| scholarly article | Q13442814 |
| P2093 | author name string | Gerald R Crabtree | |
| Monte M Winslow | |||
| Eun Mi Hur | |||
| Joel R Neilson | |||
| P2860 | cites work | A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of Thymocytes | Q63408334 |
| Effects of cyclosporine A on T cell development and clonal deletion | Q68097628 | ||
| Raf regulates positive selection | Q71740162 | ||
| Effects of a constitutively active form of calcineurin on T cell activation and thymic selection | Q73084733 | ||
| Cytokines, virokines and the evolution of immunity | Q73150485 | ||
| CD3delta couples T-cell receptor signalling to ERK activation and thymocyte positive selection | Q74144662 | ||
| Essential role for ZAP-70 in both positive and negative selection of thymocytes | Q24321424 | ||
| Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen | Q27748865 | ||
| Structural basis of 2C TCR allorecognition of H-2Ld peptide complexes | Q27758459 | ||
| Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity | Q27860643 | ||
| Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice | Q28137811 | ||
| Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons | Q28176698 | ||
| BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes | Q28203083 | ||
| Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature | Q28204868 | ||
| Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum | Q28508556 | ||
| The transcription factor NF-ATc is essential for cardiac valve formation | Q28508583 | ||
| CD3 delta deficiency arrests development of the alpha beta but not the gamma delta T cell lineage | Q28589169 | ||
| Defective T cell development and function in calcineurin A beta -deficient mice | Q28592115 | ||
| Neuronal specification in the spinal cord: inductive signals and transcriptional codes | Q29616039 | ||
| T cell receptor antagonist peptides induce positive selection | Q29618820 | ||
| Activation of the MKK/ERK pathway during somatic cell mitosis: direct interactions of active ERK with kinetochores and regulation of the mitotic 3F3/2 phosphoantigen. | Q30442086 | ||
| Positive and negative selection of T cells | Q34157557 | ||
| Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes. | Q34545142 | ||
| Contingent genetic regulatory events in T lymphocyte activation | Q34679681 | ||
| Regulation of the calmodulin-stimulated protein phosphatase, calcineurin | Q34747325 | ||
| Regulatory principles of developmental signaling | Q34762470 | ||
| Signaling life and death in the thymus: timing is everything | Q35089616 | ||
| Stimulation with specific antigen can block superantigen-mediated deletion of T cells in vivo | Q35091986 | ||
| Evolutionary relationships among Rel domains indicate functional diversification by recombination | Q35893955 | ||
| T cell receptor-mediated signaling events in CD4+CD8+ thymocytes undergoing thymic selection: requirement of calcineurin activation for thymic positive selection but not negative selection. | Q36364509 | ||
| T cell responses in calcineurin A alpha-deficient mice | Q36366258 | ||
| Tec family kinases modulate thresholds for thymocyte development and selection | Q36368982 | ||
| Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation | Q38342696 | ||
| In irradiation chimeras, K or D regions of the chimeric host, not of the donor lymphocytes, determine immune responsiveness of antiviral cytotoxic T cells | Q39624236 | ||
| Cyclosporin A sensitivity of the NF-kappa B site of the IL2R alpha promoter in untransformed murine T cells | Q40400073 | ||
| In a radiation chimaera, host H–2 antigens determine immune responsiveness of donor cytotoxic cells | Q40658124 | ||
| A motif in the alphabeta T-cell receptor controls positive selection by modulating ERK activity | Q40862851 | ||
| JNK is involved in signal integration during costimulation of T lymphocytes. | Q41461688 | ||
| L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons | Q41698468 | ||
| Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells | Q41700451 | ||
| Natural and engineered disorders of lymphocyte development | Q41735894 | ||
| Thymic selection and cell division | Q42943203 | ||
| Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes | Q44851100 | ||
| Evidence for a differential avidity model of T cell selection in the thymus | Q45155438 | ||
| Different nuclear signals are activated by the B cell receptor during positive versus negative signaling. | Q45965344 | ||
| A MAP kinase-dependent spindle assembly checkpoint in Xenopus egg extracts | Q46344684 | ||
