GATA3 regulates FLG and FLG2 expression in human primary keratinocytes

scientific article published on 19 September 2017

GATA3 regulates FLG and FLG2 expression in human primary keratinocytes is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1091688636
P356DOI10.1038/S41598-017-10252-X
P932PMC publication ID5605628
P698PubMed publication ID28928464

P2093author name stringThomas Werfel
Christina Brandenberger
Jana Zeitvogel
Ilona Klug
Neele Jokmin
Samira Rieker
P2860cites workIKKalpha controls formation of the epidermis independently of NF-kappaB.Q42502421
Green tea polyphenol stimulates a Ras, MEKK1, MEK3, and p38 cascade to increase activator protein 1 factor-dependent involucrin gene expression in normal human keratinocytesQ43792260
Expression pattern of GATA-3 in embryonic and fetal human skin suggests a role in epidermal and follicular morphogenesis.Q51927254
IL-33 impacts on the skin barrier by downregulating the expression of filaggrin.Q52822524
GATA3 inhibits proliferation and induces expression of both early and late differentiation markers in keratinocytes of the human epidermis.Q54428265
GATA-3 regulates differentiation-specific loricrin gene expression in keratinocytes.Q54470836
Regulation of human involucrin promoter activity by a protein kinase C, Ras, MEKK1, MEK3, p38/RK, AP1 signal transduction pathwayQ77228988
Expression of GATA-3 in epidermis and hair follicle: relationship to p63Q80615439
Human keratinocytes respond to interleukin-18: implication for the course of chronic inflammatory skin diseasesQ81847638
The distal and proximal regulatory regions of the involucrin gene promoter have distinct functions and are required for in vivo involucrin expressionQ82066783
Abundant expression of Kallikrein 1 gene in human keratinocytes was mediated by GATA3Q24312921
GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiationQ24569631
IKK1-deficient mice exhibit abnormal development of skin and skeletonQ24604269
Loricrin expression in cultured human keratinocytes is controlled by a complex interplay between transcription factors of the Sp1, CREB, AP1, and AP2 familiesQ28219317
Fos-related antigen (Fra-1), junB, and junD activate human involucrin promoter transcription by binding to proximal and distal AP1 sites to mediate phorbol ester effects on promoter activityQ28301991
Suppression of GATA-3 nuclear import and phosphorylation: a novel mechanism of corticosteroid action in allergic diseaseQ28475451
GATA-3: an unexpected regulator of cell lineage determination in skinQ28512924
p63 is essential for regenerative proliferation in limb, craniofacial and epithelial developmentQ28587664
p63 is a p53 homologue required for limb and epidermal morphogenesisQ28588206
p63 is upstream of IKK alpha in epidermal developmentQ28591802
Transcriptome and phenotypic analysis reveals Gata3-dependent signalling pathways in murine hair folliclesQ28593467
Human keratinocytes are efficiently immortalized by a Rho kinase inhibitorQ28750471
Transcriptional regulation of T lymphocyte development and functionQ33652463
Th2 cells and GATA-3 in asthma: new insights into the regulation of airway inflammationQ33753434
GATA3 expression is decreased in psoriasis and during epidermal regeneration; induction by narrow-band UVB and IL-4Q33911353
Allergen-induced asthmatic responses modified by a GATA3-specific DNAzymeQ34476656
Lipid defect underlies selective skin barrier impairment of an epidermal-specific deletion of Gata-3.Q36119225
GATA3 Expression in Normal Skin and in Benign and Malignant Epidermal and Cutaneous Adnexal NeoplasmsQ36973436
Cytokine modulation of atopic dermatitis filaggrin skin expressionQ37159649
Role of GATA-3 in allergic diseasesQ37239744
Filaggrin in atopic dermatitis.Q37261751
GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumorsQ37709857
IL-4 and IL-13 negatively regulate TNF-alpha- and IFN-gamma-induced beta-defensin expression through STAT-6, suppressor of cytokine signaling (SOCS)-1, and SOCS-3.Q40109996
The combination of ubiquitous transcription factors AP-1 and Sp1 directs keratinocyte-specific and differentiation-specific gene expression in vitroQ40183429
Transcription factor Sp1 activates involucrin promoter activity in non-epithelial cell typesQ40979165
Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinaseQ41644582
Rho kinase inhibitor Y-27632 prolongs the life span of adult human keratinocytes, enhances skin equivalent development, and facilitates lentiviral transduction.Q42235645
Fos and jun proteins are specifically expressed during differentiation of human keratinocytesQ42472984
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)11847
P577publication date2017-09-19
P1433published inScientific ReportsQ2261792
P1476titleGATA3 regulates FLG and FLG2 expression in human primary keratinocytes
P478volume7

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cites work (P2860)
Q89714182Elevated circulating Th2 but not group 2 innate lymphoid cell responses characterize canine atopic dermatitis
Q90462072Hydrangenol Isolated from the Leaves of Hydrangea serrata Attenuates Wrinkle Formation and Repairs Skin Moisture in UVB-Irradiated Hairless Mice

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