scholarly article | Q13442814 |
P2093 | author name string | G. S. McKnight | |
E. P. Brandon | |||
R. L. Idzerda | |||
P2860 | cites work | Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death | Q24563654 |
Targeted mutation in the neurotrophin-3 gene results in loss of muscle sensory neurons | Q24564570 | ||
Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production | Q28114945 | ||
Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease | Q28202655 | ||
Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues | Q28238680 | ||
Mice devoid of PrP are resistant to scrapie | Q28249108 | ||
Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements | Q28251523 | ||
Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents | Q28286113 | ||
Wnt-3a regulates somite and tailbud formation in the mouse embryo | Q28504870 | ||
Function of retinoic acid receptor gamma in the mouse | Q28507388 | ||
Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin | Q28507630 | ||
Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice | Q28507847 | ||
Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4 | Q28508296 | ||
Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL | Q28508494 | ||
Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection | Q28509078 | ||
MyoD or Myf-5 is required for the formation of skeletal muscle | Q28510042 | ||
Maternal rescue of transforming growth factor-beta 1 null mice | Q28511932 | ||
WT-1 is required for early kidney development | Q28512266 | ||
Oct-2, although not required for early B-cell development, is critical for later B-cell maturation and for postnatal survival | Q28513024 | ||
Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation | Q28513619 | ||
High postnatal lethality and testis degeneration in retinoic acid receptor alpha mutant mice | Q28585392 | ||
Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limb | Q28585621 | ||
Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo | Q28586040 | ||
The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain | Q28586297 | ||
Excitation-contraction uncoupling and muscular degeneration in mice lacking functional skeletal muscle ryanodine-receptor gene | Q28587644 | ||
Characterization of gonadal sex cord-stromal tumor cell lines from inhibin-alpha and p53-deficient mice: the role of activin as an autocrine growth factor | Q41451412 | ||
Shutdown of class switch recombination by deletion of a switch region control element. | Q41573717 | ||
Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses | Q42488424 | ||
Lymphoid development in mice congenitally lacking T cell receptor alpha beta-expressing cells | Q42806482 | ||
Pim-1 levels determine the size of early B lymphoid compartments in bone marrow | Q42942006 | ||
Alloreactive cytotoxic T cells can develop and function in mice lacking both CD4 and CD8. | Q43416478 | ||
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein | Q43522858 | ||
Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages | Q44151375 | ||
Requirement for a functional Rb-1 gene in murine development | Q44462954 | ||
Evidence for a differential avidity model of T cell selection in the thymus | Q45155438 | ||
Severe sensory and sympathetic deficits in mice lacking neurotrophin-3. | Q46049557 | ||
RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis. | Q46123728 | ||
The nuclear receptor steroidogenic factor 1 acts at multiple levels of the reproductive axis | Q46182351 | ||
Prion protein is necessary for normal synaptic function | Q48087355 | ||
Endothelial NOS and the blockade of LTP by NOS inhibitors in mice lacking neuronal NOS. | Q48087631 | ||
No propagation of prions in mice devoid of PrP. | Q48101222 | ||
The role of Rab3A in neurotransmitter release | Q48106348 | ||
The midbrain-hindbrain phenotype of Wnt-1-/Wnt-1- mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum | Q48480210 | ||
PKC gamma mutant mice exhibit mild deficits in spatial and contextual learning. | Q51138420 | ||
Enhanced aggressive behavior in mice lacking 5-HT1B receptor. | Q52214193 | ||
Genetic analysis of RXR alpha developmental function: convergence of RXR and RAR signaling pathways in heart and eye morphogenesis. | Q52214194 | ||
Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. | Q52214235 | ||
p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens. | Q52214399 | ||
Combined deficiencies of Src, Fyn, and Yes tyrosine kinases in mutant mice. | Q52214725 | ||