| Abnormal differentiation of thymocytes in mice treated with cyclosporin A. | Q46966737 | ||
| Positive selection through a motif in the alphabeta T cell receptor | Q47725705 | ||
| Dual inhibition of sister chromatid separation at metaphase | Q48873086 | ||
| Requirement for MAPK activation for normal mitotic progression in Xenopus egg extracts. | Q50741978 | ||
| Selective requirement for MAP kinase activation in thymocyte differentiation. | Q51126213 | ||
| Conversion of an extracellular Dpp/BMP morphogen gradient into an inverse transcriptional gradient. | Q52106477 | ||
| Disruption of T cell signaling networks and development by Grb2 haploid insufficiency. | Q52137761 | ||
| Disruption of T cell development and repertoire selection by calcineurin inhibition in vivo. | Q52507544 | ||
| Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis. | Q52547440 | ||
| T cell tolerance by clonal elimination in the thymus | Q56922465 | ||
| P433 | issue | 3 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | thymocyte | Q7799635 |
| P304 | page(s) | 255-266 | |
| P577 | publication date | 2004-03-01 | |
| P1433 | published in | Immunity | Q6005457 |
| P1476 | title | Calcineurin B1 is essential for positive but not negative selection during thymocyte development | |
| P478 | volume | 20 |
| Q36402834 | A severe defect in CRAC Ca2+ channel activation and altered K+ channel gating in T cells from immunodeficient patients |
| Q41660964 | Aberrant Signaling Pathways in T-Cell Acute Lymphoblastic Leukemia |
| Q36892161 | Agonist-selected T cell development requires strong T cell receptor signaling and store-operated calcium entry. |
| Q54463854 | An alternative NFAT-activation pathway mediated by IL-7 is critical for early thymocyte development. |
| Q28590236 | BCL11B is required for positive selection and survival of double-positive thymocytes |
| Q36116776 | Bcl-2 differentially regulates Ca2+ signals according to the strength of T cell receptor activation |
| Q38197005 | Bcl-2 regulation of the inositol 1,4,5-trisphosphate receptor and calcium signaling in normal and malignant lymphocytes: potential new target for cancer treatment |
| Q36414539 | Beta-catenin/Tcf determines the outcome of thymic selection in response to alphabetaTCR signaling |
| Q40689085 | C/EBPβ and Nuclear Factor of Activated T Cells Differentially Regulate Adamts-1 Induction by Stimuli Associated with Vascular Remodeling. |
| Q24338983 | CIB1 is a regulator of pathological cardiac hypertrophy |
| Q55107300 | Calcineurin B in CD4+ T Cells Prevents Autoimmune Colitis by Negatively Regulating the JAK/STAT Pathway. |
| Q84263344 | Calcineurin B subunit triggers innate immunity and acts as a novel Engerix-B HBV vaccine adjuvant |
| Q64235808 | Calcineurin B1 subunit in human peripheral blood mononuclear cells and its role in idiopathic membranous nephropathy |
| Q33903361 | Calcineurin inactivation leads to decreased responsiveness to LPS in macrophages and dendritic cells and protects against LPS-induced toxicity in vivo |
| Q38713993 | Calcineurin inhibitors exacerbate coronary arteritis via the MyD88 signalling pathway in a murine model of Kawasaki disease |
| Q30549880 | Calcineurin is required in urinary tract mesenchyme for the development of the pyeloureteral peristaltic machinery. |
| Q36207266 | Calcineurin mediates homeostatic synaptic plasticity by regulating retinoic acid synthesis |
| Q33839890 | Calcineurin regulates innate antifungal immunity in neutrophils |
| Q37679908 | Calcineurin sets the bandwidth for discrimination of signals during thymocyte development |
| Q39288437 | Calcineurin signaling regulates neural induction through antagonizing the BMP pathway |
| Q53323303 | Calcineurin-NFAT Signaling Controls Somatic Cell Reprogramming in a Stage-Dependent Manner. |
| Q28588209 | Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation |
| Q34567627 | Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and function |
| Q24676318 | Calcineurin/Nfat signaling is required for perinatal lung maturation and function |
| Q46769839 | Calcium oscillations regulate thymocyte motility during positive selection in the three-dimensional thymic environment |
| Q33878792 | Calcium signaling in immune cells. |
| Q34783180 | Calcium signaling in lymphocytes |
| Q37160059 | Calmodulin-dependent phosphatase, kinases, and transcriptional corepressors involved in T-cell activation |
