Functional and Phenotypic Plasticity of CD4(+) T Cell Subsets

scientific article published on 25 October 2015

Functional and Phenotypic Plasticity of CD4(+) T Cell Subsets is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1155/2015/521957
P932PMC publication ID4637038
P698PubMed publication ID26583116
P5875ResearchGate publication ID283965760

P2093author name stringTiffany Caza
Steve Landas
P2860cites workInterchromosomal associations between alternatively expressed lociQ22122480
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Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells.Q45299244
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Early commitment of naïve human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12.Q50731194
Functional plasticity in memory T helper cell responses.Q50906418
Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells.Q50968365
Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment.Q51083007
T-cell lineage commitment and cytokine responses of thymic progenitorsQ51121944
Decision making during the conception and career of CD4+ T cells.Q51941777
Genetic Reprogramming of Primary Human T Cells Reveals Functional Plasticity in Th Cell DifferentiationQ52005548
A role for mucosal IL-22 production and Th22 cells in HIV-associated mucosal immunopathogenesis.Q52628213
Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset.Q53446140
Expression of Helios in Peripherally Induced Foxp3+ Regulatory T CellsQ56888758
CD4(+)CD25high regulatory T cells increase with tumor stage in patients with gastric and esophageal cancersQ56901953
Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by TH1 clonesQ70030269
Th1 and Th2 CD4+ T cells provide help for B cell clonal expansion and antibody synthesis in a similar manner in vivoQ74279868
CD4+CD25+ regulatory T cells in the peripheral blood of patients with breast cancer and non-small cell lung cancerQ81323711
Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?Q83125659
Phenotypical characterization of human Th17 cells unambiguously identified by surface IL-17A expressionQ84754845
Comprehensive intestinal T helper cell profiling reveals specific accumulation of IFN-γ+IL-17+coproducing CD4+ T cells in active inflammatory bowel diseaseQ85362928
Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodelingQ24647357
The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cellsQ24655751
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signalingQ24672005
Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsionQ24676901
IL-17 and Th17 CellsQ27860566
mTOR activation is a biomarker and a central pathway to autoimmune disorders, cancer, obesity, and agingQ28081442
The development and in vivo function of T helper 9 cellsQ28083375
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The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacityQ28252642
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1Q28506431
T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gammaQ28506783
IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cellsQ28590243
Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteinsQ29547534
Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineagesQ29547871
The lineage decisions of helper T cellsQ29614841
Activation of a metabolic gene regulatory network downstream of mTOR complex 1Q29615179
Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trialQ29618031
Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clonesQ29622840
Direct control of mitochondrial function by mTOR.Q33552261
CD45RA-Foxp3high but not CD45RA+Foxp3low suppressive T regulatory cells increased in the peripheral circulation of patients with head and neck squamous cell carcinoma and correlated with tumor progression.Q33615788
Rapamycin reduces disease activity and normalizes T cell activation-induced calcium fluxing in patients with systemic lupus erythematosusQ33664993
The late endosome is essential for mTORC1 signalingQ33689824
Immunoregulatory functions of mTOR inhibition.Q33761278
Selecting and maintaining a diverse T-cell repertoireQ33783983
Ablation of TSC2 enhances insulin secretion by increasing the number of mitochondria through activation of mTORC1Q34008821
Helios expression is a marker of T cell activation and proliferation.Q34019821
Dendritic cell regulation of TH1-TH2 developmentQ34023428
Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environmentQ34093086
The molecular basis of T helper 1 and T helper 2 cell differentiationQ34106569
Signal strength in thymic selection and lineage commitment.Q34167971
IL-10 elicits IFNγ-dependent tumor immune surveillance.Q34240935
Molecular aspects of T-cell differentiationQ34255440
Mechanistic target of rapamycin complex 1 expands Th17 and IL-4+ CD4-CD8- double-negative T cells and contracts regulatory T cells in systemic lupus erythematosusQ34412837
T helper 17 cells play a critical pathogenic role in lung cancerQ34413917