Mice develop normally without tenascin | Q52477879 | ||
Mouse P0 gene disruption leads to hypomyelination, abnormal expression of recognition molecules, and degeneration of myelin and axons. | Q52477890 | ||
Phosphorylation of c-Src on Tyrosine 527 by Another Protein Tyrosine Kinase | Q52480438 | ||
Targeted disruption of the neuronal nitric oxide synthase gene. | Q52507290 | ||
Notch1 is essential for postimplantation development in mice. | Q52512097 | ||
Retinoic acid receptor beta 2 (RAR beta 2) null mutant mice appear normal. | Q52512474 | ||
A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. | Q52514982 | ||
Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse | Q28587672 | ||
Absence of the blood-clotting regulator thrombomodulin causes embryonic lethality in mice before development of a functional cardiovascular system | Q28587880 | ||
TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells | Q28589574 | ||
Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene | Q28590408 | ||
Targeted disruption of the murine VCAM1 gene: essential role of VCAM-1 in chorioallantoic fusion and placentation | Q28590767 | ||
Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death | Q28591473 | ||
Mice with targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 reveal synergistic interactions | Q28591882 | ||
RAG-1-deficient mice have no mature B and T lymphocytes | Q28592133 | ||
Altered microtubule organization in small-calibre axons of mice lacking tau protein | Q28592483 | ||
Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development | Q28593581 | ||
Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes | Q28593744 | ||
Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice | Q28593915 | ||
RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement | Q28594711 | ||
Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice | Q28594763 | ||
Expression of relB is required for the development of thymic medulla and dendritic cells | Q28594949 | ||
Tumour predisposition in mice heterozygous for a targeted mutation in Nf1 | Q28594951 | ||
Disruption of the transthyretin gene results in mice with depressed levels of plasma retinol and thyroid hormone | Q28609142 | ||
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours | Q29547697 | ||
Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice | Q29547898 | ||
p53-dependent apoptosis modulates the cytotoxicity of anticancer agents | Q29615031 | ||
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia | Q29615437 | ||
Effects of an Rb mutation in the mouse | Q29619196 | ||
Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis | Q29619200 | ||
p53 is required for radiation-induced apoptosis in mouse thymocytes | Q29620281 | ||
Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret | Q29620364 | ||
A novel nonreceptor tyrosine kinase, Srm: cloning and targeted disruption | Q30194028 | ||
Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities | Q33491173 | ||
Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice. | Q33491174 | ||
Plasminogen activator inhibitor-1 gene-deficient mice. I. Generation by homologous recombination and characterization | Q33909797 | ||
Mice lacking vimentin develop and reproduce without an obvious phenotype | Q34059745 | ||
Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel family | Q34317095 | ||
Short-term synaptic plasticity is altered in mice lacking synapsin I. | Q34321716 | ||
The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development | Q34330300 | ||
Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene. | Q34338664 | ||
Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice. | Q34347328 | ||
Mice lacking TdT: mature animals with an immature lymphocyte repertoire | Q34353306 | ||
Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors. | Q53478233 | ||
Different roles of alpha beta and gamma delta T cells in immunity against an intracellular bacterial pathogen. | Q54231147 | ||
Thymocyte apoptosis induced by p53-dependent and independent pathways. | Q54242475 | ||
Rescue of neurophysiological phenotype seen in PrP null mice by transgene encoding human prion protein | Q57093026 | ||
Development and proliferation of lymphocytes in mice deficient for both interleukins-2 and -4 | Q57198387 | ||
Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice | Q57222709 | ||
