular and molecular requirements for the selection of in vitro-generated CD8 T cells reveal a role for Notch |
| Q35694446 | Central and peripheral autoantigen presentation in immune tolerance |
| Q37132892 | Characterizing and optimizing immune responses to leukaemia antigens after allogeneic stem cell transplantation |
| Q36960980 | Chimerism and tetragametic chimerism in humans: implications in autoimmunity, allorecognition and tolerance |
| Q22010693 | Cloning of a novel MHC-encoded serine peptidase highly expressed by cortical epithelial cells of the thymus |
| Q73115340 | Collaboration of TCR-, CD4- and CD28-mediated signalling in antigen-specific MHC class II-restricted T-cells |
| Q34071227 | Combined anti-CD40 conditioning and well-timed immunization prolongs CD8+ T cell accumulation and control of established brain tumors |
| Q40374666 | Control of T-cell development by the pre-T and alpha beta T-cell receptor |
| Q63408331 | Control of pre-T cell proliferation and differentiation by the GTPase Rac-1 |
| Q27649963 | Crossreactive T Cells Spotlight the Germline Rules for αβ T Cell-Receptor Interactions with MHC Molecules |
| Q37418280 | Cutting edge: Expression of FcγRIIB tempers memory CD8 T cell function in vivo. |
| Q33855482 | DNA immunization to prevent autoimmune diabetes |
| Q52025060 | DNA vaccination to treat autoimmune diabetes. |
| Q41515285 | Death and dying in the immune system |
| Q73115332 | Defective depletion of CD45-null thymocytes by the Staphylococcus aureus enterotoxin B superantigen |
| Q60641123 | Deficient Positive Selection of CD4 T Cells in Mice Displaying Altered Repertoires of MHC Class II–Bound Self-Peptides |
| Q24673373 | Degeneracy of antigen recognition as the molecular basis for the high frequency of naive A2/Melan-a peptide multimer(+) CD8(+) T cells in humans |
| Q36820591 | Difference in antigen presentation pathways between cortical and medullary thymic epithelial cells |
| Q36067105 | Differences in the level of expression of class I major histocompatibility complex proteins on thymic epithelial and dendritic cells influence the decision of immature thymocytes between positive and negative selection |
| Q41570922 | Differential effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin, bis(tri-n-butyltin) oxide and cyclosporine on thymus histophysiology |
| Q71930359 | Differential expression of CLIP:MHC class II and conventional endogenous peptide:MHC class II complexes by thymic epithelial cells and peripheral antigen-presenting cells |
| Q51111516 | Differential induction of helper and killer T cells from isolated CD4+CD8+ thymocytes in suspension culture. |
| Q41390449 | Differential reactivity of residual CD8+ T lymphocytes in TAP1 and beta 2-microglobulin mutant mice |
| Q44556255 | Differential roles of ERK and p38 MAP kinase pathways in positive and negative selection of T lymphocytes. |
| Q34048781 | Dissociation of peripheral T cell responses from thymocyte negative selection by weak agonists supports a spare receptor model of T cell activation |
| Q77328529 | Divergent changes in the sensitivity of maturing T cells to structurally related ligands underlies formation of a useful T cell repertoire |
| Q35575391 | Diversity of T cell repertoire shaped by a single peptide ligand is critically affected by its amino acid residue at a T cell receptor contact. |
| Q73814879 | Double-positive T cell receptor(high) thymocytes are resistant to peptide/major histocompatibility complex ligand-induced negative selection |
| Q36369018 | Dynamic tuning of T cell reactivity by self-peptide-major histocompatibility complex ligands |
| Q73304605 | Effects of glucocorticoids on rat thymus and apoptosis |
| Q74122543 | Elevated Bcl-2 is not a causal event in the positive selection of T cells |
| Q36366390 | Endogenous altered peptide ligands can affect peripheral T cell responses |
| Q36401074 | Endogenous myelin basic protein inactivates the high avidity T cell repertoire |
| Q73295972 | Engagement of a T cell receptor by major histocompatibility complex irrespective of peptide |
| Q42819942 | Enhancement of activation-induced cell death by fibronectin in murine CD4+ CD8+ thymocytes |
| Q40973329 | Essential flexibility in the T-cell recognition of antigen |
| Q59652622 | Establishment of tissue-specific tolerance is driven by regulatory T cells selected by thymic epithelium |
| Q72691884 | Evidence for a selective and multi-step model of T cell differentiation: CD4+CD8low thymocytes selected by a transgenic T cell receptor on major histocompatibility complex class I molecules |