Epigenetic control of T-helper-cell differentiationQ37371624
At the crossroads of T helper lineage commitment-Epigenetics points the way.Q37375215
RUNX proteins in transcription factor networks that regulate T-cell lineage choiceQ37376016
The different faces of Notch in T-helper-cell differentiationQ37376021
How are T(H)1 and T(H)2 effector cells made?Q37449444
Plasticity of CD4(+) FoxP3(+) T cellsQ37509592
Developmental plasticity of Th17 and Treg cells.Q37518502
Epigenetic regulation of cytokine gene expression in T lymphocytesQ37536992
Th9 and allergic diseaseQ37552040
New insights into the differentiation and function of T follicular helper cells.Q37621244
A modified model of T-cell differentiation based on mTOR activity and metabolismQ37691889
Th1 cells induce and Th2 inhibit antigen-dependent IL-12 secretion by dendritic cellsQ41029994
T cell-derived Act1 is necessary for IL-25-mediated Th2 responses and allergic airway inflammationQ41131335
Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodiesQ41854046
T regulatory type 1 cells in squamous cell carcinoma of the head and neck: mechanisms of suppression and expansion in advanced diseaseQ41888065
STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healingQ41953828
Instruction for cytokine expression in T helper lymphocytes in relation to proliferation and cell cycle progressionQ42267729
Stat4 regulates multiple components of IFN-gamma-inducing signaling pathwaysQ42497340
The mTOR kinase differentially regulates effector and regulatory T cell lineage commitmentQ42593305
A "Toll" for Th17 cell expansionQ42742596
Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment.Q34419957
Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunityQ34596060
Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cellsQ34617154
Control of regulatory T cell lineage commitment and maintenanceQ34658594
T-cell development and the CD4-CD8 lineage decisionQ34659128
Th1/Th17 plasticity is a marker of advanced β cell autoimmunity and impaired glucose tolerance in humansQ34756902
The functional plasticity of T cell subsetsQ34786657
The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2.Q34801853
Plasticity of CD4+ T cell lineage differentiation.Q34982725
Hematopoietic cytokines can instruct lineage choiceQ34991616
Cellular size as a means of tracking mTOR activity and cell fate of CD4+ T cells upon antigen recognitionQ35304382
Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets.Q35404457
Mammalian target of rapamycin (mTOR) inhibitors as anti-cancer agentsQ35971876
N-acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients: a randomized, double-blind, placebo-controlled trialQ36139749
Helper T cell differentiation enters a new era: le roi est mort; vive le roi!Q36228555
Reversibility of T helper 1 and 2 populations is lost after long-term stimulationQ36365975
Expanding the effector CD4 T-cell repertoire: the Th17 lineage.Q36449975
T helper cell differentiation: regulation by cis elements and epigeneticsQ36450906
The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cellsQ36509846
Th17: an effector CD4 T cell lineage with regulatory T cell tiesQ36510274
Signal transduction pathways and transcriptional regulation in the control of Th17 differentiationQ36571580
Transcriptional reprogramming of mature CD4⁺ helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytesQ36635015
T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR.Q36693820
Th1 and Th2 cells form morphologically distinct immunological synapses.Q36740495
Induction of Th17 cells in the tumor microenvironment improves survival in a murine model of pancreatic cancerQ36957222
Immunological decision-making: how does the immune system decide to mount a helper T-cell response?Q36993451
Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient miceQ37111353
Interferon-dependent IL-10 production by Tregs limits tumor Th17 inflammationQ37259195
Th9 cell development requires a BATF-regulated transcriptional networkQ37259259
IDO: a double-edged sword for T(H)1/T(H)2 regulationQ37281950
Nine lives: plasticity among T helper cell subsetsQ37292800
IL-9 induces differentiation of TH17 cells and enhances function of FoxP3+ natural regulatory T cellsQ37293226
The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR.Q37319760
Regulation of T-helper-cell lineage development by osteopontin: the inside storyQ37354848
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectcellQ7868
phenotypic plasticityQ295130
immune toleranceQ1356761
lymphocyte subsetsQ66004891
hemic and immune systemsQ70202933
P304page(s)521957
P577publication date2015-10-25
P1433published inBioMed Research InternationalQ17509958
P1476titleFunctional and Phenotypic Plasticity of CD4(+) T Cell Subsets
P478volume2015

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cites work (P2860)
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