T cell receptor δ gene mutant mice: Independent generation of αβ T cells and programmed rearrangements of γδ TCR genes | Q57557410 | ||
Tumour incidence, spectrum and ploidy in mice with a large deletion in the p53 gene | Q58423654 | ||
CD3 components at the surface of pro-T cells can mediate pre-T cell developmentin vivo | Q58451232 | ||
Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways | Q59050520 | ||
An HMG-box-containing T-cell factor required for thymocyte differentiation. | Q59058515 | ||
Physiological consequences of loss of plasminogen activator gene function in mice | Q59069678 | ||
Immunoglobulin synthesis and generalized autoimmunity in mice congenitally deficient in αβ(+) T cells | Q59092671 | ||
Modified hippocampal long-term potentiation in PKCγ-mutant mice | Q59272473 | ||
In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice | Q62088781 | ||
Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus | Q63363368 | ||
Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53 | Q67521108 | ||
Activation of the c-Src tyrosine kinase is required for the induction of mammary tumors in transgenic mice | Q71606712 | ||
High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice | Q71641038 | ||
Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide Synthase | Q71647466 | ||
Role of TCR zeta chain in T cell development and selection | Q71658710 | ||
Tenascin knockout mice: barrels, boundary molecules, and glial scars | Q71680909 | ||
T Cell Development in Mice that Lack the ζ Chain of the T Cell Antigen Receptor Complex | Q72090378 | ||
Histomorphometric and immunocytochemical studies of src-related osteopetrosis | Q72093589 | ||
Immune dysregulation in TGF-beta 1-deficient mice | Q72108750 | ||
p53-dependent apoptosis suppresses tumor growth and progression in vivo | Q72149266 | ||
Graft rejection by T cells not restricted by conventional major histocompatibility complex molecules | Q72233954 | ||
Targeted deletion of the TGF-beta 1 gene causes rapid progression to squamous cell carcinoma | Q72801082 | ||
p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis | Q72874160 | ||
Analysis of Pim-1 function in mutant mice | Q72902867 | ||
The murine N-ras gene is not essential for growth and development | Q34650223 | ||
Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning. | Q34727007 | ||
Gamma delta T cells contribute to immunity against the liver stages of malaria in alpha beta T-cell-deficient mice | Q34957552 | ||
Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells | Q35088549 | ||
Synthetic fibronectin peptides interrupt inflammatory cell infiltration in transforming growth factor beta 1 knockout mice | Q35398178 | ||
Altered natural killer cell repertoire in Tap-1 mutant mice | Q35579938 | ||
Positive selection of self- and alloreactive CD8+ T cells in Tap-1 mutant mice. | Q35580258 | ||
Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in mice | Q35607627 | ||
Calorie restriction delays spontaneous tumorigenesis in p53-knockout transgenic mice | Q35611007 | ||
In vivo analysis of Pim-1 deficiency | Q35859661 | ||
Immune function in mice lacking the perforin gene | Q35882128 | ||
A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity | Q35923516 | ||
Disruption of the compacted myelin sheath of axons of the central nervous system in proteolipid protein-deficient mice | Q35931734 | ||
Lymphocyte proliferation in mice congenitally deficient in T-cell receptor alpha beta + cells | Q35949649 | ||
CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation. | Q35962812 | ||
Normal development and growth of mice carrying a targeted disruption of the alpha 1 retinoic acid receptor gene | Q36116474 | ||
Mice lacking major histocompatibility complex class I and class II molecules | Q36271130 | ||
Osteopetrosis in Src-deficient mice is due to an autonomous defect of osteoclasts. | Q36301037 | ||
RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development | Q36303172 | ||
Fc gamma RII/III and CD2 expression mark distinct subpopulations of immature CD4-CD8- murine thymocytes: in vivo developmental kinetics and T cell receptor beta chain rearrangement status. | Q36361527 | ||
Human CD4-major histocompatibility complex class II (DQw6) transgenic mice in an endogenous CD4/CD8-deficient background: reconstitution of phenotype and human-restricted function. | Q36363974 | ||