| Q71169443 | Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response |
| Q34019945 | Evolution of the CD8 T-cell repertoire during infections |
| Q34278725 | Evolution of the thymus size in response to physiological and random events throughout life |
| Q33928549 | Fast on-rates allow short dwell time ligands to activate T cells |
| Q24655060 | Functional cleavage of the common cytokine receptor gamma chain (gammac) by calpain |
| Q39164395 | Generation of Peptides That Promote Positive Selection in the Thymus |
| Q34051992 | Genetic aspects of inherent B-cell abnormalities associated with SLE and B-cell malignancy: lessons from New Zealand mouse models |
| Q40927315 | Genetic background and environment contribute synergistically to the onset of autoimmune diseases |
| Q36816677 | Genetic susceptibility to type 1 diabetes in the intracellular pathway of antigen processing - a subject review and cross-study comparison |
| Q36453976 | Genetic vaccination with "self" tyrosinase-related protein 2 causes melanoma eradication but not vitiligo |
| Q28504958 | H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection |
| Q77589702 | Helix-loop-helix proteins regulate pre-TCR and TCR signaling through modulation of Rel/NF-kappaB activities |
| Q34155233 | High affinity of interaction between superantigen and T cell receptor Vbeta molecules induces a high level and prolonged expansion of superantigen-reactive CD4+ T cells |
| Q77769114 | High- and low-potency ligands with similar affinities for the TCR: the importance of kinetics in TCR signaling |
| Q33303162 | High-affinity TCRs generated by phage display provide CD4+ T cells with the ability to recognize and kill tumor cell lines. |
| Q35918289 | High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins |
| Q42024302 | Highly restricted T cell repertoire shaped by a single major histocompatibility complex-peptide ligand in the presence of a single rearranged T cell receptor beta chain |
| Q26801632 | How Does Thymus Infection by Coxsackievirus Contribute to the Pathogenesis of Type 1 Diabetes? |
| Q36380676 | How many thymocytes audition for selection? |
| Q34378731 | How specificity for self-peptides shapes the development and function of regulatory T cells |
| Q52045269 | Human leukocyte antigen phenotype imposes complex constraints on the antigen-specific cytotoxic T lymphocyte repertoire. |
| Q73302832 | Identification of a naturally occurring ligand for thymic positive selection |
| Q37358062 | Identification of an immunodominant mouse minor histocompatibility antigen (MiHA). T cell response to a single dominant MiHA causes graft-versus-host disease |
| Q36366113 | Ig-specific T cell receptor-transgenic T cells are not deleted in the thymus and are functional in vivo |
| Q44066636 | Immature CD4(+)CD8(+) thymocytes form a multifocal immunological synapse with sustained tyrosine phosphorylation |
| Q35837479 | Immunobiology of cytotoxic T-cell escape mutants of lymphocytic choriomeningitis virus |
| Q34207168 | Immunodominant minor histocompatibility antigens expressed by mouse leukemic cells can serve as effective targets for T cell immunotherapy |
| Q40433260 | Immunologic Mechanisms and Therapy in Multiple Sclerosis |
| Q35883954 | Immunological ignorance of an E7-encoded cytolytic T-lymphocyte epitope in transgenic mice expressing the E7 and E6 oncogenes of human papillomavirus type 16. |
| Q73406538 | Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletion |
| Q37152076 | Impaired specific CD8 T cell response with aging is not due to decreased expression of CD90 on TCR transgenic T cells |
| Q35738738 | Improving TCR Gene Therapy for Treatment of Haematological Malignancies |
| Q79074350 | In Vivo Treatment of Class II MHC-Deficient Mice with Anti-TCR Antibody Restores the Generation of Circulating CD4 T Cells and Optimal Architecture of Thymic Medulla |
| Q41434481 | In vitro priming of cytotoxic T lymphocytes against poorly immunogenic epitopes by engineered antigen-presenting cells |
| Q43540817 | In vitro thymocyte differentiation in MHC class I-negative Xenopus larvae |
| Q36959354 | In vivo expansion of the residual tumor antigen-specific CD8+ T lymphocytes that survive negative selection in simian virus 40 T-antigen-transgenic mice. |
| Q36364433 | Increase in positive selection of CD8+ T cells in TAP1-mutant mice by human beta 2-microglobulin transgene |
