T-cell avidity and tuning: the flexible connection between tolerance and autoimmunity.

scientific article published on May 2006

T-cell avidity and tuning: the flexible connection between tolerance and autoimmunity. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1080/08830180600743081
P932PMC publication ID3462655
P698PubMed publication ID16818373
P5875ResearchGate publication ID6967295

P50authorRosalie M. LuitenQ21264586
Jasper G van den BoornQ125348608
P2093author name stringI Caroline Le Poole
P2860cites workPositive and negative regulation of T-cell activation through kinases and phosphatasesQ24535649
CD8+ T cell immunity against a tumor/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells.Q24540429
Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytesQ24676216
An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritisQ28182995
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune diseaseQ28201947
Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?Q28207052
The danger model: a renewed sense of selfQ28214633
Interplay between TCR affinity and necessity of coreceptor ligation: high-affinity peptide-MHC/TCR interaction overcomes lack of CD8 engagementQ28512242
The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3Q29619324
Probing degeneracy in T-cell recognition using peptide combinatorial librariesQ32064768
Increased TCR avidity after T cell activation: a mechanism for sensing low-density antigenQ32138624
Specificity and degeneracy of T cellsQ33199993
Structural basis of T cell recognitionQ33652495
Selection of the T cell repertoire.Q33652536
Molecular mimicry and autoimmunity.Q33806107
Developmental control of CD8 T cell-avidity maturation in autoimmune diabetesQ33840423
CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapyQ33937501
The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling.Q33958592
Signal transduction mediated by the T cell antigen receptor: the role of adapter proteinsQ34115639
Cross-presentation in viral immunity and self-tolerance.Q34119651
CD4+CD25+ regulatory T cells limit the risk of autoimmune disease arising from T cell receptor crossreactivityQ34161141
The immunological synapse.Q34178149
Antigen bias in T cell cross-primingQ34323408
Autoimmunity provoked by infection: how good is the case for T cell epitope mimicry?Q34348969
T cell response in experimental autoimmune encephalomyelitis (EAE): role of self and cross-reactive antigens in shaping, tuning, and regulating the autopathogenic T cell repertoireQ34542240
The level of CD8 expression can determine the outcome of thymic selectionQ34561055
T-cell regulation by CD28 and CTLA-4.Q34572202
Tuning immune responses: diversity and adaptation of the immunological synapse.Q34650772
T-cell signalling and autoimmunity: molecular mechanisms of diseaseQ34716347
Selection and fine-tuning of the autoimmune T-cell repertoireQ34718125
Molecular interactions mediating T cell antigen recognitionQ35077424
The many important facets of T-cell repertoire diversityQ35709655
New views of the immunological synapse: variations in assembly and functionQ35768909
Breaking tolerance in cancer immunotherapy: time to ACT.Q36070715
Antigen receptor engagement delivers a stop signal to migrating T lymphocytes.Q36107275
Cellular and genetic mechanisms of self tolerance and autoimmunityQ36148399
An unusual lineage of alpha/beta T cells that contains autoreactive cellsQ36230612
Role of CD4 in thymocyte selection and maturationQ36356408
Dual T cell receptor beta chain expression on human T lymphocytesQ36364748
T cell affinity maturation by selective expansion during infectionQ36367796
Perinatal blockade of b7-1 and b7-2 inhibits clonal deletion of highly pathogenic autoreactive T cellsQ36370130
The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's diseaseQ36370178
The Strength of Persistent Antigenic Stimulation Modulates Adaptive Tolerance in Peripheral CD4+ T CellsQ36371739
High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: mechanisms of selection of the self-reactive repertoireQ36376026
Negative selection during the peripheral immune response to antigenQ36376090
Private specificities of CD8 T cell responses control patterns of heterologous immunityQ36403228
T cell receptor (TCR)-mediated repertoire selection and loss of TCR vbeta diversity during the initiation of a CD4(+) T cell response in vivoQ36404561
FOXP3: of mice and men.Q36427333
Specificity and degeneracy of minor histocompatibility antigen-specific MHC-restricted CTL.Q36798073
Self-MHC-restricted peptides recognized by an alloreactive T lymphocyte cloneQ36813012
Adaptive cellular interactions in the immune system: the tunable activation threshold and the significance of subthreshold responsesQ37277286
Molecular mimicry as a mechanism for virus-induced autoimmunityQ38610595
