GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation

scientific article

GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1038/NRI2476
P3181OpenCitations bibliographic resource ID2438425
P932PMC publication ID2998182
P698PubMed publication ID19151747
P5875ResearchGate publication ID23798843

P2093author name stringSung-Yun Pai
I-Cheng Ho
Tzong-Shyuan Tai
P2860cites workExpression of tal-1 and GATA-binding proteins during human hematopoiesisQ24337571
Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha geneQ24561490
DNA-binding specificities of the GATA transcription factor familyQ24603801
Regulation of Th2 cytokine expression in NKT cells: unconventional use of Stat6, GATA-3, and NFAT2Q82176327
Regulation of lineage commitment distinct from positive selection.Q51084799
Notch1 expression in early lymphopoiesis influences B versus T lineage determination.Q51085324
MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent.Q51115513
Notch signaling is necessary for GATA3 function in the initiation of T cell development.Q51960652
Modulation of coreceptor transcription during positive selection dictates lineage fate independently of TCR/coreceptor specificity.Q52043550
Inactivation of Notch1 impairs VDJbeta rearrangement and allows pre-TCR-independent survival of early alpha beta Lineage Thymocytes.Q52117223
Stat6 is required for mediating responses to IL-4 and for development of Th2 cells.Q55066450
GATA-3 Promotes Maturation, IFN-γ Production, and Liver-Specific Homing of NK CellsQ58478744
Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent MechanismQ61357092
Functional analysis and in vivo footprinting implicate the erythroid transcription factor GATA-1 as a positive regulator of its own promoterQ70178242
Regulation of IL-4 gene expression by distal regulatory elements and GATA-3 at the chromatin levelQ73835273
Coreceptor reversal in the thymus: signaled CD4+8+ thymocytes initially terminate CD8 transcription even when differentiating into CD8+ T cellsQ74137391
A 3' enhancer in the IL-4 gene regulates cytokine production by Th2 cells and mast cellsQ74548143
Expression of the transcription factor GATA-3 is required for the development of the earliest T cell progenitors and correlates with stages of cellular proliferation in the thymusQ77924879
Cutting edge: the differential involvement of the N-finger of GATA-3 in chromatin remodeling and transactivation during Th2 developmentQ78346665
Critical YxKxHxxxRP motif in the C-terminal region of GATA3 for its DNA binding and functionQ79287363
Stat5 activation plays a critical role in Th2 differentiationQ79291245
Long-range intrachromosomal interactions in the T helper type 2 cytokine locusQ80587027
The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selectionQ81483894
GATA-3 maintains the differentiation of the luminal cell fate in the mammary glandQ24649647
Development of all CD4 T lineages requires nuclear factor TOXQ24652128
GATA-3 links tumor differentiation and dissemination in a luminal breast cancer modelQ24657350
Crystal Structures of Multiple GATA Zinc Fingers Bound to DNA Reveal New Insights into DNA Recognition and Self-Association by GATAQ27651158
Cutting edge: Identification of an alternative GATA-3 promoter directing tissue-specific gene expression in mouse and humanQ28215575
Essential role of Stat6 in IL-4 signallingQ28276199
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 geneQ28276209
TH17 cells in development: an updated view of their molecular identity and genetic programmingQ28276449
The biology of NKT cellsQ28277482
Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesisQ28505151
Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3Q28511275
Critical roles for transcription factor GATA-3 in thymocyte developmentQ28511459
Mast cell lineage diversion of T lineage precursors by the essential T cell transcription factor GATA-3Q28511685
Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous systemQ28512290
GATA-3: an unexpected regulator of cell lineage determination in skinQ28512924
Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cellsQ28585402
Transcription factor GATA-3 is required for development of the T-cell lineageQ28587190
GATA-3 regulates the development and function of invariant NKT cellsQ28590905
Notch directly regulates Gata3 expression during T helper 2 cell differentiationQ28594834
Direct regulation of Gata3 expression determines the T helper differentiation potential of NotchQ28594879
The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cellsQ29614226
Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targetingQ29614543
Distinct structural requirements of GATA-3 for the regulation of thymocyte and Th2 cell differentiation.Q30366992
Critical functions for c-Myb at three checkpoints during thymocyte developmentQ30433753
Molecular identity of hematopoietic precursor cells emerging in the human embryo.Q31978561
Molecular dissection of prethymic progenitor entry into the T lymphocyte developmental pathwayQ33288223
Characterization of purified intraembryonic hematopoietic stem cells as a tool to define their site of origin.Q33715031
Gene expression profile of murine long-term reconstituting vs. short-term reconstituting hematopoietic stem cellsQ33830673
GATA motifs regulate early hematopoietic lineage-specific expression of the Gata2 geneQ33924853
A mechanism for the initiation of allergen-induced T helper type 2 responsesQ34010133
Progression of regulatory gene expression states in fetal and adult pro-T-cell developmentQ34150401
Signal strength in thymic selection and lineage commitment.Q34167971
An IL-4-independent and CD25-mediated function of c-maf in promoting the production of Th2 cytokinesQ34191294
New perspectives on a developmental dilemma: the kinetic signaling model and the importance of signal duration for the CD4/CD8 lineage decisionQ34547220
Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiationQ34573593
T cell development: bottoms-upQ34671215
Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choiceQ34831201
CD4/CD8-lineage differentiation in the thymus: from nuclear effectors to membrane signalsQ35824059
GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cellsQ35834668
Signaling pathways in Th2 developmentQ35951832
Receptor signals and nuclear events in CD4 and CD8 T cell lineage commitmentQ36070683
Regulation of lymphoid development, differentiation, and function by the Notch pathway.Q36072476
Lipid defect underlies selective skin barrier impairment of an epidermal-specific deletion of Gata-3.Q36119225
HD mice: a novel mouse mutant with a specific defect in the generation of CD4(+) T cellsQ36171328
The requirement for Notch signaling at the beta-selection checkpoint in vivo is absolute and independent of the pre-T cell receptor.Q36227978
Intermediate steps in positive selection: differentiation of CD4+8int TCRint thymocytes into CD4-8+TCRhi thymocytesQ36364765
Unraveling a revealing paradox: Why major histocompatibility complex I-signaled thymocytes "paradoxically" appear as CD4+8lo transitional cells during positive selection of CD8+ T cellsQ36370932
Role of the transcription factor Th-POK in CD4:CD8 lineage commitmentQ36382776
Commitment issues: linking positive selection signals and lineage diversification in the thymusQ36382781
GATA-3 promotes Th2 responses through three different mechanisms: induction of Th2 cytokine production, selective growth of Th2 cells and inhibition of Th1 cell-specific factorsQ36391825
CD4/CD8 lineage commitment: light at the end of the tunnel?Q36397545
Independent roles for IL-2 and GATA-3 in stimulating naive CD4+ T cells to generate a Th2-inducing cytokine environmentQ36403025
Interleukin-7 is necessary to maintain the B cell potential in common lymphoid progenitorsQ36403344
Regulation of Th2 differentiation and Il4 locus accessibility.Q36427376
GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cellsQ36604402
Notch signalling during peripheral T-cell activation and differentiationQ36684906
GATA-3 - not just for Th2 cells anymoreQ36755958
Development in motion: helper T cells at workQ36785612
Control points in NKT-cell developmentQ36858868
Interleukin 2 plays a central role in Th2 differentiation.Q37095134
RUNX proteins in transcription factor networks that regulate T-cell lineage choiceQ37376016
The different faces of Notch in T-helper-cell differentiationQ37376021
Enforced expression of the GATA-3 transcription factor affects cell fate decisions in hematopoiesisQ38297965
GATA-3 dominant negative mutant. Functional redundancy of the T cell receptor alpha and beta enhancersQ38299593
Structure and specificity of GATA proteins in Th2 developmentQ38302372
Calcineurin B1 is essential for positive but not negative selection during thymocyte developmentQ39679218
Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses.Q39697358
Analysis of Notch1 function by in vitro T cell differentiation of Pax5 mutant lymphoid progenitors.Q40517723
Induction of T cell development and establishment of T cell competence from embryonic stem cells differentiated in vitroQ40575680
Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro.Q40683787
Unexpectedly complex regulation of CD4/CD8 coreceptor expression supports a revised model for CD4+CD8+ thymocyte differentiation.Q40922234
Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 geneQ41093086
Expression of GATA-3 during lymphocyte differentiation and mouse embryogenesisQ41650230
GATA-binding transcription factors in mast cells regulate the promoter of the mast cell carboxypeptidase A geneQ41653357
DNA-binding specificity of GATA family transcription factorsQ42078566
c-Myb regulates lineage choice in developing thymocytes via its target gene Gata3.Q42082679
ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineageQ42220100
Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signalingQ42254951
Function of GATA transcription factors in preadipocyte-adipocyte transitionQ42835284
Interaction between GATA-3 and the transcriptional coregulator Pias1 is important for the regulation of Th2 immune responsesQ43684415
Deficient T cell fate specification in mice with an induced inactivation of Notch1.Q45345200
Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets.Q46001789
GATA-3 expression is controlled by TCR signals and regulates CD4/CD8 differentiationQ46044258
Regulation of alphabeta/gammadelta T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signalingQ47607371
Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development.Q48075133
Enforced expression of GATA-3 severely reduces human thymic cellularityQ49057606
T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genesQ50111962
The initial response of CD4+ IL-4-producing cells.Q50699300
The interleukin-4 enhancer CNS-2 is regulated by Notch signals and controls initial expression in NKT cells and memory-type CD4 T cells.Q50726643
Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate.Q50777703
CD4-CD8 lineage commitment is regulated by a silencer element at the ThPOK transcription-factor locus.Q50799741
The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment.Q50977520
Enforced expression of GATA-3 during T cell development inhibits maturation of CD8 single-positive cells and induces thymic lymphoma in transgenic mice.Q51064947
Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment.Q51083007
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectcell differentiationQ210861
P304page(s)125-35
P577publication date2009-02-01
P1433published inNature Reviews ImmunologyQ43355
P1476titleGATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation
P478volume9

Reverse relations

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