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| Q41180608 | Insights into T cell development and signal transduction provided by TCR-zeta chain deficient mice |
| Q52196099 | Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus. |
| Q34012661 | Interactions between double positive thymocytes and high affinity ligands presented by cortical epithelial cells generate double negative thymocytes with T cell regulatory activity |
| Q36096780 | Interactions with multiple peptide ligands determine the fate of developing thymocytes. |
| Q28512242 | Interplay between TCR affinity and necessity of coreceptor ligation: high-affinity peptide-MHC/TCR interaction overcomes lack of CD8 engagement |
| Q33896888 | Intracellular MHC class II controls regulatory tolerance to allogeneic transplants |
| Q40519658 | Intraepithelial lymphocytes and the immune system. |
| Q52193798 | Intrathymic delta selection events in gammadelta cell development. |
| Q61882075 | Inverse modulation of IL-10 and IL-12 in the blood of women with preneoplastic lesions of the uterine cervix |
| Q37693679 | Involvement of p21ras distinguishes positive and negative selection in thymocytes |
| Q34285825 | Kinetic proofreading in T-cell receptor signal transduction |
| Q34572115 | Knockout mice: a paradigm shift in modern immunology |
| Q24563099 | Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice |
| Q77436009 | Level of HgCl2-mediated phosphorylation of intracellular proteins determines death of thymic T-lymphocytes with or without DNA fragmentation |
| Q40414738 | Lifespan of lymphocytes |
| Q36672184 | Ligation of CD8 leads to apoptosis of thymocytes that have not undergone positive selection |
| Q33731857 | Limited expansion of virus-specific CD8 T cells in the aged environment. |
| Q74058882 | Limiting dilution analysis of primary cytotoxic T-cell precursors |
| Q52949814 | Long-term CD4+ and CD8+ memory T cells developed in severe combined immunodeficiency mice during homoeostasis exhibit differences in sensitivity to antigen. |
| Q35979288 | Long-term T cell memory requires the surface expression of self-peptide/major histocompatibility complex molecules |
| Q30477773 | Low T cell receptor expression and thermal fluctuations contribute to formation of dynamic multifocal synapses in thymocytes |
| Q34065191 | Lymphocytes selected in allogeneic thymic epithelium mediate dominant tolerance toward tissue grafts of the thymic epithelium haplotype |
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| Q33814941 | MHC structure and autoimmune T cell repertoire development |
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| Q36364266 | Mass spectrometric identification of a naturally processed melanoma peptide recognized by CD8+ cytotoxic T lymphocytes |
| Q33760914 | Maturation-dependent licensing of naive T cells for rapid TNF production |
| Q46509216 | Maturational stage-dependent thymocyte responses to TCR engagement |
| Q41881444 | Mature T cell reactivity altered by peptide agonist that induces positive selection |
| Q35670840 | Mechanisms of genetic susceptibility to type I diabetes: beyond HLA. |
| Q33617746 | Mechanisms of self-nonself discrimination and possible clinical relevance |
| Q41628489 | Mechanisms underlying the loss of self tolerance in NOD mice |
| Q37140066 | MerTK regulates thymic selection of autoreactive T cells |
| Q73701505 | Mice resistant to experimental autoimmune encephalomyelitis have increased thymic expression of myelin basic protein and increased MBP specific T cell tolerance |
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| Q33630981 | Molecular mimicry and multiple sclerosis: degenerate T-cell recognition and the induction of autoimmunity |
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| Q37737987 | Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease |
| Q50425147 | Murine CD8+ Invariant Natural Killer T Cells are Negatively Selected by CD1d Expressed on Thymic Epithelial Cells and Dendritic Cells |
| Q28504777 | Murine Schnurri-2 is required for positive selection of thymocytes |
| Q35213326 | Negative selection of CD4+ CD8+ thymocytes by T-cell receptor peptide antagonists |
| Q35136005 | Negative selection--clearing out the bad apples from the T-cell repertoire |
| Q24800305 | New approaches to eliciting protective immunity through T cell repertoire manipulation: the concept of thymic vaccination |
| Q38958324 | On Peptides and Altered Peptide Ligands: From Origin, Mode of Action and Design to Clinical Application (Immunotherapy). |