| Q47120998 | Combination of calcineurin B subunit (CnB) and 5-fluorouracil reverses 5-fluorouracil-induced immunosuppressive effect and enhances the antitumor activity in hepatocellular carcinoma |
| Q36382781 | Commitment issues: linking positive selection signals and lineage diversification in the thymus |
| Q43152094 | Complementation in trans of altered thymocyte development in mice expressing mutant forms of the adaptor molecule SLP76. |
| Q35215430 | Concurrent visualization of trafficking, expansion, and activation of T lymphocytes and T-cell precursors in vivo |
| Q38298134 | Conditional disruption of calcineurin B1 in osteoblasts increases bone formation and reduces bone resorption. |
| Q37896127 | Control of early stages in invariant natural killer T-cell development. |
| Q33763027 | Cutting edge: Extracellular signal-related kinase is not required for negative selection of developing T cells |
| Q34518356 | Cyclosporin A promotes tumor angiogenesis in a calcineurin-independent manner by increasing mitochondrial reactive oxygen species |
| Q34802728 | Dampening of death pathways by schnurri-2 is essential for T-cell development |
| Q36073436 | Decision checkpoints in the thymus |
| Q92689353 | Deletion of Calcineurin Promotes a Protumorigenic Fibroblast Phenotype |
| Q90794970 | Deletion of calcineurin from GFAP-expressing astrocytes impairs excitability of cerebellar and hippocampal neurons through astroglial Na+ /K+ ATPase |
| Q24652128 | Development of all CD4 T lineages requires nuclear factor TOX |
| Q33713890 | Direct and indirect interactions between calcineurin-NFAT and MEK1-extracellular signal-regulated kinase 1/2 signaling pathways regulate cardiac gene expression and cellular growth |
| Q41892123 | Divergent effects of calcineurin Aβ on regulatory and conventional T-cell homeostasis. |
| Q24642248 | Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance |
| Q36982963 | Egr2 is required for Bcl-2 induction during positive selection |
| Q33163160 | Epicardial calcineurin-NFAT signals through Smad2 to direct coronary smooth muscle cell and arterial wall development |
| Q40818861 | Epithelial calcineurin controls microbiota-dependent intestinal tumor development |
| Q42709956 | Expression of Twist2 is controlled by T-cell receptor signaling and determines the survival and death of thymocytes. |
| Q39005875 | Extracellular Signal-Regulated Protein Kinase, c-Jun N-Terminal Protein Kinase, and Calcineurin Regulate Transient Receptor Potential M3 (TRPM3) Induced Activation of AP-1. |
| Q59054107 | Feedback inhibition of calcineurin and Ras by a dual inhibitory protein Carabin |
| Q24569631 | GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation |
| Q28510355 | Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes |
| Q37101616 | Genetic disruption of calcineurin improves skeletal muscle pathology and cardiac disease in a mouse model of limb-girdle muscular dystrophy |
| Q30493276 | Heart-specific deletion of CnB1 reveals multiple mechanisms whereby calcineurin regulates cardiac growth and function |
| Q30491332 | Impaired contractile function and calcium handling in hearts of cardiac-specific calcineurin b1-deficient mice |
| Q51743725 | It's up to you Egr2. |
| Q50978065 | Leukemia-initiating cell activity requires calcineurin in T-cell acute lymphoblastic leukemia. |
| Q34241131 | Lipid Signaling in T-Cell Development and Function |
| Q38957223 | Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia |
| Q39491192 | Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion. |
| Q30544059 | Low ligand requirement for deletion and lack of synapses in positive selection enforce the gauntlet of thymic T cell maturation |
| Q30538232 | Macrophage Wnt-Calcineurin-Flt1 signaling regulates mouse wound angiogenesis and repair |
| Q64253603 | MiR-146a wild-type 3' sequence identity is dispensable for proper innate immune function in vivo |
| Q38810904 | Microenvironmental cues for T-cell acute lymphoblastic leukemia development |
| Q28505205 | Modulatory calcineurin-interacting proteins 1 and 2 function as calcineurin facilitators in vivo |
| Q37801270 | Molecular and genetic parameters defining T-cell clonal selection |
| Q42378884 | NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection. |
| Q28253919 | NFAT proteins: key regulators of T-cell development and function |
| Q37218514 | NFAT5 induction by the pre-T-cell receptor serves as a selective survival signal in T-lymphocyte development |
