| scholarly article | Q13442814 |
| P819 | ADS bibcode | 1998PNAS...95.8187D |
| P356 | DOI | 10.1073/PNAS.95.14.8187 |
| P932 | PMC publication ID | 20951 |
| P698 | PubMed publication ID | 9653162 |
| P5875 | ResearchGate publication ID | 24451873 |
| P2093 | author name string | R R Hardy | |
| D Allman | |||
| V P Dave | |||
| D J Kappes | |||
| R Keefe | |||
| P2860 | cites work | Profound block in thymocyte development in mice lacking p56lck | Q24298882 |
| Essential role for ZAP-70 in both positive and negative selection of thymocytes | Q24321424 | ||
| The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck | Q28506433 | ||
| Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4 | Q28511808 | ||
| Mice lacking MHC class II molecules | Q28588991 | ||
| CD3 delta deficiency arrests development of the alpha beta but not the gamma delta T cell lineage | Q28589169 | ||
| A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development | Q28589467 | ||
| T cell receptor-mediated negative selection of autoreactive T lymphocyte precursors occurs after commitment to the CD4 or CD8 lineages | Q36353463 | ||
| Maturational arrest from CD4+8+ to CD4+8- thymocytes in a mutant strain (LEC) of rat. | Q36354135 | ||
| Evidence for differential intracellular signaling via CD4 and CD8 molecules | Q36362755 | ||
| Intermediate steps in positive selection: differentiation of CD4+8int TCRint thymocytes into CD4-8+TCRhi thymocytes | Q36364765 | ||
| Positive selection of T cells: rescue from programmed cell death and differentiation require continual engagement of the T cell receptor. | Q36365004 | ||
| Replacement of pre-T cell receptor signaling functions by the CD4 coreceptor | Q36376694 | ||
| CD8 lineage commitment in the absence of CD8. | Q37436864 | ||
| Disruption of T lymphocyte positive and negative selection in mice lacking the CD8 beta chain | Q38306843 | ||
| Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4. | Q40872594 | ||
| T cell development in mice lacking the CD3-zeta/eta gene. | Q40874332 | ||
| Developmental and functional impairment of T cells in mice lacking CD3 zeta chains. | Q40874338 | ||
| Unexpectedly complex regulation of CD4/CD8 coreceptor expression supports a revised model for CD4+CD8+ thymocyte differentiation. | Q40922234 | ||
| A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development | Q41460845 | ||
| Requirement for CD8 beta chain in positive selection of CD8-lineage T cells | Q41486547 | ||
| A role for the cytoplasmic tail of the beta chain of CD8 in thymic selection | Q43691761 | ||
| An activated form of Notch influences the choice between CD4 and CD8 T cell lineages | Q46109980 | ||
| Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes. | Q46778527 | ||
| An enhancer that directs lineage-specific expression of CD8 in positively selected thymocytes and mature T cells. | Q51100653 | ||
| Peptide-induced positive selection of TCR transgenic thymocytes in a coreceptor-independent manner. | Q51103760 | ||
| MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent. | Q51115513 | ||
| Intermediate steps in thymic positive selection. Generation of CD4-8+ T cells in culture from CD4+8+, CD4int8+, and CD4+8int thymocytes with up-regulated levels of TCR-CD3. | Q51120703 | ||
| Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: a new perspective on thymic commitment and selection. | Q51125295 | ||
| Another view of the selective model of thymocyte selection. | Q51142565 | ||
| Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage. | Q51161910 | ||
| Engagement of the CD4 molecule influences cell surface expression of the T-cell receptor on thymocytes. | Q52249516 | ||
| Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice. | Q52481758 | ||
| Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex | Q59071991 | ||
| Helper T-cell development in the absence of CD4-p56 Ick association | Q60065823 | ||
| Recent thymic emigrants are distinct from most medullary thymocytes | Q62230549 | ||
| CD4+8- and CD4-8+ mature thymocytes require different post-selection processing for final development | Q62817912 | ||
| Inheritance of T helper immunodeficiency (thid) in LEC mutant rats | Q67898386 | ||
| Inhibition of T cell receptor expression and function in immature CD4+CD8+ cells by CD4 | Q68360514 | ||
| The lack of CD8 alpha cytoplasmic domain resulted in a dramatic decrease in efficiency in thymic maturation but only a moderate reduction in cytotoxic function of CD8+ T lymphocytes | Q72564592 | ||
| Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points | Q72628282 | ||
| A region in the CD8 gene locus that directs expression to the mature CD8 T cell subset in transgenic mice | Q73838329 | ||
| P433 | issue | 14 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 8187-8192 | |
| P577 | publication date | 1998-07-01 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | HD mice: a novel mouse mutant with a specific defect in the generation of CD4(+) T cells | |
| P478 | volume | 95 |
| Q35729215 | An alternative to current thinking about positive selection, negative selection and activation of T cells |
| Q36402496 | An antagonist peptide mediates positive selection and CD4 lineage commitment of MHC class II-restricted T cells in the absence of CD4 |
| Q30749750 | Automated discovery of tissue-targeting enhancers and transcription factors from binding motif and gene function data |
| Q41763674 | Bcl11b represses a mature T-cell gene expression program in immature CD4(+)CD8(+) thymocytes |
| Q36202203 | CD4-CD8 lineage commitment: an inside view |
| Q36071442 | CD4-CD8 lineage differentiation: Thpok-ing into the nucleus |
| Q51050378 | CD83 expression influences CD4+ T cell development in the thymus. |
| Q50777703 | Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate. |
| Q33839945 | Co-receptor choice by V alpha14i NKT cells is driven by Th-POK expression rather than avoidance of CD8-mediated negative selection |
| Q36382781 | Commitment issues: linking positive selection signals and lineage diversification in the thymus |
| Q34117165 | Common promoter elements in odorant and vomeronasal receptor genes. |
| Q37802426 | Expanding roles for ThPOK in thymic development |
| Q24569631 | GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation |
| Q61446384 | HDAC3 restrains CD8-lineage genes to maintain a bi-potential state in CD4CD8 thymocytes for CD4-lineage commitment |
| Q37714507 | Heritable Gene Regulation in the CD4:CD8 T Cell Lineage Choice. |
| Q39654957 | Identification of important regulatory region of Th-POK |
| Q64884264 | Immunology: guide for a cell-fate decision. |
| Q37811064 | Interplay of transcription factors in T-cell differentiation and function: the role of Runx |
| Q33529096 | Itk derived signals regulate the expression of Th-POK and controls the development of CD4 T cells |
| Q34831201 | Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice |
| Q34619122 | Maturational arrest of thymocyte development is caused by a deletion in the receptor-like protein tyrosine phosphatase kappa gene in LEC rats |
| Q37376016 | RUNX proteins in transcription factor networks that regulate T-cell lineage choice |
| Q35005536 | RUNX transcription factor-mediated association of Cd4 and Cd8 enables coordinate gene regulation |
| Q28586757 | Regulation of GATA-3 expression during CD4 lineage differentiation. |
| Q36382776 | Role of the transcription factor Th-POK in CD4:CD8 lineage commitment |
| Q50974901 | Switching sides: transcriptional control of CD4 thymocyte lineage commitment. |
| Q34021127 | TCR-mediated ThPOK induction promotes development of mature (CD24-) gammadelta thymocytes. |
| Q35566626 | TOX is required for development of the CD4 T cell lineage gene program |
| Q42220100 | ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage |
| Q38034839 | The BTB-ZF transcription factors |
| Q37781936 | The network of transcription factors that underlie the CD4 versus CD8 lineage decision |
| Q36440062 | The transcription factor Th-POK negatively regulates Th17 differentiation in Vα14i NKT cells |
| Q45345537 | The transcription factor ThPOK suppresses Runx3 and imposes CD4(+) lineage fate by inducing the SOCS suppressors of cytokine signaling. |
| Q50977520 | The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment. |
| Q27023639 | Transcriptional control of CD4 and CD8 coreceptor expression during T cell development |
| Q34248566 | Transcriptional control of invariant NKT cell development |
| Q37379435 | Upregulation of CD4 expression during MHC class II-specific positive selection is essential for error-free lineage choice |
| Q27011507 | Using mouse models to study function of transcriptional factors in T cell development |
| Q38810888 | Views on helper/cytotoxic lineage choice from a bottom-up approach |
| Q36448823 | ZBTB7B (Th-POK) regulates the development of IL-17-producing CD1d-restricted mouse NKT cells |
| Q39660793 | p300-Mediated Acetylation Stabilizes the Th-Inducing POK Factor |
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