Progression of regulatory gene expression states in fetal and adult pro-T-cell development

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Progression of regulatory gene expression states in fetal and adult pro-T-cell development is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1111/J.0105-2896.2006.00355.X
P932PMC publication ID4157939
P698PubMed publication ID16448545

P50authorTom TaghonQ88702932
Ellen V. RothenbergQ38321159
Mary A. YuiQ59661556
P2093author name stringHua Wang
Elizabeth-Sharon David-Fung
Marissa Morales
Rochelle A Diamond
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The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progressionQ28508171
NKT cells derive from double-positive thymocytes that are positively selected by CD1dQ28508188
The ETS protein MEF plays a critical role in perforin gene expression and the development of natural killer and NK-T cellsQ28512367
Viable c-Kit(W/W) mutants reveal pivotal role for c-kit in the maintenance of lymphopoiesisQ28513136
Redundant regulation of T cell differentiation and TCRalpha gene expression by the transcription factors LEF-1 and TCF-1Q28513432
Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- miceQ28513839
Spi-B can functionally replace PU.1 in myeloid but not lymphoid developmentQ28585427
GA binding protein regulates interleukin 7 receptor alpha-chain gene expression in T cellsQ28587621
The role of the Ets2 transcription factor in the proliferation, maturation, and survival of mouse thymocytesQ28590149
STAT5 is required for thymopoiesis in a development stage-specific mannerQ28592686
The Ikaros gene is required for the development of all lymphoid lineagesQ28594316
Expression and function of a stem cell promoter for the murine CBFalpha2 gene: distinct roles and regulation in natural killer and T cell development.Q30659791
Precise developmental regulation of Ets family transcription factors during specification and commitment to the T cell lineageQ30718652
Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascadeQ31929689
Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolismQ40390896
Runx3 regulates integrin alpha E/CD103 and CD4 expression during development of CD4-/CD8+ T cellsQ40395229
Subversion of T lineage commitment by PU.1 in a clonal cell line systemQ40424959
Enforced expression of Spi-B reverses T lineage commitment and blocks beta-selectionQ40425565
Analysis of Notch1 function by in vitro T cell differentiation of Pax5 mutant lymphoid progenitors.Q40517723
Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiationQ40564386
Induction of T cell development and establishment of T cell competence from embryonic stem cells differentiated in vitroQ40575680
Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro.Q40683787
The common myelolymphoid progenitor: a key intermediate stage in hemopoiesis generating T and B cellsQ40702395
Induction of germline transcription in the human TCR gamma locus by STAT5.Q40797253
Generation of macrophages from early T progenitors in vitroQ40807363
The docking molecule gab2 is induced by lymphocyte activation and is involved in signaling by interleukin-2 and interleukin-15 but not other common gamma chain-using cytokinesQ40874856
Gamma/delta cells.Q40898241
Gene targeting reveals a hierarchy of transcription factors regulating specification of lymphoid cell fatesQ41049000
A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cellsQ41175024
Defective activation and survival of T cells lacking the Ets-1 transcription factorQ41281933
Increased T-cell apoptosis and terminal B-cell differentiation induced by inactivation of the Ets-1 proto-oncogeneQ41281946
Specific regulation of fos family transcription factors in thymocytes at two developmental checkpointsQ41665482
Disruption of alpha beta but not of gamma delta T cell development by overexpression of the helix-loop-helix protein Id3 in committed T cell progenitorsQ41828305
Early thymocyte development is regulated by modulation of E2A protein activityQ41828914
Extracellular signal-regulated kinase (ERK) activation by the pre-T cell receptor in developing thymocytes in vivo.Q41838088
Kinetics of steady-state differentiation and mapping of intrathymic-signaling environments by stem cell transplantation in nonirradiated miceQ41854796
Essential requirement for c-kit and common gamma chain in thymocyte development cannot be overruled by enforced expression of Bcl-2.Q41878318
Commitment of common T/Natural killer (NK) progenitors to unipotent T and NK progenitors in the murine fetal thymus revealed by a single progenitor assayQ42033907
Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation.Q42194328
Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signalingQ42254951
Distinct signals mediate maturation and allelic exclusion in lymphocyte progenitorsQ42321307
A multipotent precursor in the thymus maps to the branching point of the T versus B lineage decisionQ42972238
The fetal liver counterpart of adult common lymphoid progenitors gives rise to all lymphoid lineages, CD45+CD4+CD3- cells, as well as macrophagesQ43612834
