Positive selection of self- and alloreactive CD8+ T cells in Tap-1 mutant mice.

scientific article published on July 1994

Positive selection of self- and alloreactive CD8+ T cells in Tap-1 mutant mice. is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode1994PNAS...91.6525A
P356DOI10.1073/PNAS.91.14.6525
P932PMC publication ID44235
P698PubMed publication ID8022816
P5875ResearchGate publication ID253662855

P50authorSusumu TonegawaQ108602
Luc Van KaerQ37839914
P2093author name stringJ Forman
P G Ashton-Rickardt
C J Aldrich
H G Ljunggren
P2860cites workHost resistance directed selectively against H-2-deficient lymphoma variants. Analysis of the mechanismQ36351357
Positive selection of CD8+ T cells induced by major histocompatibility complex binding peptides in fetal thymic organ cultureQ36361722
Cellular and peptide requirements for in vitro clonal deletion of immature thymocytesQ37217909
Major histocompatibility complex class I-specific and -restricted killing of beta 2-microglobulin-deficient cells by CD8+ cytotoxic T lymphocytesQ37321654
Antigen processing mutant T2 cells present viral antigen restricted through H-2KbQ41535379
TAP2-defective RMA-S cells present Sendai virus antigen to cytotoxic T lymphocytesQ41535386
Transporter-independent processing of HIV-1 envelope protein for recognition by CD8+ T cellsQ41542329
Major histocompatibility complex (MHC)-encoded HAM2 is necessary for antigenic peptide loading onto class I MHC moleculesQ41619596
Cytotoxic T lymphocytes against the antigen-processing-defective RMA-S tumor cell lineQ41620803
On the nature of peptides involved in T cell alloreactivityQ41657428
Transport protein genes in the murine MHC: possible implications for antigen processingQ41710121
Empty MHC class I molecules come out in the coldQ41725383
The CD8+ T cell repertoire in beta 2-microglobulin-deficient mice is biased towards reactivity against self-major histocompatibility class I.Q42942183
The effects of MHC gene dosage and allelic variation on T cell receptor selectionQ43632062
Presentation of endogenous peptides to MHC class I-restricted cytotoxic T lymphocytes in transport deletion mutant T2 cellsQ44427823
Evidence for a differential avidity model of T cell selection in the thymusQ45155438
Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells.Q52483113
Beta 2-microglobulin deficient mice lack CD4-8+ cytolytic T cells.Q52483263
MHC class II region encoding proteins related to the multidrug resistance family of transmembrane transporters.Q54309821
Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defence strategy.Q54432520
Mutations in the major histocompatibility complex class I antigen-presenting groove affect both negative and positive selection of T cellsQ58451234
Role of self-peptides in positively selecting the T-cell repertoireQ59080090
Tolerance induction by clonal deletion of CD4+8+ thymocytes in vitro does not require dedicated antigen-presenting cellsQ61454446
Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymusQ63363368
Immunodominant T cell epitope from signal sequenceQ67541704
Peptide-induced changes in class I heavy chains alter allorecognitionQ70503943
TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selectiveQ72873502
Selective and ATP-dependent translocation of peptides by the MHC-encoded transporterQ28260944
Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transportersQ28266805
A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathwayQ28266815
Restoration of antigen presentation to the mutant cell line RMA-S by an MHC-linked transporterQ28571055
Ham-2 corrects the class I antigen-processing defect in RMA-S cellsQ28585027
TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cellsQ28589574
T cell receptor antagonist peptides induce positive selectionQ29618820
HLA-A2.1-associated peptides from a mutant cell line: a second pathway of antigen presentationQ30434689
Positive selection of transgenic receptor-bearing thymocytes by Kb antigen is altered by Kb mutations that involve peptide bindingQ33741290
HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptidesQ34372218
Highly lytic CD8+, alpha beta T-cell receptor cytotoxic T cells with major histocompatibility complex (MHC) class I antigen-directed cytotoxicity in beta 2-microglobulin, MHC class I-deficient miceQ36202548
RMA/S cells present endogenously synthesized cytosolic proteins to class I-restricted cytotoxic T lymphocytesQ36230742
An endogenous antigenic peptide bypasses the class I antigen presentation defect in RMA-SQ36231070
Skin graft rejection by beta 2-microglobulin-deficient miceQ36231155
Functionally conformed free class I heavy chains exist on the surface of beta 2 microglobulin negative cellsQ36231782
P433issue14
P407language of work or nameEnglishQ1860
P304page(s)6525-6528
P577publication date1994-07-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titlePositive selection of self- and alloreactive CD8+ T cells in Tap-1 mutant mice
P478volume91

