Study of the Mechanism of TCR Antagonism Using Dual-TCR-Expressing T Cells

scientific article published on May 1, 2003

Study of the Mechanism of TCR Antagonism Using Dual-TCR-Expressing T Cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.4049/JIMMUNOL.170.9.4532
P953full work available at URLhttps://journals.aai.org/jimmunol/article-pdf/170/9/4532/1165178/4532.pdf
P698PubMed publication ID12707330
P5875ResearchGate publication ID10794726

P2093author name stringWen Yang
Howard M. Grey
P2860cites workEvidence for a differential avidity model of T cell selection in the thymusQ45155438
Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptorQ45986774
A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonistsQ46121537
Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands [corrected]Q46842083
An unusual mechanism for ligand antagonismQ47793287
Correlations between T-cell specificity and the structure of the antigen receptorQ48365072
Identification of conserved T cell receptor CDR3 residues contacting known exposed peptide side chains from a major histocompatibility complex class I-bound determinantQ57082205
Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cellsQ59078526
An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitisQ63535314
Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligandQ67903498
Cross-antagonism of a T cell clone expressing two distinct T cell receptorsQ73065666
Inhibition of TCR triggering by a spectrum of altered peptide ligands suggests the mechanism for TCR antagonismQ77530678
Three-dimensional segregation of supramolecular activation clusters in T cellsQ28282528
T cell receptor antagonist peptides induce positive selectionQ29618820
Antigen presentation by Ia+ B cell hybridomas to H-2-restricted T cell hybridomasQ30450024
Selection of the T cell repertoire.Q33652536
Negative selection of CD4+ CD8+ thymocytes by T-cell receptor peptide antagonistsQ35213326
Effect of T-cell receptor antagonism on interaction between T cells and antigen-presenting cells and on T-cell signaling eventsQ36191499
Clone-specific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cellsQ36361774
Dimerization of soluble major histocompatibility complex-peptide complexes is sufficient for activation of T cell hybridoma and induction of unresponsivenessQ36365206
The stimulation of low-affinity, nontolerized clones by heteroclitic antigen analogues causes the breaking of tolerance established to an immunodominant T cell epitopeQ36375353
Potent T cell activation with dimeric peptide-major histocompatibility complex class II ligand: the role of CD4 coreceptorQ36401714
Ligands for the T-cell receptor: hard times for avidity modelsQ40543526
Antigen analogs/MHC complexes as specific T cell receptor antagonistsQ40661137
The relationship of MHC-peptide binding and T cell activation probed using chemically defined MHC class II oligomersQ40831490
Peptide antagonism and T cell receptor interactions with peptide-MHC complexesQ40996486
T-cell-receptor affinity and thymocyte positive selectionQ41192128
Vaccination and protection from a lethal viral infection: identification, incorporation, and use of a cytotoxic T lymphocyte glycoprotein epitopeQ41720879
Altered peptide ligands can control CD4 T lymphocyte differentiation in vivoQ41761641
T cell receptor (TCR) antagonism without a negative signal: evidence from T cell hybridomas expressing two independent TCRsQ41826109
Antigen-specific signaling by a soluble, dimeric peptide/major histocompatibility complex class II/Fc chimera leading to T helper cell type 2 differentiationQ41875914
Tolerance induction in double specific T-cell receptor transgenic mice varies with antigenQ43554100
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectimmunologyQ101929
P304page(s)4532-4538
P577publication date2003-05-01
P1433published inJournal of ImmunologyQ3521441
P1476titleStudy of the mechanism of TCR antagonism using dual-TCR-expressing T cells
Study of the Mechanism of TCR Antagonism Using Dual-TCR-Expressing T Cells
P478volume170

Reverse relations

cites work (P2860)
Q34486338A CD4+ T cell antagonist epitope down-regulates activating signaling proteins, up-regulates inhibitory signaling proteins and abrogates HIV-specific T cell function
Q39611811A unique unresponsive CD4+ T cell phenotype post TCR antagonism
Q36923916Antagonism of HIV-specific CD4+ T cells by C-terminal truncation of a minimum epitope
Q35794602Defining the parameters necessary for T-cell recognition of ligands that vary in potency.
Q38958324On Peptides and Altered Peptide Ligands: From Origin, Mode of Action and Design to Clinical Application (Immunotherapy).
Q36237834Peripheral CD8+ T cell tolerance to self-proteins is regulated proximally at the T cell receptor.
Q37023214Recombinase-activating gene 1-associated expression of the myelin basic protein 1-11-specific transgenic T-cell receptor in H-2b mice
Q36322171T cell receptor antagonism interferes with MHC clustering and integrin patterning during immunological synapse formation
Q24626152T cell recognition of weak ligands: roles of signaling, receptor number, and affinity
Q41774778T-cell activation: A queuing theory analysis at low agonist density
Q30492783T-cell antagonism by short half-life pMHC ligands can be mediated by an efficient trapping of T-cell polarization toward the APC
Q38477340Taming the TCR: antigen-specific immunotherapeutic agents for autoimmune diseases

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