Targeting the mouse genome: a compendium of knockouts (part III)

scientific article published on 01 August 1995

Targeting the mouse genome: a compendium of knockouts (part III) is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0960-9822(95)00177-1
P953full work available at URLhttp://www.cell.com/article/S0960982295001771/pdf
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https://api.elsevier.com/content/article/PII:S0960982295001771?httpAccept=text/plain
P698PubMed publication ID7583145

P2093author name stringG. S. McKnight
E. P. Brandon
R. L. Idzerda
P2860cites workTransforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early deathQ24563654
Targeted mutation in the neurotrophin-3 gene results in loss of muscle sensory neuronsQ24564570
Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide productionQ28114945
Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory diseaseQ28202655
Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissuesQ28238680
Mice devoid of PrP are resistant to scrapieQ28249108
Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movementsQ28251523
Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferentsQ28286113
Wnt-3a regulates somite and tailbud formation in the mouse embryoQ28504870
Function of retinoic acid receptor gamma in the mouseQ28507388
Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxinQ28507630
Leukocyte rolling and extravasation are severely compromised in P selectin-deficient miceQ28507847
Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4Q28508296
Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCLQ28508494
Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infectionQ28509078
MyoD or Myf-5 is required for the formation of skeletal muscleQ28510042
Maternal rescue of transforming growth factor-beta 1 null miceQ28511932
WT-1 is required for early kidney developmentQ28512266
Oct-2, although not required for early B-cell development, is critical for later B-cell maturation and for postnatal survivalQ28513024
Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiationQ28513619
High postnatal lethality and testis degeneration in retinoic acid receptor alpha mutant miceQ28585392
Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limbQ28585621
Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryoQ28586040
The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brainQ28586297
Excitation-contraction uncoupling and muscular degeneration in mice lacking functional skeletal muscle ryanodine-receptor geneQ28587644
Characterization of gonadal sex cord-stromal tumor cell lines from inhibin-alpha and p53-deficient mice: the role of activin as an autocrine growth factorQ41451412
Shutdown of class switch recombination by deletion of a switch region control element.Q41573717
Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responsesQ42488424
Lymphoid development in mice congenitally lacking T cell receptor alpha beta-expressing cellsQ42806482
Pim-1 levels determine the size of early B lymphoid compartments in bone marrowQ42942006
Alloreactive cytotoxic T cells can develop and function in mice lacking both CD4 and CD8.Q43416478
Normal development and behaviour of mice lacking the neuronal cell-surface PrP proteinQ43522858
Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stagesQ44151375
Requirement for a functional Rb-1 gene in murine developmentQ44462954
Evidence for a differential avidity model of T cell selection in the thymusQ45155438
Severe sensory and sympathetic deficits in mice lacking neurotrophin-3.Q46049557
RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis.Q46123728
The nuclear receptor steroidogenic factor 1 acts at multiple levels of the reproductive axisQ46182351
Prion protein is necessary for normal synaptic functionQ48087355
Endothelial NOS and the blockade of LTP by NOS inhibitors in mice lacking neuronal NOS.Q48087631
No propagation of prions in mice devoid of PrP.Q48101222
The role of Rab3A in neurotransmitter releaseQ48106348
The midbrain-hindbrain phenotype of Wnt-1-/Wnt-1- mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitumQ48480210
PKC gamma mutant mice exhibit mild deficits in spatial and contextual learning.Q51138420
Enhanced aggressive behavior in mice lacking 5-HT1B receptor.Q52214193
Genetic analysis of RXR alpha developmental function: convergence of RXR and RAR signaling pathways in heart and eye morphogenesis.Q52214194
Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages.Q52214235
p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.Q52214399
Combined deficiencies of Src, Fyn, and Yes tyrosine kinases in mutant mice.Q52214725
Mice develop normally without tenascinQ52477879
Mouse P0 gene disruption leads to hypomyelination, abnormal expression of recognition molecules, and degeneration of myelin and axons.Q52477890
Phosphorylation of c-Src on Tyrosine 527 by Another Protein Tyrosine KinaseQ52480438
Targeted disruption of the neuronal nitric oxide synthase gene.Q52507290