Characterization of the transcriptional expression of Notch-1 signaling pathway members, Deltex and HES-1, in developing mouse thymocytes.Q44006494
Transcription from the RAG1 locus marks the earliest lymphocyte progenitors in bone marrowQ44114694
Analysis of gamma c-family cytokine target genes. Identification of dual-specificity phosphatase 5 (DUSP5) as a regulator of mitogen-activated protein kinase activity in interleukin-2 signalingQ44219218
CD4 expressed on earliest T-lineage precursor cells in the adult murine thymusQ44248643
Origin of Thy-1+ dendritic epidermal cells of adult mice from fetal thymic precursorsQ44285153
PU.1 determines the self-renewal capacity of erythroid progenitor cellsQ44739059
A dose effect of IL-7 on thymocyte developmentQ44904607
New insights into the proliferation and differentiation of early mouse thymocytesQ44936590
Sustained early growth response gene 3 expression inhibits the survival of CD4/CD8 double-positive thymocytesQ44947142
Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cellsQ45085155
Lymphotoxin-mediated regulation of gammadelta cell differentiation by alphabeta T cell progenitorsQ45182811
Mastermind critically regulates Notch-mediated lymphoid cell fate decisions.Q45345202
Requirement for Notch1 signals at sequential early stages of intrathymic T cell developmentQ45345203
Notch signaling controls the generation and differentiation of early T lineage progenitorsQ45345206
Constitutive expression of PU.1 in fetal hematopoietic progenitors blocks T cell development at the pro-T cell stageQ46277443
Different developmental arrest points in RAG-2 -/- and SCID thymocytes on two genetic backgrounds: developmental choices and cell death mechanisms before TCR gene rearrangementQ46319975
Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment.Q46455047
Identification of clonogenic common lymphoid progenitors in mouse bone marrowQ46782262
Differential transcriptional regulation of individual TCR V beta segments before gene rearrangementQ46862481
Pleiotropic changes controlled by the pre-T-cell receptorQ33632421
Induction of germline transcription in the TCRgamma locus by Stat5: implications for accessibility control by the IL-7 receptorQ33873924
Lineage infidelity in myeloid cells with TCR gene rearrangement: a latent developmental potential of proT cells revealed by ectopic cytokine receptor signalingQ34048754
Thymic and intestinal intraepithelial T lymphocyte development are each regulated by the gammac-dependent cytokines IL-2, IL-7, and IL-15.Q34086016
Branching out to gain control: how the pre-TCR is linked to multiple functionsQ34103329
Sea-level fingerprinting as a direct test for the source of global meltwater pulse IA.Q34118671
The transcription factor Spi-B is expressed in plasmacytoid DC precursors and inhibits T-, B-, and NK-cell developmentQ34155756
An architectural perspective on signaling by the pre-, alphabeta and gammadelta T cell receptorsQ34180840
Stepwise lineage restriction of progenitors in lympho-myelopoiesisQ34244347
AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesisQ34299077
Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutationQ34412659
Ontogeny and genetics of the hemato/lymphopoietic systemQ34547199
On the brink of becoming a T cell.Q34547213
The function of E- and Id proteins in lymphocyte developmentQ34572188
Redefinition of lymphoid progenitorsQ34575336
Elements of transcription factor network design for T-lineage specificationQ34654801
Cytokine and cytokine receptor pleiotropy and redundancyQ34693494
Regulation of thymocyte differentiation: pre-TCR signals and beta-selectionQ34831686
The role of Notch signaling during hematopoietic lineage commitmentQ34941712
Lineage plasticity and commitment in T-cell developmentQ34941755
Nature or nurture? Steady-state lymphocyte formation in adults does not recapitulate ontogenyQ34941774
A positive look at double-negative thymocytesQ34988374
Regulation of early lymphocyte development by E2A family proteinsQ35012075
T-lineage specification and commitment: a gene regulation perspectiveQ35012089
Regulatory coding of lymphoid lineage choice by hematopoietic transcription factorsQ35084267
Notch signaling in lymphopoiesis.Q35101882
The development of functionally responsive T cellsQ35348304
Early T lineage progenitors: new insights, but old questions remainQ35591526
Cell migration and the control of post-natal T-cell lymphopoiesis in the thymusQ35605426
T-cell development made simpleQ35620087
Cytokine functions in the formative stages of a lymphocyte's lifeQ35692180
Propensity of adult lymphoid progenitors to progress to DN2/3 stage thymocytes with Notch receptor ligationQ35746052
Commitment to natural killer cells requires the helix-loop-helix inhibitor Id2Q35866730
The IL-7 receptor controls the accessibility of the TCRgamma locus by Stat5 and histone acetylationQ77307375
The Ets-1 transcription factor is required for the development of natural killer cells in miceQ77526138