| Q34000887 | On the definition of a criterion of immunogenicity |
| Q34967410 | On the issue of peptide recognition in T cell development |
| Q58024439 | On the role of high- and low-abundance class II MHC–peptide complexes in the thymic positive selection of CD4+ T cells |
| Q34118353 | PKCtheta is necessary for efficient activation of NFkappaB, NFAT, and AP-1 during positive selection of thymocytes |
| Q37259568 | PR1 vaccination in myeloid malignancies |
| Q33930556 | Paradoxical intrathymic positive selection in mice with only a covalently presented agonist peptide |
| Q57228141 | Peptide antagonists that promote positive selection are inefficient at T cell activation and thymocyte deletion |
| Q36364528 | Peptide influences the folding and intracellular transport of free major histocompatibility complex class I heavy chains |
| Q51103760 | Peptide-induced positive selection of TCR transgenic thymocytes in a coreceptor-independent manner. |
| Q71118175 | Peptides derived from IgE heavy chain constant region induce profound IgE isotype-specific tolerance |
| Q36954389 | Peptidoglycan recognition protein-SD provides versatility of receptor formation in Drosophila immunity. |
| Q34715443 | Peripheral antigen-expressing cells and autoimmunity |
| Q52202268 | Permissive recognition during positive selection. |
| Q40495464 | Physiological T‐Cell Death: Susceptibility is Modulated by Activation, Aging, and Transformation, but the Mechanism is Constant |
| Q62590795 | Positive and Negative CD4+ Thymocyte Selection by a Single MHC Class II/Peptide Ligand Affected by Its Expression Level in the Thymus |
| Q36367050 | Positive and negative selection invoke distinct signaling pathways. |
| Q35556452 | Positive and negative selection of T cell repertoires during differentiation in allogeneic bone marrow chimeras |
| Q46281335 | Positive selection in autoimmunity: Abnormal immune responses to a bacterial dnaJ antigenic determinant in patients with early rheumatoid arthritis |
| Q36369555 | Positive selection of CD4(+) T cells is induced in vivo by agonist and inhibited by antagonist peptides |
| Q52214778 | Positive selection of CD4+ T cells by TCR ligation without aggregation even in the absence of MHC. |
| Q41429700 | Positive selection of T cells: fastidious or promiscuous? |
| Q40937456 | Positive selection of an H2-M3 restricted T cell receptor |
| Q35580258 | Positive selection of self- and alloreactive CD8+ T cells in Tap-1 mutant mice. |
| Q41429671 | Positive selection of thymocytes bearing alpha beta T cell receptors. |
| Q36401236 | Preselection thymocytes are more sensitive to T cell receptor stimulation than mature T cells |
| Q36376999 | Presentation of a T cell receptor antagonist peptide by immunoglobulins ablates activation of T cells by a synthetic peptide or proteins requiring endocytic processing |
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| Q36380789 | Selection of antigen-specific T cells by a single IEk peptide combination |
| Q35832518 | Selection of the T-cell repertoire: receptor-controlled checkpoints in T-cell development |
| Q79125476 | Selective Depletion of Nonspecific T Cells During the Early Stage of Immune Responses to Infection |
| Q36366862 | Selective activation of Fas/Fas ligand-mediated cytotoxicity by a self peptide |
| Q40473381 | Self and non-self antigen in diabetic autoimmunity: Molecules and mechanisms |
| Q47631646 | Self-reactivity in thymic double-positive cells commits cells to a CD8 alpha alpha lineage with characteristics of innate immune cells |
| Q77488329 | Shifting T-cell activation thresholds in autoimmunity and determinant spreading |
| Q40500421 | Signal transduction by the antigen receptors of B and T lymphocytes. |
| Q40495457 | Signal transduction, mitotic catastrophes, and death in T-cell development |
| Q40495484 | Signalling and Chromatin Fragmentation in Thymocyte Apoptosis |
| Q40845418 | Skewed TCRV beta repertoire in human thymus persists after thymic emigration: influence of genomic imposition, thymic maturation and environmental challenge on human TCRV beta usage in vivo. |
| Q41096347 | Specific recognition of thymic self-peptides induces the positive selection of cytotoxic T lymphocytes |
| Q41665482 | Specific regulation of fos family transcription factors in thymocytes at two developmental checkpoints |
| Q42644707 | Specificity and flexibility in thymic selection |
| Q73170826 | Split tolerance to the MHC class I molecule H-2Dd in animals transgenic for its soluble analog |
