Aging increases cell-to-cell transcriptional variability upon immune stimulation

scientific article published on March 2017

Aging increases cell-to-cell transcriptional variability upon immune stimulation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1126/SCIENCE.AAH4115
P1325external data available at URLhttps://www.ebi.ac.uk/arrayexpress/experiments/E-MTAB-4888
P932PMC publication ID5405862
P698PubMed publication ID28360329

P50authorHung-Chang ChenQ64496861
Michael J T StubbingtonQ85457729
Sarah TeichmannQ19501099
Duncan OdomQ29654050
Lovorka StojicQ37368627
John MarioniQ38320103
Tim RaynerQ47502905
Aleksandra A KolodziejczykQ48042798
Nils ElingQ57496148
Catalina A VallejosQ57496156
P2093author name stringMaike de la Roche
Frances Connor
Celia Pilar Martinez-Jimenez
P2860cites workComparative studies of gene expression and the evolution of gene regulationQ22122000
GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiationQ24569631
Full-length mRNA-Seq from single-cell levels of RNA and individual circulating tumor cellsQ24630239
CD4 T-cell subsets and tumor immunity: the helpful and the not-so-helpfulQ27010682
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resourcesQ27860739
Comparative RNA sequencing reveals substantial genetic variation in endangered primatesQ28730817
Meta-analysis of age-related gene expression profiles identifies common signatures of aging.Q29347048
Differentiation of effector CD4 T cell populations (*)Q29614838
The evolution of gene expression levels in mammalian organsQ29617170
T cell exhaustionQ29620463
Computational analysis of cell-to-cell heterogeneity in single-cell RNA-sequencing data reveals hidden subpopulations of cellsQ30884891
BASiCS: Bayesian Analysis of Single-Cell Sequencing DataQ30976555
Computational assignment of cell-cycle stage from single-cell transcriptome dataQ30978560
AGEMAP: a gene expression database for aging in miceQ33310467
Understanding immunosenescence to improve responses to vaccinesQ34281329
Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phaseQ34299819
T cell fate and clonality inference from single-cell transcriptomesQ34517214
Increased cell-to-cell variation in gene expression in ageing mouse heartQ34540791
Thymic output in aged miceQ34694301
Mice as a mammalian model for research on the genetics of agingQ34780553
Classification of low quality cells from single-cell RNA-seq dataQ35926590
Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cellsQ36333706
Extensive compensatory cis-trans regulation in the evolution of mouse gene expressionQ36446194
Conservation and divergence in the transcriptional programs of the human and mouse immune systemsQ36637283
The Aging EpigenomeQ37029584
Expanding roles for CD4⁺ T cells in immunity to viruses.Q37150560
Comparative kinetic analyses of gene profiles of naïve CD4+ and CD8+ T cells from young and old animals reveal novel age-related alterations.Q37574503
The biology of recent thymic emigrantsQ38057392
CD4 T cell defects in the aged: causes, consequences and strategies to circumventQ38179732
Computational and analytical challenges in single-cell transcriptomicsQ38335021
Comparing genomic expression patterns across species identifies shared transcriptional profile in agingQ38522233
The mechanisms shaping the single-cell transcriptional landscape.Q38709299
Beyond comparisons of means: understanding changes in gene expression at the single-cell levelQ39847418
Accounting for technical noise in single-cell RNA-seq experiments.Q42774165
Transcriptional instability is not a universal attribute of aging.Q45981666
Continued maturation of thymic emigrants in the peripheryQ48022294
Altered Th1/Th2 commitment in human CD4+ T cells with ageing.Q51081117
Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans.Q51415097
Production of Ribosome Components in Effector CD4+ T Cells Is Accelerated by TCR Stimulation and Coordinated by ERK-MAPKQ57201963
P4510describes a project that usesspleenQ9371
P433issue6332
P407language of work or nameEnglishQ1860
P921main subjectsingle cell transcriptomicsQ105406038
P304page(s)1433-1436
P577publication date2017-03-01
P1433published inScienceQ192864
P1476titleAging increases cell-to-cell transcriptional variability upon immune stimulation
P478volume355