Notch1 is essential for postimplantation development in mice.Q52512097
Retinoic acid receptor beta 2 (RAR beta 2) null mutant mice appear normal.Q52512474
A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation.Q52514982
Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapseQ28587672
Absence of the blood-clotting regulator thrombomodulin causes embryonic lethality in mice before development of a functional cardiovascular systemQ28587880
TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cellsQ28589574
Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide geneQ28590408
Targeted disruption of the murine VCAM1 gene: essential role of VCAM-1 in chorioallantoic fusion and placentationQ28590767
Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal deathQ28591473
Mice with targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 reveal synergistic interactionsQ28591882
RAG-1-deficient mice have no mature B and T lymphocytesQ28592133
Altered microtubule organization in small-calibre axons of mice lacking tau proteinQ28592483
Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar developmentQ28593581
Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenesQ28593744
Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient miceQ28593915
RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangementQ28594711
Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient miceQ28594763
Expression of relB is required for the development of thymic medulla and dendritic cellsQ28594949
Tumour predisposition in mice heterozygous for a targeted mutation in Nf1Q28594951
Disruption of the transthyretin gene results in mice with depressed levels of plasma retinol and thyroid hormoneQ28609142
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumoursQ29547697
Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in miceQ29547898
p53-dependent apoptosis modulates the cytotoxicity of anticancer agentsQ29615031
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasiaQ29615437
Effects of an Rb mutation in the mouseQ29619196
Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesisQ29619200
p53 is required for radiation-induced apoptosis in mouse thymocytesQ29620281
Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor RetQ29620364
A novel nonreceptor tyrosine kinase, Srm: cloning and targeted disruptionQ30194028
Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalitiesQ33491173
Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice.Q33491174
Plasminogen activator inhibitor-1 gene-deficient mice. I. Generation by homologous recombination and characterizationQ33909797
Mice lacking vimentin develop and reproduce without an obvious phenotypeQ34059745
Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel familyQ34317095
Short-term synaptic plasticity is altered in mice lacking synapsin I.Q34321716
The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid developmentQ34330300
Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene.Q34338664
Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice.Q34347328
Mice lacking TdT: mature animals with an immature lymphocyte repertoireQ34353306
Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors.Q53478233
Different roles of alpha beta and gamma delta T cells in immunity against an intracellular bacterial pathogen.Q54231147
Thymocyte apoptosis induced by p53-dependent and independent pathways.Q54242475
Rescue of neurophysiological phenotype seen in PrP null mice by transgene encoding human prion proteinQ57093026
Development and proliferation of lymphocytes in mice deficient for both interleukins-2 and -4Q57198387
Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient miceQ57222709
T cell receptor δ gene mutant mice: Independent generation of αβ T cells and programmed rearrangements of γδ TCR genesQ57557410
Tumour incidence, spectrum and ploidy in mice with a large deletion in the p53 geneQ58423654
CD3 components at the surface of pro-T cells can mediate pre-T cell developmentin vivoQ58451232
Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathwaysQ59050520
An HMG-box-containing T-cell factor required for thymocyte differentiation.Q59058515
Physiological consequences of loss of plasminogen activator gene function in miceQ59069678
Immunoglobulin synthesis and generalized autoimmunity in mice congenitally deficient in αβ(+) T cellsQ59092671
Modified hippocampal long-term potentiation in PKCγ-mutant miceQ59272473
In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient miceQ62088781
Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymusQ63363368
Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53Q67521108
Activation of the c-Src tyrosine kinase is required for the induction of mammary tumors in transgenic miceQ71606712
High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic miceQ71641038
Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide SynthaseQ71647466
Role of TCR zeta chain in T cell development and selectionQ71658710
