c-Myb and GATA-3 cooperatively regulate IL-13 expression via conserved GATA-3 response element and recruit mixed lineage leukemia (MLL) for histone modification of the IL-13 locus

scientific article published on 28 October 2011

c-Myb and GATA-3 cooperatively regulate IL-13 expression via conserved GATA-3 response element and recruit mixed lineage leukemia (MLL) for histone modification of the IL-13 locus is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.1100550
P932PMC publication ID3221810
P698PubMed publication ID22039304
P5875ResearchGate publication ID51753874

P2093author name stringAlan M Gewirtz
Susan Shetzline
Yuji Nakata
Mayumi Sugita
Teruhiko Kozuka
P2860cites workIdentification of a Coordinate Regulator of Interleukins 4, 13, and 5 by Cross-Species Sequence ComparisonsQ22065547
c-Myb, Menin, GATA-3, and MLL form a dynamic transcription complex that plays a pivotal role in human T helper type 2 cell developmentQ24313643
GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiationQ24569631
The myb gene family in cell growth, differentiation and apoptosisQ28137891
MLL targets SET domain methyltransferase activity to Hox gene promotersQ28609771
ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulationQ29618299
Critical functions for c-Myb at three checkpoints during thymocyte developmentQ30433753
GATA3 in development and cancer differentiation: cells GATA have it!Q30480099
c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesisQ33604849
Signaling and transcription in T helper developmentQ33932729
Lineage commitment in the immune system: the T helper lymphocyte grows up.Q33970744
Nuclease hypersensitive sites in chromatinQ34164152
Computational and biological analysis of 680 kb of DNA sequence from the human 5q31 cytokine gene cluster regionQ34426011
CD4 T cells: fates, functions, and faultsQ34813153
The function role of GATA-3 in Th1 and Th2 differentiation.Q35208763
Regulation of Th2 differentiation and Il4 locus accessibility.Q36427376
Development in motion: helper T cells at workQ36785612
Launching the T-cell-lineage developmental programmeQ37039580
Initiation and maintenance of Th2 cell identity.Q37172660
MYB function in normal and cancer cellsQ37198576
Critical roles for c-Myb in hematopoietic progenitor cells.Q37201695
Requirement of c-myb in T cell development and in mature T cell functionQ37570509
Stimulation of interleukin-13 expression by human T-cell leukemia virus type 1 oncoprotein Tax via a dually active promoter element responsive to NF-kappaB and NFAT.Q38359936
Progression through key stages of haemopoiesis is dependent on distinct threshold levels of c-Myb.Q39918427
NF-E2 and GATA binding motifs are required for the formation of DNase I hypersensitive site 4 of the human beta-globin locus control region.Q40805375
Cytokines induce the development of functionally heterogeneous T helper cell subsetsQ41732572
DNA-binding specificity of GATA family transcription factorsQ42078566
c-Myb regulates lineage choice in developing thymocytes via its target gene Gata3.Q42082679
c-Myb contributes to G2/M cell cycle transition in human hematopoietic cells by direct regulation of cyclin B1 expressionQ42924839
Cutting edge: chromatin remodeling at the IL-4/IL-13 intergenic regulatory region for Th2-specific cytokine gene clusterQ73306717
Regulation of IL-4 gene expression by distal regulatory elements and GATA-3 at the chromatin levelQ73835273
Cell-type-restricted binding of the transcription factor NFAT to a distal IL-4 enhancer in vivoQ73998192
A 3' enhancer in the IL-4 gene regulates cytokine production by Th2 cells and mast cellsQ74548143
The cell type-specific expression of the murine IL-13 gene is regulated by GATA-3Q74601841
Identification of a conserved GATA3 response element upstream proximal from the interleukin-13 gene locusQ74694893
Modulation of chromatin structure regulates cytokine gene expression during T cell differentiationQ77769108
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)5974-5982
P577publication date2011-10-28
P1433published inJournal of ImmunologyQ3521441
P1476titlec-Myb and GATA-3 cooperatively regulate IL-13 expression via conserved GATA-3 response element and recruit mixed lineage leukemia (MLL) for histone modification of the IL-13 locus
P478volume187

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cites work (P2860)
Q57052275A common atopy-associated variant in the Th2 cytokine locus control region impacts transcriptional regulation and alters SMAD3 and SP1 binding
Q28536743Genetic interaction between mutations in c-Myb and the KIX domains of CBP and p300 affects multiple blood cell lineages and influences both gene activation and repression
Q37339132Genomics of lymphoid malignancies reveal major activation pathways in lymphocytes
Q38133656Histone methyltransferase and histone methylation in inflammatory T-cell responses
Q33924236IFN-α suppresses GATA3 transcription from a distal exon and promotes H3K27 trimethylation of the CNS-1 enhancer in human Th2 cells
Q51530407IL-1 is a critical regulator of group 2 innate lymphoid cell function and plasticity.
Q30543236LASAGNA: a novel algorithm for transcription factor binding site alignment
Q35770991PU.1 Suppresses Th2 Cytokine Expression via Silencing of GATA3 Transcription in Dendritic Cells
Q36761521Phase 2 clinical trial of rapamycin-resistant donor CD4+ Th2/Th1 (T-Rapa) cells after low-intensity allogeneic hematopoietic cell transplantation
Q37560621Rapid Recall Ability of Memory T cells is Encoded in their Epigenome.
Q49545028Respecifying human iPSC-derived blood cells into highly engraftable hematopoietic stem and progenitor cells with a single factor
Q38163576Transcriptional regulation of T helper type 2 differentiation

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