Reverse relations

described by source (P1343)
Q109282922Mus musculus castaneus naive CD4 + T cell
Q109282925Mus musculus domesticus memory CD4+ T cell

cites work (P2860)
Q57188247A Single-Cell Transcriptome Atlas of the Aging Drosophila Brain
Q98383279A human circulating immune cell landscape in aging and COVID-19
Q101166907Age-related loss of gene-to-gene transcriptional coordination among single cells
Q90287830Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells
Q90538157Aging induces aberrant state transition kinetics in murine muscle stem cells
Q92924617Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes
Q64096733An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics
Q92199284Challenges in measuring and understanding biological noise
Q100944043Clinical characteristics of covid-19 with cardiac injury: a systematic review and meta-analysis
Q58694528Correcting the Mean-Variance Dependency for Differential Variability Testing Using Single-Cell RNA Sequencing Data
Q92050119Emerging Insights into the Metabolic Alterations in Aging Using Metabolomics
Q90438838Engineering cell heterogeneity into organs-on-a-chip
Q39448979Epigenetic plasticity and the hallmarks of cancer.
Q90155542Evaluating stably expressed genes in single cells
Q51766515Gene expression hallmarks of cellular ageing.
Q57793623Gene expression variability across cells and species shapes innate immunity
Q39333493Genome instability: a conserved mechanism of ageing?
Q58763780Genome organization and chromatin analysis identify transcriptional downregulation of insulin-like growth factor signaling as a hallmark of aging in developing B cells
Q91702845IL-7-dependent compositional changes within the γδ T cell pool in lymph nodes during ageing lead to an unbalanced anti-tumour response
Q90340070Identification of reference genes for RT-qPCR data normalisation in aging studies
Q57800520Integrating cellular senescence with the concept of damage accumulation in aging: Relevance for clearance of senescent cells
Q89081238Integrative Genome-Wide Analysis of Long Noncoding RNAs in Diverse Immune Cell Types of Melanoma Patients
Q59288063KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance.
Q92668029Mechanisms underlying T cell ageing
Q64271996Multi-level remodeling of transcriptional landscapes in aging and longevity
Q38607708Multicohort analysis reveals baseline transcriptional predictors of influenza vaccination responses
Q41686661Noise reduction as an emergent property of single-cell aging
Q57039635Peripheral immune system in aging and Alzheimer's disease
Q47595178Proteomics and phosphoproteomics in precision medicine: applications and challenges.
Q90303977Quantitative genetic analysis deciphers the impact of cis and trans regulation on cell-to-cell variability in protein expression levels
Q88175232Quantitative single-cell transcriptomics
Q64886183RNA-Seq-Based Gene Expression Pattern and Morphological Alterations in Chick Thymus during Postnatal Development.
Q91844958Revolutionizing immunology with single-cell RNA sequencing
Q52715866Single-Cell Chromatin Modification Profiling Reveals Increased Epigenetic Variations with Aging.
Q92154849Single-Cell Expression Variability Implies Cell Function
Q98735806Single-Cell Transcriptome Analysis Reveals Six Subpopulations Reflecting Distinct Cellular Fates in Senescent Mouse Embryonic Fibroblasts
Q99574277Single-cell analyses of aging, inflammation and senescence
Q89737953Single-cell analysis reveals different age-related somatic mutation profiles between stem and differentiated cells in human liver
Q47913182Single-cell epigenomics: Recording the past and predicting the future
Q97643289Single-cell omics in ageing: a young and growing field
Q90263029Single-cell transcriptomic profiling of the aging mouse brain
Q42641259Single-cell transcriptomics to explore the immune system in health and disease
Q64110534Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan
Q100512277Single-nucleus RNA-seq and FISH identify coordinated transcriptional activity in mammalian myofibers
Q108127009Single-nucleus RNA-seq2 reveals functional crosstalk between liver zonation and ploidy
Q58732929Systematic evaluation of signal-to-noise ratio in variant detection from single cell genome multiple displacement amplification and exome sequencing
Q56535000Systems Immunology: Learning the Rules of the Immune System
Q90091386Temporal changes in the gene expression heterogeneity during brain development and aging
Q58766674The Systems Biology of Single-Cell Aging
Q39432413The emerging role of alternative splicing in senescence and aging.
Q88081580The impact of single-cell RNA sequencing on understanding the functional organization of the immune system
Q92486016The single-cell sequencing: new developments and medical applications
Q47291933The twilight of immunity: emerging concepts in aging of the immune system
Q64259127The widespread increase in inter-individual variability of gene expression in the human brain with age
Q89123769Tissue aging: the integration of collective and variant responses of cells to entropic forces over time
Q56418744Variety is the spice of life: how to explore a redox-dependent heterogeneity in genomically identical cellular populations

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