Distinct roles of the phosphatidylinositol 3-kinase and STAT5 pathways in IL-7-mediated development of human thymocyte precursorsQ77879053
Notch signaling in lymphocyte developmentQ78589773
Thymopoiesis independent of common lymphoid progenitorsQ78754522
Characterization of thymic progenitors in adult mouse bone marrowQ78946182
A domain of Foxn1 required for crosstalk-dependent thymic epithelial cell differentiationQ79121883
Heterogeneity among DN1 prothymocytes reveals multiple progenitors with different capacities to generate T cell and non-T cell lineagesQ80184669
Ontogeny and regulation of IL-7-expressing thymic epithelial cellsQ81178166
Thymic anlage is colonized by progenitors restricted to T, NK, and dendritic cell lineagesQ81434861
Functional domains of Runx1 are differentially required for CD4 repression, TCRbeta expression, and CD4/8 double-negative to CD4/8 double-positive transition in thymocyte developmentQ81482643
TCR signal strength influences alphabeta/gammadelta lineage fateQ81747999
Differential roles of cytokine receptors in the development of epidermal gamma delta T cellsQ95721688
A thymic precursor to the NK T cell lineageQ95783850
Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalitiesQ35911056
Lymphoid progenitors and primary routes to becoming cells of the immune systemQ36070680
Molecular genetics of T cell developmentQ36072446
Regulation of lymphoid development, differentiation, and function by the Notch pathway.Q36072476
Thymus-derived signals regulate early T-cell developmentQ36161319
The kinetics of T cell antigen receptor expression by subgroups of CD4+8+ thymocytes: delineation of CD4+8+3(2+) thymocytes as post-selection intermediates leading to mature T cellsQ36229856
The effect of in vivo IL-7 deprivation on T cell maturationQ36364680
Differential effects of interleukin-15 and interleukin-2 on differentiation of bipotential T/natural killer progenitor cellsQ36367193
The common cytokine receptor gamma chain and the pre-T cell receptor provide independent but critically overlapping signals in early alpha/beta T cell developmentQ36367760
Positive and negative regulation of V(D)J recombination by the E2A proteinsQ36367956
The interleukin 7 receptor is required for T cell receptor gamma locus accessibility to the V(D)J recombinaseQ36368336
The transcriptional repressor Gfi1 affects development of early, uncommitted c-Kit+ T cell progenitors and CD4/CD8 lineage decision in the thymusQ36370712
Defective development of gamma/delta T cells in interleukin 7 receptor-deficient mice is due to impaired expression of T cell receptor gamma genesQ36375349
Identification of a novel developmental stage marking lineage commitment of progenitor thymocytesQ36380389
The common cytokine receptor gamma chain controls survival of gamma/delta T cellsQ36380706
Maintenance of T cell specification and differentiation requires recurrent notch receptor-ligand interactionsQ36399587
IL-7 receptor signals inhibit expression of transcription factors TCF-1, LEF-1, and RORgammat: impact on thymocyte development.Q36399671
Interleukin 7 receptor control of T cell receptor gamma gene rearrangement: role of receptor-associated chains and locus accessibilityQ36401355
PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesisQ36403595
Cross-lineage expression of Ig-beta (B29) in thymocytes: positive and negative gene regulation to establish T cell identityQ36491392
Regulation of AP-1 and NFAT transcription factors during thymic selection of T cellsQ36557490
The beginning and the end of the development of TCR gamma delta cells in the thymusQ37106700
Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytesQ37428286
Correlating notch signaling with thymocyte maturationQ37462948
The Ets-1 transcription factor is required for complete pre-T cell receptor function and allelic exclusion at the T cell receptor beta locusQ37595701
Definition of regulatory network elements for T cell development by perturbation analysis with PU.1 and GATA-3.Q38289001
Molecular basis for developmental changes in interleukin-2 gene inducibilityQ38322912
Wnt target genes identified by DNA microarrays in immature CD34+ thymocytes regulate proliferation and cell adhesion.Q38346260
VWRPY motif–dependent and –independent roles of AML1/Runx1 transcription factor in murine hematopoietic developmentQ38350194
Direct induction of T lymphocyte-specific gene expression by the mammalian Notch signaling pathwayQ39753737
Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cellsQ40251801
Regulation of thymus size by competition for stromal niches among early T cell progenitorsQ47413321
Regulation of alphabeta/gammadelta T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signalingQ47607371
Surface expression of Notch1 on thymocytes: correlation with the double-negative to double-positive transitionQ47677676
Localization of the domains in Runx transcription factors required for the repression of CD4 in thymocytesQ47914889
Thymocytes between the beta-selection and positive selection checkpoints are nonresponsive to IL-7 as assessed by STAT-5 phosphorylationQ47915031