| Q42265829 | Stochastic coreceptor shut-off is restricted to the CD4 lineage maturation pathway |
| Q38353298 | Strength of TCR signal from self-peptide modulates autoreactive thymocyte deletion and Foxp3(+) Treg-cell formation |
| Q36367500 | Structural basis for T cell recognition of altered peptide ligands: a single T cell receptor can productively recognize a large continuum of related ligands |
| Q40894111 | Structurally diverse forms of HLA-B27 molecules are displayed in vivo in a cell type-dependent manner |
| Q40653232 | Study of the Mechanism of TCR Antagonism Using Dual-TCR-Expressing T Cells |
| Q43850977 | Synchronous deletion of Mtv-superantigen-reactive thymocytes in the CD3(medium/high) CD4(+)CD8(+) subset |
| Q36954496 | Synergistic control of T cell development and tumor suppression by diacylglycerol kinase alpha and zeta |
| Q36989026 | Systematic simulation of cross-reactivity predicts ambiguity in Tk memory: it may save lives of the infected, but limits specificities vital for further responses |
| Q56922149 | T Cells Can Be Activated by Peptides That Are Unrelated in Sequence to Their Selecting Peptide |
| Q47373840 | T cell activation: in vivo veritas |
| Q40410980 | T cell differentiation: control by the pre-TCR and alpha beta TCR. |
| Q36475871 | T cell positive selection by a high density, low affinity ligand |
| Q33805885 | T cell receptor V genes in multiple sclerosis: increased use of TCRAV8 and TCRBV5 in MBP-specific clones |
| Q34976927 | T cell receptor interactions with class I heavy-chain influence T cell selection |
| Q36365637 | T cell receptor repertoire for a viral epitope in humans is diversified by tolerance to a background major histocompatibility complex antigen |
| Q37823023 | T cell receptor signaling kinetics takes the stage |
| Q36364509 | T cell receptor-mediated signaling events in CD4+CD8+ thymocytes undergoing thymic selection: requirement of calcineurin activation for thymic positive selection but not negative selection. |
| Q44251540 | T cell repertoire formation displays characteristics of qualitative models of thymic selection |
| Q41312334 | T cell selection and autoimmunity: flexibility and tuning |
| Q52016064 | T cells down-modulate peptide-MHC complexes on APCs in vivo. |
| Q57704231 | T-cell apoptosis and differential human leucocyte antigen class II expression in human thymus |
| Q36526360 | T-cell avidity and tuning: the flexible connection between tolerance and autoimmunity. |
| Q33632307 | T-cell development: a role for self-peptides in positive selection |
| Q33886507 | T-cell receptor ligation by peptide/MHC induces activation of a caspase in immature thymocytes: the molecular basis of negative selection. |
| Q54023030 | T-cell regulation. Tails of phosphorylation and T-cell activation. |
| Q46139464 | T-cell responses to myelin basic protein in normal and MBP-deficient mice |
| Q74591317 | T-cell selection |
| Q40629928 | T-cell selection. Accentuating the positive |
| Q41192128 | T-cell-receptor affinity and thymocyte positive selection |
| Q35589560 | T-helper cell tolerance to ubiquitous nuclear antigens |
| Q56953631 | TAP1-deficient mice select a CD8+ T cell repertoire that displays both diversity and peptide specificity |
| Q48370565 | TARPP, a novel protein that accompanies TCR gene rearrangement and thymocyte education |
| Q45866968 | Tap-1 and Tap-2 Gene Therapy Selectively Restores Conformationally Dependent HLA Class I Expression in Type I Diabetic Cells |
| Q33638172 | Targeting p53 as a general tumor antigen |
| Q71798201 | Targeting the mouse genome: a compendium of knockouts (part III) |
| Q34418401 | The MHC reactivity of the T cell repertoire prior to positive and negative selection. |
| Q46014500 | The Src-like adaptor protein downregulates the T cell receptor on CD4+CD8+ thymocytes and regulates positive selection. |
| Q41393104 | The agonist-antagonist balance in positive selection. |
| Q52199699 | The alpha beta T cell receptor can replace the gamma delta receptor in the development of gamma delta lineage cells. |
| Q72715937 | The balance between deletion and activation of CD4+8+ thymocytes is controlled by T cell receptor-antigen interactions and is affected by cyclosporin A |
| Q35762283 | The effects of thymic selection on the range of T cell cross-reactivity |
| Q36376752 | The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands |
| Q41088682 | The enigmatic specificity of gamma delta T cells |
| Q71918555 | The influence of invariant chain on the positive selection of single T cell receptor specificities |