Tenascin knockout mice: barrels, boundary molecules, and glial scarsQ71680909
T Cell Development in Mice that Lack the ζ Chain of the T Cell Antigen Receptor ComplexQ72090378
Histomorphometric and immunocytochemical studies of src-related osteopetrosisQ72093589
Immune dysregulation in TGF-beta 1-deficient miceQ72108750
p53-dependent apoptosis suppresses tumor growth and progression in vivoQ72149266
Graft rejection by T cells not restricted by conventional major histocompatibility complex moleculesQ72233954
Targeted deletion of the TGF-beta 1 gene causes rapid progression to squamous cell carcinomaQ72801082
p53-deficient mice are extremely susceptible to radiation-induced tumorigenesisQ72874160
Analysis of Pim-1 function in mutant miceQ72902867
The murine N-ras gene is not essential for growth and developmentQ34650223
Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning.Q34727007
Gamma delta T cells contribute to immunity against the liver stages of malaria in alpha beta T-cell-deficient miceQ34957552
Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cellsQ35088549
Synthetic fibronectin peptides interrupt inflammatory cell infiltration in transforming growth factor beta 1 knockout miceQ35398178
Altered natural killer cell repertoire in Tap-1 mutant miceQ35579938
Positive selection of self- and alloreactive CD8+ T cells in Tap-1 mutant mice.Q35580258
Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in miceQ35607627
Calorie restriction delays spontaneous tumorigenesis in p53-knockout transgenic miceQ35611007
In vivo analysis of Pim-1 deficiencyQ35859661
Immune function in mice lacking the perforin geneQ35882128
A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicityQ35923516
Disruption of the compacted myelin sheath of axons of the central nervous system in proteolipid protein-deficient miceQ35931734
Lymphocyte proliferation in mice congenitally deficient in T-cell receptor alpha beta + cellsQ35949649
CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation.Q35962812
Normal development and growth of mice carrying a targeted disruption of the alpha 1 retinoic acid receptor geneQ36116474
Mice lacking major histocompatibility complex class I and class II moleculesQ36271130
Osteopetrosis in Src-deficient mice is due to an autonomous defect of osteoclasts.Q36301037
RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte developmentQ36303172
Fc gamma RII/III and CD2 expression mark distinct subpopulations of immature CD4-CD8- murine thymocytes: in vivo developmental kinetics and T cell receptor beta chain rearrangement status.Q36361527
Human CD4-major histocompatibility complex class II (DQw6) transgenic mice in an endogenous CD4/CD8-deficient background: reconstitution of phenotype and human-restricted function.Q36363974
Loss of expression of transforming growth factor beta in skin and skin tumors is associated with hyperproliferation and a high risk for malignant conversionQ36392971
Cell proliferation, DNA repair, and p53 function are not required for programmed death of prostatic glandular cells induced by androgen ablationQ36561116
Transforming growth factor beta 1 (TGF-beta 1) controls expression of major histocompatibility genes in the postnatal mouse: aberrant histocompatibility antigen expression in the pathogenesis of the TGF-beta 1 null mouse phenotypeQ36623685
Ablation of the prion protein (PrP) gene in mice prevents scrapie and facilitates production of anti-PrP antibodiesQ36663046
Amino acid substitutions in the floor of the putative antigen-binding site of H-2T22 affect recognition by a gamma delta T-cell receptorQ36703460
Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilonQ36703755
Genetic deletion of a neural cell adhesion molecule variant (N-CAM-180) produces distinct defects in the central nervous systemQ36759141
The vav proto-oncogene is required early in embryogenesis but not for hematopoietic development in vitro.Q37693271
Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophagesQ38299607
Studies on the metabolism of retinol and retinol-binding protein in transthyretin-deficient mice produced by homologous recombinationQ38299796
Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes.Q38321834
Plasminogen activator inhibitor-1 gene-deficient mice. II. Effects on hemostasis, thrombosis, and thrombolysisQ40305997
Susceptibility to scrapie in mice is dependent on PrPC.Q40624594
Role of the PrP gene in transmissible spongiform encephalopathiesQ40863106
T cell development in mice lacking the CD3-zeta/eta gene.Q40874332
Developmental and functional impairment of T cells in mice lacking CD3 zeta chains.Q40874338
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)873-881
P577publication date1995-08-01
P1433published inCurrent BiologyQ1144851
P1476titleTargeting the mouse genome: a compendium of knockouts (Part III)
Targeting the mouse genome: a compendium of knockouts (part III)
P478volume5

Reverse relations

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