| Q57201013 | New therapeutic targets in immune disorders: ItpkB, Orai1 and UNC93B |
| Q50421080 | Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning. |
| Q58483028 | Noncanonical NFATc1 activation in DN thymocytes |
| Q34118353 | PKCtheta is necessary for efficient activation of NFkappaB, NFAT, and AP-1 during positive selection of thymocytes |
| Q39417313 | Phosphoproteomics analyses show subnetwork systems in T-cell receptor signaling. |
| Q42061814 | Placing ion channels into a signaling network of T cells: from maturing thymocytes to healthy T lymphocytes or leukemic T lymphoblasts. |
| Q37102903 | Protein kinase C-theta is required for efficient positive selection |
| Q42392644 | Raf signaling but not the ERK effector SAP-1 is required for regulatory T cell development |
| Q54108534 | Regulation of Hematopoietic Cell Development and Function Through Phosphoinositides. |
| Q24631587 | Regulation of immune cell development through soluble inositol-1,3,4,5-tetrakisphosphate |
| Q35832518 | Selection of the T-cell repertoire: receptor-controlled checkpoints in T-cell development |
| Q36969291 | Selective role of calcineurin in haematopoiesis and lymphopoiesis |
| Q53700246 | Sequential gene regulatory events leading to glucocorticoid-evoked apoptosis of CEM human leukemic cells:interactions of MAPK, MYC and glucocorticoid pathways. |
| Q28510733 | Signaling by the kinase MINK is essential in the negative selection of autoreactive thymocytes |
| Q33581708 | Small interfering RNA screen for phosphatases involved in IgE-mediated mast cell degranulation |
| Q42548151 | Spatial and temporal regulation of coronary vessel formation by calcineurin-NFAT signaling |
| Q42380589 | Store-operated Ca2+ entry through ORAI1 is critical for T cell-mediated autoimmunity and allograft rejection |
| Q38353298 | Strength of TCR signal from self-peptide modulates autoreactive thymocyte deletion and Foxp3(+) Treg-cell formation |
| Q37087575 | T cell Receptor Signal Transduction in T lymphocytes |
| Q42049006 | TCR activation kinetics and feedback regulation in primary human T cells |
| Q81026508 | TM1 and TM2: two mutant alleles that are involved in the pre-TCR/TCR signaling |
| Q37623440 | Targeted therapy in T-cell malignancies: dysregulation of the cellular signaling pathways |
| Q37341230 | Targeting Bcl-2 based on the interaction of its BH4 domain with the inositol 1,4,5-trisphosphate receptor. |
| Q90573731 | Targeting Bcl-2-IP3 receptor interaction to treat cancer: A novel approach inspired by nearly a century treating cancer with adrenal corticosteroid hormones |
| Q40130034 | Targeting calcineurin activation as a therapeutic strategy for T-cell acute lymphoblastic leukemia |
| Q34137305 | Tenuous paths in unexplored territory: From T cell receptor signaling to effector gene expression during thymocyte selection |
| Q51439967 | The calcineurin protein phosphatase is dispensable for BCR-ABL-induced B-ALL maintenance, propagation and response to dasatinib. |
| Q37449706 | The calcium/NFAT pathway: role in development and function of regulatory T cells |
| Q37310026 | The gene encoding early growth response 2, a target of the transcription factor NFAT, is required for the development and maturation of natural killer T cells |
| Q24803143 | The quantal theory of how the immune system discriminates between "self and non-self" |
| Q35892504 | The secondary heart field is a new site of calcineurin/Nfatc1 signaling for semilunar valve development |
| Q36346996 | The synergistic interaction between the calcineurin B subunit and IFN-γ enhances macrophage antitumor activity |
| Q30443379 | The timing of TCR alpha expression critically influences T cell development and selection |
| Q38159692 | Thymic regulatory T cell development: role of signalling pathways and transcription factors |
| Q38363596 | Transcription factors and target genes of pre-TCR signaling. |
| Q52584757 | Tumor Tolerance-Promoting Function of Regulatory T Cells Is Optimized by CD28, but Strictly Dependent on Calcineurin. |
| Q36184405 | Unique features of the pre-T-cell receptor alpha-chain: not just a surrogate |
| Q37190443 | Unravelling the association of partial T-cell immunodeficiency and immune dysregulation |
| Q33796333 | c-Cbl promotes T cell receptor-induced thymocyte apoptosis by activating the phosphatidylinositol 3-kinase/Akt pathway |
| Q42082679 | c-Myb regulates lineage choice in developing thymocytes via its target gene Gata3. |
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