| Q34580927 | The insulin gene in diabetes |
| Q41096340 | The interferon regulatory transcription factor IRF-1 controls positive and negative selection of CD8+ thymocytes. |
| Q41077099 | The molecular jury: deciding whether immature thymocytes should live or die. |
| Q81420783 | The multigenic structure of the MHC locus contributes to positive selection efficiency: a role for MHC class II gene-specific restriction |
| Q71118244 | The myelin basic protein-specific T cell repertoire in (transgenic) Lewis rat/SCID mouse chimeras: preferential V beta 8.2 T cell receptor usage depends on an intact Lewis thymic microenvironment |
| Q33538639 | The new numerology of immunity mediated by virus-specific CD8(+) T cells |
| Q34238425 | The origin and regulation of autopathogenic T cells |
| Q33575769 | The presence of CD8+ invariant NKT cells in mice |
| Q90124443 | The presentation of neuroendocrine self-peptides in the thymus: an essential event for individual life and vertebrate survival |
| Q53600866 | The quantitative assessment of MHC II on thymic epithelium: implications in cortical thymocyte development. |
| Q40734979 | The regulation of DNAse activities in subcellular compartments of activated thymocytes |
| Q52887226 | The repertoire of T cells shaped by a single MHC/peptide ligand. |
| Q37939604 | The role of the thymus in the integrated evolution of the recombinase-dependent adaptive immune response and the neuroendocrine system |
| Q36375626 | The selection of M3-restricted T cells is dependent on M3 expression and presentation of N-formylated peptides in the thymus |
| Q46259603 | The somatically generated portion of T cell receptor CDR3α contributes to the MHC allele specificity of the T cell receptor |
| Q28592120 | The specificity and orientation of a TCR to its peptide-MHC class II ligands |
| Q30304514 | The tyrosine phosphatase SHP-1 influences thymocyte selection by setting TCR signaling thresholds. |
| Q36365359 | The use of mammary tumor virus (Mtv)-negative and single-Mtv mice to evaluate the effects of endogenous viral superantigens on the T cell repertoire |
| Q81416925 | Thymic cortical epithelium induces self tolerance |
| Q36363937 | Thymic selection and adaptability of cytotoxic T lymphocyte responses in transgenic mice expressing a viral protein in the thymus |
| Q73688337 | Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide |
| Q35076679 | Thymic selection revisited: how essential is it? |
| Q39773899 | Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling |
| Q42739551 | Thymic self-antigen expression for the design of a negative/tolerogenic self-vaccine against type 1 diabetes |
| Q33815802 | Thymic tolerance to only one viral protein reduces lymphocytic choriomeningitis virus-induced immunopathology and increases survival in perforin-deficient mice. |
| Q40460172 | Thymocyte Apoptosis by Glucocorticoids and cAMP |
| Q38578530 | Thymocyte selection in Vav and IRF-1 gene-deficient mice |
| Q52181530 | Thymocyte selection: not by TCR alone. |
| Q36367667 | Thymocytes can become mature T cells without passing through the CD4+ CD8+, double-positive stage |
| Q93371103 | Thymus machinery for T-cell selection |
| Q36377298 | Thymus-derived glucocorticoids regulate antigen-specific positive selection |
| Q36376876 | Tolerance to p53 by A2.1-restricted cytotoxic T lymphocytes. |
| Q33725380 | Treatment of an autoimmune disease with "classical" T cell veto: a proposal |
| Q44990750 | Ubiquitin-fusion degradation pathway plays an indispensable role in naked DNA vaccination with a chimeric gene encoding a syngeneic cytotoxic T lymphocyte epitope of melanocyte and green fluorescent protein |
| Q36366238 | Unresponsiveness to a self-peptide of mouse lysozyme owing to hindrance of T cell receptor-major histocompatibility complex/peptide interaction caused by flanking epitopic residues |
| Q77368905 | Use of explant technology in the study of in vitro immune responses |
| Q41225504 | Using transgenic mouse models to dissect the pathogenesis of virus-induced autoimmune disorders of the islets of Langerhans and the central nervous system |
| Q41312501 | Virus-induced autoimmune disease |
| Q34329801 | Without peripheral interference, thymic deletion is mediated in a cohort of double-positive cells without classical activation |
| Q40889962 | p53 and thymic 'death by neglect': thymic epithelial cell-induced apoptosis of CD4+8+ thymocytes is p53-independent |
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