Mutations in the major histocompatibility complex class I antigen-presenting groove affect both negative and positive selection of T cells

scientific article published on 01 October 1990

Mutations in the major histocompatibility complex class I antigen-presenting groove affect both negative and positive selection of T cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/EJI.1830201024
P698PubMed publication ID2147006

P50authorHeinz JacobsQ42680060
P2093author name stringBerns A
Von Boehmer H
Melief CJ
P2860cites workIn transgenic mice the introduced functional T cell receptor beta gene prevents expression of endogenous beta genesQ48327246
Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cellsQ58991849
Positive selection of antigen-specific T cells in thymus by restricting MHC moleculesQ59080081
Role of self-peptides in positively selecting the T-cell repertoireQ59080090
The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigensQ59092174
Evidence that multiple residues on both the alpha-helices of the class I MHC molecule are simultaneously recognized by the T cell receptorQ68094902
Studies of twoH-2D b mutants: B6.C-H-2 bm13 and B6.C-H-2 bm14Q72620564
Structure of the human class I histocompatibility antigen, HLA-A2Q24297966
Specificity pockets for the side chains of peptide antigens in HLA-Aw68Q27700642
Cytotoxic T lymphocyte nonresponsiveness to the male antigen H-Y in the H-2Db mutants bm13 and bm14. Complementation of the response in F1 crosses with the I-Ab mutant bm12 nonresponder and failure of B6 or Db mutant mice tolerant of each other to rQ36348150
The antigen-specific, major histocompatibility complex-restricted receptor on T cells. VI. An antibody to a receptor allotypeQ36349414
Expression of a murine polyclonal T cell receptor marker correlates with the use of specific members of the V beta 8 gene segment subfamilyQ36352318
Three spontaneous H-2Db mutants are generated by genetic micro-recombination (gene conversion) events. Impact on the H-2-restricted immune responsivenessQ36355667
Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 moleculesQ36356209
MHC restriction, alloreactivity, and thymic education: a common link?Q38219862
The developmental biology of T lymphocytesQ39647331
Xenogeneic Monoclonal Antibodies to Mouse Lymphoid Differentiation Antigens*Q39858455
H-2 restricted cytolytic and noncytolytic T cell clones: isolation, specificity and functional analysisQ40100676
Clones of killer and helper T cells: growth requirements, specificity and retention of function in long-term cultureQ40293127
The outline structure of the T-cell alpha beta receptor.Q41094902
Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytesQ44851100
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectimmunologyQ101929
P304page(s)2333-2337
P577publication date1990-10-01
P1433published inEuropean Journal of ImmunologyQ5412727
P1476titleMutations in the major histocompatibility complex class I antigen-presenting groove affect both negative and positive selection of T cells
P478volume20

Reverse relations

cites work (P2860)
Q71704829A mutation in the alpha 3 domain of Db that abrogates CD8 binding does not affect presentation of an immunodominant H-Y peptide
Q36230612An unusual lineage of alpha/beta T cells that contains autoreactive cells
Q40615110Are MHC-bound peptides a nuisance for positive selection?
Q35575391Diversity of T cell repertoire shaped by a single peptide ligand is critically affected by its amino acid residue at a T cell receptor contact.
Q61419908Early degenerate selection of thymocytes by class I major histocompatibility complex
Q45155438Evidence for a differential avidity model of T cell selection in the thymus
Q40041611Identification of an H-2 Kb-presented Moloney murine leukemia virus cytotoxic T-lymphocyte epitope that displays enhanced recognition in H-2 Db mutant bm13 mice.
Q41652382Low Affinity Interaction of Peptide-MHC Complexes with T Cell Receptors
Q37209084Molecular cloning and characterisation of the rock bream, Oplegnathus fasciatus, Fas (CD95/APO-1), and its expression analysis in response to bacterial or viral infection
Q63363368Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus
Q41517427Peptide variants reveal how antibodies recognize major histocompatibility complex class I.
Q62590795Positive and Negative CD4+ Thymocyte Selection by a Single MHC Class II/Peptide Ligand Affected by Its Expression Level in the Thymus
Q37094142Positive and negative selection of the αβ T-cell repertoire in vivo
Q35580258Positive selection of self- and alloreactive CD8+ T cells in Tap-1 mutant mice.
Q36400972Quantitative analysis of the T cell repertoire selected by a single peptide-major histocompatibility complex
Q40801703Repertoire-determining role of peptide in the positive selection of CD8+ T cells
Q40410980T cell differentiation: control by the pre-TCR and alpha beta TCR.
Q41312334T cell selection and autoimmunity: flexibility and tuning
Q56953631TAP1-deficient mice select a CD8+ T cell repertoire that displays both diversity and peptide specificity
Q36362663The T cell receptor repertoire of CD4-8+ thymocytes is altered by overexpression of the BCL-2 protooncogene in the thymus
Q41393104The agonist-antagonist balance in positive selection.