Distinct roles of the interleukin-7 receptor alpha chain in fetal and adult thymocyte development revealed by analysis of interleukin-7 receptor alpha-deficient miceQ47915929
Distinct requirements for IL-7 in development of TCR gamma delta cells during fetal and adult lifeQ47983517
Developmental and functional defects of thymic and epidermal V gamma 3 cells in IL-15-deficient and IFN regulatory factor-1-deficient miceQ49046023
Enforced expression of GATA-3 severely reduces human thymic cellularityQ49057606
Attenuation of gammadeltaTCR signaling efficiently diverts thymocytes to the alphabeta lineage.Q50969471
T/B lineage choice occurs prior to intrathymic Notch signaling.Q50971535
Efficient thymic immigration of B220+ lymphoid-restricted bone marrow cells with T precursor potential.Q51019745
T cell development in PU.1-deficient mice.Q51088420
Precocious expression of T cell functional response genes in vivo in primitive thymocytes before T lineage commitment.Q51093154
Direct evidence for the commitment of hematopoietic stem cells to T, B and myeloid lineages in murine fetal liver.Q51102224
The role of Notch and IL-7 signaling in early thymocyte proliferation and differentiation.Q52054979
The earliest subpopulation of mouse thymocytes contains potent T, significant macrophage, and natural killer cell but no B-lymphocyte potential.Q52086022
Deranged early T cell development in immunodeficient strains of nonobese diabetic mice.Q52086557
T/NK Bipotent Progenitors in the Thymus Retain the Potential to Generate Dendritic CellsQ52100133
Extensive proliferation of T cell lineage-restricted progenitors in the thymus: an essential process for clonal expression of diverse T cell receptor beta chains.Q52108429
Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development.Q52111650
Inactivation of Notch1 impairs VDJbeta rearrangement and allows pre-TCR-independent survival of early alpha beta Lineage Thymocytes.Q52117223
Interleukin-7 inhibits pre-T-cell differentiation induced by the pre-T-cell receptor signal and the effect is mimicked by hGM-CSF in hGM-CSF receptor transgenic mice.Q52119028
Early growth response transcription factors are required for development of CD4(-)CD8(-) thymocytes to the CD4(+)CD8(+) stage.Q52124406
Somatic activation of beta-catenin bypasses pre-TCR signaling and TCR selection in thymocyte development.Q52130337
Co-ordination of the expression of the protein tyrosine kinase p56(lck) with the pre-T cell receptor during thymocyte development.Q52172429
The linkage between T-cell and dendritic cell development in the mouse thymus.Q52181534
Inhibition of gamma delta T cell development and early thymocyte maturation in IL-7 -/- mice.Q52199817
Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages.Q52214235
Cutting edge: histone acetylation and recombination at the TCR gamma locus follows IL-7 induction.Q53882779
Pro-Thymocyte Expansion by c-kit and the Common Cytokine Receptor γ Chain Is Essential for Repertoire FormationQ58478784
Tracing lymphopoiesis with the aid of a pTα-controlled reporter geneQ58621049
An HMG-box-containing T-cell factor required for thymocyte differentiation.Q59058515
Clonal Characterization of a Bipotent T Cell and NK Cell Progenitor in the Mouse Fetal ThymusQ59123104
Early intrathymic precursor cells acquire a CD4(low) phenotypeQ59123146
Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic miceQ67939725
A population of early fetal thymocytes expressing Fc gamma RII/III contains precursors of T lymphocytes and natural killer cellsQ68054236
Implication of the common gamma chain of the IL-7 receptor in intrathymic development of pro-T cellsQ72403459
Intrathymic lymphoid precursor cells during fetal thymus developmentQ72620496
Unexpectedly late expression of intracellular CD3epsilon and TCR gammadelta proteins during adult thymus developmentQ73045892
The common gamma-chain of cytokine receptors regulates intrathymic T cell development at multiple stagesQ73128616
Control of T cell development in vivo by subdomains within the IL-7 receptor alpha-chain cytoplasmic tailQ73311842
PU.1 exhibits partial functional redundancy with Spi-B, but not with Ets-1 or Elf-1Q73785072
Down-regulation of the orphan nuclear receptor ROR gamma t is essential for T lymphocyte maturationQ73812182
Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decisionQ74211426
The beta-catenin--TCF-1 pathway ensures CD4(+)CD8(+) thymocyte survivalQ74286666
A linkage between dendritic cell and T-cell development in the mouse thymus: the capacity of sequential T-cell precursors to form dendritic cells in cultureQ77075277
The ETS-domain transcription factor familyQ77199453
P407language of work or nameEnglishQ1860
P304page(s)212-236
P577publication date2006-02-01
P1433published inImmunological ReviewsQ15724582
P1476titleProgression of regulatory gene expression states in fetal and adult pro-T-cell development
P478volume209

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