Loss of expression of transforming growth factor beta in skin and skin tumors is associated with hyperproliferation and a high risk for malignant conversion | Q36392971 | ||
Cell proliferation, DNA repair, and p53 function are not required for programmed death of prostatic glandular cells induced by androgen ablation | Q36561116 | ||
Transforming growth factor beta 1 (TGF-beta 1) controls expression of major histocompatibility genes in the postnatal mouse: aberrant histocompatibility antigen expression in the pathogenesis of the TGF-beta 1 null mouse phenotype | Q36623685 | ||
Ablation of the prion protein (PrP) gene in mice prevents scrapie and facilitates production of anti-PrP antibodies | Q36663046 | ||
Amino acid substitutions in the floor of the putative antigen-binding site of H-2T22 affect recognition by a gamma delta T-cell receptor | Q36703460 | ||
Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon | Q36703755 | ||
Genetic deletion of a neural cell adhesion molecule variant (N-CAM-180) produces distinct defects in the central nervous system | Q36759141 | ||
The vav proto-oncogene is required early in embryogenesis but not for hematopoietic development in vitro. | Q37693271 | ||
Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages | Q38299607 | ||
Studies on the metabolism of retinol and retinol-binding protein in transthyretin-deficient mice produced by homologous recombination | Q38299796 | ||
Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes. | Q38321834 | ||
Plasminogen activator inhibitor-1 gene-deficient mice. II. Effects on hemostasis, thrombosis, and thrombolysis | Q40305997 | ||
Susceptibility to scrapie in mice is dependent on PrPC. | Q40624594 | ||
Role of the PrP gene in transmissible spongiform encephalopathies | Q40863106 | ||
T cell development in mice lacking the CD3-zeta/eta gene. | Q40874332 | ||
Developmental and functional impairment of T cells in mice lacking CD3 zeta chains. | Q40874338 | ||
P433 | issue | 8 | |
P407 | language of work or name | English | Q1860 |
P304 | page(s) | 873-881 | |
P577 | publication date | 1995-08-01 | |
P1433 | published in | Current Biology | Q1144851 |
P1476 | title | Targeting the mouse genome: a compendium of knockouts (Part III) | |
Targeting the mouse genome: a compendium of knockouts (part III) | |||
P478 | volume | 5 |
Q30498660 | Bioassaying putative RNA-binding motifs in a protein encoded by a gene that influences courtship and visually mediated behavior in Drosophila: in vitro mutagenesis of nonA. |
Q40927692 | Cytokines at the research-clinical interface: potential applications. |
Q91823072 | Development and evolution of the metazoan heart |
Q41099983 | Early mouse development: lessons from gene targeting |
Q77567177 | Efficient repetitive alteration of the mouse Huntington's disease gene by management of background in the tag and exchange gene targeting strategy |
Q33889628 | Expression of the LIM-homeobox gene LH2 generates immortalized steel factor-dependent multipotent hematopoietic precursors. |
Q60287328 | Factors affecting the efficiency of introducing precise genetic changes in ES cells by homologous recombination: tag-and-exchange versus the Cre-loxp system |
Q34303207 | Functional genomics of the murine immune system |
Q30657334 | Gene trap: a way to identify novel genes and unravel their biological function |
Q37576797 | Generation of mice with a 200-kb amyloid precursor protein gene deletion by Cre recombinase-mediated site-specific recombination in embryonic stem cells |
Q41099961 | Mice as models of human developmental disorders: natural and artificial mutants |
Q38008579 | New routes for transgenesis of the mouse |
Q41541408 | PKA isoforms, neural pathways, and behaviour: making the connection |
Q40892666 | Recent advances in transgenic technology |
Q38359006 | Regulation of Cre recombinase activity by the synthetic steroid RU 486. |
Q33885880 | Saturation of the human phenome |
Q40920187 | Site-specific heterodimerization by paired class homeodomain proteins mediates selective transcriptional responses |
Q37532678 | Skin wounds and severed nerves heal normally in mice lacking tenascin-C |
Q34784750 | Stem cells and their clinical application |
Q41462860 | Studies of neoplasia in the Min mouse |
Q24631266 | Targeted transgenesis |
Q41099948 | Transcription factors in disease |
Q73284728 | Use of gene targeting for compromising energy homeostasis in neuro-muscular tissues: the role of sarcomeric mitochondrial creatine kinase |