Reverse relations

cites work (P2860)
Q51319062A novel spontaneous mutation in the TAP2 gene unravels its role in macrophage survival.
Q40438837Altered MHC class I expression: A role for transplantation and IDDM autoimmunity
Q26864074Alternative Antigen Processing for MHC Class I: Multiple Roads Lead to Rome
Q34801818Antigen degradation or presentation by MHC class I molecules via classical and non-classical pathways
Q53666747Autoreactivity to self H-2Kb peptides in TAP1 mice. Intravenous administration of H-2Kb class I-derived peptides induces long-term survival of grafts from C57BL/6 donors.
Q73527740Characterization of extrathymic CD8 alpha beta T cells in the liver and intestine in TAP-1 deficient mice
Q73092735Development of spontaneous arthritis in beta2-microglobulin-deficient mice without expression of HLA-B27: association with deficiency of endogenous major histocompatibility complex class I expression
Q41390449Differential reactivity of residual CD8+ T lymphocytes in TAP1 and beta 2-microglobulin mutant mice
Q41722133Generation and TAP-mediated transport of peptides for major histocompatibility complex class I molecules.
Q36816677Genetic susceptibility to type 1 diabetes in the intracellular pathway of antigen processing - a subject review and cross-study comparison
Q28504958H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection
Q36671094Homeostatic expansion and phenotypic conversion of naïve T cells in response to self peptide/MHC ligands
Q44715940Impaired immune responses and altered peptide repertoire in tapasin-deficient mice
Q36364433Increase in positive selection of CD8+ T cells in TAP1-mutant mice by human beta 2-microglobulin transgene
Q34297816Latent tuberculosis infection: myths, models, and molecular mechanisms
Q36525599Major histocompatibility complex (MHC) class I KbDb -/- deficient mice possess functional CD8+ T cells and natural killer cells
Q33802993Naturally occurring TAP-dependent specific T-cell tolerance for a variant of an immunodominant retroviral cytotoxic T-lymphocyte epitope
Q34967410On the issue of peptide recognition in T cell development
Q78733975Polymorphisms of human TAP2 detected by denaturing gradient gel electrophoresis
Q34374495Predisposing factors in the spondyloarthropathies: new insights into the role of HLA-B27.
Q40967335Recognition of the major histocompatibility complex restriction element modulates CD8(+) T cell specificity and compensates for loss of T cell receptor contacts with the specific peptide
Q44815361Reduced expression of peptide‐loaded HLA class I molecules on multiple sclerosis lymphocytes
Q63363331Rejection of grafts with no H-2 disparity in TAP1 mutant mice: CD4 T cells are important effector cells and self H-2b class I molecules are target
Q36403649SOCS-1 regulates IL-15-driven homeostatic proliferation of antigen-naive CD8 T cells, limiting their autoimmune potential
Q34293700Similar intracellular peptide profile of TAP1/β2 microglobulin double-knockout mice and C57BL/6 wild-type mice as revealed by peptidomic analysis.
Q36367900Susceptibility of mice deficient in CD1D or TAP1 to infection with Mycobacterium tuberculosis
Q35913406Systemic CD8 T-cell memory response to a Salmonella pathogenicity island 2 effector is restricted to Salmonella enterica encountered in the gastrointestinal mucosa
Q36226061Systemic control of plasmacytoid dendritic cells by CD8+ T cells and commensal microbiota
Q34976927T cell receptor interactions with class I heavy-chain influence T cell selection
Q58850710TAP1 mutant mice reject heart grafts from donors with no MHC disparity
Q42594791TAP1-/- mice present oligoclonal BV-BJ expansions following the rejection of grafts bearing self antigens
Q34221791TAP1-deficiency does not alter atherosclerosis development in Apoe-/- mice
Q56953631TAP1-deficient mice select a CD8+ T cell repertoire that displays both diversity and peptide specificity
Q45866968Tap-1 and Tap-2 Gene Therapy Selectively Restores Conformationally Dependent HLA Class I Expression in Type I Diabetic Cells
Q71798201Targeting the mouse genome: a compendium of knockouts (part III)

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