Qualitative difference between the cytotoxic T lymphocyte responses to melanocyte antigens in melanoma and vitiligo.Q40362128
CD8+ T cell cross-priming via transfer of proteasome substratesQ40551130
Optimal colocalization of TCR and CD8 as a novel mechanism for the control of functional avidityQ40702403
A T cell clone's avidity is a function of its activation stateQ40790783
Bm-CPI-2, a cystatin homolog secreted by the filarial parasite Brugia malayi, inhibits class II MHC-restricted antigen processing.Q40812914
Specific T cell recognition of minimally homologous peptides: evidence for multiple endogenous ligandsQ41342616
A kinetic basis for T cell receptor repertoire selection during an immune responseQ41649927
Low avidity recognition of self-antigen by T cells permits escape from central tolerance.Q41671634
Developmental regulation of Lck targeting to the CD8 coreceptor controls signaling in naive and memory T cellsQ41834240
Mature T cell reactivity altered by peptide agonist that induces positive selectionQ41881444
CD8 T cell sensory adaptation dependent on TCR avidity for self-antigens.Q42486766
Fine tuning of TCR signaling by CD5.Q42503170
Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT.Q43566798
Amino acid homology between the encephalitogenic site of myelin basic protein and virus: mechanism for autoimmunityQ44765063
Evidence for a differential avidity model of T cell selection in the thymusQ45155438
Ligand recognition by alpha beta T cell receptorsQ46222293
Continuous T cell receptor signaling required for synapse maintenance and full effector potentialQ46556005
Thymic expression of a gastritogenic epitope results in positive selection of self-reactive pathogenic T cellsQ47644515
Natural recovery and protection from autoimmune encephalomyelitis: contribution of CD4+CD25+ regulatory cells within the central nervous system.Q53846430
The cellular mechanism of Aire control of T cell tolerance.Q55041159
Analysis of a microsatellite polymorphism of the cytotoxic T-lymphocyte antigen-4 gene in patients with vitiligoQ56907304
CD40–CD40Ligand interactions and their role in cytotoxic T lymphocyte priming and anti-tumor immunityQ58235015
Progression of autoimmune diabetes driven by avidity maturation of a T-cell populationQ58328335
Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortexQ59071991
Immunogenicity, Including Vitiligo, and Feasibility of Vaccination With AutologousGM-CSF–Transduced Tumor Cells in Metastatic Melanoma PatientsQ60628792
Association of HLA-DR4 with vitiligoQ70983098
Positive and negative thymocyte selection induced by different concentrations of a single peptideQ72293139
High antigen dose and activated dendritic cells enable Th cells to escape regulatory T cell-mediated suppression in vitroQ73147966
Antigen-presenting cell activation: a link between infection and autoimmunity?Q73831735
TCR avidity: it's not how strong you make it, it's how you make it strongQ74286634
Functional avidity maturation of CD8(+) T cells without selection of higher affinity TCRQ74286685
Adaptive tolerance of CD4+ T cells in vivo: multiple thresholds in response to a constant level of antigen presentationQ74321454
Development and function of autospecific dual TCR+ T lymphocytesQ74527785
A very high level of crossreactivity is an essential feature of the T-cell receptorQ77324273
Inhibition of TCR triggering by a spectrum of altered peptide ligands suggests the mechanism for TCR antagonismQ77530678
Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cellsQ78806915
CD4+ CD25+ regulatory T cells inhibit the maturation but not the initiation of an autoantibody responseQ81245701
Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient miceQ81377810
P433issue3-4
P304page(s)235-258
P577publication date2006-05-01
P1433published inInternational Reviews of ImmunologyQ6052764
P1476titleT-cell avidity and tuning: the flexible connection between tolerance and autoimmunity
P478volume25

Reverse relations

cites work (P2860)
Q51799957Autoimmune destruction of skin melanocytes by perilesional T cells from vitiligo patients.
Q33730136CCR6 is expressed on an IL-10-producing, autoreactive memory T cell population with context-dependent regulatory function
Q37289023Changes in autoreactive T cell avidity during type 1 diabetes development.
Q33586122Effective melanoma immunotherapy in mice by the skin-depigmenting agent monobenzone and the adjuvants imiquimod and CpG.
Q37147938Long-lasting tissue inflammatory processes trigger autoimmune responses to extracellular matrix molecules.
Q37187413Reduced skin homing by functional Treg in vitiligo
Q37412169Relationship between CD8-dependent antigen recognition, T cell functional avidity, and tumor cell recognition
Q37042011Retrogenic modeling of experimental allergic encephalomyelitis associates T cell frequency but not TCR functional affinity with pathogenicity
Q36711556T-cell migration: a naive paradigm?

Search more.